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Six immune-related promising biomarkers may promote hepatocellular carcinoma prognosis: a bioinformatics analysis and experimental validation
Six immune-related promising biomarkers may promote hepatocellular carcinoma prognosis: a bioinformatics analysis and experimental validation
Abnormal miRNA and mRNA expression and dysregulated immune microenvironment have been found to frequently induce the progr...
Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5
Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5
Non-small cell lung cancer is a heterogeneous disease driven by extensive molecular alterations. Exosomes are small vesicl...
SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD
SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD
As an oncogene, SETD8 can promote tumour growth and tumour cell proliferation. This study aims to reveal the relationship ...
The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients
The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients
The disruption of epithelial features represents a critical step during breast cancer spread. In this context, the dysregu...
BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway
BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its invasiveness and ability to metastasize co...
Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis
Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis
Glioblastoma multiforme (GBM) is characterized by an unfavorable prognosis for patients affected. During standard-of-care ...
Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h
Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h
Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumor...
Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations
Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations
In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, i...
ncRNAs-mediated overexpression of STIL predict unfavorable prognosis and correlated with the efficacy of immunotherapy of hepatocellular carcinoma
ncRNAs-mediated overexpression of STIL predict unfavorable prognosis and correlated with the efficacy of immunotherapy of hepatocellular carcinoma
STIL centriolar assembly protein (STIL) is a cytoplasmic protein implicated in cellular growth and proliferation as well a...
Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma
Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common cancer and t...
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data
Head and neck squamous cell carcinoma (HNSCC) remains an unmet medical challenge. Metabolic reprogramming is a hallmark of...
A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1
A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1
Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and ...
Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis
Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis
The chorioallantoic membrane (CAM) assay is a well-established technique to evaluate tumor invasion and angiogenesis and m...
The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-dep...
The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis
The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis
The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different ca...
MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptio...
Correction: Current view of liver cancer cell-of-origin and proposed mechanisms precluding its proper determination
Correction: Current view of liver cancer cell-of-origin and proposed mechanisms precluding its proper determination
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
The role of LncRNAs in tumor immunotherapy
The role of LncRNAs in tumor immunotherapy
Cancer immunotherapy is a major breakthrough in the history of tumor therapy in the last decade. Immune checkpoint inhibit...
Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis
Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis
Circadian disruption is an emerging driver of breast cancer (BCa), with epidemiological studies linking shift work and chr...
Retraction Note: LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance
Retraction Note: LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
MMP2 is a immunotherapy related biomarker and correlated with cancer-associated fibroblasts infiltrate in melanoma
MMP2 is a immunotherapy related biomarker and correlated with cancer-associated fibroblasts infiltrate in melanoma
Mounting evidence supports that matrix metalloproteinase (MMPs) are highly associated with tumor progression and that targ...
Long non-coding RNA CCL14-AS suppresses invasiveness and lymph node metastasis of colorectal cancer cells by regulating MEP1A
Long non-coding RNA CCL14-AS suppresses invasiveness and lymph node metastasis of colorectal cancer cells by regulating MEP1A
Long non-coding RNAs (lncRNAs) play important roles in the biology of colorectal cancer (CRC). There are several lncRNAs a...
Long non-coding RNA signature in colorectal cancer: research progression and clinical application
Long non-coding RNA signature in colorectal cancer: research progression and clinical application
Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are as...
Study on the correlation between B vitamins and breast cancer
Study on the correlation between B vitamins and breast cancer
Relevant studies suggest that serum vitamin level is related to the risk of breast cancer, and dietary pattern and drug su...
In vitro and in vivo analyses on anti-NSCLC activity of apatinib: rediscovery of a new drug target V600E mutation
In vitro and in vivo analyses on anti-NSCLC activity of apatinib: rediscovery of a new drug target V600E mutation
Apatinib (YN968D1) is the first small-molecule-targeting drug with anti-tumor activity created in China for the treatment ...
The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies
The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies
After skin malignancy, breast cancer is the most widely recognized cancer detected in women in the United States. Breast c...
Clinicopathological significance and prognostic role of LAG3 + tumor-infiltrating lymphocytes in colorectal cancer; relationship with sidedness
Clinicopathological significance and prognostic role of LAG3 + tumor-infiltrating lymphocytes in colorectal cancer; relationship with sidedness
It is well-documented that the interplay between tumor-infiltrating lymphocytes (TILs) and tumor cells is a major determin...
Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues
Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues
Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific sy...
Changes in HER3 expression profiles between primary and recurrent gynecological cancers
Changes in HER3 expression profiles between primary and recurrent gynecological cancers
Human epidermal growth factor receptor-3 (HER3) is a member of the epidermal growth factor receptor family of receptor tyr...
BRAFV600E mutational status assessment in cutaneous melanocytic neoplasms in a group of the Egyptian population
BRAFV600E mutational status assessment in cutaneous melanocytic neoplasms in a group of the Egyptian population
Melanocytic neoplasms range from banal nevi to malignant melanomas. The genetic background has been extensively studied in...
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