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Cost-effectiveness analysis of pharmaceutical care in adult critically ill patients: based on a prospective cohort study
Cost-effectiveness analysis of pharmaceutical care in adult critically ill patients: based on a prospective cohort study
BackgroundThe medication regimen for critically ill patients is complex and dynamic, leading to a high incidence of drug-r...
Observational study on stability of within-day glycemic variability of type 2 diabetes inpatients treated with decoctions of traditional Chinese medicine
Observational study on stability of within-day glycemic variability of type 2 diabetes inpatients treated with decoctions of traditional Chinese medicine
BackgroundWithin-day glycemic variability (GV), characterized by frequent and significant fluctuations in blood glucose le...
Monoterpene antifungal activities: evaluating geraniol, citronellal, and linalool on Candida biofilm, host inflammatory responses, and structure–activity relationships
Monoterpene antifungal activities: evaluating geraniol, citronellal, and linalool on Candida biofilm, host inflammatory responses, and structure–activity relationships
Introduction: Despite the rising concern with fungal resistance, a myriad of molecules has yet to be explored. Geraniol, l...
Recent advances and applications of nitroreductase activable agents for tumor theranostic
Recent advances and applications of nitroreductase activable agents for tumor theranostic
Nitroreductase activable agents offer a personalized and targeted approach to cancer theranostics by selectively activatin...
Editorial: New trends and approaches in perioperative pharmacotherapy, volume III
The perioperative period increases the existing stress for patients and healthcare providers and raises many problems for ...
Research progress of treating hyperuricemia in rats and mice with traditional Chinese medicine
Research progress of treating hyperuricemia in rats and mice with traditional Chinese medicine
Hyperuricemia (HUA) is a common chronic metabolic disease caused by abnormal purine metabolism and uric acid excretion. De...
The impact of sarcopenia on the efficacy of PD-1 inhibitors in non-small cell lung cancer and potential strategies to overcome resistance
The impact of sarcopenia on the efficacy of PD-1 inhibitors in non-small cell lung cancer and potential strategies to overcome resistance
Recent studies have revealed that sarcopenia can adversely affect the efficacy of PD-1 inhibitors in the treatment of non-...
Assessing the role of statin therapy in bladder cancer: evidence from a Mendelian Randomization study
Assessing the role of statin therapy in bladder cancer: evidence from a Mendelian Randomization study
BackgroundStatins, which are medications that lower lipid levels, are extensively used to decrease cardiovascular disease ...
Melatonin modulates TLR4/MyD88/NF-κB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats
Melatonin modulates TLR4/MyD88/NF-κB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats
Sleep deprivation (SD) is commonplace in today’s fast-paced society. SD is a severe public health problem globally since i...
V-doped MoS2 nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy
V-doped MoS2 nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy
Introduction: The tumor microenvironment and multidrug resistance of tumor cells seriously impair the activity of the nano...
Corrigendum: Ginsenoside Re attenuates high glucose-induced RF/6A injury via regulating PI3K/AKT inhibited HIF-1a/VEGF signaling pathway
Corrigendum: Ginsenoside Re attenuates high glucose-induced RF/6A injury via regulating PI3K/AKT inhibited HIF-1a/VEGF signaling pathway
Weijie Xie1†Ping Zhou1†Muwen Qu2Ziru Dai1Xuelian Zhang1Chenyang Zhang1Xi Dong1Guibo Sun1*Xiaobo Sun1*1Institute of Medicin...
Ethnobotanical study of traditional medicinal plants used to treat human ailments in West Shewa community, Oromia, Ethiopia
Ethnobotanical study of traditional medicinal plants used to treat human ailments in West Shewa community, Oromia, Ethiopia
Introduction: Plants have formed the basis of traditional medicine (TM) systems, which have been used for thousands of yea...
Leonurine: a comprehensive review of pharmacokinetics, pharmacodynamics, and toxicology
Leonurine: a comprehensive review of pharmacokinetics, pharmacodynamics, and toxicology
Leonurine is an alkaloid unique to the Leonurus genus, which has many biological activities, such as uterine contraction, ...
RAB42 overexpression correlates with poor prognosis, immune cell infiltration and chemoresistance
RAB42 overexpression correlates with poor prognosis, immune cell infiltration and chemoresistance
BackgroundRAB42 (Ras-related protein 42) is a new small GTPase that controls the vesicular trafficking from endosomes to t...
