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Exosomal long non-coding RNA AU020206 alleviates macrophage pyroptosis in atherosclerosis by suppressing CEBPB-mediated NLRP3 transcription
Exosomal long non-coding RNA AU020206 alleviates macrophage pyroptosis in atherosclerosis by suppressing CEBPB-mediated NLRP3 transcription
Atherosclerosis is a primary cause of cardiovascular disease (CVD), a leading contributor to morbidity and mortality in bo...
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
The head and neck cancer (HNC) means the cancer which emerges in the oral cavity, tongue, nasopharynx, hypopharynx, oropha...
KN-93 Promotes HDAC4 Nucleus Translocation to promote fatty acid oxidation in Myocardial Infarction
KN-93 Promotes HDAC4 Nucleus Translocation to promote fatty acid oxidation in Myocardial Infarction
Acute myocardial infarction (MI), frequently occurring and lethal globally, is identified by an isufficient blood supply t...
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway
Urinary tract cancer originated from the bladder, known as bladder cancer (Bca), is the second most previlent type of canc...
STING Mediates LPS-induced Acute Lung Injury by Regulating Ferroptosis
STING Mediates LPS-induced Acute Lung Injury by Regulating Ferroptosis
The pathogenesis of acute lung injury is not fully understood. Stimulator of interferon genes (STING) and ferroptosis have...
GFP-labeled Schwann cell-like cells derived from hair follicle epidermal neural crest stem cells promote the acellular nerve allografts to repair facial nerve defects in rats
GFP-labeled Schwann cell-like cells derived from hair follicle epidermal neural crest stem cells promote the acellular nerve allografts to repair facial nerve defects in rats
To date, an autologous nerve graft, such as the sural nerve and greater auricular nerve, remains the gold standard for rep...
Inactivation of VRK1 Sensitizes Ovarian Cancer to PARP Inhibition through regulating DNA-PK stability
Inactivation of VRK1 Sensitizes Ovarian Cancer to PARP Inhibition through regulating DNA-PK stability
Ovarian cancer (OC) is the fifth-most deadly cancer in women, worldwide, and the most lethal gynecological cancer [1]. The...
eCRUIS captures RNA-protein interaction in vitro and in vivo
eCRUIS captures RNA-protein interaction in vitro and in vivo
Available online 16 April 2024, 114051Author links open overlay panel, , ABSTRACTAs an information bridge between DNA and ...
Ketohexokinase-A deficiency attenuates the proliferation via reducing β-catenin in gastric cancer cells
Ketohexokinase-A deficiency attenuates the proliferation via reducing β-catenin in gastric cancer cells
Gastric cancer (GC) remains a global health burden, with approximate 1.09 million new cases and 0.79 million deaths were e...
Dihydroartemisinin is an inhibitor of trained immunity through Akt/mTOR/HIF1α signaling pathway
Dihydroartemisinin is an inhibitor of trained immunity through Akt/mTOR/HIF1α signaling pathway
The memory immunity response via long-term metabolic and epigenetic reprogramming in innate immune cells has been termed “...
Identification and Immunological Characteristics of Anoikis-associated Molecular Clusters in Lung Adenocarcinoma
Identification and Immunological Characteristics of Anoikis-associated Molecular Clusters in Lung Adenocarcinoma
Anoikis plays a crucial role in the progression, prognosis, and immune response of lung adenocarcinoma (LUAD). However, it...
Unveiling the role of PD-L1 in vascular endothelial dysfunction: Insights into the mtros/NLRP3/caspase-1 mediated pyroptotic pathway
Unveiling the role of PD-L1 in vascular endothelial dysfunction: Insights into the mtros/NLRP3/caspase-1 mediated pyroptotic pathway
Acute lung injury (ALI) is the common and clinically severe complication of bacterial sepsis, and is markedly associated w...
12,13-diHOME attenuates high glucose-induced calcification of vascular smooth muscle cells through repressing CPT1A-mediated HMGB1 succinylation
12,13-diHOME attenuates high glucose-induced calcification of vascular smooth muscle cells through repressing CPT1A-mediated HMGB1 succinylation
Diabetes mellitus, a metabolic disorder characterized by high morbidity, is associated with complications that significant...
AR-V7 expression facilitates accelerated G2/M phase transition in castration-resistant prostate cancer
AR-V7 expression facilitates accelerated G2/M phase transition in castration-resistant prostate cancer
Despite substantial efforts being made over the years, prostate cancer remains one of the most common cancers to cause dea...
Ferroptosis contributes to airway epithelial E-cadherin disruption in a mixed granulocytic asthma mouse model
Ferroptosis contributes to airway epithelial E-cadherin disruption in a mixed granulocytic asthma mouse model
Asthma is a complex and heterogeneous disease characterized by chronic airway inflammation [1]. According to the inflammat...
Development and in-depth characterization of BRAFi-resistant melanoma cell lines in vitro and in vivo
Development and in-depth characterization of BRAFi-resistant melanoma cell lines in vitro and in vivo
Melanoma is a form of cancer that develops from pigment-producing cells called melanocytes and is responsible for 80 % of ...
Role of ONECUT family transcription factors in cancer and other diseases
Role of ONECUT family transcription factors in cancer and other diseases
ONECUT gene family members of transcription factors (TFs) are documented for their DNA binding region's single-cut domain ...
The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1
The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1
Ovarian cancer remains the most deadly malignant gynecological tumor [1]. The majority of ovarian cancer patients are diag...
Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production
Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production
Cutaneous melanoma (CM) is a malignancy arising from melanocytes or original nevus cells of the skin with an increased inc...
Single-cell transcriptomics reveals the intra-tumoral heterogeneity and SQSTM1/P62 and Wnt/β-catenin mediated epithelial to mesenchymal transition and stemness of triple-negative breast cancer
Single-cell transcriptomics reveals the intra-tumoral heterogeneity and SQSTM1/P62 and Wnt/β-catenin mediated epithelial to mesenchymal transition and stemness of triple-negative breast cancer
Triple-negative breast cancer is characterized by heterogeneity that influences treatment response and patient outcome. Th...
Effects of sevoflurane on lung alveolar epithelial wound healing and survival in a sterile in vitro model of acute respiratory distress syndrome
Effects of sevoflurane on lung alveolar epithelial wound healing and survival in a sterile in vitro model of acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is a serious lung condition that often leads to hospitalization in intensive ca...
The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia
The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia
A major obstacle in improving survival in pediatric T-cell acute lymphoblastic leukemia is understanding how to predict an...
PD-1 and LAG-3 positive T cells are related with the prognosis of patients with chronic kidney disease
PD-1 and LAG-3 positive T cells are related with the prognosis of patients with chronic kidney disease
Available online 3 April 2024, 114027Author links open overlay panel, , Highlights•The frequencies of LAG-3+PD-1+, LAG-3+ ...
Naringenin inhibits APAP-induced acute liver injury through activating PPARA-dependent signaling pathway
Naringenin inhibits APAP-induced acute liver injury through activating PPARA-dependent signaling pathway
Acute liver injury (ALI) is a clinical syndrome characterized by jaundice, ascites, coagulopathy, or hepatic encephalopath...
A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer
A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer
Ovarian cancer is one of the most common gynecological tumors worldwide. Despite the availability of multiple treatments f...
Alterations of UHRF family Expression and was regulated by High Risk Type HPV16 in Uterine Cervical Cancer
Alterations of UHRF family Expression and was regulated by High Risk Type HPV16 in Uterine Cervical Cancer
The altered protein expression of inverted CCAAT box-binding protein of 90 kDa/ubiquitin-like with PHD and RING finger dom...
In vivo tracking of mesenchymal stem cell dynamics and therapeutics in LPS-induced acute lung injury models
In vivo tracking of mesenchymal stem cell dynamics and therapeutics in LPS-induced acute lung injury models
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are recognized as the most significant health chall...
Truncated variants of thyroid hormone receptor beta display disease-inflicting malfunctioning at cellular level
Truncated variants of thyroid hormone receptor beta display disease-inflicting malfunctioning at cellular level
Thyroid hormone receptor (THR) belongs to the nuclear receptor (NR) superfamily that facilitates thyroid hormone (TH) sign...
Dysregulated MicroRNAs and long non-coding RNAs associated with extracellular matrix stiffness
Dysregulated MicroRNAs and long non-coding RNAs associated with extracellular matrix stiffness
The extracellular matrix (ECM) is an intricate network of multiple macromolecules, consisting mainly of collagen, non-coll...
Decoding the epigenetic mechanism of mammalian sex determination: Updates, emerging hypothesis and unsolved questions
Decoding the epigenetic mechanism of mammalian sex determination: Updates, emerging hypothesis and unsolved questions
In mammals, after fertilization, a single egg develops into a large number (>200) of cell types through a cascade of ev...
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