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SLC7A5 correlated with malignancies and immunotherapy response in bladder cancer
SLC7A5 correlated with malignancies and immunotherapy response in bladder cancer
Metabolic reprogramming contributes to bladder cancer development. This study aimed to understand the role of SLC7A5 in bl...
Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent conditions
Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent conditions
Although rare, uveal melanoma (UM) is a life-threatening malignancy. Understanding its biology is necessary to improve dis...
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21
Radiotherapy (RT) has been identified as a vital treatment for esophageal squamous cell carcinoma (ESCC), while the develo...
EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability
EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability
The incidence and mortality of lung cancer is the highest in China and the world. Brain is the most common distant metasta...
Comprehensive insights into AML relapse: genetic mutations, clonal evolution, and clinical outcomes
Comprehensive insights into AML relapse: genetic mutations, clonal evolution, and clinical outcomes
Acute myeloid leukemia (AML) is a complex hematologic malignancy characterized by uncontrolled proliferation of myeloid pr...
Comprehensive analysis of KLF family reveals KLF6 as a promising prognostic and immune biomarker in pancreatic ductal adenocarcinoma
Comprehensive analysis of KLF family reveals KLF6 as a promising prognostic and immune biomarker in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors worldwide, with extremely aggressive and complicate...
Smad2/3/4 complex could undergo liquid liquid phase separation and induce apoptosis through TAT in hepatocellular carcinoma
Smad2/3/4 complex could undergo liquid liquid phase separation and induce apoptosis through TAT in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) represents one of the most significant causes of mortality due to cancer-related deaths. It...
MDM2: current research status and prospects of tumor treatment
MDM2: current research status and prospects of tumor treatment
Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53....
HPV16-miRNAs exert oncogenic effects through enhancers in human cervical cancer
HPV16-miRNAs exert oncogenic effects through enhancers in human cervical cancer
Cervical cancer is a human papillomavirus (HPV)-related disease. HPV type 16 (HPV16), which is the predominant cause of ce...
A novel prognostic signature based on smoking-associated genes for predicting prognosis and immune microenvironment in NSCLC smokers
A novel prognostic signature based on smoking-associated genes for predicting prognosis and immune microenvironment in NSCLC smokers
As a highly heterogeneous tumor, non-small cell lung cancer (NSCLC) is famous for its high incidence and mortality worldwi...
Forkhead box E1, frequently downregulted by promoter methylation, inhibits colorectal cancer cell growth and migration
Forkhead box E1, frequently downregulted by promoter methylation, inhibits colorectal cancer cell growth and migration
Forkhead box E1 (FOXE1), also known as thyroid transcription factor 2 (TTF-2), belongs to a large family of forkhead trans...
A novel disulfide death-related genes prognostic signature identifies the role of IPO4 in glioma progression
A novel disulfide death-related genes prognostic signature identifies the role of IPO4 in glioma progression
“Disulfide death,” a form of cellular demise, is triggered by the abnormal accumulation of intracellular disul...
Erianin inhibits the progression of triple-negative breast cancer by suppressing SRC-mediated cholesterol metabolism
Erianin inhibits the progression of triple-negative breast cancer by suppressing SRC-mediated cholesterol metabolism
Triple-negative breast cancer (TNBC) is highly malignant and lacks effective biotherapeutic targets. The development of ef...
The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation
The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation
Esophageal squamous cell carcinoma (ESCC) is one of most prevalent cancers worldwide, especially in China. Lacking in dept...
PI3K/AKT pathway as a pivotal regulator of epithelial-mesenchymal transition in lung tumor cells
PI3K/AKT pathway as a pivotal regulator of epithelial-mesenchymal transition in lung tumor cells
Lung cancer, as the leading cause of cancer related deaths, is one of the main global health challenges. Despite various p...
Characterization of alternative splicing events and prognostic signatures in gastric cancer
Characterization of alternative splicing events and prognostic signatures in gastric cancer
Accumulating evidences indicate that the specific alternative splicing (AS) events are linked to the occurrence and progno...
New insights into targeted therapy of glioblastoma using smart nanoparticles
New insights into targeted therapy of glioblastoma using smart nanoparticles
In recent times, the intersection of nanotechnology and biomedical research has given rise to nanobiomedicine, a captivati...
Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21
Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21
Single nuclear polymorphisms (SNPs) have been published to be correlated with multiple diseases. Transcription Factor 21 (...
Iron metabolism: backfire of cancer cell stemness and therapeutic modalities
Iron metabolism: backfire of cancer cell stemness and therapeutic modalities
Cancer stem cells (CSCs), with their ability of self-renewal, unlimited proliferation, and multi-directional differentiati...
Exosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma
Exosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma
The exosome-mediated extracellular secretion of miRNAs occurs in many cancers, and RAB27A is a potent regulator of exosome...
circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation
circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation
Ovarian cancer (OC) is a malignancy among female globally. Circular RNAs (circRNAs) are a family of circular endogenous RN...
Antitumor mechanisms and future clinical applications of the natural product triptolide
Antitumor mechanisms and future clinical applications of the natural product triptolide
Triptolide (TPL) is a compound sourced from Tripterygium wilfordii Hook. F., a traditional Chinese medicinal herb recogniz...
Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma
Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma
Small ubiquitin-like modifier (SUMO) modification is increasingly recognized as critical in tumorigenesis and progression....
C6orf15 promotes liver metastasis via WNT/β-catenin signalling in colorectal cancer
C6orf15 promotes liver metastasis via WNT/β-catenin signalling in colorectal cancer
Colon cancer ranks third among global tumours and second in cancer-related mortality, prompting an urgent need to explore ...
PPP2R1A silencing suppresses LUAD progression by sensitizing cells to nelfinavir-induced apoptosis and pyroptosis
PPP2R1A silencing suppresses LUAD progression by sensitizing cells to nelfinavir-induced apoptosis and pyroptosis
Lung adenocarcinoma is a major public health problem with the low 5-year survival rate (15%) among cancers. Aberrant alter...
CDCA5-EEF1A1 interaction promotes progression of clear cell renal cell carcinoma by regulating mTOR signaling
CDCA5-EEF1A1 interaction promotes progression of clear cell renal cell carcinoma by regulating mTOR signaling
Cell division cycle associated 5 (CDCA5) plays ontogenetic role in various human cancers. However, its specific function a...