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Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex
Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex
Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and...
Machine learning models for predicting of PD-1 treatment efficacy in Pan-cancer patients based on routine hematologic and biochemical parameters
Machine learning models for predicting of PD-1 treatment efficacy in Pan-cancer patients based on routine hematologic and biochemical parameters
Immune checkpoint blockade therapy targeting the programmed death-1(PD-1) pathway has shown remarkable efficacy and durabl...
Function of serine/arginine-rich splicing factors in hematopoiesis and hematopoietic malignancies
Function of serine/arginine-rich splicing factors in hematopoiesis and hematopoietic malignancies
The serine/arginine-rich splicing factors (SRSFs) play an important role in regulating the alternative splicing of precurs...
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Cisplatin is integral to ovarian cancer treatment, yet resistance to this drug often results in adverse patient outcomes. ...
ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival
ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival
Glioblastoma (GBM) is the most aggressive among the tumors of the central nervous system (CNS), and has a dismal prognosis...
CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review
CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review
Medulloblastoma is one of the common primary central nervous system (CNS) malignancies in pediatric patients. The main tre...
PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression
PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression
To investigate the mechanism by which cancer-associated fibroblasts (CAFs) affect the growth and immune evasion of lung ca...
MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
Hypoxia represents one of the key factors that stimulates the growth of leukemic cells in their niche. Leukemic cells in h...
The relationship and clinical significance of lactylation modification in digestive system tumors
The relationship and clinical significance of lactylation modification in digestive system tumors
Lactylation, an emerging post-translational modification, plays a pivotal role in the initiation and progression of digest...
Therapeutic potential of Pien Tze Huang in colitis-associated colorectal cancer: mechanistic insights from a mouse model
Therapeutic potential of Pien Tze Huang in colitis-associated colorectal cancer: mechanistic insights from a mouse model
Pien Tze Huang (PZH), a traditional Chinese medicine formulation, is recognized for its therapeutic effect on colitis and ...
Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells
Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells
Microtubule polymerization is usually considered as the upstream of apoptotic cell death induced by taxanes, but recently ...
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells
Multiple genetic and epigenetic regulatory mechanisms are crucial in the development and tumorigenesis process. Transcript...
Inhibition of ABI2 ubiquitination-dependent degradation suppresses TNBC cell growth via down-regulating PI3K/Akt signaling pathway
Inhibition of ABI2 ubiquitination-dependent degradation suppresses TNBC cell growth via down-regulating PI3K/Akt signaling pathway
Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanis...
Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution
Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution
A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diag...
WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis
WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis
Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatment...
Monitoring measurable residual disease in paediatric acute lymphoblastic leukaemia using immunoglobulin gene clonality based on next-generation sequencing
Monitoring measurable residual disease in paediatric acute lymphoblastic leukaemia using immunoglobulin gene clonality based on next-generation sequencing
Assessment of measurable residual disease (MRD) is an essential prognostic tool for B-lymphoblastic leukaemia (B-ALL). In ...
The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha
The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha
Acute myeloid leukemia (AML), a malignancy Often resistant to common chemotherapy regimens (Cytarabine (Ara-c) +R...
Antiproliferative effect of indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogues on IL-6 mediated STAT3 and role of the apoptotic pathway in albino Wistar rats of ethyl carbamate-induced lung carcinoma: In-silico, In-vitro, and In-vivo study
Antiproliferative effect of indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogues on IL-6 mediated STAT3 and role of the apoptotic pathway in albino Wistar rats of ethyl carbamate-induced lung carcinoma: In-silico, In-vitro, and In-vivo study
Lung cancer (LC) ranks second most prevalent cancer in females after breast cancer and second in males after prostate canc...
Muscone abrogates breast cancer progression through tumor angiogenic suppression via VEGF/PI3K/Akt/MAPK signaling pathways
Muscone abrogates breast cancer progression through tumor angiogenic suppression via VEGF/PI3K/Akt/MAPK signaling pathways
Angiogenesis strongly reflects poor breast cancer outcome and an important contributor to breast cancer (BC) metastasis; t...
LncRNA PGM5-AS1 inhibits non-small cell lung cancer progression by targeting miRNA-423-5p/SLIT2 axis
LncRNA PGM5-AS1 inhibits non-small cell lung cancer progression by targeting miRNA-423-5p/SLIT2 axis
Non-small cell lung cancer (NSCLC) is a common and aggressive primary malignancy worldwide. Dysregulation of long non-codi...
CDK4/6 inhibition enhances T-cell immunotherapy on hepatocellular carcinoma cells by rejuvenating immunogenicity
CDK4/6 inhibition enhances T-cell immunotherapy on hepatocellular carcinoma cells by rejuvenating immunogenicity
Hepatocellular carcinoma (HCC) poses a significant clinical challenge, necessitating the integration of immunotherapeutic ...
Integrated profiling identifies DXS253E as a potential prognostic marker in colorectal cancer
Integrated profiling identifies DXS253E as a potential prognostic marker in colorectal cancer
Increasing evidence suggests that DXS253E is critical for cancer development and progression, but the function and potenti...
Integration of mult-omics and nucleotide metabolism reprogramming signature analysis reveals gastric cancer immunological and prognostic features
Integration of mult-omics and nucleotide metabolism reprogramming signature analysis reveals gastric cancer immunological and prognostic features
Gastric cancer is a frequent and lethal solid tumor that has a poor prognosis and treatment result. Reprogramming of nucle...
DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma
DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma
Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The stud...
MicroRNA-98: the multifaceted regulator in human cancer progression and therapy
MicroRNA-98: the multifaceted regulator in human cancer progression and therapy
MicroRNA-98 (miR-98) stands as an important molecule in the intricate landscape of oncology. As a subset of microRNAs, the...
Comprehensive characterization of B7 family members in breast cancer: B7-H5 switch reverses breast cancer from “immuno-cold” into “immuno-hot” status
Comprehensive characterization of B7 family members in breast cancer: B7-H5 switch reverses breast cancer from “immuno-cold” into “immuno-hot” status
The members of the classic B7 family regulate the immune microenvironment of several malignant tumors. However, the potent...
TEX19 increases the levels of CDK4 and promotes breast cancer by disrupting SKP2-mediated CDK4 ubiquitination
TEX19 increases the levels of CDK4 and promotes breast cancer by disrupting SKP2-mediated CDK4 ubiquitination
Globally, breast cancer in women is the fifth leading cause of cancer death. There is an urgent need to explore the molecu...
Targeted silencing of SOCS1 by DNMT1 promotes stemness of human liver cancer stem-like cells
Targeted silencing of SOCS1 by DNMT1 promotes stemness of human liver cancer stem-like cells
Human liver cancer stem-like cells (HLCSLCs) are widely acknowledged as significant factors in the recurrence and eradicat...
Mortalin promotes the evolution of androgen-independent prostate cancer through Wnt/β-catenin signaling pathway
Mortalin promotes the evolution of androgen-independent prostate cancer through Wnt/β-catenin signaling pathway
Prostate cancer (PC) is a major global health concern affecting male individuals. Among its variants, androgen-independent...
SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling
SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling
Colorectal cancer (CRC) has the third highest incidence and second mortality rate of malignant tumors globally, highlighti...
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