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Integrative analysis reveals the potential prognostic roles and immunological values of unc-5 netrin receptor A (UNC5A) in glioma
Integrative analysis reveals the potential prognostic roles and immunological values of unc-5 netrin receptor A (UNC5A) in glioma
UNC5A had been reported to play crucial roles in multiple cancers. However, little was known about the associations among ...
Ataxin-2: a powerful RNA-binding protein
Ataxin-2: a powerful RNA-binding protein
Ataxin-2 (ATXN2) was originally discovered in the context of spinocerebellar ataxia type 2 (SCA2), but it has become a key...
The roles of FGFR3 and c-MYC in urothelial bladder cancer
The roles of FGFR3 and c-MYC in urothelial bladder cancer
Bladder cancer is one of the most frequently occurring cancers worldwide. At diagnosis, 75% of urothelial bladder cancer c...
Angiogenesis related genes based prognostic model of glioma patients developed by multi-omics approach
Angiogenesis related genes based prognostic model of glioma patients developed by multi-omics approach
Glioma, particularly glioblastoma (GBM), is a highly malignant brain tumor with poor prognosis despite current therapeutic...
Cellular and molecular events in colorectal cancer: biological mechanisms, cell death pathways, drug resistance and signalling network interactions
Cellular and molecular events in colorectal cancer: biological mechanisms, cell death pathways, drug resistance and signalling network interactions
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, affecting millions each year. It emerges fr...
Neutrophil extracellular traps-related lncRNAs prognostic signature for gastric cancer and immune infiltration: potential biomarkers for predicting overall survival and clinical therapy
Neutrophil extracellular traps-related lncRNAs prognostic signature for gastric cancer and immune infiltration: potential biomarkers for predicting overall survival and clinical therapy
Gastric cancer (GC) is one of the most common digestive tract malignant tumors in the world. At the time of initial diagno...
Investigating the effect of Fusobacterium nucleatum on the aggressive behavior of cancer-associated fibroblasts in colorectal cancer
Investigating the effect of Fusobacterium nucleatum on the aggressive behavior of cancer-associated fibroblasts in colorectal cancer
Fusobacterium nucleatum, (F. nucleatum) as a known factor in inducing oncogenic, invasive, and inflammatory responses, can...
The chemokine CCL14 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma
The chemokine CCL14 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma
Chemokine ligand 14, which has a C–C motif (CCL14), mediates the immunological milieu around tumors. However, its ro...
Mapping alternative splicing events in colorectal cancer
Mapping alternative splicing events in colorectal cancer
Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CR...
The regulatory mechanism of m6A modification in gastric cancer
The regulatory mechanism of m6A modification in gastric cancer
To the best of our knowledge, N6-Methyladenosine (m6A) exerts a significant role in the occurrence and development of vari...
Construction and assessment of an angiogenesis-related gene signature for prognosis of head and neck squamous cell carcinoma
Construction and assessment of an angiogenesis-related gene signature for prognosis of head and neck squamous cell carcinoma
Angiogenesis-associated genes (AAGs) play a critical role in cancer patient survival. However, there are insufficient repo...
AURKB promotes immunogenicity and immune infiltration in clear cell renal cell carcinoma
AURKB promotes immunogenicity and immune infiltration in clear cell renal cell carcinoma
Chromatin regulators (CRs) are capable of causing epigenetic alterations, which are significant features of cancer. Howeve...
Establishing an oxidative stress mitochondria-related prognostic model in hepatocellular carcinoma based on multi-omics characteristics and machine learning computational framework
Establishing an oxidative stress mitochondria-related prognostic model in hepatocellular carcinoma based on multi-omics characteristics and machine learning computational framework
Hepatocellular carcinoma (HCC) has high incidence and mortality rates worldwide. Damaged mitochondria are characterized by...
Clinical and structural insights into the rare but oncogenic HER2-activating missense mutations in non-small cell lung cancer: a retrospective ATLAS cohort study
Clinical and structural insights into the rare but oncogenic HER2-activating missense mutations in non-small cell lung cancer: a retrospective ATLAS cohort study
Unlike human epidermal growth factor receptor 2 (HER2) amplification or exon 20 insertions, missense mutations in the extr...
