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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
The ability of animal cells to sense, adhere to and remodel their local extracellular matrix (ECM) is central to control o...
The forks guardian
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is important for replication-fork reversal under replication str...
Cell competition in development, homeostasis and cancer
Cell competition in development, homeostasis and cancer
Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue ...
Current understanding of osteoarthritis pathogenesis and relevant new approaches
Current understanding of osteoarthritis pathogenesis and relevant new approaches
Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the...
Persisting through apoptosis
Kalkavan et al. show how drug-tolerant persister cells evade apoptosis by release of sublethal cytochrome c and activation...
Decoding the Ca2+ signal for salt tolerance
Decoding the Ca2+ signal for salt tolerance
Steinhorst et al. show how calcium signal induced by salt stress is ‘decoded’ by plant roots to provide system...
The emerging mechanisms and functions of microautophagy
The emerging mechanisms and functions of microautophagy
‘Autophagy’ refers to an evolutionarily conserved process through which cellular contents, such as damaged org...
Emerging roles and functional mechanisms of PIWI-interacting RNAs
Emerging roles and functional mechanisms of PIWI-interacting RNAs
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with proteins of the PIWI clade of the ...
Mechanisms and roles of podosomes and invadopodia
Mechanisms and roles of podosomes and invadopodia
Cell invasion into the surrounding extracellular matrix or across tissue boundaries and endothelial barriers occurs in bot...
Biomechanics and mechanobiology of the bone matrix
Biomechanics and mechanobiology of the bone matrix
The bone matrix plays an indispensable role in the human body, and its unique biomechanical and mechanobiological properti...
Mechanism of pathogen-induced cap-independent translation in plants
Mechanism of pathogen-induced cap-independent translation in plants
Translation reprogramming in plants in response to innate-immunity induction relies on a novel cap-independent translation...
Regulation of membrane protein structure and function by their lipid nano-environment
Regulation of membrane protein structure and function by their lipid nano-environment
Transmembrane proteins comprise ~30% of the mammalian proteome, mediating metabolism, signalling, transport and many other...
Aneuploidy in mammalian oocytes and the impact of maternal ageing
Aneuploidy in mammalian oocytes and the impact of maternal ageing
During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo...
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles
A long-standing paradigm in molecular biology assumes a direct relationship between increases in mRNA levels and the abund...
A-to-I editing prevents self-RNA sensing
Leilei Chen describes the discovery that adenosine-to-inosine editing by ADAR1 marks endogenous double-stranded RNA as sel...
Advances in Biomaterials for Promoting Vascularization
Advances in Biomaterials for Promoting Vascularization
Tissue engineered constructs (TECs)—commonly developed using natural or synthetic biomaterials—are crucially n...
Septic arthritis in an in vivo murine model induced by Staphylococcus aureus
Septic arthritis in an in vivo murine model induced by Staphylococcus aureus
AimsStaphylococcus aureus is a major cause of septic arthritis, and in vitro studies suggest α haemolysin (Hla) is respons...
Diagnosing periprosthetic joint infections
Diagnosing periprosthetic joint infections
AimsThis study evaluated the definitions developed by the European Bone and Joint Infection Society (EBJIS) 2021, the Inte...
Effectiveness of mechanical cleaning, antibiotics, and induction heating on eradication of Staphylococcus aureus in mature biofilms
Effectiveness of mechanical cleaning, antibiotics, and induction heating on eradication of Staphylococcus aureus in mature biofilms
AimsHere we used a mature seven-day biofilm model of Staphylococcus aureus, exposed to antibiotics up to an additional sev...
Meaningful values of the EQ-5D-3L in patients undergoing primary knee arthroplasty
Meaningful values of the EQ-5D-3L in patients undergoing primary knee arthroplasty
AimsThe aim of this study was to report the meaningful values of the EuroQol five-dimension three-level questionnaire (EQ-...
Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA) remain unknown. No pharmacological ...
Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration
Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration
The restoration of bone defects caused by osteoporosis remains a challenge for surgeons. Strontium ranelate has been appli...
Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Ammonia plays an important role in cellular metabolism. However, ammonia is considered a toxic product. In bone marrow-der...
Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation
Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation
Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in...
To fuse or to divide, that was the question
Elizabeth Chen looks back on the work by Beatrice Mintz and Wilber Baker (1967) that settled the debate on the origin of m...
Re-evaluate evaluation letters — set scientists free!
Re-evaluate evaluation letters — set scientists free!
Academia’s dependence on evaluation letters is toxic. Scientists know that bad letters might derail their career or ...
Regulation, functions and transmission of bivalent chromatin during mammalian development
Regulation, functions and transmission of bivalent chromatin during mammalian development
Cells differentiate and progress through development guided by a dynamic chromatin landscape that mediates gene expression...