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In-vivo evaluation of analgesic and anti-inflammatory activities of the 80% methanol extract of Acacia seyal stem bark in rodent models
In-vivo evaluation of analgesic and anti-inflammatory activities of the 80% methanol extract of Acacia seyal stem bark in rodent models
Pain and inflammation are the major medical condition commonly addressed with traditional remedies. Acacia seyal is a trad...
Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide
Study on the chemical stability of β-lactam antibiotics in concomitant simple suspensions with magnesium oxide
A simple suspension method, where solid formulations are disintegrated and suspended by being soaked in warm water followe...
Efficacy of a melatonin receptor agonist and orexin receptor antagonists in preventing delirium symptoms in the olderly patients with stroke: a retrospective study
Efficacy of a melatonin receptor agonist and orexin receptor antagonists in preventing delirium symptoms in the olderly patients with stroke: a retrospective study
Post-stroke delirium affects between 24% and 43% of patients, and negatively impacts patient outcomes. Recently, research ...
Compatibility of hypokalaemia caused by low-dose prednisolone plus abiraterone acetate therapy for metastatic castration-resistant prostate cancer
Compatibility of hypokalaemia caused by low-dose prednisolone plus abiraterone acetate therapy for metastatic castration-resistant prostate cancer
This study aimed to investigate the relationship between low-dose prednisolone (PSL) and the incidence of hypokalaemia at ...
Development and validation of the prediction score for augmented renal clearance in critically Ill Japanese adults
Development and validation of the prediction score for augmented renal clearance in critically Ill Japanese adults
Augmented renal clearance (ARC) decreases the therapeutic concentration of drugs excreted by the kidneys in critically ill...
A qualitative study on the current status and problems of pharmacists in home healthcare from the viewpoint of care managers in medically underpopulated areas in Japan
A qualitative study on the current status and problems of pharmacists in home healthcare from the viewpoint of care managers in medically underpopulated areas in Japan
Unlike in urban areas, community healthcare in medically underpopulated areas in Japan is constantly challenged because of...
Effects of famotidine use during pregnancy: an observational cohort study
Effects of famotidine use during pregnancy: an observational cohort study
Famotidine, a histamine2-receptor antagonist (H2Ras), is widely used to treat and prevent gastrointestinal symptoms during...
Comparison of facilities with and without additional medical fees for nutrition support team activity during the COVID-19 pandemic
Comparison of facilities with and without additional medical fees for nutrition support team activity during the COVID-19 pandemic
This study aimed to clarify the effectiveness of nutrition support team (NST) facilities for preventing central line-assoc...
Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice
Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice
Fluoroquinolone (FQ) antimicrobials have antipyretic effects during the treatment of bacterial infections; however, it is ...
Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report
Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report
Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active me...
Factors influencing the discontinuation of biologic therapies in patients with ulcerative colitis
Factors influencing the discontinuation of biologic therapies in patients with ulcerative colitis
The therapeutic landscape for ulcerative colitis (UC) has recently broadened to include anti-TNFα, anti-integrin, and...
A decision tree approach for investigating the background of research activity of community and hospital pharmacists in Mie Prefecture: a retrospective questionnaire-based survey
A decision tree approach for investigating the background of research activity of community and hospital pharmacists in Mie Prefecture: a retrospective questionnaire-based survey
The support system for research activities has not been sufficiently established in clinical settings. A survey should be ...
Safety and efficacy of oxycodone for refractory dyspnea in end-stage heart failure patients with chronic kidney disease: a case series of eight patients
Safety and efficacy of oxycodone for refractory dyspnea in end-stage heart failure patients with chronic kidney disease: a case series of eight patients
Morphine is effective in palliative care for patients with end-stage heart failure; however, its use is avoided in patient...
Usefulness of driver’s eye movement measurement to detect potential risks under combined conditions of taking second-generation antihistamines and calling tasks
Usefulness of driver’s eye movement measurement to detect potential risks under combined conditions of taking second-generation antihistamines and calling tasks
Concerns persist regarding the potential reduction in driving performance due to taking second-generation antihistamines o...
Assessing the effects of interprofessional education by hospital pharmacists on pharmaceutical students using a self-evaluation scale
Assessing the effects of interprofessional education by hospital pharmacists on pharmaceutical students using a self-evaluation scale
Understanding the roles and competencies of professions outside of one’s specialty is essential for providing effici...
Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis
Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis
We examined whether denosumab-induced hypocalcaemia is evident in osteoporosis when given loop diuretics that pro...
