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Identifying therapeutic target for prostate cancer: exploring Diosmetin as a CYP inhibitor
Identifying therapeutic target for prostate cancer: exploring Diosmetin as a CYP inhibitor
Prostate cancer is a prevalent and highly heterogeneous malignancy that affects men globally. Despite the availability of ...
Efficacy and prognostic factors of anti-PD1 and nivolumab-ipilimumab therapy in advanced melanoma patients resistant to prior ICI treatment
Efficacy and prognostic factors of anti-PD1 and nivolumab-ipilimumab therapy in advanced melanoma patients resistant to prior ICI treatment
Immune checkpoint inhibitors (ICIs) have significantly improved the five-year survival rate for advanced melanoma. However...
Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization
Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization
Previous clinical studies have suggested an increased risk of tumor development in patients with pulmonary arterial hypert...
Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer
Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer
High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic ta...
Prediction of prognosis, efficacy of lung adenocarcinoma by machine learning model based on immune and metabolic related genes
Prediction of prognosis, efficacy of lung adenocarcinoma by machine learning model based on immune and metabolic related genes
The aim of this study is to integrate immune and metabolism-related genes in order to construct a predictive model for pre...
Developmental trends and knowledge frameworks in the application of radiomics in prostate cancer: a bibliometric analysis from 2000 to 2024
Developmental trends and knowledge frameworks in the application of radiomics in prostate cancer: a bibliometric analysis from 2000 to 2024
This research utilized the bibliometrics method to analyze the published literature related to prostate cancer (PCa) imagi...
Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression
Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression
TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents ...
A rare case of huge intracranial yolk sac tumor presenting as an orbital mass in an infant: case report and literature review
A rare case of huge intracranial yolk sac tumor presenting as an orbital mass in an infant: case report and literature review
Primary intracranial yolk sac tumor (YST) with orbital involvement is an exceedingly rare extragonadal germ cell tumor, wi...
Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value
Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value
Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked t...
RGD peptide-conjugated polydopamine nanoparticles loaded with doxorubicin for combined chemotherapy and photothermal therapy in thyroid cancer
RGD peptide-conjugated polydopamine nanoparticles loaded with doxorubicin for combined chemotherapy and photothermal therapy in thyroid cancer
To construct polydopamine (PDA)-based nanoparticles (NPs) for combined chemotherapy (CT) and photothermal therapy (PTT) of...
Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI
Differentiating clinically significant prostate cancer from clinically insignificant prostate cancer using qualitative and semi-quantitative indices of dynamic contrast-enhanced MRI
To investigate the utility of qualitative and semi-quantitative evaluation of DCE-MRI for detecting clinically significant...
Circular RNA NINL accelerates the malignant progression of cervical cancer
Circular RNA NINL accelerates the malignant progression of cervical cancer
The study’s aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC). Tumor tissue...
Unraveling the causal relationship and potential mechanisms between osteoarthritis and breast cancer: insights from mendelian randomization and bioinformatics analysis
Unraveling the causal relationship and potential mechanisms between osteoarthritis and breast cancer: insights from mendelian randomization and bioinformatics analysis
To investigate the effect of osteoarthritis (OA) on the development of breast cancer (BC), and reveal the potential mechan...
The landscape in telomere related gene prognostic signature for survival and medication treatment effectiveness prediction in hepatocellular carcinoma
The landscape in telomere related gene prognostic signature for survival and medication treatment effectiveness prediction in hepatocellular carcinoma
Telomeres, made of repetitive DNA sequences and shelterin complexes, which were found at the ends of chromosomes and had b...
Enhancing CD4+/CD8+ T cell ratio and accelerating recovery in HNSCC patients through immunonutrition intervention
Enhancing CD4+/CD8+ T cell ratio and accelerating recovery in HNSCC patients through immunonutrition intervention
Malnutrition is a common issue in patients with head and neck squamous cell carcinoma (HNSCC), leading to compromised immu...
Revolutionizing cancer treatment: the rise of personalized immunotherapies
Revolutionizing cancer treatment: the rise of personalized immunotherapies
Interest in biological therapy for cancer has surged due to its precise targeting of cancer cells and minimized impact on ...
