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SLC1A3 is a novel prognostic biomarker associated with immunity and EMT in hepatocellular carcinoma
SLC1A3 is a novel prognostic biomarker associated with immunity and EMT in hepatocellular carcinoma
Solute carrier family 1 member 3(SLC1A3), a member of the glutamate transporter family, is implicated in the progression o...
Aberrant expression of MRAS and HEG1 as the biomarkers for osimertinib resistance in LUAD
Aberrant expression of MRAS and HEG1 as the biomarkers for osimertinib resistance in LUAD
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the most applied targeted therapy for EGFR-m...
Causal relationship between immune cells and acute myeloid leukemia: a two-sample Mendelian randomization study
Causal relationship between immune cells and acute myeloid leukemia: a two-sample Mendelian randomization study
Immune cells are crucial in the etiology of acute myeloid leukemia (AML). Given the genetic, epigenetic, and clonal comple...
Identification and validation of a novel prognostic signature and key genes related to development of anaplastic thyroid carcinoma
Identification and validation of a novel prognostic signature and key genes related to development of anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a rare but the most aggressive type of thyroid carcinoma. Nevertheless, limited adva...
GLN2 as a key biomarker and therapeutic target: evidence from a comprehensive pan-cancer study using molecular, functional, and bioinformatic analyses
GLN2 as a key biomarker and therapeutic target: evidence from a comprehensive pan-cancer study using molecular, functional, and bioinformatic analyses
GNL2, a nuclear protein, is involved in ribosome production and cell cycle regulation. However, its expression and functio...
Targeting ferroptosis reveals a new strategy for breast cancer treatment: a bibliometric study
Targeting ferroptosis reveals a new strategy for breast cancer treatment: a bibliometric study
Studies exploring the role of ferroptosis in the pathogenesis of breast cancer have proliferated over the past decade, esp...
Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors
Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors
Although oxidative stress is strongly connected to the initiation and progression of cancer, the underlying molecular path...
Pyroptosis-related lncRNAs are potential biomarkers for predicting prognoses and immune landscapes in patients with gastric adenocarcinoma
Pyroptosis-related lncRNAs are potential biomarkers for predicting prognoses and immune landscapes in patients with gastric adenocarcinoma
The purpose of this study was to investigate the significance of pyroptosis-related lncRNAs (PRlncRNA) in predicting progn...
Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study
Prognostic analysis of early-onset and late-onset nasopharyngeal carcinoma: a retrospective study
There are few studies on early-onset and late-onset nasopharyngeal cancer (EONPC and LONPC, defined as cancers in those ag...
KLF4 promotes cisplatin resistance by activating mTORC1 signaling in ovarian cancer
KLF4 promotes cisplatin resistance by activating mTORC1 signaling in ovarian cancer
Ovarian cancer (OC) is a highly fatal gynecological malignancy worldwide, and cisplatin (CDDP) is commonly used as an init...
Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance
Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance
The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development and progres...
The potential of kaempferol in digestive system tumors: recent advances and mechanistic insights
The potential of kaempferol in digestive system tumors: recent advances and mechanistic insights
Digestive system neoplasms are a heterogeneous group of cancers characterized by diverse symptoms, complex diagnosis, and ...
Research trends, hotspots and future directions of tertiary lymphoid structures in cancer: a comprehensive informatics analysis and visualization study
Research trends, hotspots and future directions of tertiary lymphoid structures in cancer: a comprehensive informatics analysis and visualization study
Many studies have reported the presence of tertiary lymphoid structures (TLSs) in cancer, but the research progress of TLS...
Single-cell expression and immune infiltration analysis of polyamine metabolism in breast cancer
Single-cell expression and immune infiltration analysis of polyamine metabolism in breast cancer
Breast cancer is one of the most threatening women health diseases worldwide and its molecular heterogeneity offers a rang...
SLITRK2 as a prognostic and immunological biomarker in gastric cancer
SLITRK2 as a prognostic and immunological biomarker in gastric cancer
SLIT and NTRK-like protein 2 (SLITRK2) encodes a transmembrane protein that regulates neurite outgrowth. Some studies have...
Construction of a novel lipid drop-mitochondria-associated genetic profile for predicting the survival and prognosis of lung adenocarcinoma
Construction of a novel lipid drop-mitochondria-associated genetic profile for predicting the survival and prognosis of lung adenocarcinoma
Lung adenocarcinoma (LUAD) is one of the most common malignant tumors. Although several treatments have been proposed, the...
TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells
TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells
Ferroptosis and inflammation are involved in cancer progression. The aim of this study was to identify inflammation-associ...
Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study
Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study
We aimed to examine the importance of an lncRNA, namely LINC00852, in the pathogenesis of breast cancer. In the current st...
Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcoma
Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcoma
Osteosarcoma (OSA) is a primary bone malignancy characterized by its aggressive nature and high propensity for metastasis....
Multi-omics analysis reveals the role of the autophagy-related gene AGT in chemotherapy resistance in colorectal cancer and the therapeutic potential of its inhibitors
Multi-omics analysis reveals the role of the autophagy-related gene AGT in chemotherapy resistance in colorectal cancer and the therapeutic potential of its inhibitors
Autophagy is a crucial mechanism for maintaining cellular homeostasis and responding to environmental stress, and it is cl...
Circ_0124346 facilitates cell proliferation of pancreatic adenocarcinoma cells by regulating lipid metabolism via miR-223-3p/ACSL3 axis
Circ_0124346 facilitates cell proliferation of pancreatic adenocarcinoma cells by regulating lipid metabolism via miR-223-3p/ACSL3 axis
Both lipid metabolism and cyclic RNAs (circRNAs) have been found to be involved in pancreatic adenocarcinoma (PAAD) progre...
ATP6V1C1, associated with the tumor microenvironment and mTORC1 signaling pathway, is a potential diagnostic, prognostic, and therapeutic biomarker for hepatocellular carcinoma
ATP6V1C1, associated with the tumor microenvironment and mTORC1 signaling pathway, is a potential diagnostic, prognostic, and therapeutic biomarker for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a global health challenge with high mortality. ATP6V1C1, one of the subunit genes of vac...
Radiotherapy in patients with brain metastases with and without concomitant immunotherapy: comparison of patient outcome and neurotoxicity
Radiotherapy in patients with brain metastases with and without concomitant immunotherapy: comparison of patient outcome and neurotoxicity
Recently, immune checkpoint inhibitors (ICI) have been added to the treatment of brain metastases. While combining radioth...
Enhancing antitumor activity of herceptin in HER2-positive breast cancer cells: a novel DNMT-1 inhibitor approach
Enhancing antitumor activity of herceptin in HER2-positive breast cancer cells: a novel DNMT-1 inhibitor approach
HER2 antagonists remain the cornerstone of therapy for patients with HER2-positive breast cancer. This study introduces a ...
Expression of the lncRNA TPT1-AS1 in lung squamous cell carcinoma and its prognostic value
Expression of the lncRNA TPT1-AS1 in lung squamous cell carcinoma and its prognostic value
Lung squamous cell carcinoma is typically associated with a poor prognosis, highlighting the need for a reliable prognosti...
Identification of a coagulation-related gene signature for predicting prognosis in recurrent glioma
Identification of a coagulation-related gene signature for predicting prognosis in recurrent glioma
Recurrent gliomas rapidly progress and have high mortality and poor prognosis in the central nervous system. Therefore, fu...
Polymer-drug conjugates: revolutionizing nanotheranostic agents for diagnosis and therapy
Polymer-drug conjugates: revolutionizing nanotheranostic agents for diagnosis and therapy
Nanotheranostics, an amalgamation of therapeutic and diagnostic capabilities at the nanoscale, is revolutionizing personal...
Circ_0001741 exerts as a tumor promoter in ovarian cancer through the regulation of miR-491-5p/PRSS8 axis
Circ_0001741 exerts as a tumor promoter in ovarian cancer through the regulation of miR-491-5p/PRSS8 axis
Circular RNAs (circRNAs) are important regulators for ovarian cancer (OC). Circ_0001741 has been found to be highly expres...
Enrichment of cancer stem cell subpopulation alters the glycogene expression profile of colorectal cancer cells
Enrichment of cancer stem cell subpopulation alters the glycogene expression profile of colorectal cancer cells
Colorectal cancer (CRC) has a high mortality rate, resulting from the processes of metastasis and disease recurrence. Canc...
Late side effects of testicular cancer and treatment: a comprehensive review
Late side effects of testicular cancer and treatment: a comprehensive review
Testicular cancer is a rare solid organ tumour associated with high cure rates and young age at diagnosis, hence it has a ...
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