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Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation
Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation
BackgroundSkin photoaging induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation manifests as skin roughness, de...
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset, limited unresponsiveness ...
Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections
Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections
There is clinical evidence showing that the Pelargonium sidoides root extract EPs 7630 is a safe and effective treatment f...
Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2
Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2
BackgroundDengue virus (DENV) infection, spread by Aedes aegypti mosquitoes, is a significant public health concern in tro...
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
IntroductionDue to the high mortality rate and increasing severity of antibiotic resistance, there is a growing interest i...
Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Introduction: Major depressive disorder (MDD), characterized by severe neuropsychiatric symptoms and significant cognitive...
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
IntroductionHelicobacter pylori causes chronic gastric diseases in nearly 50% of people around the world. It is suggested ...
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
BackgroundFluoroquinolones are broad-spectrum antibiotics with significant antimicrobial activity. Despite their therapeut...
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Background: Increasing student numbers and logistical challenges in pharmacy education limit patient counselling and clini...
Willingness to pay and price elasticity of demand for long-acting injectable cabotegravir among men who have sex with men in Guangxi, China
Willingness to pay and price elasticity of demand for long-acting injectable cabotegravir among men who have sex with men in Guangxi, China
ObjectivesThere is still no study focused on willingness to pay for long-acting injectable cabotegravir (CAB-LA) after it ...
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
IntroductionEthambutol, a key anti-tuberculosis medication, is associated with optic neuropathy, which can lead to signifi...
Naringenin modulates oxidative stress and lipid metabolism: Insights from network pharmacology, mendelian randomization, and molecular docking
Naringenin modulates oxidative stress and lipid metabolism: Insights from network pharmacology, mendelian randomization, and molecular docking
BackgroundPrevious studies have demonstrated that naringenin possesses lipid-lowering effects; however, the underlying mec...
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
IntroductionPolypharmacy is a growing concern in healthcare systems. While available data on potential drug-drug interacti...
Radiotherapy plus lenvatinib versus radiotherapy plus sorafenib for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study
Radiotherapy plus lenvatinib versus radiotherapy plus sorafenib for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study
Background and AimsPortal vein tumor thrombus (PVTT) occurs frequently in hepatocellular carcinoma (HCC) patients. However...
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
ObjectivesSingle-strand DNA-binding protein 1 (SSB1) plays a crucial role in the cellular response to DNA damage. This stu...
Rapid identification of chemical profiles in vitro and in vivo of Huan Shao Dan and potential anti-aging metabolites by high-resolution mass spectrometry, sequential metabolism, and deep learning model
Rapid identification of chemical profiles in vitro and in vivo of Huan Shao Dan and potential anti-aging metabolites by high-resolution mass spectrometry, sequential metabolism, and deep learning model
BackgroundAging is marked by the gradual deterioration of cells, tissues, and organs and is a major risk factor for many c...
Community pharmacists’ role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study
Community pharmacists’ role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study
IntroductionThe misuse or abuse and dependence of medications containing codeine continue to be a major global public heal...
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Squamous cell carcinoma of the head and neck (HNSCC) is a difficult-to-treat cancer and treatment is challenging due to re...
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonl...
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
IntroductionThe resolution of the skin’s inflammatory response is only possible if its barrier function is restored. TRPV1...
Supramolecular nanomedicine in the intelligent cancer therapy: recent advances and future
Supramolecular nanomedicine in the intelligent cancer therapy: recent advances and future
In recent years, the incidence of cancer has been increasing year by year, and the burden of the disease and the economic ...
ED50 of ciprofol combined with different doses of remifentanil during upper gastrointestinal endoscopy in school-aged children: a prospective dose-finding study using an up-and-down sequential allocation method
ED50 of ciprofol combined with different doses of remifentanil during upper gastrointestinal endoscopy in school-aged children: a prospective dose-finding study using an up-and-down sequential allocation method
ObjectiveThis study aimed to determine the 50% effective dose (ED50) of ciprofol when combined with different doses of rem...
Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354
Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of individuals worldwide. A new eff...
HLA-B allele frequencies and implications for pharmacogenetics in the Kuwaiti population
HLA-B allele frequencies and implications for pharmacogenetics in the Kuwaiti population
Objective: This study explores the frequency of human leukocyte antigen (HLA) genes, particularly HLA-B alleles, within th...
Corrigendum: AMPK activation alleviates myocardial ischemia-reperfusion injury by regulating Drp1-mediated mitochondrial dynamics
Corrigendum: AMPK activation alleviates myocardial ischemia-reperfusion injury by regulating Drp1-mediated mitochondrial dynamics
Corrigendum: AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial D...
Shaping cardiac destiny: the role of post-translational modifications on endoplasmic reticulum – mitochondria crosstalk in cardiac remodeling
Shaping cardiac destiny: the role of post-translational modifications on endoplasmic reticulum – mitochondria crosstalk in cardiac remodeling
Cardiac remodeling is a shared pathological change in most cardiovascular diseases. Encompassing both adaptive physiologic...
Novel β-lactam antibiotics versus other antibiotics for treatment of complicated urinary tract infections: a systematic review and meta-analysis
Novel β-lactam antibiotics versus other antibiotics for treatment of complicated urinary tract infections: a systematic review and meta-analysis
BackgroundNovel β-lactam antibiotics as well as other kinds of antibiotics have been used to treat complicated urinary tra...
Inulin alleviates atherosclerosis through improving lipid metabolism, inflammation, and gut microbiota in ApoE-knockout mice: the short-chain is more efficacious
Inulin alleviates atherosclerosis through improving lipid metabolism, inflammation, and gut microbiota in ApoE-knockout mice: the short-chain is more efficacious
IntroductionAtherosclerosis (AS) is considered the underlying cause of many diseases, particularly cardiovascular and cere...
Sea buckthorn and its flavonoids isorhamnetin, quercetin, and kaempferol favorably influence bone and breast tissue health
Sea buckthorn and its flavonoids isorhamnetin, quercetin, and kaempferol favorably influence bone and breast tissue health
Bone tissue and breast tissue are interrelated, as demonstrated by breast microcalcifications, breast cancer bone metastas...
Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis
Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis
The gut microbiota offers numerous benefits to the human body, including the promotion of nutrient absorption, participati...
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