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Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity
Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity
<p>Due to its high prevalence, poor prognosis, and heavy burden on healthcare costs, diabetic vascular complications...
Factors determining the sensitivity to proteasome inhibitors of multiple myeloma cells
Factors determining the sensitivity to proteasome inhibitors of multiple myeloma cells
<p>Multiple myeloma is an incurable cancer that originates from antibody-producing plasma cells. It is characterized...
Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives
Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives
<p>This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative ag...
Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors
Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors
<p><bold>Background:</bold> ORIN1001, a first-in-class oral IRE1-α endoribonuclease inhibitor to block t...
The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer
The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer
<p>Breast cancer (BC) is a heterogenous disease, with prognosis and treatment options depending on Estrogen, Progest...
Role and regulation of FOXO3a: new insights into breast cancer therapy
Role and regulation of FOXO3a: new insights into breast cancer therapy
<p>Breast cancer is the most common malignancy in the world, particularly affecting female cancer patients. Enhancin...
Erratum: Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs
Erratum: Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs
Due to a production error, there was a mistake in Figure 4 as published. The background was black rather than white. The c...
Effect of aromatic substituents on thermoresponsive functional polycaprolactone micellar carriers for doxorubicin delivery
Effect of aromatic substituents on thermoresponsive functional polycaprolactone micellar carriers for doxorubicin delivery
<p>Amphiphilic functional polycaprolactone (PCL) diblock copolymers are excellent candidates for micellar drug deliv...
Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells
Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells
<p>Neuroblastoma (NB) is the most common extracranial pediatric solid tumor originating from the abnormal developmen...
A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
<p>Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and com...
Ultrasound combined with microbubble mediated immunotherapy for tumor microenvironment
Ultrasound combined with microbubble mediated immunotherapy for tumor microenvironment
<p>The tumor microenvironment (TME) plays an important role in dynamically regulating the progress of cancer and inf...
Editorial: Application of data mining in pharmaceutical research
Editorial: Application of data mining in pharmaceutical research
Big data from medical public databases and data-mining techniques are pivotal to advancing various healthcare fields, part...
Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors
Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors
<p><bold>Introduction:</bold> We have developed a delivery approach that uses two pHLIP peptides that co...
A pathway to strengthening open science: comments on the draft South African Ethics in Health Research Guidelines
A pathway to strengthening open science: comments on the draft South African Ethics in Health Research Guidelines
<p>The recently released <italic>draft South African Ethics in Health Research Guidelines: Principles, Process...
Optimization and preparation of a compound cod liver oil film former agent: an orthogonal design
Optimization and preparation of a compound cod liver oil film former agent: an orthogonal design
<p><bold>Background:</bold> Cod liver oil has anti-inflammatory properties and could help regulate recur...
Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development
Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development
<p><bold>Introduction:</bold> Depression is a complex psychiatric disorder with substantial societal imp...