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Safety and pharmacokinetics of vepdegestrant in Japanese patients with ER+ advanced breast cancer: a phase 1 study
Safety and pharmacokinetics of vepdegestrant in Japanese patients with ER+ advanced breast cancer: a phase 1 study
Vepdegestrant (ARV-471) is an oral PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader. This phase 1 st...
Electronic patient-reported outcomes as digital therapeutics for patients with cancer: a narrative review of current practices and future directions
Electronic patient-reported outcomes as digital therapeutics for patients with cancer: a narrative review of current practices and future directions
Improved cancer treatment outcomes have increased the demand for medical care that considers the quality of life of patien...
Real-world outcomes of avelumab plus axitinib in patients with advanced renal cell carcinoma in Japan: long-term follow-up from the J-DART2 retrospective study
Real-world outcomes of avelumab plus axitinib in patients with advanced renal cell carcinoma in Japan: long-term follow-up from the J-DART2 retrospective study
Avelumab + axitinib was approved for advanced renal cell carcinoma (aRCC) in Japan in December 2019. We report...
Phase Ib study of the oral PI3Kδ inhibitor linperlisib in patients with advanced solid tumors
Phase Ib study of the oral PI3Kδ inhibitor linperlisib in patients with advanced solid tumors
Patients with advanced solid tumors have a suboptimal prognosis. This study investigated the safety and feasibility of lin...
Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection
Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection
To improve the outcome in newly diagnosed glioblastoma patients with maximal resection, we aimed to evaluate the efficacy ...
Efficacy and safety of multi-day antiemetic treatment for patients undergoing multi-day chemotherapy: a systematic review of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology
Efficacy and safety of multi-day antiemetic treatment for patients undergoing multi-day chemotherapy: a systematic review of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology
A standardized multi-day antiemetic regimen for multi-day chemotherapy remains elusive. This systematic review evaluated t...
Lymphadenectomy and chemotherapy are effective treatments for patients with 2023 international federation of gynecology and obstetrics stage IIC-high risk endometrial cancer in Japan
Lymphadenectomy and chemotherapy are effective treatments for patients with 2023 international federation of gynecology and obstetrics stage IIC-high risk endometrial cancer in Japan
In early-stage endometrial cancer (EC), the treatment of aggressive histological subtypes (endometrioid carcinoma grade 3,...
Predictive factors of immediate continence after conventional robot-assisted radical prostatectomy: a single-institution retrospective study
Predictive factors of immediate continence after conventional robot-assisted radical prostatectomy: a single-institution retrospective study
To assess the predictive factors of immediate urinary continence after robot-assisted radical prostatectomy. This study in...
Efficacy and safety of lenvatinib and pembrolizumab as first-line treatment for advanced renal cell carcinoma patients: real-world experience in Japan
Efficacy and safety of lenvatinib and pembrolizumab as first-line treatment for advanced renal cell carcinoma patients: real-world experience in Japan
Combined treatment with lenvatinib and pembrolizumab is currently regarded as one of the standard first-line therapies for...
Predicting time to castration resistance with androgen-receptor signaling inhibitors in hormone-sensitive prostate cancer: data from ULTRA-Japan Consortium
Predicting time to castration resistance with androgen-receptor signaling inhibitors in hormone-sensitive prostate cancer: data from ULTRA-Japan Consortium
Androgen-receptor signaling inhibitors (ARSIs) become the new standard of care for metastatic hormone-sensitive prostate c...
Lynch syndrome screening in patients with young-onset extra-colorectal Lynch syndrome-associated cancers
Lynch syndrome screening in patients with young-onset extra-colorectal Lynch syndrome-associated cancers
Lynch syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline variants in mismatch repair (MMR) genes,...
Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with highly emetogenic risk antineoplastic agents: a systematic review and meta-analysis of the Clinical Practice Guidelines for Antiemesis 2023 from the Japan Society of Clinical Oncology
Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with highly emetogenic risk antineoplastic agents: a systematic review and meta-analysis of the Clinical Practice Guidelines for Antiemesis 2023 from the Japan Society of Clinical Oncology
Chemotherapy-induced nausea and vomiting (CINV) are common side effects, classified according to timing and severity. Conv...
Research on biomarkers using innovative artificial intelligence systems in breast cancer
Research on biomarkers using innovative artificial intelligence systems in breast cancer
Cancer is highly diverse and heterogeneous. Accurate and rapid analysis of the characteristics of individual cancer cells,...
Identification of clinical prognosis features and significant DNA methylation regulation in pineoblastoma
Identification of clinical prognosis features and significant DNA methylation regulation in pineoblastoma
Pineoblastoma (PB) represents a great challenge for clinical management due to lack of a specific therapeutic regimen. Thi...
Conversion surgery for esophageal and esophagogastric junction cancer
Conversion surgery for esophageal and esophagogastric junction cancer
As a result of the recent advances in first-line treatment including chemotherapy, radiation therapy, targeted therapy, an...
