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Highly Dynamic Cytoskeletal Networks Support Productive Viral Infection and Host Innate Immune Response Activation
Highly Dynamic Cytoskeletal Networks Support Productive Viral Infection and Host Innate Immune Response Activation
Increasing evidence shows that the onset of the host cytoskeleton changes during the viral infection process. The attainme...
Machine Learning-based Host–Pathogen Protein–Protein Interaction Prediction
Machine Learning-based Host–Pathogen Protein–Protein Interaction Prediction
This review examines machine learning methods for host–pathogen protein–protein interaction (PPI) prediction. ...
Potential Influence of Antifungal-drug Resistant Pathogens in Patients with Cholangiocarcinoma and the Application of Nanoparticle Mechanisms as Novel Antifungal and Anticancer Agents
Potential Influence of Antifungal-drug Resistant Pathogens in Patients with Cholangiocarcinoma and the Application of Nanoparticle Mechanisms as Novel Antifungal and Anticancer Agents
Cholangiocarcinoma (CCA) is the most lethal and common malignant tumours that occur in the bile ducts. Although it is rela...
Agent-Based Models of Virus Infection
Agent-Based Models of Virus Infection
Agent-based modelling (ABM) is a robust computational tool for investigating the dynamics of infectious disease spread and...
Molecular Insights Into the Interplay Between Host Platelets and Fungal Pathogens
Molecular Insights Into the Interplay Between Host Platelets and Fungal Pathogens
Despite the rise in invasive fungal infections, little is understood about these illnesses, especially the relationship be...
Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections
Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections
Bacterial infections and antibiotic resistance contribute to global mortality. Despite many infections being preventable a...
Candida albicans Virulence Traits in Commensalism and Disease
Candida albicans Virulence Traits in Commensalism and Disease
Candida albicans is a common constituent of the normal human microbiota of the oro-gastrointestinal and vaginal tract. The...
Myeloid Cell Reservoirs: Role in HIV-Host Interplay and Strategies for Myeloid Reservoir Elimination
Myeloid Cell Reservoirs: Role in HIV-Host Interplay and Strategies for Myeloid Reservoir Elimination
Despite host antiviral responses and antiretroviral therapy, HIV-1 continues to persist in myeloid cell reservoirs. Hence,...
Candida auris Resistance Mechanisms to Amphotericin B Alternative Treatments Development
Candida auris Resistance Mechanisms to Amphotericin B Alternative Treatments Development
Systemic fungal infections caused by Candida auris have been identified since 2009, with mortality rates and drug resistan...
Molecular Mechanisms of KSHV Latency Establishment and Maintenance
Molecular Mechanisms of KSHV Latency Establishment and Maintenance
This review summarizes results from recent studies that shed light on viral and cellular mechanisms that contribute to lat...
Update on the Regulation and Maintenance of Epstein-Barr Virus Latency
Update on the Regulation and Maintenance of Epstein-Barr Virus Latency
As the first identified human oncogenic virus, Epstein-Barr virus (EBV) is widely circulating in humans. EBV presents main...
Foodborne Helminthiasis
Foodborne Helminthiasis
This review focuses on key foodborne helminths: providing an overview of their lifecycles and major transmission routes to...
Modulation of Wnt Signaling Pathway during Cytomegalovirus Latency and Reactivation
Modulation of Wnt Signaling Pathway during Cytomegalovirus Latency and Reactivation
The Wnt signaling pathway is one of the key pathways involved in hematopoietic progenitor cell (HPC) proliferation and dif...
SARS-CoV-2 Resistance to Small Molecule Inhibitors
SARS-CoV-2 Resistance to Small Molecule Inhibitors
SARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Co...
Host-vaginal microbiota interaction: shaping the vaginal microenvironment and bacterial vaginosis
Host-vaginal microbiota interaction: shaping the vaginal microenvironment and bacterial vaginosis
This review comprehensively examines host-vaginal microbiota interactions, the composition of the vaginal microbiota, and ...
