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Mechanism and regulation of kinesin motors
Mechanism and regulation of kinesin motors
Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental roles in intracellular transport, ...
Metabolic reprogramming in skeletal cell differentiation
Metabolic reprogramming in skeletal cell differentiation
The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and miner...
The discovery of oncogene-induced senescence
The discovery of oncogene-induced senescence
Akiko Takahashi discusses the seminal 1997 paper by Serrano et al. who found that oncogene activation results in a similar...
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small frac...
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness increases susceptibility to dis...
Mechanisms and regulation of substrate degradation by the 26S proteasome
Mechanisms and regulation of substrate degradation by the 26S proteasome
The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a ...
Sorting membrane proteins by size in the Golgi
Sorting membrane proteins by size in the Golgi
De Caestecker and Macara find that the sorting of membrane proteins in the Golgi relies on a size filter that enables corr...
Following the electric current
Following the electric current
Elias Barriga discusses a seminal 2006 paper from Zhao et al., which was the first study to integrate electrotaxis signals...
Proteoforms: a tale of two (initiation) sites
Proteoforms: a tale of two (initiation) sites
mRNAs with alternative in-frame translation initiation sites can yield proteoforms with distinct localization and functions.
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation
In sexually reproducing organisms, life begins with the fusion of transcriptionally silent gametes, the oocyte and sperm. ...
The role and regulation of integrins in cell migration and invasion
The role and regulation of integrins in cell migration and invasion
Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell&...
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonuni...
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall surviv...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
Author Correction: The role of the haematopoietic stem cell niche in development and ageing
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking
Authors and AffiliationsDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel A...
Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels
Authors and AffiliationsDepartment of Molecular Biology, Princeton University, Princeton, NJ, USAJian HuangInstitute of Bi...
Mechanisms of mechanotransduction and physiological roles of PIEZO channels
Mechanisms of mechanotransduction and physiological roles of PIEZO channels
Mechanical force is an essential physical element that contributes to the formation and function of life. The discovery of...
The role of the haematopoietic stem cell niche in development and ageing
The role of the haematopoietic stem cell niche in development and ageing
Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic stem and progenitor cells (HSPCs) tha...
CLASPing and squeezing during cell migration
CLASPing and squeezing during cell migration
This study finds that microtubules act as a mechanostat during cell migration, becoming mechanically reinforced in respons...
Dynamics of DNA replication speeds in single cells
In this Tools of the Trade article, Jeroen van den Berg (van Oudenaarden lab) presents a new method based on pulse-labelli...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed to the dysfunction of nucleu...
Mechanisms of assembly and remodelling of the extracellular matrix
Mechanisms of assembly and remodelling of the extracellular matrix
The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms the scaffold that surrounds and ...
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclast is critical in skeletal development and fracture healing, yet the impact and underlying mechanisms of their met...
Epigenetic gene regulation in plants and its potential applications in crop improvement
Epigenetic gene regulation in plants and its potential applications in crop improvement
DNA methylation, also known as 5-methylcytosine, is an epigenetic modification that has crucial functions in plant growth,...
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due to a range of genetic variants...
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients, effective treatmen...
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