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SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53
Bladder cancer (BCa) is one of the most common malignancies worldwide. However, the lack of accurate and effective targete...
Targeting MYH9 represses USP14-mediated NAP1L1 deubiquitination and cell proliferation in glioma
Targeting MYH9 represses USP14-mediated NAP1L1 deubiquitination and cell proliferation in glioma
Myosin heavy chain 9 (MYH9) plays an important role in a number of diseases. Nevertheless, the function of MYH9 in glioma ...
Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model
Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model
Recently, natural killer (NK) cells emerged as a treatment option for various solid tumors. However, the immunosuppressive...
FAP promotes clear cell renal cell carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway
FAP promotes clear cell renal cell carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway
Herein, we aimed at exploring the FAP expression in clear cell renal cell carcinoma (ccRCC) along with its clinical implic...
Disulfidptosis-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in colon adenocarcinoma
Disulfidptosis-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in colon adenocarcinoma
Disulfidptosis is independent of apoptosis, ferroptosis, and cuproptosis and is associated with cancer progression, treatm...
Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
Luteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, t...
Retraction Note: Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT
Retraction Note: Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Machine learning-derived identification of tumor-infiltrating immune cell-related signature for improving prognosis and immunotherapy responses in patients with skin cutaneous melanoma
Machine learning-derived identification of tumor-infiltrating immune cell-related signature for improving prognosis and immunotherapy responses in patients with skin cutaneous melanoma
Immunoblockade therapy based on the PD-1 checkpoint has greatly improved the survival rate of patients with skin cutaneous...
Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma
Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma
The aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarco...
DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress
DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress
Lung cancer is a leading cause of cancer-related deaths, and the most common type is lung adenocarcinoma (LUAD). LUAD is f...
Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma
Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma
Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin syste...
The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo
The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo
Pancreatic cancer is one of the leading causes of cancer death in Western societies. Its late diagnosis and resistance to ...
Synergistic effects of flavonoids and paclitaxel in cancer treatment: a systematic review
Synergistic effects of flavonoids and paclitaxel in cancer treatment: a systematic review
Paclitaxel is a natural anticancer compound with minimal toxicity, the capacity to stabilize microtubules, and high effici...
Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
Deubiquitinating enzymes (DUBs) comprise a family of proteases responsible for cleaving the peptide or isopeptide bond bet...
The novel oncogenic factor TET3 combines with AHR to promote thyroid cancer lymphangiogenesis via the HIF-1α/VEGF signaling pathway
The novel oncogenic factor TET3 combines with AHR to promote thyroid cancer lymphangiogenesis via the HIF-1α/VEGF signaling pathway
Lymphangiogenesis has been reported to play crucial roles in the metastasis of thyroid cancer (THCA), but despite the sign...
Retraction Note: Targeting a novel LncRNA SNHG15/miR-451/c-Myc signaling cascade is effective to hamper the pathogenesis of breast cancer (BC) in vitro and in vivo
Retraction Note: Targeting a novel LncRNA SNHG15/miR-451/c-Myc signaling cascade is effective to hamper the pathogenesis of breast cancer (BC) in vitro and in vivo
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to...
ARF6 promotes hepatocellular carcinoma proliferation through activating STAT3 signaling
ARF6 promotes hepatocellular carcinoma proliferation through activating STAT3 signaling
Hepatocellular Carcinoma (HCC) possesses the high mortality in cancers worldwide. Nevertheless, the concrete mechanism und...
Enhancing HCC Treatment: innovatively combining HDAC2 inhibitor with PD-1/PD-L1 inhibition
Enhancing HCC Treatment: innovatively combining HDAC2 inhibitor with PD-1/PD-L1 inhibition
Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality but lacks effective treatments thus far. ...
HER3 functions as an effective therapeutic target in triple negative breast cancer to potentiate the antitumor activity of gefitinib and paclitaxel
HER3 functions as an effective therapeutic target in triple negative breast cancer to potentiate the antitumor activity of gefitinib and paclitaxel
Triple negative breast cancer (TNBC) represents a significant clinical challenge. Chemotherapy remains the mainstay for a ...
Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds
Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds
A growing body of evidence indicates that the anticancer effect of the immune system can be activated by the immunogenic m...
EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis
EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis
Hepatitis B virus (HBV)-encoded X antigen, HBx, assists in the development of hepatocellular carcinoma (HCC) through compl...
LncRNA SNHG1: role in tumorigenesis of multiple human cancers
LncRNA SNHG1: role in tumorigenesis of multiple human cancers
Small nucleolar RNA host gene 1 (SNHG1) is an important member of the SNHG family. This family is composed of a group of h...
Identification and validation of a novel prognosis model based on m5C-related long non-coding RNAs in colorectal cancer
Identification and validation of a novel prognosis model based on m5C-related long non-coding RNAs in colorectal cancer
The prognosis of tumor patients can be assessed by measuring the levels of lncRNAs (long non-coding RNAs), which play a ro...
Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA)
Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA)
Telomerase can overcome replicative senescence by elongation of telomeres but is also a specific element in most cancer ce...
PTBP1 plays an important role in the development of gastric cancer
PTBP1 plays an important role in the development of gastric cancer
Polypyrimidine tract binding protein 1 (PTBP1) has been found to play an important role in the occurrence and development ...
Safety and efficacy of T-cell-redirecting bispecific antibodies for patients with multiple myeloma: a systematic review and meta-analysis
Safety and efficacy of T-cell-redirecting bispecific antibodies for patients with multiple myeloma: a systematic review and meta-analysis
In recent years, several bispecific antibodies (BsAbs) have been introduced that revolutionized the treatment approach for...
LncRNA CYP4A22-AS1 promotes the progression of lung adenocarcinoma through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes
LncRNA CYP4A22-AS1 promotes the progression of lung adenocarcinoma through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes
Lung adenocarcinoma (LUAD) exhibits a higher fatality rate among all cancer types worldwide, yet the precise mechanisms un...
Investigating genomic, proteomic, and post-transcriptional regulation profiles in colorectal cancer: a comparative study between primary tumors and associated metastases
Investigating genomic, proteomic, and post-transcriptional regulation profiles in colorectal cancer: a comparative study between primary tumors and associated metastases
Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the poss...
Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma
Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma
Progranulin (PGRN), a glycoprotein secreted by a wide range of epithelial cells and plays an important role in inflammator...
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