The Ecology of Pathogenic Onygenales Fungi and the Impacts of Climate Change
The Ecology of Pathogenic Onygenales Fungi and the Impacts of Climate Change
Onygenalean fungi have the potential to cause disease in vertebrates, including humans, due to their possession of various...
The Impact of Climate Change on Human Fungal Pathogen Distribution and Disease Incidence
The Impact of Climate Change on Human Fungal Pathogen Distribution and Disease Incidence
This review aims to compile the current knowledge on the impact of climate change on human pathogenic fungi. Ongoing surve...
Nutritional Immunity and Fungal Pathogens: A New Role for Manganese
Nutritional Immunity and Fungal Pathogens: A New Role for Manganese
Copper, zinc, iron, and manganese are essential micronutrients for all living organisms. Microbial pathogens must acquire ...
Fish Acanthocephalans as Potential Human Pathogens
Fish Acanthocephalans as Potential Human Pathogens
Acanthocephalans attach to the gastro-intestinal mucosa of the host (mammals, birds, reptiles, amphibians, fish) by use of...
Exploring the Potential Role of the Genus Kudoa (Myxosporea: Kudoidae) as an Emerging Seafood-Borne Parasite in Humans
Exploring the Potential Role of the Genus Kudoa (Myxosporea: Kudoidae) as an Emerging Seafood-Borne Parasite in Humans
This article reviews and summarises the recent findings on emerging seafood-borne parasites, Kudoa spp., that have receive...
Occurrence of Genetic Diversity, Virulence, and Resistance Genes Among Campylobacter species in Nigeria: A Review
Occurrence of Genetic Diversity, Virulence, and Resistance Genes Among Campylobacter species in Nigeria: A Review
Infectious diseases are serious threats to public health globally. Therefore, regional understanding of pathogens in Niger...
Post-COVID Postural Orthostatic Tachycardia Syndrome and Inappropriate Sinus Tachycardia in the Pediatric Population
Post-COVID Postural Orthostatic Tachycardia Syndrome and Inappropriate Sinus Tachycardia in the Pediatric Population
Long COVID, or post-COVID Condition, is increasingly recognized in children and adolescents, despite being less studied co...
Disease Burden of Primary HHV-6B Infection in Immunocompetent Children
Disease Burden of Primary HHV-6B Infection in Immunocompetent Children
Exanthema subitum, which is caused by primary human herpesvirus 6B (HHV-6B) infection, is generally self-limited. However,...
Bringing Balance: Immune Interactions Regulating Murine Gammaherpesvirus 68 Latency
Bringing Balance: Immune Interactions Regulating Murine Gammaherpesvirus 68 Latency
Gammaherpesviruses constitute the chief virus family that is capable of exhibiting true latency. Latency allows the viral ...
Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations
Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations
This review provides an overview of the role of dysbiosis (imbalanced gut microbiota) in the maintenance of host homeostas...
Porin-Mediated Carbapenem Resistance in Klebsiella pneumoniae: an Alarming Threat to Global Health
Porin-Mediated Carbapenem Resistance in Klebsiella pneumoniae: an Alarming Threat to Global Health
Carbapenem resistance among Gram-negative bacteria is becoming a global threat to community health and elevates the antibi...
Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms
Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms
The current review focuses on opportunities for new areas and new methods to isolate microorganisms from soil that could l...
Engineered Therapeutic Antibody Against SARS-CoV-2
Engineered Therapeutic Antibody Against SARS-CoV-2
The success and failure of therapeutic antibodies against SARS-CoV-2 offer a lesson on therapeutic antibody design and dev...
Bacterial and Fungal Keratitis: Current Trends in Its Diagnosis and Management
Bacterial and Fungal Keratitis: Current Trends in Its Diagnosis and Management
Infectious keratitis is the fifth most prevalent cause of blindness worldwide. The primary diagnostic test to identify the...
Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective
Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective
The main obstacle to an HIV-1 cure is the reservoir of HIV-1 infected cells. While antiretroviral therapy (ART) eliminates...
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