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Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study
Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study
The Anticholinergic Risk Scale and Total Anticholinergic Load were developed to assess the risks associated with anticholi...
Toxic epidermal necrolysis with thrombocytopenia induced by intravenous immunoglobulin: a case report and mini review
Toxic epidermal necrolysis with thrombocytopenia induced by intravenous immunoglobulin: a case report and mini review
Toxic epidermal necrolysis (TEN), a severe cutaneous hypersensitivity reaction induced particularly by drugs, is diagnosed...
Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy
Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy
Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost effi...
Remdesivir-induced severe hypoglycemia in an elderly man without diabetes: a case report
Remdesivir-induced severe hypoglycemia in an elderly man without diabetes: a case report
Remdesivir is recommended to treat hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is known to ...
Factors associated with assertiveness among Japanese community pharmacists: a cross-sectional study
Factors associated with assertiveness among Japanese community pharmacists: a cross-sectional study
Community pharmacists play a crucial role in promoting medication safety within the community healthcare team. Effective c...
Drug-drug interaction between ensitrelvir and tacrolimus in a patient undergoing treatment for COVID-19: a case report
Drug-drug interaction between ensitrelvir and tacrolimus in a patient undergoing treatment for COVID-19: a case report
Ensitrelvir is a novel SARS-CoV-2 3-chymotrypsin-like protease inhibitor, similar to nirmatrelvir/ritonavir. Several case ...
Comparison of continuous subcutaneous hydromorphone hydrochloride and morphine hydrochloride injection on skin disorders incidence: a retrospective study
Comparison of continuous subcutaneous hydromorphone hydrochloride and morphine hydrochloride injection on skin disorders incidence: a retrospective study
Continuous subcutaneous administration of injectable opioids is simple and effective; however, skin disorders may occur wh...
Pharmacist intervention and identification of adverse events related to treatment efficacy in cancer chemotherapy to improve clinical outcomes
Pharmacist intervention and identification of adverse events related to treatment efficacy in cancer chemotherapy to improve clinical outcomes
Adverse events (AEs) induced by cancer chemotherapy reduce not only patient quality of life (QOL) but also the efficacy of...
Effect of changes in skin properties due to diabetes mellitus on the titration period of transdermal fentanyl: single-center retrospective study and diabetic animal model study
Effect of changes in skin properties due to diabetes mellitus on the titration period of transdermal fentanyl: single-center retrospective study and diabetic animal model study
In the dose titration of transdermal fentanyl to prevent unrelieved pain, it is important to consider not only dose adjust...
Clinical characteristics of patients requiring emergency hospitalization due to immune-related adverse events: a retrospective study
Clinical characteristics of patients requiring emergency hospitalization due to immune-related adverse events: a retrospective study
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, offering hope for various malignancies by enhanc...
Impact of pharmacist-led aminoglycoside stewardship: a 10-year observational study
Impact of pharmacist-led aminoglycoside stewardship: a 10-year observational study
Aminoglycosides are crucial for treating multidrug-resistant gram-negative infections and endocarditis. However, aminoglyc...
The risk of upper gastrointestinal bleeding associated with concomitant proton pump inhibitor administration during dual antiplatelet therapy with aspirin and prasugrel: a retrospective single-center study
The risk of upper gastrointestinal bleeding associated with concomitant proton pump inhibitor administration during dual antiplatelet therapy with aspirin and prasugrel: a retrospective single-center study
Dual‐antiplatelet therapy (DAPT) and proton pump inhibitor (PPI) are frequently prescribed after percutaneous corona...
In-vivo evaluation of analgesic and anti-inflammatory activities of the 80% methanol extract of Acacia seyal stem bark in rodent models
In-vivo evaluation of analgesic and anti-inflammatory activities of the 80% methanol extract of Acacia seyal stem bark in rodent models
Pain and inflammation are the major medical condition commonly addressed with traditional remedies. Acacia seyal is a trad...
Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide
Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide
A simple suspension method, where solid formulations are disintegrated and suspended by being soaked in warm water followe...
Efficacy of a melatonin receptor agonist and orexin receptor antagonists in preventing delirium symptoms in the olderly patients with stroke: a retrospective study
Efficacy of a melatonin receptor agonist and orexin receptor antagonists in preventing delirium symptoms in the olderly patients with stroke: a retrospective study
Post-stroke delirium affects between 24% and 43% of patients, and negatively impacts patient outcomes. Recently, research ...