Impact of automated pop-up alerts on simultaneous prescriptions of antimicrobial agents and metal cations
Impact of automated pop-up alerts on simultaneous prescriptions of antimicrobial agents and metal cations
Antimicrobial agents (AMAs) are essential for treating infections. A part of AMAs chelate with metal cations (MCs), reduci...
Effectiveness of tramadol-including multimodal analgesia in spinal surgery: a single-center, retrospective cohort study
Effectiveness of tramadol-including multimodal analgesia in spinal surgery: a single-center, retrospective cohort study
Multimodal analgesia (MMA) is recommended for postoperative pain management; however, studies evaluating the effect of tra...
Changes in urinary output due to concomitant administration of sacubitril/valsartan and atrial natriuretic peptide in patients with heart failure: a multicenter retrospective cohort study
Changes in urinary output due to concomitant administration of sacubitril/valsartan and atrial natriuretic peptide in patients with heart failure: a multicenter retrospective cohort study
Sacubitril/valsartan is an angiotensin receptor neprilysin inhibitor (ARNI) that inhibits the degradation of endogenous na...
Comparison of kidney and hepatic outcomes among sodium-glucose cotransporter-2 inhibitors: a retrospective study using multiple propensity scores
Comparison of kidney and hepatic outcomes among sodium-glucose cotransporter-2 inhibitors: a retrospective study using multiple propensity scores
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been reported to have effects beyond lowering blood glucose levels...
Evaluation of the drug-drug interactions management system for appropriate use of nirmatrelvir/ritonavir: a retrospective observational study
Evaluation of the drug-drug interactions management system for appropriate use of nirmatrelvir/ritonavir: a retrospective observational study
While nirmatrelvir/ritonavir (NMV-r) has been positioned as a first-line treatment for mild to moderate COVID-19, it has m...
Enhancement of therapeutic efficacy of Brinzolamide for Glaucoma by nanocrystallization and tyloxapol addition
Enhancement of therapeutic efficacy of Brinzolamide for Glaucoma by nanocrystallization and tyloxapol addition
Brinzolamide (BRI) suspensions are used for the treatment of glaucoma; however, sufficient drug delivery to the target tis...
Patient resuscitated after cardiopulmonary arrest exhibits abnormally increased phenytoin metabolic rate due to unknown factors: a case report
Patient resuscitated after cardiopulmonary arrest exhibits abnormally increased phenytoin metabolic rate due to unknown factors: a case report
Fosphenytoin (FOS) is a prodrug of phenytoin (PHT) with a metabolism that exhibits Michaelis–Menten-type kinetics. G...
Effect of blood pressure control on the risk of proteinuria during bevacizumab treatment in patients with colorectal cancer: a single-center retrospective cohort study
Effect of blood pressure control on the risk of proteinuria during bevacizumab treatment in patients with colorectal cancer: a single-center retrospective cohort study
Pre-existing hypertension is reportedly a major risk factor for bevacizumab-induced proteinuria. However, few studies have...
Fasudil hydrochloride and ozagrel sodium combination therapy for patients with aneurysmal subarachnoid hemorrhage: a cross-sectional study using a nationwide inpatient database
Fasudil hydrochloride and ozagrel sodium combination therapy for patients with aneurysmal subarachnoid hemorrhage: a cross-sectional study using a nationwide inpatient database
Fasudil and ozagrel are drugs with the same indications for the treatment of cerebral vasospasm in Japan. However, there h...
Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report
Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report
Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced ...
A retrospective study examining the association between polypharmacy and complications after laparoscopic surgery for colorectal cancer
A retrospective study examining the association between polypharmacy and complications after laparoscopic surgery for colorectal cancer
Polypharmacy is an escalating public health concern across various healthcare settings worldwide. We aimed to comprehensiv...
Characteristics of CYP3A4-related potential drug-drug interactions in outpatients receiving prescriptions from multiple clinical departments
Characteristics of CYP3A4-related potential drug-drug interactions in outpatients receiving prescriptions from multiple clinical departments
Drug-drug interactions (DDIs) increase the incidence of adverse drug reactions (ADRs). In a previous report, we revealed t...
Hyperkalemic effect of drug–drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study
Hyperkalemic effect of drug–drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study
We examined whether the pharmacodynamic drug–drug interaction between esaxerenone and trimethoprim enhances the hype...
Eggshell membrane and green seaweed (Ulva lactuca) micronized powders for in vivo diabetic wound healing in albino rats: a comparative study
Eggshell membrane and green seaweed (Ulva lactuca) micronized powders for in vivo diabetic wound healing in albino rats: a comparative study
Nonhealing diabetic wounds are a serious complication associated with extremely lethargic wound closure and a high risk of...
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