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Voices of the new generation: importance of emotional ‘match’ in mentoring relationships
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships
On the basis of his personal experience, Alexios-Fotios Mentis urges mentor-seekers to consider emotional ‘matchR...
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
This paper briefly describes recent mathematical models that use stochastic and deterministic approaches to understand ste...
Chilling paternal chloroplasts
Chilling paternal chloroplasts
Organelles are normally transmitted to progeny exclusively through the maternal germ line. Chung et al. now describe genet...
Comprehensive overview of microRNA function in rheumatoid arthritis
Comprehensive overview of microRNA function in rheumatoid arthritis
MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have emerged as vital epigenetic regulator...
Younger endogenous retroviruses make us older
Younger endogenous retroviruses make us older
The increased expression of certain human endogenous retroviruses induces the cGAS–STING pathway and drives cell sen...
Voices of the new generation: normalizing career choices outside academia
Voices of the new generation: normalizing career choices outside academia
Although you might not see many academics publicly criticizing non-academic career choices, there is still a clear bias ag...
Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23
Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23
Osteocytes act within a hypoxic environment to control key steps in bone formation. FGF23, a critical phosphate-regulating...
Knee immobilization reproduces key arthrofibrotic phenotypes in mice
Knee immobilization reproduces key arthrofibrotic phenotypes in mice
AimsAs has been shown in larger animal models, knee immobilization can lead to arthrofibrotic phenotypes. Our study includ...
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
AimsAfter a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their ph...
A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses
A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses
AimsArthroplasty surgery of the knee and hip is performed in two to three million patients annually. Periprosthetic joint ...
Instruction of epigenetic states from DNA sequences
Yonatan Stelzer highlights a landmark work from the lab of Howard Cedar that addresses how genome-wide DNA methylation pat...
Metabolites as signalling molecules
Metabolites as signalling molecules
Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becomin...
Anterior cruciate ligament remnant preservation attenuates apoptosis and enhances the regeneration of hamstring tendon graft
Anterior cruciate ligament remnant preservation attenuates apoptosis and enhances the regeneration of hamstring tendon graft
AimsThe effects of remnant preservation on the anterior cruciate ligament (ACL) and its relationship with the tendon graft...
Nuclear pore complexes as clocks of zygotic genome activation
Nuclear pore complexes as clocks of zygotic genome activation
Early zebrafish embryos increase the size and complexity of their nuclear pore complexes, enabling efficient nuclear impor...
A novel G9A–PRC2 complex silences developmental genes in prostate cancer
Fong et al. describe a novel complex that links between H3K9 methylation and H3K27 methylation and has a role in gene sile...
Regulation of axonal regeneration after mammalian spinal cord injury
Regulation of axonal regeneration after mammalian spinal cord injury
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern neuroscience, stated that neurons o...
Hallmarks of peripheral nerve function in bone regeneration
Hallmarks of peripheral nerve function in bone regeneration
Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the cr...
Long non-coding RNAs: definitions, functions, challenges and recommendations
Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term R...
A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories
A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories
Subclassification of tumors based on molecular features may facilitate therapeutic choice and increase the response rate o...
Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression
Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression
Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I collagen, α2-antiplasmin and ...
The role of TGF-beta3 in cartilage development and osteoarthritis
The role of TGF-beta3 in cartilage development and osteoarthritis
Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood vessels, lymphatics and n...
Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing
Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing
Maturation of the 3′ end of almost all eukaryotic messenger RNAs (mRNAs) requires cleavage and polyadenylation. Most...
Characterizing the tumor microenvironment at the single-cell level reveals a novel immune evasion mechanism in osteosarcoma
Characterizing the tumor microenvironment at the single-cell level reveals a novel immune evasion mechanism in osteosarcoma
The immune microenvironment extensively participates in tumorigenesis as well as progression in osteosarcoma (OS). However...
Migrasomes promote angiogenesis
Migrasomes promote angiogenesis
Zhang et al. report that angiogenesis in the chick embryo is supported by migrasomes — recently described organelles...
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins (PFPs) that function as execution...
Transitioning through the continuum of differentiation
Transitioning through the continuum of differentiation
Cockburn et al. report that cells exiting the epidermal stem cell layer show a gradual progression of transcriptional chan...
Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis
Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis
AimsOsteoarthritis (OA) is a common degenerative joint disease worldwide, which is characterized by articular cartilage le...