Identification of hub genes and potential molecular mechanisms in MSS/MSI classifier primary colorectal cancer based on multiple datasets
Identification of hub genes and potential molecular mechanisms in MSS/MSI classifier primary colorectal cancer based on multiple datasets
MSI has a better prognosis than MSS in colorectal cancer patients, and the main objective of this study was to screen for ...
Application of CAR-T cell therapy targeting mesothelin in solid tumor treatment
Application of CAR-T cell therapy targeting mesothelin in solid tumor treatment
Chimeric antigen receptor (CAR)-T-cell therapy is one of the most effective immunotherapies. CAR-T-cell therapy has achiev...
The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis
The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis
LOXL2, an enzyme belonging to the LOX family, facilitates the cross-linking of extracellular matrix (ECM) elements. Howeve...
Comprehensive bioinformatics analysis of integrator complex subunits: expression patterns, immune infiltration, and prognostic signature, validated through experimental approaches in hepatocellular carcinoma
Comprehensive bioinformatics analysis of integrator complex subunits: expression patterns, immune infiltration, and prognostic signature, validated through experimental approaches in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common gastrointestinal malignancy with a high incidence and poor prognosis. The subun...
Understanding the heterogeneity in liver hepatocellular carcinoma with a special focus on malignant cell through single-cell analysis
Understanding the heterogeneity in liver hepatocellular carcinoma with a special focus on malignant cell through single-cell analysis
Hepatocellular carcinoma (HCC) is the most common form of liver cancer globally and remains a major cause of cancer-relate...
Diagnostic value of immune-related biomarker FAM83A in differentiating malignant from benign pleural effusion in lung adenocarcinoma
Diagnostic value of immune-related biomarker FAM83A in differentiating malignant from benign pleural effusion in lung adenocarcinoma
Malignant pleural effusion (MPE) is frequently observed in patients with advanced lung adenocarcinoma (LUAD). Pleural flui...
The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer
The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer
The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal can...
miR-200a-3p promotes the malignancy of endometrial carcinoma through negative regulation of epithelial-mesenchymal transition
miR-200a-3p promotes the malignancy of endometrial carcinoma through negative regulation of epithelial-mesenchymal transition
miR-200a-3p is involved in the progression of malignant behavior in various tumors, and its mechanism of action in endomet...
BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the ...
Establishment and validation of a novel disulfidptosis-related immune checkpoint gene signature in clear cell renal cell carcinoma
Establishment and validation of a novel disulfidptosis-related immune checkpoint gene signature in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal tumors and is associated with a unfavorable...
Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
Pancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside ...
Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq
Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq
CD8+ T lymphocytes are critical in the immune response against neoplasms, yet the prognostic relevance of CD8+ ...
DcR3-associated risk score: correlating better prognosis and enhanced predictive power in colorectal cancer
DcR3-associated risk score: correlating better prognosis and enhanced predictive power in colorectal cancer
Decoy receptor 3 (DcR3), a novel soluble protein belonging to the tumor necrosis factor receptor (TNFR) family, has been p...
Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
The prognosis for Cutaneous Melanoma (CM), a skin malignant tumor that is extremely aggressive, is not good. A recently id...
Exploring prognostic values of DNA ploidy, stroma-tumor fraction and nucleotyping in stage II colon cancer patients
Exploring prognostic values of DNA ploidy, stroma-tumor fraction and nucleotyping in stage II colon cancer patients
To assess the prognostic value of three novel biomarkers, DNA ploidy, stroma-tumor fraction, and nucleotyping, seeking for...
Resection of intrahepatic cholangiocarcinoma in octogenarians: a single-center analysis
Resection of intrahepatic cholangiocarcinoma in octogenarians: a single-center analysis
The rapidly aging population in industrialized countries comes with an increased incidence of intrahepatic cholangiocarcin...
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