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Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation
Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation
ObjectiveThis research aims to explore how Puerariae Lobatae Radix regulates sebaceous gland secretion using network pharm...
Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs
Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs
ATP-binding cassette (ABC) transporters are transmembrane proteins expressed commonly in metabolic and excretory organs to...
The effects of baicalin in depression: preclinical evidence construction based on meta-analysis
The effects of baicalin in depression: preclinical evidence construction based on meta-analysis
BackgroundDepression manifests as a mental disorder characterized by a low mood, suicidal tendencies, disturbances in slee...
Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age
Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age
Alzheimer’s disease (AD) has an increasing prevalence, complicated pathogenesis and no effective cure. Emerging evidences ...
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study
BackgroundThe effect of combining prone ventilation with traditional Chinese medicine on severe pneumonia remains unclear....
CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression
CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression
Chromobox (CBX) 2, a member of the CBX protein family and a crucial component of the polycomb repressive complex (PRC), ex...
Commercial Chinese polyherbal preparation: current status and future perspectives
Commercial Chinese polyherbal preparation: current status and future perspectives
ObjectiveWith the modernization of traditional Chinese medicine (TCM) industry, the investment in research and development...
Editorial: State of the science of pharmacogenomics implementation in healthcare systems and communities
Editorial: State of the science of pharmacogenomics implementation in healthcare systems and communities
This Research Topic on the “State of the science of pharmacogenomics implementation in healthcare systems and communities”...
Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseases
Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseases
The transition of fibroblasts to myofibroblasts (FMT) represents a pivotal process in wound healing, tissue repair, and fi...
In silico and in vitro chemometrics, cell toxicity and permeability of naringenin 8-sulphonate and derivatives
In silico and in vitro chemometrics, cell toxicity and permeability of naringenin 8-sulphonate and derivatives
BackgroundSulphur containing natural compounds are among the most biologically relevant metabolites in vivo. Naringenin 8-...
Roles of distinct nuclear receptors in diabetic cardiomyopathy
Roles of distinct nuclear receptors in diabetic cardiomyopathy
Diabetes mellitus induces a pathophysiological disorder known as diabetic cardiomyopathy and may eventually cause heart fa...
Supportive care of female hormones in brain health: what and how?
Supportive care of female hormones in brain health: what and how?
Female hormones, functioning as neuroactive steroids, are utilized beyond menopausal hormone therapy. The rapid onset of a...
Anti-TNFα in inflammatory bowel disease: from originators to biosimilars
Anti-TNFα in inflammatory bowel disease: from originators to biosimilars
The introduction of anti-tumor necrosis factor α (TNFα) biologics significantly innovated inflammatory bowel disease (IBD)...
Research progress on nonsteroidal anti-inflammatory drugs in the treatment of pituitary neuroendocrine tumors
Pituitary neuroendocrine tumor is the third most common primary intracranial tumor. Its main clinical manifestations inclu...
Adverse events related to neuromuscular blocking agents: a disproportionality analysis of the FDA adverse event reporting system
Adverse events related to neuromuscular blocking agents: a disproportionality analysis of the FDA adverse event reporting system
Background: Neuromuscular blocking agents (NMBAs) are primarily used during surgical procedures to facilitate endotracheal...
The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer
The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer
The xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a...
Dynamic phenotypic shifts and M2 receptor downregulation in bladder smooth muscle cells induced by mirabegron
Dynamic phenotypic shifts and M2 receptor downregulation in bladder smooth muscle cells induced by mirabegron
IntroductionMirabegron is available for treatment of overactive bladder (OAB). However, mechanisms underlying symptom impr...
Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration
IntroductionWe read with interest the recent publication by Ma et al., Effect of curcumin nanoparticles on proliferation a...
A real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events for sunitinib
A real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events for sunitinib
BackgroundSunitinib is approved for the treatment of metastatic renal cell carcinoma (mRCC), imatinib-resistant gastrointe...
Crotoxin induces cytotoxic effects in human malignant melanoma cells in both native and detoxified forms
Crotoxin induces cytotoxic effects in human malignant melanoma cells in both native and detoxified forms
Introduction: Melanoma, a highly aggressive skin cancer originating in melanocytes, poses a significant threat due to its ...
Cost-effectiveness analysis of pharmaceutical care in adult critically ill patients: based on a prospective cohort study
Cost-effectiveness analysis of pharmaceutical care in adult critically ill patients: based on a prospective cohort study
BackgroundThe medication regimen for critically ill patients is complex and dynamic, leading to a high incidence of drug-r...
Observational study on stability of within-day glycemic variability of type 2 diabetes inpatients treated with decoctions of traditional Chinese medicine
Observational study on stability of within-day glycemic variability of type 2 diabetes inpatients treated with decoctions of traditional Chinese medicine
BackgroundWithin-day glycemic variability (GV), characterized by frequent and significant fluctuations in blood glucose le...
Monoterpene antifungal activities: evaluating geraniol, citronellal, and linalool on Candida biofilm, host inflammatory responses, and structure–activity relationships
Monoterpene antifungal activities: evaluating geraniol, citronellal, and linalool on Candida biofilm, host inflammatory responses, and structure–activity relationships
Introduction: Despite the rising concern with fungal resistance, a myriad of molecules has yet to be explored. Geraniol, l...
Recent advances and applications of nitroreductase activable agents for tumor theranostic
Recent advances and applications of nitroreductase activable agents for tumor theranostic
Nitroreductase activable agents offer a personalized and targeted approach to cancer theranostics by selectively activatin...
Editorial: New trends and approaches in perioperative pharmacotherapy, volume III
The perioperative period increases the existing stress for patients and healthcare providers and raises many problems for ...
Research progress of treating hyperuricemia in rats and mice with traditional Chinese medicine
Research progress of treating hyperuricemia in rats and mice with traditional Chinese medicine
Hyperuricemia (HUA) is a common chronic metabolic disease caused by abnormal purine metabolism and uric acid excretion. De...
The impact of sarcopenia on the efficacy of PD-1 inhibitors in non-small cell lung cancer and potential strategies to overcome resistance
The impact of sarcopenia on the efficacy of PD-1 inhibitors in non-small cell lung cancer and potential strategies to overcome resistance
Recent studies have revealed that sarcopenia can adversely affect the efficacy of PD-1 inhibitors in the treatment of non-...
Assessing the role of statin therapy in bladder cancer: evidence from a Mendelian Randomization study
Assessing the role of statin therapy in bladder cancer: evidence from a Mendelian Randomization study
BackgroundStatins, which are medications that lower lipid levels, are extensively used to decrease cardiovascular disease ...
Melatonin modulates TLR4/MyD88/NF-κB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats
Melatonin modulates TLR4/MyD88/NF-κB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats
Sleep deprivation (SD) is commonplace in today’s fast-paced society. SD is a severe public health problem globally since i...
V-doped MoS2 nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy
V-doped MoS2 nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy
Introduction: The tumor microenvironment and multidrug resistance of tumor cells seriously impair the activity of the nano...
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