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Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury: A Phase 2a Intervention Design Study
Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury: A Phase 2a Intervention Design Study
Targeted beta-blockade after severe traumatic brain injury may reduce secondary brain injury by attenuating the sympathoad...
Prospective Evaluation of a Modified Apnea Test in Brain Death Candidates that Does Not Require Disconnection from the Ventilator
Prospective Evaluation of a Modified Apnea Test in Brain Death Candidates that Does Not Require Disconnection from the Ventilator
The apnea test (AT) is an important component in the determination of brain death/death by neurologic criteria (BD/DNC) an...
Multi-omics Study of Hypoxic-Ischemic Brain Injury After Cardiopulmonary Resuscitation in Swine
Multi-omics Study of Hypoxic-Ischemic Brain Injury After Cardiopulmonary Resuscitation in Swine
Hypoxic-ischemic brain injury is a common cause of mortality after cardiac arrest (CA) and cardiopulmonary resuscitation; ...
Comparison of Continuous Intracortical and Scalp Electroencephalography in Comatose Patients with Acute Brain Injury
Comparison of Continuous Intracortical and Scalp Electroencephalography in Comatose Patients with Acute Brain Injury
Depth electroencephalography (dEEG) is a recent invasive monitoring technique used in patients with acute brain injury. Th...
Arterial Spin Labeling Magnetic Resonance Imaging for Acute Disorders of Consciousness in the Intensive Care Unit
Arterial Spin Labeling Magnetic Resonance Imaging for Acute Disorders of Consciousness in the Intensive Care Unit
To investigate patients with disorders of consciousness (DoC) for residual awareness, guidelines recommend quantifying glu...
Anisocoria After Direct Light Stimulus is Associated with Poor Outcomes Following Acute Brain Injury
Anisocoria After Direct Light Stimulus is Associated with Poor Outcomes Following Acute Brain Injury
Assessing pupil size and reactivity is the standard of care in neurocritically ill patients. Anisocoria observed in critic...
Acute Skeletal Muscle Wasting is Associated with Prolonged Hospital Stay in Critical Illness with Brain Injury
Acute Skeletal Muscle Wasting is Associated with Prolonged Hospital Stay in Critical Illness with Brain Injury
Acute muscle wasting is common in critically ill patients, and this can lead to unfavorable clinical outcomes. The aim of ...
Gerstmann Syndrome: What is the Possible Role of Deep Brain Stimulation?
Gerstmann Syndrome: What is the Possible Role of Deep Brain Stimulation?
Gerstmann syndrome, characterized by a tetrad of symptoms, which are agraphia, acalculia, left–right disorientation,...
Beyond Control: Temperature Burden in Patients with Spontaneous Subarachnoid Hemorrhage—An Observational Study
Beyond Control: Temperature Burden in Patients with Spontaneous Subarachnoid Hemorrhage—An Observational Study
Temperature abnormalities are common after spontaneous subarachnoid hemorrhage (SAH). Here, we aimed to describe the evolu...
The Effects of Head Elevation on Intracranial Pressure, Cerebral Perfusion Pressure, and Cerebral Oxygenation Among Patients with Acute Brain Injury: A Systematic Review and Meta-Analysis
The Effects of Head Elevation on Intracranial Pressure, Cerebral Perfusion Pressure, and Cerebral Oxygenation Among Patients with Acute Brain Injury: A Systematic Review and Meta-Analysis
Head elevation is recommended as a tier zero measure to decrease high intracranial pressure (ICP) in neurocritical patient...
Association Between Early Hyperoxemia Exposure and Intensive Care Unit Mortality in Intracerebral Hemorrhage: An Observational Cohort Analysis
Association Between Early Hyperoxemia Exposure and Intensive Care Unit Mortality in Intracerebral Hemorrhage: An Observational Cohort Analysis
Supraphysiologic levels of oxygen could have potential adverse effects on the brain that may be dose and time dependent in...
Equity in Clinical Care and Research Involving Persons with Disorders of Consciousness
Equity in Clinical Care and Research Involving Persons with Disorders of Consciousness
People with disorders of consciousness (DoC) are characteristically unable to synchronously participate in decision-making...
Blood Pressure Management in Early Aneurysmal Subarachnoid Hemorrhage: A National Cross-Sectional Survey of Canadian Intensivists and Cerebrovascular Neurosurgeons
Blood Pressure Management in Early Aneurysmal Subarachnoid Hemorrhage: A National Cross-Sectional Survey of Canadian Intensivists and Cerebrovascular Neurosurgeons
In aneurysmal subarachnoid hemorrhage (aSAH), rebleeding of the culprit aneurysm is associated with significant morbidity ...
Social Determinants of Health and Limitation of Life-Sustaining Therapy in Neurocritical Care: A CHoRUS Pilot Project
Social Determinants of Health and Limitation of Life-Sustaining Therapy in Neurocritical Care: A CHoRUS Pilot Project
Social determinants of health (SDOH) have been linked to neurocritical care outcomes. We sought to examine the extent to w...
Peak Edema Extension Distance: An Edema Measure Independent from Hematoma Volume Associated with Functional Outcome in Intracerebral Hemorrhage
Peak Edema Extension Distance: An Edema Measure Independent from Hematoma Volume Associated with Functional Outcome in Intracerebral Hemorrhage
Our objective was to test the association between hematoma volume and long-term (> 72 h) edema exten...
