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Pan-cancer analysis and single-cell analysis identifies the CENPN as a biomarker for survival prognosis and immunotherapy
Pan-cancer analysis and single-cell analysis identifies the CENPN as a biomarker for survival prognosis and immunotherapy
Centromere protein N (CENPN), located on chromosome 16q23.2, encodes vital nucleosome-associated complexes that are essent...
Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p
Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p
Nonylphenol (NP) is a common environmental contaminant and endocrine disruptor. Our previous research demonstrated that NP...
A risk signature constructed by Tregs-related genes predict the clinical outcomes and immune therapeutic response in kidney cancer
A risk signature constructed by Tregs-related genes predict the clinical outcomes and immune therapeutic response in kidney cancer
Regulatory T cells (Tregs) have been found to be related to immune therapeutic resistance in kidney cancer. However, the p...
Revolutionizing ESCC prognosis: the efficiency of tumor-infiltrating immune cells (TIIC) signature score
Revolutionizing ESCC prognosis: the efficiency of tumor-infiltrating immune cells (TIIC) signature score
Patients suffer from esophageal squamous cell carcinoma (ESCC), which is the ninth highly aggressive malignancy. Tumor-inf...
Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance
Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance
Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins ...
Silymarin: a promising modulator of apoptosis and survival signaling in cancer
Silymarin: a promising modulator of apoptosis and survival signaling in cancer
Cancer, one of the deadliest diseases, has remained the epicenter of biological research for more than seven decades. Yet ...
A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers t...
Machine learning-based prognostic model for patients with anaplastic thyroid carcinoma
Machine learning-based prognostic model for patients with anaplastic thyroid carcinoma
Despite the identification of various prognostic factors for anaplastic thyroid carcinoma (ATC) patients over the years, a...
The role of MRO as an M2 macrophage-associated gene in non-small cell lung cancer: insights into immune infiltration, prognostic significance, and therapeutic implications
The role of MRO as an M2 macrophage-associated gene in non-small cell lung cancer: insights into immune infiltration, prognostic significance, and therapeutic implications
Non-small cell lung cancer (NSCLC), including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), is influ...
Causal role of ischemic heart disease in ovarian cancer subtypes
Causal role of ischemic heart disease in ovarian cancer subtypes
Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such ...
Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems
Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems
Cancer remains the second leading cause of death globally, driving the need for innovative therapies. Among natural compou...
Aging and tumors: a dynamic interaction
Aging and tumors: a dynamic interaction
Aging is an inevitable physiological process in organisms, and the development of tumors is closely associated with cellul...
Anti-cancer effect of midazolam via downregulating YWHAH in papillary thyroid cancer cells
Anti-cancer effect of midazolam via downregulating YWHAH in papillary thyroid cancer cells
The work is aimed to investigate whether midazolam functions in thyroid cancer and reveal the potential mechanism of actio...
NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma
NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma
Nucleolar protein 7 (NOL7), a specific protein found in the nucleolus, is crucial for maintaining cell division and prolif...
Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma
Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma
This study aimed to investigate the role of the autophagy-related long noncoding RNA (lncRNA) MIR210HG in hepatocellular c...
Overexpressed RPS6KA1 and its potential diagnostic value in head and neck squamous cell carcinoma
Overexpressed RPS6KA1 and its potential diagnostic value in head and neck squamous cell carcinoma
RPS6KA1 express disorder is associated with many cancers, but the role in head and neck squamous cell carcinoma (HNSCC) an...
FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia
FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia
Acute myeloid leukemia (AML) has a poor prognosis and high heterogeneity. Most cases of leukemias are caused by environmen...
Efficacy of preoperative pulmonary rehabilitation in lung cancer patients: a systematic review and meta-analysis of randomized controlled trials
Efficacy of preoperative pulmonary rehabilitation in lung cancer patients: a systematic review and meta-analysis of randomized controlled trials
Although previous studies have shown that preoperative pulmonary rehabilitation training may improve postoperative prognos...
LncRNA MANCR is downregulated in non-small cell lung cancer and predicts poor survival
LncRNA MANCR is downregulated in non-small cell lung cancer and predicts poor survival
It is known that genomic instability contributes to cancer development. Mitotically associated long non-coding RNA (MANCR)...
Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study
Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study
Plasma proteins contribute to the identification, diagnosis, and prognosis of human illnesses, which may be conducive to u...
Assessing cross-country inequalities in global burden of gastrointestinal cancers: slope and concentration index approach
Assessing cross-country inequalities in global burden of gastrointestinal cancers: slope and concentration index approach
New cases and deaths of gastrointestinal cancers are predicted to increase significantly by 2040. This study aims...
Integrated bioinformatics and experimental analysis of CHAF1B as a novel biomarker and immunotherapy target in LUAD
Integrated bioinformatics and experimental analysis of CHAF1B as a novel biomarker and immunotherapy target in LUAD
The prognosis and treatment efficacy of lung adenocarcinoma (LUAD), a disease with a high incidence, remains unsatisfactor...
A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data
A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data
Thyroid carcinoma (THCA) is the most common cancer of the endocrine system. Natural killer (NK) cell play an important rol...
Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024
Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024
Prostate cancer (PCa) ranks as the second most common disease among men and the fourth most prevalent cancer worldwide. En...
Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme
Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme
Glioblastoma multiforme (GBM) is a highly aggressive brain cancer with poor prognosis and limited treatment options. Despi...
Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database
Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database
Glioma is the most prevalent tumor of the central nervous system. The poor clinical outcomes and limited therapeutic effic...
A comprehensive pan-cancer analysis of RNF187 in human tumors
A comprehensive pan-cancer analysis of RNF187 in human tumors
RING Finger 187 (RNF187) has recently emerged as a potential contributor to tumorigenesis. However, a comprehensive pan-ca...
The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer
The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer
The occurrence and progression of breast cancer (BCa) are complex processes involving multiple factors and multiple steps....
Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway
Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway
A recent study revealed the oncogenic role of box C/D small nucleolar RNA 52 (SNORD52) in hepatocellular carcinoma (HCC) b...
Global research trends and emerging hotspots in nano-drug delivery systems for lung cancer: a comprehensive bibliometric analysis (1998–2024)
Global research trends and emerging hotspots in nano-drug delivery systems for lung cancer: a comprehensive bibliometric analysis (1998–2024)
Nano-drug delivery systems (NDDS) have become a promising alternative and adjunctive strategy for lung cancer (LC) treatme...
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