Identification of gastric cancer subtypes based on disulfidptosis-related genes: GPC3 as a novel biomarker for prognosis prediction
Identification of gastric cancer subtypes based on disulfidptosis-related genes: GPC3 as a novel biomarker for prognosis prediction
Gastric cancer (GC) is the fourth most common cancer type. “Disulfidptosis,” a distinct form of cell death, is...
Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis
Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis
To elucidate the mechanism by which tyrosine phosphatase SHP2 protects CRC through modulation of TFEB-mediated ferritinoph...
Impact of prolactin treatment on enhancing the cellular responses of MCF7 breast cancer cells to tamoxifen treatment
Impact of prolactin treatment on enhancing the cellular responses of MCF7 breast cancer cells to tamoxifen treatment
Breast cancer remains one of the most challenging diseases to treat due to its heterogeneity, propensity to recur, capacit...
microRNA-875-5p-conjugated gold nanoparticles suppress breast cancer progression through the MTDH/PTEN/AKT signaling pathway
microRNA-875-5p-conjugated gold nanoparticles suppress breast cancer progression through the MTDH/PTEN/AKT signaling pathway
A lack of effective delivery methods has hampered the study of therapeutics targeting miR-875-5p for breast cancer (BC). T...
The T cell-mediated tumor killing patterns revealed tumor heterogeneous and proposed treatment recommendation in ovary cancer
The T cell-mediated tumor killing patterns revealed tumor heterogeneous and proposed treatment recommendation in ovary cancer
Immune checkpoint inhibitors (ICIs) have greatly improved cancer treatment, but the role of genes related to T cell-mediat...
Single-cell RNA sequencing analysis reveals potential key prognostic markers in hepatocellular carcinoma
Single-cell RNA sequencing analysis reveals potential key prognostic markers in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the sixth most frequently diagnosed cancer worldwide accompanied by a low 5-year surviva...
Identification and validation of cigarette smoking-related genes in predicting prostate cancer development through bioinformatic analysis and experiments
Identification and validation of cigarette smoking-related genes in predicting prostate cancer development through bioinformatic analysis and experiments
The morbidity and mortality rates of prostate cancer (PCa) are high among elderly men worldwide. Several factors, such as ...
Investigating the role of KARS in lung adenocarcinoma via single-cell RNA sequencing
Investigating the role of KARS in lung adenocarcinoma via single-cell RNA sequencing
Lung Adenocarcinoma (LUAD) is one of the leading causes to cancer-related deaths worldwide and exhibited extensive molecul...
Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies
Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies
Glioblastoma (GBM) is a highly aggressive primary brain tumor with limited treatment success and poor prognosis. Despite s...
Multi-omics joint screening of biomarkers related to M2 macrophages in gastric cancer
Multi-omics joint screening of biomarkers related to M2 macrophages in gastric cancer
Due to high mortality rate and limited treatments in gastric cancer (GC), call for deeper exploration of M2 macrophages as...
Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization
Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization
Sporadic vestibular schwannoma, a benign tumor affecting the vestibulocochlear nerve, poses significant health challenges ...
Evaluating KLHDC8A as a biomarker for glioma: impact on survival and proliferation through the Wnt/β-catenin pathway
Evaluating KLHDC8A as a biomarker for glioma: impact on survival and proliferation through the Wnt/β-catenin pathway
Glioma is one of the most common malignant tumors and shows a high metastasis rate and poor prognosis. KLHDC8A has been im...
Treatment of metastatic breast cancer by stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS)
Treatment of metastatic breast cancer by stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS)
The role of local ablative radiotherapy (stereotactic body radiotherapy (SBRT)/stereotactic radiosurgery (SRS)) in the man...
Investigating the biomarker value of circRNAs in the diagnosis of colorectal cancer: a systematic review
Investigating the biomarker value of circRNAs in the diagnosis of colorectal cancer: a systematic review
Circular RNAs (circRNAs) has recently been considered a class of endogenous RNAs that form a continuous closed loop with a...
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