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Mechanisms and regulation of human mitochondrial transcription
Mechanisms and regulation of human mitochondrial transcription
The expression of mitochondrial genes is regulated in response to the metabolic needs of different cell types, but the bas...
Mechanisms controlling cellular and systemic iron homeostasis
Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital processes such as mitochon...
Lasker Award for AlphaFold
Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.
Mitochondrial proteome research: the road ahead
Mitochondrial proteome research: the road ahead
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic metabolism, bioenergetics, cellular sign...
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts a...
A quick guide to (transmembrane) planar cell polarity mouse strains
In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains...
Author Correction: The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Author Correction: The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Author notesThese authors contributed equally: Claire Goul, Roberta Peruzzo.Authors and AffiliationsDepartment of Molecula...
Osteomodulin downregulation is associated with osteoarthritis development
Osteomodulin downregulation is associated with osteoarthritis development
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD)...
Machine Learning Approaches for Stem Cells
Machine Learning Approaches for Stem Cells
Machine learning (ML) enables high-throughput analysis of multimodal data generated from stem cell experiments such as gen...
Understanding mechanisms of antioxidant action in health and disease
Understanding mechanisms of antioxidant action in health and disease
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in the development of certain human...
FOXO transcription factors as mediators of stress adaptation
FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mamm...
The discovery of simple repeats that cause complex disorders
Two papers published in 1991 established a new class of human genetic disorders, caused by expansion of simple DNA repeats.
Smelling your way to longevity
The first study to show, in C. elegans, that sensory neurons have a role in lifespan regulation.
Transcription factors crossing the cell membrane
Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochia...
Alternative to lysosomal degradation: mitochondrial removal via EVs
Alternative to lysosomal degradation: mitochondrial removal via EVs
Liang et al. show that mitochondria can be expelled from cells via extracellular vesicles as a route of quality control th...
Mechanisms and pathology of protein misfolding and aggregation
Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how pro...
The double-edged sword of bivalency
Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this ...
Interoceptive regulation of skeletal tissue homeostasis and repair
Interoceptive regulation of skeletal tissue homeostasis and repair
Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process kn...
STINGing through the membrane to channel protons
To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a ...
The neuronal epigenome is special
Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with post...
The translation m(o)TOR that propels regeneration
The translation m(o)TOR that propels regeneration
In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial fo...
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signa...
Control of stem cell renewal and fate by YAP and TAZ
Control of stem cell renewal and fate by YAP and TAZ
Complex physiological processes control whether stem cells self-renew, differentiate or remain quiescent. Two decades of r...
Genetic wrinkles in time
Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolism. As part of mTOR c...
α-parvin controls chondrocyte column formation and regulates long bone development
α-parvin controls chondrocyte column formation and regulates long bone development
Endochondral ossification requires proper control of chondrocyte proliferation, differentiation, survival, and organizatio...
Publisher Correction: Reading, writing and erasing mRNA methylation
Publisher Correction: Reading, writing and erasing mRNA methylation
In the version of this article initially published, there were errors in the pseudouridine (Ψ) structure displayed in the ...
Unbiased mapping of protein trafficking with TransitID
In this Tools of the Trade article, Joleen Cheah (from the Ting lab) discusses the development of TransitID, which allows ...
RNF26 and vimentin orchestrate ER stress recovery
Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinucl...
Has translation in the nucleus found its purpose?
Translation in the nucleus is a long-standing controversial issue with unclear physiological importance. Recent studies sh...
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