Compatibility of hypokalaemia caused by low-dose prednisolone plus abiraterone acetate therapy for metastatic castration-resistant prostate cancer
Compatibility of hypokalaemia caused by low-dose prednisolone plus abiraterone acetate therapy for metastatic castration-resistant prostate cancer
This study aimed to investigate the relationship between low-dose prednisolone (PSL) and the incidence of hypokalaemia at ...
Development and validation of the prediction score for augmented renal clearance in critically Ill Japanese adults
Development and validation of the prediction score for augmented renal clearance in critically Ill Japanese adults
Augmented renal clearance (ARC) decreases the therapeutic concentration of drugs excreted by the kidneys in critically ill...
A qualitative study on the current status and problems of pharmacists in home healthcare from the viewpoint of care managers in medically underpopulated areas in Japan
A qualitative study on the current status and problems of pharmacists in home healthcare from the viewpoint of care managers in medically underpopulated areas in Japan
Unlike in urban areas, community healthcare in medically underpopulated areas in Japan is constantly challenged because of...
Effects of famotidine use during pregnancy: an observational cohort study
Effects of famotidine use during pregnancy: an observational cohort study
Famotidine, a histamine2-receptor antagonist (H2Ras), is widely used to treat and prevent gastrointestinal symptoms during...
Comparison of facilities with and without additional medical fees for nutrition support team activity during the COVID-19 pandemic
Comparison of facilities with and without additional medical fees for nutrition support team activity during the COVID-19 pandemic
This study aimed to clarify the effectiveness of nutrition support team (NST) facilities for preventing central line-assoc...
Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice
Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice
Fluoroquinolone (FQ) antimicrobials have antipyretic effects during the treatment of bacterial infections; however, it is ...
Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report
Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report
Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active me...
Factors influencing the discontinuation of biologic therapies in patients with ulcerative colitis
Factors influencing the discontinuation of biologic therapies in patients with ulcerative colitis
The therapeutic landscape for ulcerative colitis (UC) has recently broadened to include anti-TNFα, anti-integrin, and...
A decision tree approach for investigating the background of research activity of community and hospital pharmacists in Mie Prefecture: a retrospective questionnaire-based survey
A decision tree approach for investigating the background of research activity of community and hospital pharmacists in Mie Prefecture: a retrospective questionnaire-based survey
The support system for research activities has not been sufficiently established in clinical settings. A survey should be ...
Safety and efficacy of oxycodone for refractory dyspnea in end-stage heart failure patients with chronic kidney disease: a case series of eight patients
Safety and efficacy of oxycodone for refractory dyspnea in end-stage heart failure patients with chronic kidney disease: a case series of eight patients
Morphine is effective in palliative care for patients with end-stage heart failure; however, its use is avoided in patient...
Usefulness of driver’s eye movement measurement to detect potential risks under combined conditions of taking second-generation antihistamines and calling tasks
Usefulness of driver’s eye movement measurement to detect potential risks under combined conditions of taking second-generation antihistamines and calling tasks
Concerns persist regarding the potential reduction in driving performance due to taking second-generation antihistamines o...
Assessing the effects of interprofessional education by hospital pharmacists on pharmaceutical students using a self-evaluation scale
Assessing the effects of interprofessional education by hospital pharmacists on pharmaceutical students using a self-evaluation scale
Understanding the roles and competencies of professions outside of one’s specialty is essential for providing effici...
Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis
Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis
We examined whether denosumab-induced hypocalcaemia is evident in osteoporosis when given loop diuretics that pro...
Impact of automated pop-up alerts on simultaneous prescriptions of antimicrobial agents and metal cations
Impact of automated pop-up alerts on simultaneous prescriptions of antimicrobial agents and metal cations
Antimicrobial agents (AMAs) are essential for treating infections. A part of AMAs chelate with metal cations (MCs), reduci...
Effectiveness of tramadol-including multimodal analgesia in spinal surgery: a single-center, retrospective cohort study
Effectiveness of tramadol-including multimodal analgesia in spinal surgery: a single-center, retrospective cohort study
Multimodal analgesia (MMA) is recommended for postoperative pain management; however, studies evaluating the effect of tra...
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