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Gender Related Differences in Gastrointestinal Bleeding With Oral Anticoagulation in Atrial Fibrillation
Gender Related Differences in Gastrointestinal Bleeding With Oral Anticoagulation in Atrial Fibrillation
Background:DOACs are characterized by a higher incidence of gastrointestinal bleeding and this may be different among male...
Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure
Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure
Purpose:Low plasma concentrations of the amino acid homoarginine (HA) have been shown to correlate with adverse cardiovasc...
IV Sodium Ferric Gluconate Complex in Patients Hospitalized Due to Acute Decompensated Heart Failure and Iron Deficiency
IV Sodium Ferric Gluconate Complex in Patients Hospitalized Due to Acute Decompensated Heart Failure and Iron Deficiency
Background:Patients suffering from heart failure (HF) and iron deficiency (ID) have worse outcomes. Treatment with intra-v...
The Efficacy and Safety of Sacubitril/Valsartan in Heart Failure Patients: A Review
The Efficacy and Safety of Sacubitril/Valsartan in Heart Failure Patients: A Review
Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide. Sacubitril/valsartan, an angiotensin...
Vorapaxar for Prevention of Major Adverse Cardiovascular and Limb Events in Peripheral Artery Disease
Vorapaxar for Prevention of Major Adverse Cardiovascular and Limb Events in Peripheral Artery Disease
Peripheral artery disease (PAD) is a severe manifestation of atherosclerosis. Patients with PAD are at heightened risk for...
A Review of Pulmonary Arterial Hypertension Treatment in Extracorporeal Membrane Oxygenation: A Case Series of Adult Patients
A Review of Pulmonary Arterial Hypertension Treatment in Extracorporeal Membrane Oxygenation: A Case Series of Adult Patients
Background:Little data is published describing the use of medications prescribed for pulmonary arterial hypertension (PAH)...
Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial
Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial
Aim:This retrospective cohort study aimed to evaluate the prognostic implications of the distinct atrial fibrillation (AF)...
QT Prolongation in Critically Ill Patients With SARS-CoV-2 Infection
QT Prolongation in Critically Ill Patients With SARS-CoV-2 Infection
Background:Several reports linked the use of repurposed drugs such as hydroxychloroquine (HCQ), azithromycin, lopinavir/ri...
Hydrochlorothiazide Reduces Cardiac Hypertrophy, Fibrosis and Rho-Kinase Activation in DOCA-Salt Induced Hypertension
Hydrochlorothiazide Reduces Cardiac Hypertrophy, Fibrosis and Rho-Kinase Activation in DOCA-Salt Induced Hypertension
Background:Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothia...
Factors Influencing the Selection of Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients With Non-Valvular Atrial Fibrillation
Factors Influencing the Selection of Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients With Non-Valvular Atrial Fibrillation
Background:Major atrial fibrillation (AF) guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) over w...
The β3 Adrenergic Receptor Antagonist L-748,337 Attenuates Dobutamine-Induced Cardiac Inefficiency While Preserving Inotropy in Anesthetized Pigs
The β3 Adrenergic Receptor Antagonist L-748,337 Attenuates Dobutamine-Induced Cardiac Inefficiency While Preserving Inotropy in Anesthetized Pigs
Excessive myocardial oxygen consumption (MVO2) is considered a limitation for catecholamines, termed oxygen cost of contra...
Absent or Mild Coronary Calcium Predicts Low-Risk Stress Test Results and Outcomes in Patients Considered for Flecainide Therapy
Absent or Mild Coronary Calcium Predicts Low-Risk Stress Test Results and Outcomes in Patients Considered for Flecainide Therapy
Background:Flecainide is a useful antiarrhythmic for atrial fibrillation (AF). However, because of ventricular proarrhythm...
Controlling Reperfusion Injury With Controlled Reperfusion: Historical Perspectives and New Paradigms
Controlling Reperfusion Injury With Controlled Reperfusion: Historical Perspectives and New Paradigms
Cardiac reperfusion injury is a well-established outcome following treatment of acute myocardial infarction and other type...
The Role of sGC Stimulators and Activators in Heart Failure With Reduced Ejection Fraction
The Role of sGC Stimulators and Activators in Heart Failure With Reduced Ejection Fraction
Over the past decade, soluble guanylate cyclase (sGC) activators and stimulators have been developed and studied to improv...
Impact of Reticulated Platelets on Platelet Reactivity in Neonates
Impact of Reticulated Platelets on Platelet Reactivity in Neonates
Neonatal megakaryopoiesis and platelet turnover form a developmentally unique pattern by generating a pool of newly releas...
Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats
Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats
Background:Vascular stiffness and endothelial dysfunction are accelerated by acute myocardial infarction (AMI) and subsequ...
Direct Oral Anticoagulants: A Delicate and Dynamic Balance
Direct Oral Anticoagulants: A Delicate and Dynamic Balance
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Cardioprotective and Vasoprotective Effects of Corticotropin-Releasing Hormone and Urocortins: Receptors and Signaling
Cardioprotective and Vasoprotective Effects of Corticotropin-Releasing Hormone and Urocortins: Receptors and Signaling
Despite the recent progress in research and therapy, cardiovascular diseases are still the most common cause of death worl...
Treating Acute Myocardial Infarctions With Anti-Inflammatory Agents
Treating Acute Myocardial Infarctions With Anti-Inflammatory Agents
1. Stone, GW, Selker, HP, Thiele, H, et al. Relationship between infarct size and outcomes following primary PCI: patient-...
Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction
Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction
Although decreased protein kinase G (PKG) activity was proposed as potential therapeutic target in heart failure with pres...
The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart
The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart
While ischemia itself can kill heart muscle, much of the infarction after a transient period of coronary artery occlusion ...
Safety and Efficacy of Triple Therapy With Ticagrelor or Prasugrel Versus Clopidogrel After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Safety and Efficacy of Triple Therapy With Ticagrelor or Prasugrel Versus Clopidogrel After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Background:Patients on dual antiplatelet therapy following percutaneous coronary intervention often have indications for c...
Testosterone Deficiency, Long-Term Testosterone Therapy, and Inflammation
Testosterone Deficiency, Long-Term Testosterone Therapy, and Inflammation
Objectives:We aimed to evaluate the association of testosterone deficiency with inflammation and how long-term testosteron...
Effects of a Novel Oral Testosterone Undecanoate on Ambulatory Blood Pressure in Hypogonadal Men
Effects of a Novel Oral Testosterone Undecanoate on Ambulatory Blood Pressure in Hypogonadal Men
Background:Testosterone replacement therapies may increase blood pressure (BP) with chronic use but the mechanism is not c...
Omega-3 Fatty Acids and Cardiovascular Disease: A Narrative Review for Pharmacists
Omega-3 Fatty Acids and Cardiovascular Disease: A Narrative Review for Pharmacists
Background:Atherosclerotic cardiovascular disease is a significant cause of morbidity and mortality worldwide. While use o...
Prescribing Errors With Direct Oral Anticoagulants and Their Impact on the Risk of Bleeding in Patients With Atrial Fibrillation
Prescribing Errors With Direct Oral Anticoagulants and Their Impact on the Risk of Bleeding in Patients With Atrial Fibrillation
Introduction:Anticoagulants are associated with significant harm when used in error, but there are limited data on potenti...
Targeting the Cholesterol Paradigm in the Risk Reduction for Atherosclerotic Cardiovascular Disease: Does the Mechanism of Action of Pharmacotherapy Matter for Clinical Outcomes?
Targeting the Cholesterol Paradigm in the Risk Reduction for Atherosclerotic Cardiovascular Disease: Does the Mechanism of Action of Pharmacotherapy Matter for Clinical Outcomes?
Hypercholesterolemia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD). Low-density lip...
Association of Body Mass Index With Clinical Outcomes in Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan
Association of Body Mass Index With Clinical Outcomes in Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan
Background:Only limited data are available that address the association between body mass index (BMI) and clinical outcome...
Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Type 1 Cardiorenal Syndrome
Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Type 1 Cardiorenal Syndrome
Introduction:Angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin receptor blocker (ARB) discontinuation during...
ClC-3: A Novel Promising Therapeutic Target for Atherosclerosis
ClC-3: A Novel Promising Therapeutic Target for Atherosclerosis
Chloride channel 3 (ClC-3), a Cl−/H+ antiporter, has been well established as a member of volume-regulated chloride channe...
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