Prognostic impact of aspirin in patients with hepatocellular carcinoma after liver resection: propensity-score-matched analysis
Prognostic impact of aspirin in patients with hepatocellular carcinoma after liver resection: propensity-score-matched analysis
The association between aspirin and hepatocellular carcinoma (HCC) has been reported to prevent carcinogenesis caused by h...
Influence of major hepatectomy on gemcitabine-based chemotherapy for recurrent biliary tract cancer after surgery: a subgroup analysis of JCOG1113
Influence of major hepatectomy on gemcitabine-based chemotherapy for recurrent biliary tract cancer after surgery: a subgroup analysis of JCOG1113
Major hepatectomy (MH) can increase the risk of adverse events (AEs) owing to impaired drug metabolism due to decreased li...
Clinical significance of CD155 expression in surgically resected lung squamous cell carcinoma
Clinical significance of CD155 expression in surgically resected lung squamous cell carcinoma
Cluster of differentiation 155 (CD155) is expressed in many tumor types. CD155 is involved in the immune avoidance of tumo...
Treatment selection and influencing factors for chronic lymphocytic leukemia: a physician survey in Japan
Treatment selection and influencing factors for chronic lymphocytic leukemia: a physician survey in Japan
Chronic lymphocytic leukemia (CLL) is a rare form of lymphoma in Japan. This study aimed to explore hematologists’ m...
Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy: a systematic review and meta-analysis of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology
Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy: a systematic review and meta-analysis of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology
Palonosetron, a second-generation 5-HT3 receptor antagonist (5-HT3RA), is more effective than first-generation 5-HT3RA. Se...
Lateral node metastasis in low rectal cancer as a hallmark to predict recurrence patterns
Lateral node metastasis in low rectal cancer as a hallmark to predict recurrence patterns
Lateral node metastasis confers a poor prognosis in rectal cancer. Several multidisciplinary treatments have been proposed...
Reproductive organ involvement in women undergoing radical cystectomy for urothelial bladder cancer: a nationwide multicenter study
Reproductive organ involvement in women undergoing radical cystectomy for urothelial bladder cancer: a nationwide multicenter study
Radical cystectomy in women generally includes the removal of the uterus, ovaries, and anterior vaginal wall, but the crit...
First-line pembrolizumab with or without chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up of the Japanese population of KEYNOTE‑048
First-line pembrolizumab with or without chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up of the Japanese population of KEYNOTE‑048
Previously reported results from phase III KEYNOTE-048 demonstrated similar or improved overall survival (OS) with pembrol...
Effect of extending the period from oral administration of 5-aminolevulinic acid hydrochloride to photodynamic diagnosis during transurethral resection for non-muscle invasive bladder cancer on diagnostic accuracy and safety: a single-arm multicenter phase III trial
Effect of extending the period from oral administration of 5-aminolevulinic acid hydrochloride to photodynamic diagnosis during transurethral resection for non-muscle invasive bladder cancer on diagnostic accuracy and safety: a single-arm multicenter phase III trial
In Japan, the authorized period (2–4 h) between oral administration of 5-aminolevulinic acid hydrochloride (5-ALA) a...
Diagnostic performance of TILs–US score and LPBC in biopsy specimens for predicting pathological complete response in patients with breast cancer
Diagnostic performance of TILs–US score and LPBC in biopsy specimens for predicting pathological complete response in patients with breast cancer
Tumor-infiltrating lymphocytes–ultrasonography (TILs–US) score is used to predict lymphocyte-predominant breas...
Prognostic significance of inflammatory markers in patients with advanced renal cell carcinoma receiving nivolumab plus ipilimumab
Prognostic significance of inflammatory markers in patients with advanced renal cell carcinoma receiving nivolumab plus ipilimumab
A useful biomarker for the efficacy of immune checkpoint inhibitors (ICIs) in advanced renal cell carcinoma (RCC) has not ...
A phase 2 study of mobocertinib as first-line treatment in Japanese patients with non-small cell lung cancer harboring EGFR exon 20 insertion mutations
A phase 2 study of mobocertinib as first-line treatment in Japanese patients with non-small cell lung cancer harboring EGFR exon 20 insertion mutations
Mobocertinib is a novel, synthetic, orally administered tyrosine kinase inhibitor that inhibits many activated forms of ep...
Correction to: Real‑world practice of estrogen therapy after surgery for endometrial cancer: a descriptive study using a Japanese claims database
Correction to: Real‑world practice of estrogen therapy after surgery for endometrial cancer: a descriptive study using a Japanese claims database
In Figs. 1, 2A, 5 of this article, the shadings were not shown; the Figs. 1, 2A, 5 sh...
Clinical impact of a dose-escalation strategy for lenvatinib in differentiated thyroid cancer
Clinical impact of a dose-escalation strategy for lenvatinib in differentiated thyroid cancer
 Treatment options for patients with differentiated thyroid cancer (DTC) who experience disease progression on le...
Impact of interstitial lung disease gender-age-physiology index in surgically treated lung cancer
Impact of interstitial lung disease gender-age-physiology index in surgically treated lung cancer
The postoperative prognosis of patients with interstitial lung disease (ILD) and lung cancer is poor. Recently, the ILD-ge...
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