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Integrated proteomics and metabolomics analyses reveal new insights into the antitumor effects of valproic acid plus simvastatin combination in a prostate cancer xenograft model associated with downmodulation of YAP/TAZ signaling
Integrated proteomics and metabolomics analyses reveal new insights into the antitumor effects of valproic acid plus simvastatin combination in a prostate cancer xenograft model associated with downmodulation of YAP/TAZ signaling
Despite advancements in therapeutic approaches, including taxane-based chemotherapy and androgen receptor-targeting agents...
MicroRNAome profiling of breast cancer unveils hsa-miR-5683 as a tumor suppressor microRNA predicting favorable clinical outcome
MicroRNAome profiling of breast cancer unveils hsa-miR-5683 as a tumor suppressor microRNA predicting favorable clinical outcome
Breast cancer is a heterogeneous disease with diverse molecular subtypes, underscoring a better understanding of its molec...
Single-cell RNA sequencing reveals the landscape of the cellular ecosystem of primary hepatocellular carcinoma
Single-cell RNA sequencing reveals the landscape of the cellular ecosystem of primary hepatocellular carcinoma
Hepatocellular carcinoma (HCC) cells, along with multiple nonmalignant stromal cells, such as fibroblasts, endothelial cel...
Analysis of immune status and prognostic model incorporating lactic acid metabolism-associated genes
Analysis of immune status and prognostic model incorporating lactic acid metabolism-associated genes
Cancer development is intricately linked with metabolic dysregulation, including lactic acid metabolism, which plays a piv...
Expression of HECTD2 predicts peritoneal metastasis of gastric cancer and reconstructs immune microenvironment
Expression of HECTD2 predicts peritoneal metastasis of gastric cancer and reconstructs immune microenvironment
Peritoneal metastasis (PM) is a common metastasis site and death cause of gastric cancer, which is a complex biological pr...
Ferroptosis: insight into the treatment of hepatocellular carcinoma
Ferroptosis: insight into the treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignances in the world, with high morbidity and mortality. Due ...
Olaparib enhancing radiosensitization and anti-metastatic effect of oral cancer by targeting IL-17A signal
Olaparib enhancing radiosensitization and anti-metastatic effect of oral cancer by targeting IL-17A signal
We tested whether the PARP inhibitor, Olaparib, can effectively enhance radiosensitivity while inhibiting OSCC growth and ...
E3 ubiquitin ligase HECW2: a promising target for tumour therapy
E3 ubiquitin ligase HECW2: a promising target for tumour therapy
Ubiquitination is a prevalent post-translational modification that plays a crucial role in a wide range of pathophysiologi...
Correction to: SLC39A1 contribute to malignant progression and have clinical prognostic impact in gliomas
Correction to: SLC39A1 contribute to malignant progression and have clinical prognostic impact in gliomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
High CTLA-4 gene expression is an independent good prognosis factor in breast cancer patients, especially in the HER2-enriched subtype
High CTLA-4 gene expression is an independent good prognosis factor in breast cancer patients, especially in the HER2-enriched subtype
Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-related death worldwide. This hetero...
Machine learning unveils key Redox signatures for enhanced breast Cancer therapy
Machine learning unveils key Redox signatures for enhanced breast Cancer therapy
Breast cancer remains a leading cause of mortality among women worldwide, necessitating innovative prognostic models to en...
Comprehensive review of LncRNA-mediated therapeutic resistance in non-small cell lung cancer
Comprehensive review of LncRNA-mediated therapeutic resistance in non-small cell lung cancer
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of gene expression through diverse mechanisms, including...
FUS/circZEB1/miR-128-3p/LBH feedback loop contributes to the malignant phenotype of GSCs via TNF-α-mediated NF-κB signaling pathway
FUS/circZEB1/miR-128-3p/LBH feedback loop contributes to the malignant phenotype of GSCs via TNF-α-mediated NF-κB signaling pathway
Glioblastoma (GBM) is the most lethal and common primary tumor of central nervous system with a poor prognosis. Glioma ste...
Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC
Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC
Integrin alpha 5 (ITGA5) was previously confirmed to be related to prognosis in several cancer types; however, its functio...
Exploiting acquired vulnerability to develop novel treatments for cholangiocarcinoma
Exploiting acquired vulnerability to develop novel treatments for cholangiocarcinoma
Cholangiocarcinoma (CCA) presents a formidable therapeutic challenge due to its extensive heterogeneity and plasticity, wh...
Life history dynamics of evolving tumors: insights into task specialization, trade-offs, and tumor heterogeneity
Life history dynamics of evolving tumors: insights into task specialization, trade-offs, and tumor heterogeneity
The evolution of cancer cells parallels species evolution in numerous ways. Variations arise and spread under the pressure...
The efficacy of immunotherapy in non-small cell lung cancer with KRAS mutation: a systematic review and meta-analysis
The efficacy of immunotherapy in non-small cell lung cancer with KRAS mutation: a systematic review and meta-analysis
The KRAS mutation is highly prevalent in NSCLC and is associated with poor efficacy of immunotherapy. Nevertheless, the im...
A multidimensional analysis of the impact of obesity on immune checkpoint inhibitor therapy efficacy
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Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells
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Exosome therapeutics for non-small cell lung cancer tumorigenesis
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Machine learning and single-cell RNA sequencing reveal relationship between intratumor CD8+ T cells and uveal melanoma metastasis
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The development of the occurrence and metastasis of breast cancer by single-cell sequencing
The development of the occurrence and metastasis of breast cancer by single-cell sequencing
Breast cancer is currently the most frequent malignant tumor and the leading cause of cancer death among women globally. A...
Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?
Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?
T helper (Th) 17 cells, a distinct subset of Th lymphocytes, are known for their prominent interleukin (IL)-17 production ...
Acid affairs in anti-tumour immunity
Acid affairs in anti-tumour immunity
Metabolic rewiring of cancer cells is one of the hallmarks of cancer. As a consequence, the metabolic landscape of the tum...
STAT3: Key targets of growth-promoting receptor positive breast cancer
STAT3: Key targets of growth-promoting receptor positive breast cancer
Breast cancer has become the malignant tumor with the first incidence and the second mortality among female cancers. Most ...
Reactive oxygen species from non-thermal gas plasma (CAP): implication for targeting cancer stem cells
Reactive oxygen species from non-thermal gas plasma (CAP): implication for targeting cancer stem cells
Cancer remains a major global health challenge, with the persistence of cancer stem cells (CSCs) contributing to treatment...
Identification of HSPG2 as a bladder pro-tumor protein through NID1/AKT signaling
Identification of HSPG2 as a bladder pro-tumor protein through NID1/AKT signaling
Heparan sulfate proteoglycans (HSPGs) are complex molecules found on the cell membrane and within the extracellular matrix...
Curcumin attenuates smoking and drinking activated NF-κB/IL-6 inflammatory signaling axis in cervical cancer
Curcumin attenuates smoking and drinking activated NF-κB/IL-6 inflammatory signaling axis in cervical cancer
High-risk strains of HPV are known to cause cervical cancer. Multiple clinical studies have emphasized that smoking and dr...
Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis
Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis
Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ...
Serum exosomal small nucleolar RNA (snoRNA) signatures as a predictive biomarker for benign and malignant pulmonary nodules
Serum exosomal small nucleolar RNA (snoRNA) signatures as a predictive biomarker for benign and malignant pulmonary nodules
Low-dose CT (LDCT) is increasingly recognized as the preferred method for detecting pulmonary nodules. However, distinguis...
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