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LncRNA JPX targets SERCA2a to mitigate myocardial ischemia/reperfusion injury by binding to EZH2
Ischemic heart disease is the leading cause of cardiovascular death [1]. Unrelieved ischemia produces scar tissue and subs...
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway
Ovarian cancer (OC) is one of the most common tumors in the female reproductive system and the main cause of death among g...
Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner
The growing incidence of infertility has been a topic of concern for reproductive specialists over the years [1]. Of parti...
Liquid-liquid phase separation: Galectin-3 in nuclear speckles and ribonucleoprotein complexes
KeywordsIntrinsically disordered domainsLiquid phase condensationMembrane-less organellesnuclear bodiesAbbreviationsCRDcar...
MTHFD1L confers a poor prognosis and malignant phenotype in esophageal squamous cell carcinoma by activating the ERK5 signaling pathway
As a frequent type of malignant tumor, esophageal cancer (EC) is the sixth dominant source of cancer-related mortality glo...
HOXD9 contributes to the Warburg effect and tumor metastasis in non-small cell lung cancer via transcriptional activation of PFKFB3
Lung cancer is one of the most significant causes of cancer-related deaths, with non-small cell lung cancer (NSCLC) accoun...
Integrated metabolomics and phosphoproteomics reveal the protective role of exosomes from human umbilical cord mesenchymal stem cells in naturally aging mouse livers
Aging (and ultimately death) is a certain process of life followed by all kinds of physical ailments, such as common metab...
Corrigendum to “Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines” [Exp. Cell Res. 375 (2019) 92–99]
Volume 426, Issue 1, 1 May 2023, 113569Author links open overlay panelM. Schwermer a b, M. Hiber c, S. Dreesmann d, A. Rie...
Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma
There are few effective therapies for small cell lung carcinoma (SCLC); thus, we need to develop novel and efficacious tre...
l-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase
Amino acids are the fundamental building blocks for protein synthesis, and as such, contribute to the majority of biomass ...
Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression
Colorectal cancer (CRC) is the third most common and second most deadly cancer in the world according to GLOBOCAN 2020 [1]...
PHLDA3 activated by BARX2 transcription, suppresses the malignant development of esophageal squamous cell carcinoma by downregulating PI3K/AKT levels
Esophageal squamous cell carcinoma (ESCC) is the most predominant histological type of esophageal malignancy, accounting f...
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway
Liver cancer is the fourth leading cause of cancer-related deaths worldwide, specifically in North America and China, posi...
FoxA2 represses ERβ-mediated pyroptosis in endometriosis by transcriptionally inhibiting IGF2BP1
Endometriosis is a common gynecological disorder characterized by chronic inflammation, defined as abnormal growth of endo...
Overexpression of CLDN16 in ovarian cancer is modulated by PI3K and PKC pathways
Pain interventional therapy, known as the most promising medical technology in the 21st century, refers to clinical treatm...
The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts
Myocardial fibrosis (MF) is a prevalent pathological hallmark at various stages of numerous cardiac disorders, and is the ...
Progress on the molecular mechanism of portal vein tumor thrombosis formation in hepatocellular carcinoma
Liver cancer is the sixth most common cancer worldwide, the fourth leading cause of cancer-related deaths, and the second ...
Epigenome editing based on CRISPR/dCas9p300 facilitates transdifferentiation of human fibroblasts into Leydig-like cells
Leydig cells (LCs) are distributed between the seminiferous tubules of the testis. They are the primary source of androgen...
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury through inhibiting the inflammatory activation of microglia
Cerebral ischemia (CI), also known as ischemic stroke, is a central nervous system disease caused by short, permanent redu...
Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
Pulmonary arterial hypertension (PAH) is a fatal disease caused by a narrowing pulmonary artery and ultimately results in ...
Microscopy-based phenotypic monitoring of MDA-MB-231 spheroids allows the evaluation of phenotype-directed therapy
Breast cancer (BC) is the most commonly diagnosed cancer among women. Prognosis has improved over the years, to a large ex...
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
Accumulating evidence has suggested that cell senescence participates in the onset and development of atherosclerosis [1]....
Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase
Syk is a tumor suppressor gene in some solid tumors. Currently, it remains unknown how Syk gene hypermethylation is contro...
Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants
The paralogous genes SAMD9 and SAMD9L, which are located next to each other on human chromosome 7, encode two highly homol...
Hypoxia preconditioned DPSC-derived exosomes regulate angiogenesis via transferring LOXL2
Mesenchymal stem cells (MSCs) play a crucial regulatory role in angiogenesis and tissue regeneration through exosome secre...
Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex
Fibrosis development is usually followed by cell death and/or inflammation, possibly resulting in an irreversible loss of ...
Patient-derived models: Promising tools for accelerating the clinical translation of breast cancer research findings
Breast cancer (BC) has become the most common cancer in women [1]. There is extensive, in depth, relevant research on nucl...
Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis
Intrahepatic cholangiocarcinoma (iCCA), a highly lethal cancer of the liver bile ducts, has been increasing in incidence f...
Inhibition of mitochondrial transcription by the neurotoxin MPP+
The neurotoxin MPP+ triggers cell death of dopamine neurons and induces Parkinson's disease symptoms in mice and men, but ...
Downregulation of miR-455–3p in decidual cells promotes macrophage polarization and suppresses trophoblasts invasion
PE is a frequently-occurring disorder associated with pregnancy and may produce detrimental maternal and neonatal conseque...
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