Mechanistic Evaluation of Diffusion Weighted Hyperintense Lesions After Large Spontaneous Intracerebral Hemorrhage: A Subgroup Analysis of MISTIE III
Mechanistic Evaluation of Diffusion Weighted Hyperintense Lesions After Large Spontaneous Intracerebral Hemorrhage: A Subgroup Analysis of MISTIE III
Ischemic lesions on diffusion weighted imaging (DWI) are common after acute spontaneous intracerebral hemorrhage (ICH) but...
Correction to: Cerebrospinal Fluid from Aneurysmal Subarachnoid Hemorrhage Patients Leads to Hydrocephalus in Nude Mice
Correction to: Cerebrospinal Fluid from Aneurysmal Subarachnoid Hemorrhage Patients Leads to Hydrocephalus in Nude Mice
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USAShu Wan, Jialiang Wei, Ya Hua, Sravanthi Koduri &...
CAR-T Cell Therapy and the Neurointensivist
CAR-T Cell Therapy and the Neurointensivist
Our patient had a clinical trajectory with known complications of CAR-T cell therapy, starting with CRS merging into ICANS...
Cerebral Autoregulation: A Target for Improving Neurological Outcomes in Extracorporeal Life Support
Cerebral Autoregulation: A Target for Improving Neurological Outcomes in Extracorporeal Life Support
Despite improvements in survival after illnesses requiring extracorporeal life support, cerebral injury continues to hinde...
Resting-State EEG Signature of Early Consciousness Recovery in Comatose Patients with Traumatic Brain Injury
Resting-State EEG Signature of Early Consciousness Recovery in Comatose Patients with Traumatic Brain Injury
Resting-state electroencephalography (rsEEG) is usually obtained to assess seizures in comatose patients with traumatic br...
A Comprehensive Perspective on Intracranial Pressure Monitoring and Individualized Management in Neurocritical Care: Results of a Survey with Global Experts
A Comprehensive Perspective on Intracranial Pressure Monitoring and Individualized Management in Neurocritical Care: Results of a Survey with Global Experts
Numerous trials have addressed intracranial pressure (ICP) management in neurocritical care. However, identifying its harm...
Acute-Phase Neurofilament Light and Glial Fibrillary Acidic Proteins in Cerebrospinal Fluid Predict Long-Term Outcome After Severe Traumatic Brain Injury
Acute-Phase Neurofilament Light and Glial Fibrillary Acidic Proteins in Cerebrospinal Fluid Predict Long-Term Outcome After Severe Traumatic Brain Injury
This study investigated trajectory profiles and the association of concentrations of the biomarkers neurofilament light (N...
Electroconvulsive Therapy in Refractory and Super-Refractory Status Epilepticus in Adults: A Scoping Review
Electroconvulsive Therapy in Refractory and Super-Refractory Status Epilepticus in Adults: A Scoping Review
Electroconvulsive therapy (ECT) has been suggested as a treatment option for refractory status epilepticus (RSE) and super...
Smartphone Use in the Management of Neurological Emergencies: A Simulation-Based Study
Smartphone Use in the Management of Neurological Emergencies: A Simulation-Based Study
Smartphone use in medicine is nearly universal despite a dearth of research assessing utility in clinical performance. We ...
PaCO2 Association with Outcomes of Patients with Traumatic Brain Injury at High Altitude: A Prospective Single-Center Cohort Study
PaCO2 Association with Outcomes of Patients with Traumatic Brain Injury at High Altitude: A Prospective Single-Center Cohort Study
Partial pressure of carbon dioxide (PaCO2) is generally known to influence outcome in patients with traumatic brain injury...
Hyperbaric Oxygen Therapy Reduces the Traumatic Brain Injury–Mediated Neuroinflammation Through Enrichment of Prevotella Copri in the Gut of Male Rats
Hyperbaric Oxygen Therapy Reduces the Traumatic Brain Injury–Mediated Neuroinflammation Through Enrichment of Prevotella Copri in the Gut of Male Rats
Gastrointestinal dysfunction frequently occurs following traumatic brain injury (TBI) and significantly increases posttrau...
Early Celecoxib Use in Spontaneous Intracerebral Hemorrhage is Associated with Reduced Mortality
Early Celecoxib Use in Spontaneous Intracerebral Hemorrhage is Associated with Reduced Mortality
Hemorrhagic strokes constitute 10–15% of all strokes and have the worst mortality and morbidity of all subtypes. Mor...
The Effects of IRL-1620 in Post-ischemic Brain Injury: A Systematic Review and Meta-analysis of Experimental Studies
The Effects of IRL-1620 in Post-ischemic Brain Injury: A Systematic Review and Meta-analysis of Experimental Studies
Sovateltide (IRL-1620), an endothelin B receptor agonist, has previously demonstrated neuroprotective and neuroregenerativ...
Pharmacologic Venous Thromboembolism Prophylaxis in Patients with Nontraumatic Subarachnoid Hemorrhage Requiring an External Ventricular Drain
Pharmacologic Venous Thromboembolism Prophylaxis in Patients with Nontraumatic Subarachnoid Hemorrhage Requiring an External Ventricular Drain
Optimal pharmacologic thromboprophylaxis dosing is not well described in patients with subarachnoid hemorrhage (SAH) with ...
The Early Benchmarks of Outcome Determination in Cerebral Hemorrhage
The Early Benchmarks of Outcome Determination in Cerebral Hemorrhage
Stroke (often called cerebrovascular accident in the 1950s) was mostly understood as ...
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