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Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration
In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and pl...
Heterochromatin as a balancing act between transcription and gene silencing
Heterochromatin as a balancing act between transcription and gene silencing
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
Long-lived proteomes in healthy ovaries
Long-lived proteomes in healthy ovaries
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby su...
Virus–host warfare by PROTACs
Virus–host warfare by PROTACs
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, ...
The discovery of cyclin-dependent kinases
The discovery of cyclin-dependent kinases
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast,...
Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinuclea...
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging
Bone marrow adipocytes (BMAds) affect bone homeostasis, but the mechanism remains unclear. Here, we showed that exercise i...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Pitfalls in lipid mass spectrometry of mammalian samples — a brief guide for biologists
This Comment discusses erroneous reporting of mass spectrometry analyses of lipids in mammalian samples, and provides reco...
Resolution in super-resolution microscopy — definition, trade-offs and perspectives
Super-resolution microscopy (SRM) is gaining popularity in biosciences; however, claims about optical resolution are conte...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Author Correction: Mechanisms controlling cellular and systemic iron homeostasis
Authors and AffiliationsGerman Cancer Research Center (DKFZ), Division of Virus-associated Carcinogenesis (F170), Heidelbe...
Harnessing the deep learning power of foundation models in single-cell omics
Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require furt...
Identification of RNA structures and their roles in RNA functions
Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has greatly facilitated our ability ...
Retraction Note: Circular RNA circStag1 promotes bone regeneration by interacting with HuR
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development
FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development
Stem/progenitor cells differentiate into different cell lineages during organ development and morphogenesis. Signaling pat...
Author Correction: Fundamentals of redox regulation in biology
Authors and AffiliationsInstitute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University...
Assembly and fission of tubular carriers mediating protein sorting in endosomes
Assembly and fission of tubular carriers mediating protein sorting in endosomes
Endosomes are central protein-sorting stations at the crossroads of numerous membrane trafficking pathways in all eukaryot...
Regulation of cellular and systemic sphingolipid homeostasis
Regulation of cellular and systemic sphingolipid homeostasis
One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual “Sphinx-like” lipids from...
Monitoring subcellular protein localization at scale in live cells
In this Tools of the Trade article, Reiniš and Reicher (Kubicek Lab) describe the development of a multicolour protei...
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP
This study uncovered a link between PI5P, PI5P4Ks and the Hippo pathway, whereby PI5P reinforces the inhibition of YAP, th...
A histone code controls positional identity in limb regeneration
A histone code controls positional identity in limb regeneration
Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves a...
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
This concise review delves into the pivotal role of three-dimensional (3D) nanostructured scaffolds in fostering mesenchym...
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signa...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
SenNet recommendations for detecting senescent cells in different tissues
SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological proces...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Degenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subseq...
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) ...
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