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Discussion on the optimization of personalized medication using information systems based on pharmacogenomics: an example using colorectal cancer
1 IntroductionPharmacogenomics (PGx) denotes the relationship between human genetic polymorphisms and the efficacy as well...
DNA methylation inhibitors adverse reaction characteristic analysis: an analysis based on the European spontaneous adverse event reporting system
IntroductionAcute myeloid leukemia is a malignant disorder of hematopoietic stem cells, which is characterized by the expl...
MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter
IntroductionThe 5-lipoxygenase (5-LO) enzyme fulfills several cellular functions. First, it is well known as the pivotal e...
Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies
1 IntroductionPremenstrual dysphoric disorder (PMDD) is a cyclical mood disorder, with typical symptoms including anxiety ...
Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation
IntroductionUlcerative colitis (UC) is a worldwide chronic, idiopathic, and inflammatory disorder of the rectal and coloni...
Editorial: Methods in respiratory pharmacology 2023
Dear Readers, It is our great pleasure to introduce the Research Topic "Methods in Respiratory Pharmacology 2023,...
The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review
1 IntroductionInvasive aspergillosis (IA) is a life-threatening invasive fungal infection caused by Aspergillus fungi, wit...
Case report: Tocilizumab for hypersensitivity reaction after oxaliplatin in a patient with NK/T-cell lymphoma
1 IntroductionOxaliplatin, a third-generation platinum-based cytotoxic agent, is widely used in the treatment of various m...
Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy
IntroductionThe utility of genetic testing for epilepsy diagnoses is becoming increasingly realized, particularly as it im...
Adding capivasertib to fulvestrant in patients with hormone receptor-positive advanced breast cancer: a cost-effectiveness analysis
IntroductionBreast cancer poses a substantial disease burden and stands out as the principal contributor to cancer-associa...
Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis
1 IntroductionAccording to the Global Cancer Observatory, breast cancer (BC) is the second most prevalent cancer in the wo...
Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study
1 IntroductionSepsis, a severe life-threatening condition, has a significant global incidence and mortality rate and poses...
A review of the Bovis Calculus’s intervention mechanism and clinical application in ischemic stroke
1 IntroductionBovis Calculus (BC) is the desiccated gallstone of Bos taurus domesticus Gmelin. It has been employed for ca...
Effect of prophylactic doses of enoxaparin on antifactor Xa activity confirmed by rotational thromboelastometry in critically ill patients: a preliminary prospective cohort study
1 IntroductionCritically ill patients hospitalized in the intensive care unit (ICU) often present multiple risk factors fo...
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity
1 IntroductionHearing impairment ranks among the most common human afflictions, significantly impeding communication and d...
Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke
1 IntroductionCerebrovascular diseases rank as the second leading cause of death, following heart diseases (Heron, 2007; Z...
Exploring the dielectric properties of herbal medicine and modern pharmaceuticals: an integrative review
IntroductionThe foundation of traditional medicine is the extensive endeavour that humans have made to identify solutions ...
The mechanism underlying metastasis in triple-negative breast cancer: focusing on the interplay between ferroptosis, epithelial-mesenchymal transition, and non-coding RNAs
Triple-negative breast cancer (TNBC) is a type of breast cancer with lack the expression of estrogen receptor (ER), proges...
Large variability in the alkaloid content of Corydalis yanhusuo dietary supplements
1 IntroductionThe plant Corydalis yanhusuo W.T. Wang (CY) is listed in the Chinese Pharmacopeia (Tian et al., 2020) and ha...
Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies
1 IntroductionGlaucoma is an ocular condition characterized by the pathological elevation of intraocular pressure, leading...
Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma
1 IntroductionLow-grade glioma (LGG) is a primary brain tumor originating from glial cells (Weller et al., 2024), accounti...
Clopidogrel combined with rivaroxaban in peripheral artery disease after revascularization
1 IntroductionPeripheral artery disease (PAD) is a chronic atherosclerotic condition predominantly affecting the arteries ...
Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hippo-YAP/TAZ pathway: a novel therapeutic strategy for osteoporosis
1 IntroductionOsteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, disrupted bone microarchi...
Ferroptosis in kidney disease: a bibliometric analysis from 2012 to 2024
1 IntroductionChronic kidney disease (CKD) is a common chronic progressive disease characterized by abnormal renal structu...
Pharmacological action of Angelica sinensis polysaccharides: a review
1 IntroductionAngelica sinensis is the dry root of the umbelliferae plant Angelica sinensis (Oliv.) Diels, which is record...
Editorial: Model organisms in respiratory pharmacology 2023
To advance research, accurate recapitulation of the human respiratory system using biological models such as animals and c...
Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway
IntroductionRenal fibrosis, characterized by undue extracellular matrix (ECM) deposition, destroys and replaces the functi...
Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential
1 IntroductionResveratrol (C₁₄H₁₂O₃) is a distinguished non-flavonoid polyphenolic phytoalexin (Galiniak et al., 2019) tha...
Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells
1 IntroductionColon cancer is a significant global health burden, ranking as the third most common malignancy and the seco...
Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment
1 IntroductionThe tumor microenvironment (TME) is a complex system that plays a crucial role in tumor development and sign...
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