YinChen WuLing powder attenuates non-alcoholic steatohepatitis through the inhibition of the SHP2/PI3K/NLRP3 pathway
YinChen WuLing powder attenuates non-alcoholic steatohepatitis through the inhibition of the SHP2/PI3K/NLRP3 pathway
BackgroundYinChen WuLing Powder (YCWLP) has been recommended by consensus for the treatment of non-alcoholic steatohepatit...
In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides
In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides
Glycyrrhiza uralensis polysaccharides (GUPS) are widely applied in biomedicine and functional food due to their multiple p...
Revealing the role of metformin in gastric intestinal metaplasia treatment
Revealing the role of metformin in gastric intestinal metaplasia treatment
ObjectiveGastric intestinal metaplasia (IM) is a precancerous stage associated with gastric cancer. Despite the observed b...
Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: a systematic review and meta-analysis
Effects and safety of Ophiocordyceps sinensis preparation in the adjuvant treatment for dialysis patients: a systematic review and meta-analysis
Ethnopharmacological relevanceOphiocordyceps sinensis (O. sinensis), a genus of ascomycete fungi, has been widedly used in...
Sequential model for predicting patient adherence in subcutaneous immunotherapy for allergic rhinitis
Sequential model for predicting patient adherence in subcutaneous immunotherapy for allergic rhinitis
ObjectiveSubcutaneous Immunotherapy (SCIT) is the long-lasting causal treatment of allergic rhinitis (AR). How to enhance ...
Case report: Dezocine’s rapid and sustained antidepressant effects
Case report: Dezocine’s rapid and sustained antidepressant effects
Anhedonia and motivational impairments are cardinal features of depression, against which conventional antidepressants dem...
Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL/6J mice by activating the BDNF/TrkB pathway
Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL/6J mice by activating the BDNF/TrkB pathway
BackgroundPhosphodiesterase 7 (PDE7) plays a role in neurological function. Increased expression and activity of PDE7 has ...
Case report: safety and efficacy of lidocaine infusion for the treatment of intractable zoster-associated neuralgia in solid organ transplant recipients
Case report: safety and efficacy of lidocaine infusion for the treatment of intractable zoster-associated neuralgia in solid organ transplant recipients
IntroductionSolid organ transplant recipients are at high risk for developing severe zoster-associated neuralgia, and the ...
PD-1 inhibitors in advanced esophageal squamous cell carcinoma: a survival analysis of reconstructed patient-level data
PD-1 inhibitors in advanced esophageal squamous cell carcinoma: a survival analysis of reconstructed patient-level data
BackgroundRecently, a sum of trials of programmed cell death-1 (PD-1) inhibitors combined with chemotherapy have shown exc...
Artemvulactone E isolated from Artemisia vulgaris L. ameliorates lipopolysaccharide-induced inflammation in both RAW264.7 and zebrafish model
Artemvulactone E isolated from Artemisia vulgaris L. ameliorates lipopolysaccharide-induced inflammation in both RAW264.7 and zebrafish model
IntroductionNatural plants are valuable resources for exploring new bioactive compounds. Artemisia vulgaris L. is a tradit...
Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer
Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer
Notch signaling pathway is activated abnormally in solid and hematological tumors, which perform essential functions in ce...
Ophiopogonin D: review of pharmacological activity
Ophiopogonin D: review of pharmacological activity
BackgroundOphiopogon D is an important natural organic compound in Ophiopogon japonicus, which often has significant biolo...
Uptake of evidence-based practice and its predictors among nurses in Ethiopia: a systematic review and meta-analysis
Uptake of evidence-based practice and its predictors among nurses in Ethiopia: a systematic review and meta-analysis
Background: While evidence-based practice has demonstrated its capacity to enhance healthcare quality and bolster clinical...
Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway
Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway
Immune inflammation is one of the main factors in the pathogenesis of depression. It is an effective and active way to fin...
Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023
Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023
BackgroundGlobally, the incidence rates of obesity and its related diseases, such as cardiovascular diseases and type 2 di...
Medicinal polypharmacology—a scientific glossary of terminology and concepts
Medicinal polypharmacology is one answer to the complex reality of multifactorial human diseases that are often unresponsi...
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