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RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
Authors and AffiliationsLaboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer In...
The intraflagellar transport cycle
The intraflagellar transport cycle
Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular signalling and motility. Intrafl...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
Bone loss with aging is independent of gut microbiome in mice
Bone loss with aging is independent of gut microbiome in mice
Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial fact...
Transcription regulation by biomolecular condensates
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic mod...
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
Osteonecrosis of the femoral head (ONFH) is a common complication of glucocorticoid (GC) therapy. Recent advances demonstr...
Homeostasis control in health and disease by the unfolded protein response
Homeostasis control in health and disease by the unfolded protein response
Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized transmembrane and secretory proteins &...
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
Osteoarthritis (OA) is an age-related cartilage-degenerating joint disease. Mitochondrial dysfunction has been reported to...
Epigenetic discovery by enzyme activity profiling
C. David Allis’s discovery of the first histone acetyltransferase from Tetrahymena exemplifies an approach ...
When senescence generates pluripotent stem cells
When senescence generates pluripotent stem cells
Senescent cells in the amputated head of the cnidarian Hydractinia symbiolongicarpus drive the reprogramming of somatic ce...
The double-edged sword of eliminating senescent cells
The double-edged sword of eliminating senescent cells
Removal of different types of senescent cells can be either beneficial or detrimental to health, with potential consequenc...
A nuclear morphology-based machine learning algorithm for senescence detection
A nuclear morphology-based machine learning algorithm for senescence detection
In this Tools of the Trade article, Duran (Gil lab) describes the development of novel machine learning algorithms that en...
The prompt to discover senolytics
The prompt to discover senolytics
James Kirkland discusses how work by Norman Sharpless and colleagues, published in 2004, paved the way for the development...
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
RNA modifications are essential for human health — too much or too little of them leads to serious illnesses ranging...
Molecular mechanisms of mitochondrial dynamics
Molecular mechanisms of mitochondrial dynamics
Mitochondria not only synthesize energy required for cellular functions but are also involved in numerous cellular pathway...
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Osteopetrosis is an inherited metabolic disease, characterized by increased bone density and narrow marrow cavity. Patient...
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture ris...
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing
Raffaella Di Micco discusses the importance of a 2020 study in which CAR-T cells were engineered to eliminate senescent ce...
IL-11 as a master regulator of ageing
IL-11 as a master regulator of ageing
Ana O’Loghlen highlights a recent study that indicates that inhibiting the pro-inflammatory cytokine IL-11 has anti-...
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significa...
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Myeloid cells are pivotal in the inflammatory and remodeling phases of fracture repair. Here, we investigate the effect of...
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly i...
Molecular tools for analysing in vivo senescence
Molecular tools for analysing in vivo senescence
Enrichment of senescent cells from organs holds great promise for studying cell senescence and ageing, and for identifying...
Mechanism and regulation of kinesin motors
Mechanism and regulation of kinesin motors
Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental roles in intracellular transport, ...
Metabolic reprogramming in skeletal cell differentiation
Metabolic reprogramming in skeletal cell differentiation
The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and miner...
The discovery of oncogene-induced senescence
The discovery of oncogene-induced senescence
Akiko Takahashi discusses the seminal 1997 paper by Serrano et al. who found that oncogene activation results in a similar...
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small frac...
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness increases susceptibility to dis...
Mechanisms and regulation of substrate degradation by the 26S proteasome
Mechanisms and regulation of substrate degradation by the 26S proteasome
The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a ...
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