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Extracellular vesicle-bound VEGF in oral squamous cell carcinoma and its role in resistance to Bevacizumab Therapy
Extracellular vesicle-bound VEGF in oral squamous cell carcinoma and its role in resistance to Bevacizumab Therapy
Vascular endothelial growth factor (VEGF) is an important proangiogenic factor and has been considered as a key target of ...
Characterization of the stem cell landscape and identification of a stemness-associated prognostic signature in bladder cancer
Characterization of the stem cell landscape and identification of a stemness-associated prognostic signature in bladder cancer
It is accepted that cancer stem cells (CSCs) are key to the occurrence, progression, drug resistance, and recurrence of bl...
Prognostic and immunological implications of heterogeneous cell death patterns in prostate cancer
Prognostic and immunological implications of heterogeneous cell death patterns in prostate cancer
Prostate cancer is one of the most common cancers in men with a significant proportion of patients developing biochemical ...
Complicated role of ALKBH5 in gastrointestinal cancer: an updated review
Complicated role of ALKBH5 in gastrointestinal cancer: an updated review
Gastrointestinal cancer is the most common malignancy in humans, often accompanied by poor prognosis. N6-methyladenosine (...
Lipid metabolism associated crosstalk: the bidirectional interaction between cancer cells and immune/stromal cells within the tumor microenvironment for prognostic insight
Lipid metabolism associated crosstalk: the bidirectional interaction between cancer cells and immune/stromal cells within the tumor microenvironment for prognostic insight
Cancer is closely related to lipid metabolism, with the tumor microenvironment (TME) containing numerous lipid metabolic i...
Telomerase related molecular subtype and risk model reveal immune activity and evaluate prognosis and immunotherapy response in prostate cancer
Telomerase related molecular subtype and risk model reveal immune activity and evaluate prognosis and immunotherapy response in prostate cancer
Prostate cancer ranks among the six most lethal malignancies worldwide. Telomerase, a reverse transcriptase enzyme, plays ...
Correction: AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
Correction: AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
rAj-Tspin, a soluble recombinant peptide from Apostichopus japonicus, can inhibit the integrin β1 (ITGB1)/FAK/AKT sig...
Establishment of patient-derived organoids and a characterization based drug discovery platform for treatment of gastric cancer
Establishment of patient-derived organoids and a characterization based drug discovery platform for treatment of gastric cancer
Gastric cancer (GC) encompasses many different histological and molecular subtypes. It is a major driver of cancer mortali...
Sensitization of hepatocellular carcinoma cells to HDACi is regulated through hsa-miR-342-5p/CFL1
Sensitization of hepatocellular carcinoma cells to HDACi is regulated through hsa-miR-342-5p/CFL1
Increased prevalence of hepatocellular carcinoma (HCC) remains a global health challenge. HCC chemoresistance is a clinica...
Enhancing mutation detection in multiple myeloma with an error-corrected ultra-sensitive NGS assay without plasma cell enrichment
Enhancing mutation detection in multiple myeloma with an error-corrected ultra-sensitive NGS assay without plasma cell enrichment
Risk stratification in multiple myeloma (MM) patients is crucial, and molecular genetic studies play a significant role in...
Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer
Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer
Gastric cancer (GC) stands out as one of the most prevalent malignancies affecting the digestive system, characterized by ...
Synergistic antitumor effect of liposomal-based formulations of olaparib and topotecan in primary epithelial ovarian cancer cells
Synergistic antitumor effect of liposomal-based formulations of olaparib and topotecan in primary epithelial ovarian cancer cells
Olaparib is a PARP inhibitor inducing synthetic lethality in tumors with deficient homologous recombination (HRD) caused b...
TTI-101 targets STAT3/c-Myc signaling pathway to suppress cervical cancer progression: an integrated experimental and computational analysis
TTI-101 targets STAT3/c-Myc signaling pathway to suppress cervical cancer progression: an integrated experimental and computational analysis
Cervical cancer (CC) is a significant global health concern, demanding the consideration of novel therapeutic strategies. ...
