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The senescence-associated secretory phenotype and its physiological and pathological implications
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibito...
Is endocytosis by caveolae dependent on dynamin?
Is endocytosis by caveolae dependent on dynamin?
The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
Relaying gasdermin D to the membrane
Relaying gasdermin D to the membrane
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosi...
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Early insights into co-translational assembly of protein complexes
Early insights into co-translational assembly of protein complexes
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the earl...
In memoriam Judy Campisi: spreading cellular senescence
In memoriam Judy Campisi: spreading cellular senescence
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of ...
Mechanical state transitions in the regulation of tissue form and function
Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues und...
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothe...
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the tra...
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivasc...
Modelling tauopathies
Modelling tauopathies
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.
A novel photosystem assembly line worker
A novel photosystem assembly line worker
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. de...
Seeing transcription in real time
Seeing transcription in real time
Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenou...
Opportunities and challenges in design and optimization of protein function
Opportunities and challenges in design and optimization of protein function
The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely...
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth ...
Skeletal interoception in osteoarthritis
Skeletal interoception in osteoarthritis
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals afte...
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be...
How ancient RNA survives and what we can learn from it
Although normally transient, RNA can persist postmortem when preserved by cold, desiccation or chemical treatment. In this...
Single-cell live volume measurements using the fluorescence exclusion method
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion met...
Cellular and molecular mechanisms of skin wound healing
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different tissues and cell lineages. It r...
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite ex...
Co-transcriptional gene regulation in eukaryotes and prokaryotes
Co-transcriptional gene regulation in eukaryotes and prokaryotes
Many steps of RNA processing occur during transcription by RNA polymerases. Co-transcriptional activities are deemed commo...
Localized translation in the embryo
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the im...
A code within the genetic code
A code within the genetic code
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and m...
Protein N-terminal acetylation is entering the degradation end game
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation re...
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture
The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating b...
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns
In this Tools of the Trade article, Isomursu (Ivaska lab) describes a new method for dynamic micropatterning, which enable...
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
While hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellu...
A SOX9 switch from regeneration to fibrosis
A SOX9 switch from regeneration to fibrosis
In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the ...
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