SCI时时刷

search
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Extracellular matrix (ECM) stiffening is a typical characteristic of cartilage aging, which is a quintessential feature of...
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally a...
Splicing regulation through biomolecular condensates and membraneless organelles
Splicing regulation through biomolecular condensates and membraneless organelles
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs), can form through weak multivalent interm...
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based...
Solving the Wnt nuclear puzzle
Solving the Wnt nuclear puzzle
Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear &#...
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border...
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and imp...
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Author notesThese authors contributed equally: Fereshteh Sadat Younesi, Andrew E. Miller.Authors and AffiliationsKeenan Re...
Author Correction: CRISPR technologies for genome, epigenome and transcriptome editing
Author notesThese authors contributed equally: Lukas Villiger, Julia Joung.These authors jointly supervised this work: Oma...
Integrator and U1 snRNPs steer Pol II in the right direction
Integrator and U1 snRNPs steer Pol II in the right direction
Cleavage of promoter-upstream antisense RNAs by the Integrator complex supports the preferential transcription of pre-mRNAs.
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration
Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration
Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without ...
Pannexins in the musculoskeletal system: new targets for development and disease progression
Pannexins in the musculoskeletal system: new targets for development and disease progression
During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication cha...
Epithelial–mesenchymal transition in tissue repair and degeneration
Epithelial–mesenchymal transition in tissue repair and degeneration
Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic development and cancer; du...
Targeted protein degradation: from mechanisms to clinic
Targeted protein degradation: from mechanisms to clinic
Targeted protein degradation refers to the use of small molecules to induce the selective degradation of proteins. In its ...
Fundamentals of redox regulation in biology
Fundamentals of redox regulation in biology
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and...
Is amyloid-β a friend or foe?
Is amyloid-β a friend or foe?
Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to unders...
Translation feedback control in the brain
Translation feedback control in the brain
Stephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiati...
The senescence-associated secretory phenotype and its physiological and pathological implications
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibito...
Is endocytosis by caveolae dependent on dynamin?
Is endocytosis by caveolae dependent on dynamin?
The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
Relaying gasdermin D to the membrane
Relaying gasdermin D to the membrane
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosi...
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Early insights into co-translational assembly of protein complexes
Early insights into co-translational assembly of protein complexes
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the earl...
In memoriam Judy Campisi: spreading cellular senescence
In memoriam Judy Campisi: spreading cellular senescence
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of ...
Mechanical state transitions in the regulation of tissue form and function
Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues und...
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothe...
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the tra...
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivasc...