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Cytoophidia safeguard binucleation of Drosophila male accessory gland cells
Although most cells of animal organs contain a single nucleus, a considerable number of cells are multinucleate. In some c...
A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo
Stroke is the second leading cause of death (11.6%) worldwide [1]. Since the brain is the most sensitive organ in the huma...
Up-regulation of Dsg2 confered stem cells with malignancy through wnt/β-catenin signaling pathway
In the previous study, we originally developed cancer stem cells (CSCs) models from mouse induced pluripotent stem cells (...
The path to immortalization of cells starts by managing stress through gene duplications
The genomes of immortalized cell lines (and cancer cells) are characterized by multiple types of aberrations, ranging from...
Spatial and temporal requirement of Mlp60A isoforms during muscle development and function in Drosophila melanogaster
The postnatal development of vertebrate cardiac and skeletal muscles is marked by the switching of several sarcomeric cont...
Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway
At the maternal-fetal interface, normal proliferation, migration, and invasion of trophoblast cells is essential for maint...
IFI204 protects host defense against Staphylococcus aureus-induced pneumonia by promoting extracellular traps formation
Staphylococcus aureus (S. aureus) is a significant and ubiquitous opportunistic pathogen. It is a major cause of infection...
Paeoniflorin protects NOD mice from T1D through regulating gut microbiota and TLR4 mediated myD88/TRIF pathway
Type 1 diabetes (T1D) is a chronic autoimmune disorder manifested with elevated blood glucose levels, which is attributed ...
Identification of genomic binding sites and direct target genes for the transcription factor DDIT3/CHOP
The microarray expression data is available at the ArrayExpress database [https://www.ebi.ac.uk/arrayexpress] using the ac...
Sirt6 mediates antioxidative functions by increasing Nrf2 abundance
Reactive oxygen species (ROS) and other free radicals are generated from endogenous metabolite processes and from exposure...
Enhancement of hair growth through stimulation of hair follicle stem cells by prostaglandin E2 collagen matrix
Prostaglandin metabolism is involved in the regulation of the periodic process of hair follicles. Preliminary research dat...
EBV promotes vascular mimicry of dormant cancer cells by potentiating stemness and EMT
Vascular mimicry (VM) is defined as a vascular channel-like structure composed of tumor cells that correlates with the gro...
Gastric cancer-derived mesenchymal stem cells promote gastric cancer cell lines migration by modulating CD276 expression
CD276 has been studied in a variety of cancers and diseases, but its regulatory mechanisms in gastric cancer is still uncl...
Sox9 is required in regeneration of pancreatic β cells following injury
The reduction of insulin secretion due to pancreatic β cell injury caused by autoimmune reaction is the pathological basis...
Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death
The overexpression of BMI1, a polycomb protein, correlates with cancer development and aggressiveness. We previously repor...
S100A9 induces reactive oxygen species-dependent formation of neutrophil extracellular traps in abdominal sepsis
Recent evidence suggests that targeting S100A9 reduces pathological inflammation in abdominal sepsis. Herein, we investiga...
Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD)
Aberrant ubiquitin-proteasome system (UPS) contributes to tumorigeneisis or drug resistance of Pancreatic Adenocarcinoma (...
Back to basics: Optimization of DNA and RNA transfer in muscle cells using recent transfection reagents
C2C12 cells are widely used in the muscle field, as they differentiate easily into myotubes and show limited constraints t...
Bidirectional regulation role of PARP-1 in high glucose-induced endothelial injury
Loss of poly (ADP-ribose) polymerase-1 (PARP-1) has been found to slow the progression of diabetes and diabetic angiopathy...
Modeling leukemia with zebrafish (Danio rerio): Towards precision medicine
Leukemia is a type of blood cancer characterized by high genetic heterogeneity and fatality. While chemotherapy remains th...
Inhibition of 14-3-3ε by K50 acetylation activates YAP1 to promote cholangiocarcinoma growth
14-3-3 proteins are ubiquitous adapters combining with phosphorylated serine/threonine motifs to regulate multiple cellula...
Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1
Long non-coding RNAs (lncRNAs) are closely related to the occurrence and development of tumors and have gradually become a...