AFP-HSP90 mediated MYC/MET activation promotes tumor progression in hepatocellular carcinoma and gastric cancers
AFP-HSP90 mediated MYC/MET activation promotes tumor progression in hepatocellular carcinoma and gastric cancers
Alpha-fetoprotein (AFP) elevation is a well-known biomarker in various diseases, particularly in the diagnosis of hepatoce...
Harnessing exosomes as cancer biomarkers in clinical oncology
Harnessing exosomes as cancer biomarkers in clinical oncology
Exosomes are extracellular vesicles well known for facilitating cell-to-cell communication by distributing essential macro...
Comprehensive analysis, diagnosis, prognosis, and cordycepin (CD) regulations for GSDME expressions in pan-cancers
Comprehensive analysis, diagnosis, prognosis, and cordycepin (CD) regulations for GSDME expressions in pan-cancers
The Gasdermin E gene (GSDME) plays roles in deafness and cancers. However, the roles and mechanisms in cancers are complex...
Identification of POU4F1 as a novel prognostic biomarker and therapeutic target in esophageal squamous cell carcinoma
Identification of POU4F1 as a novel prognostic biomarker and therapeutic target in esophageal squamous cell carcinoma
Esophageal cancer is a significant global health concern, ranking seventh in incidence and sixth in mortality. It encompas...
CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Cancer stem cells (CSCs) are critical factors that limit the effectiveness of gastric cancer (GC) therapy. Circular RNAs (...
Enhanced anti-tumor effects by combination of tucatinib and radiation in HER2-overexpressing human cancer cell lines
Enhanced anti-tumor effects by combination of tucatinib and radiation in HER2-overexpressing human cancer cell lines
Tucatinib (TUC), a HER2-directed tyrosine kinase inhibitor, is the first targeted drug demonstrating intracranial efficacy...
Unveiling heterogeneity and prognostic markers in ductal breast cancer through single-cell RNA-seq
Unveiling heterogeneity and prognostic markers in ductal breast cancer through single-cell RNA-seq
Breast cancer (BC) is a heterogeneous disease, with the ductal subtype exhibiting significant cellular diversity that infl...
ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development
ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development
Long non-coding RNAs (lncRNAs) have garnered significant attention in biomedical research due to their pivotal roles in ge...
Uncovering novel mechanisms of chitinase-3-like protein 1 in driving inflammation-associated cancers
Uncovering novel mechanisms of chitinase-3-like protein 1 in driving inflammation-associated cancers
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that is induced and regulated by multiple factors during in...
Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex
Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex
Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and...
Machine learning models for predicting of PD-1 treatment efficacy in Pan-cancer patients based on routine hematologic and biochemical parameters
Machine learning models for predicting of PD-1 treatment efficacy in Pan-cancer patients based on routine hematologic and biochemical parameters
Immune checkpoint blockade therapy targeting the programmed death-1(PD-1) pathway has shown remarkable efficacy and durabl...
Function of serine/arginine-rich splicing factors in hematopoiesis and hematopoietic malignancies
Function of serine/arginine-rich splicing factors in hematopoiesis and hematopoietic malignancies
The serine/arginine-rich splicing factors (SRSFs) play an important role in regulating the alternative splicing of precurs...
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Cisplatin is integral to ovarian cancer treatment, yet resistance to this drug often results in adverse patient outcomes. ...
ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival
ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival
Glioblastoma (GBM) is the most aggressive among the tumors of the central nervous system (CNS), and has a dismal prognosis...
CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review
CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review
Medulloblastoma is one of the common primary central nervous system (CNS) malignancies in pediatric patients. The main tre...
PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression
PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression
To investigate the mechanism by which cancer-associated fibroblasts (CAFs) affect the growth and immune evasion of lung ca...
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