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T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive, heterogenous hematopoetic malignancies with poor long-term prognosis. T-cel...
Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma
Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma
Circular RNAs (circRNAs), pivotal in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), remain a signific...
Identification of hub genes and diagnostic efficacy for triple-negative breast cancer through WGCNA and Mendelian randomization
Identification of hub genes and diagnostic efficacy for triple-negative breast cancer through WGCNA and Mendelian randomization
Triple-negative breast cancer (TNBC) represents a particularly aggressive form of breast cancer with a poor prognosis due ...
A combination of cuproptosis and lncRNAs predicts the prognosis and tumor immune microenvironment in cervical cancer
A combination of cuproptosis and lncRNAs predicts the prognosis and tumor immune microenvironment in cervical cancer
Cuproptosis induces proteotoxic stress and eventually leads to cell death. However, the relationship between cuproptosis a...
Application value of intraoperative electrophysiological monitoring in cerebral eloquent area glioma surgery: a retrospective cohort study
Application value of intraoperative electrophysiological monitoring in cerebral eloquent area glioma surgery: a retrospective cohort study
Surgery for gliomas involving eloquent areas is a very challenging microsurgical procedure. Maximizing both the extent of ...
Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review
Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review
Bladder cancer is one of the most frequent malignant tumors of the urinary system. The prevalence of bladder cancer among ...
Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma
Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma
Dysregulation of iron metabolism has been shown to have significant implications for cancer development. We aimed to inves...
DSCAM-AS1 promotes the development of prostate cancer
DSCAM-AS1 promotes the development of prostate cancer
The purpose of this study was to investigate the role of lncRNA DSCAM-AS1 in prostate cancer to find new therapeutic targe...
Bilateral adrenal neuroblastoma: peculiar pattern of a rare pediatric presentation
Bilateral adrenal neuroblastoma: peculiar pattern of a rare pediatric presentation
Bilateral suprarenal neuroblastoma (BSN) is a rare presentation. Few previously published literature showed BSN patients t...
Diagnostic value of circulating tumor cells in patients with thyroid cancer: a retrospective study of 1478 patients
Diagnostic value of circulating tumor cells in patients with thyroid cancer: a retrospective study of 1478 patients
Circulating tumor cell (CTC) detection is one form of liquid biopsy. It is a novel technique that is beginning to be appli...
L-cysteine contributes to destructive activities of odontogenic cysts/tumor
L-cysteine contributes to destructive activities of odontogenic cysts/tumor
Odontogenic cysts/tumor can cause severe bone destruction, which affects maxillofacial function and aesthetics. Meanwhile,...
Relationship of mTORC1 and ferroptosis in tumors
Relationship of mTORC1 and ferroptosis in tumors
Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracell...
Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological...
Efficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma
Efficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma
The combination of rituximab and chemotherapy is a first-line treatment for patients with B-cell non-Hodgkin lymphoma. Len...
BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1
BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1
Ferroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-co...
Development of chitosan-folate modified PLGA nanoparticles for targeted delivery of diosgenin as an anticancer agent
Development of chitosan-folate modified PLGA nanoparticles for targeted delivery of diosgenin as an anticancer agent
Diosgenin as a potential phytoconstituent and steroidal saponin manifested significant anticancer agents against ...
Cyclovirobuxine D inhibits hepatocellular carcinoma growth by inducing ferroptosis of hepatocellular carcinoma cells
Cyclovirobuxine D inhibits hepatocellular carcinoma growth by inducing ferroptosis of hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is one cancer with high death rates. Nowadays, there are no effective drugs to treat it. Cy...
The combined effect of MTHFR C677T and A1298C polymorphisms on the risk of digestive system cancer among a hypertensive population
The combined effect of MTHFR C677T and A1298C polymorphisms on the risk of digestive system cancer among a hypertensive population
The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in directing folate species towards nucleotide...
The predictive value of NLR, PLR and MLR in the differential diagnosis of benign uterine diseases and endometrial malignant tumors
The predictive value of NLR, PLR and MLR in the differential diagnosis of benign uterine diseases and endometrial malignant tumors
To explore the application of neutrophils to lymphocytes ratio (NLR), platelet to lymphocyte ratio (PLR) and monocyte to l...
Heterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy
Heterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy
AT-rich interaction domain 1A (ARID1A) mutant tumors show active anti-tumor immune response, which is the potential indica...
Repression of LSD1/KDM1A activity improves the response of liver cancer cells to the lenvatinib
Repression of LSD1/KDM1A activity improves the response of liver cancer cells to the lenvatinib
Lenvatinib, a multikinase inhibitor, has become a second-line treatment option for unresectable liver cancer, while its mo...
Circ_0020460 drives tumorigenesis in cervical cancer through miR-485-3p sponging
Circ_0020460 drives tumorigenesis in cervical cancer through miR-485-3p sponging
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the rol...
Mechanism of regulation of KIF23 on endometrial cancer cell growth and apoptosis
Mechanism of regulation of KIF23 on endometrial cancer cell growth and apoptosis
The global incidence of endometrial cancer, a malignant tumor in females, is on the rise. It is one of the most common gyn...
Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure
Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure
Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current ...
Circular RNA circCHSY1 silencing inhibits the malignant progression of esophageal squamous cell carcinoma
Circular RNA circCHSY1 silencing inhibits the malignant progression of esophageal squamous cell carcinoma
CircRNAs play a crucial role in the regulation of various cancers. This study aims to investigate the involvement of circC...
Excluding external iliac node irradiation during neoadjuvant radiotherapy decreases lower intestinal toxicity without compromising efficacy in T4b rectal cancer patients with tumours involving the anterior structures
Excluding external iliac node irradiation during neoadjuvant radiotherapy decreases lower intestinal toxicity without compromising efficacy in T4b rectal cancer patients with tumours involving the anterior structures
To explore the impact of excluding the external iliac node (EIN) from the clinical target volume (CTV) during preoperative...
GALNT2 targeted by miR-139-5p promotes proliferation of clear cell renal cell carcinoma via inhibition of LATS2 activation
GALNT2 targeted by miR-139-5p promotes proliferation of clear cell renal cell carcinoma via inhibition of LATS2 activation
Polypeptide N-Acetylgalactosaminyltransferase (GALNTs) are critical enzymes that initiate mucin type-O glycosylation, and ...
Role of long non-coding RNA ELFN1-AS1 in carcinogenesis
Role of long non-coding RNA ELFN1-AS1 in carcinogenesis
As one of the leading causes of death worldwide, cancer significantly burdens patients and the healthcare system. The role...
Transcriptome and single-cell transcriptomics reveal prognostic value and potential mechanism of anoikis in skin cutaneous melanoma
Transcriptome and single-cell transcriptomics reveal prognostic value and potential mechanism of anoikis in skin cutaneous melanoma
Skin cutaneous melanoma (SKCM) is a highly lethal cancer, ranking among the top four deadliest cancers. This underscores t...
Transarterial chemoembolization with/without immune checkpoint inhibitors plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: a single center, propensity score matching real-world study
Transarterial chemoembolization with/without immune checkpoint inhibitors plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: a single center, propensity score matching real-world study
To explore the efficacy and safety of Transarterial chemoembolization (TACE) in combination with immune checkpoint inhibit...
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