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Effect of gut hormones on bone metabolism and their possible mechanisms in the treatment of osteoporosis
Effect of gut hormones on bone metabolism and their possible mechanisms in the treatment of osteoporosis
Bone is a highly dynamic organ that changes with the daily circadian rhythm. During the day, bone resorption is suppressed...
Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis
Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis
ObjectiveThis study aimed to evaluate the efficacy of combining diterpene ginkgolide meglumine injection (DGMI) with edara...
Noninvasive cardiac-specific biomarkers for the diagnosis and prevention of vascular stenosis in cardiovascular disorder
Noninvasive cardiac-specific biomarkers for the diagnosis and prevention of vascular stenosis in cardiovascular disorder
Background:The most frequent lesion in the blood vessels feeding the myocardium is vascular stenosis, a condition that dev...
Editorial: Pathogen targeting in chronic respiratory diseases: prevention, therapy and management
Editorial: Pathogen targeting in chronic respiratory diseases: prevention, therapy and management
Chronic respiratory diseases (CRDs) are a major cause of morbidity and mortality globally. CRDs, including asthma, chronic...
Psychostimulants and social behaviors
Psychostimulants and social behaviors
Mounting evidence from animal models and human studies indicates that psychostimulants can significantly affect social beh...
The combination therapy of oncolytic virotherapy
The combination therapy of oncolytic virotherapy
Introduction: Compared to other cancer immunotherapies, oncolytic viruses possess several advantages, including high killi...
Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy
Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy
Osteosarcoma (OS) is the most common primary malignant bone tumor. In the clinic, usual strategies for OS treatment includ...
The effects of slow wave sleep characteristics on semantic, episodic, and procedural memory in people with epilepsy
The effects of slow wave sleep characteristics on semantic, episodic, and procedural memory in people with epilepsy
Slow wave sleep (SWS) is highly relevant for verbal and non-verbal/spatial memory in healthy individuals, but also in peop...
Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations
Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene....
Tripled likelihood: polypharmacy increases the occurrence of drug therapy problems in hospitalized pediatric patients
Tripled likelihood: polypharmacy increases the occurrence of drug therapy problems in hospitalized pediatric patients
BackgroundA drug therapy problem (DTP) is any undesirable event experienced by a patient that accompanies drug therapy, pr...
Fuyuan decoction prevents nasopharyngeal carcinoma metastasis by inhibiting circulating tumor cells/ endothelial cells interplay and enhancing anti-cancer immune response
Fuyuan decoction prevents nasopharyngeal carcinoma metastasis by inhibiting circulating tumor cells/ endothelial cells interplay and enhancing anti-cancer immune response
Distant metastasis is a major cause of treatment failure in cancer patients and a key challenge to improving cancer care t...
Functional effects of drugs and toxins interacting with NaV1.4
Functional effects of drugs and toxins interacting with NaV1.4
NaV1.4 is a voltage-gated sodium channel subtype that is predominantly expressed in skeletal muscle cells. It is essential...
Efficacy and safety of esketamine for pediatric gastrointestinal endoscopy: a meta-analysis and trial sequential analysis
Efficacy and safety of esketamine for pediatric gastrointestinal endoscopy: a meta-analysis and trial sequential analysis
Objective:The role of esketamine in pediatric gastrointestinal endoscopy is still unclear. This study aims to evaluate the...
A Chinese patent medicine’s long-term efficacy on non-dialysis patients with CKD stages 3–5: a retrospective cohort study
A Chinese patent medicine’s long-term efficacy on non-dialysis patients with CKD stages 3–5: a retrospective cohort study
BackgroundChinese patent medicine is commonly used in China as an important treatment mechanism to thwart the progression ...
Editorial: Clinical pharmacist service promotes the improvement of medical quality
Editorial: Clinical pharmacist service promotes the improvement of medical quality
IntroductionClinical pharmacists play a vital role in the healthcare system, improving the rational use of medications (Gu...
Ferroptosis targeting natural compounds as a promising approach for developing potent liver cancer agents
Ferroptosis targeting natural compounds as a promising approach for developing potent liver cancer agents
Liver cancer is the second leading cause of cancer-related death worldwide. However, treatment options, including surgical...
Atractylodes lancea (Thunb.) DC. [Asteraceae] rhizome-derived exosome-like nanoparticles suppress lipopolysaccharide-induced inflammation in murine microglial cells
Atractylodes lancea (Thunb.) DC. [Asteraceae] rhizome-derived exosome-like nanoparticles suppress lipopolysaccharide-induced inflammation in murine microglial cells
BackgroundExosome-like nanoparticles (ELNs) mediate interspecies intercellular communications and modulate gene expression...
A critical assessment of Traditional Chinese Medicine databases as a source for drug discovery
A critical assessment of Traditional Chinese Medicine databases as a source for drug discovery
Traditional Chinese Medicine (TCM) has been used for thousands of years to treat human diseases. Recently, many databases ...
Ascorbic acid-induced warfarin resistance after breast cancer surgery: a case report and literature review
Ascorbic acid-induced warfarin resistance after breast cancer surgery: a case report and literature review
Warfarin is an anticoagulant that requires INR-based dosage adjustment. Ascorbic acid may impair warfarin effectiveness ac...
Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats
Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats
Background:Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synt...
Direct antitumor activity of bevacizumab: an overlooked mechanism?
Direct antitumor activity of bevacizumab: an overlooked mechanism?
IntroductionBevacizumab, a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor A (VEGFA...
Plasma IGFBP-3 and IGFBP-5 levels are decreased during acute manic episodes in bipolar disorder patients
Plasma IGFBP-3 and IGFBP-5 levels are decreased during acute manic episodes in bipolar disorder patients
Introduction: Bipolar disorder (BD) is a recurrent and disabling psychiatric disorder related to low-grade peripheral infl...
Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis induction
Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis induction
The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggres...
Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation
Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation
Objective: To investigate the immune mechanism of osteosarcoma (OS)-specific markers to mitigate bone destruction in the a...
Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer’s disease
Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer’s disease
Introduction:Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to improve r...
Assessment of antimicrobial prescribing patterns, guidelines compliance, and appropriateness of antimicrobial prescribing in surgical-practice units: point prevalence survey in Malaysian teaching hospitals
Assessment of antimicrobial prescribing patterns, guidelines compliance, and appropriateness of antimicrobial prescribing in surgical-practice units: point prevalence survey in Malaysian teaching hospitals
Objectives: This study sought to investigate the quality of antimicrobial prescribing among adult surgical inpatients besi...
The pharmacoepigenetic paradigm in cancer treatment
The pharmacoepigenetic paradigm in cancer treatment
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial ro...
The application of multi-criteria decision analysis in evaluating the value of drug-oriented intervention: a literature review
The application of multi-criteria decision analysis in evaluating the value of drug-oriented intervention: a literature review
Objectives: Multi-Criteria Decision Analysis (MCDA) has gained increasing attention in supporting drug risk-benefit assess...
Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites
Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites
Purpose: The prevalence of non-alcoholic fatty liver disease (NAFLD) and its related mortality is increasing at an unprece...
Glucagon-like peptide-1 receptor agonists: new strategies and therapeutic targets to treat atherosclerotic cardiovascular disease
Glucagon-like peptide-1 receptor agonists: new strategies and therapeutic targets to treat atherosclerotic cardiovascular disease
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of cardiovascular mortality and is increasingly prevalen...
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