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Early “reduction to practice” of the CRISPR–Cas9 invention in eukaryotic cells
Early “reduction to practice” of the CRISPR–Cas9 invention in eukaryotic cells
The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated proteins) are microbial adap...
Structure‒function‒pathogenicity analysis of C-terminal myocilin missense variants based on experiments and 3D models
Structure‒function‒pathogenicity analysis of C-terminal myocilin missense variants based on experiments and 3D models
MYOC is a common pathogenic gene for primary open-angle glaucoma and encodes the protein named myocilin. Multiple MYOC var...
Expression, oncological and immunological characterizations of BZW1/2 in pancreatic adenocarcinoma
Expression, oncological and immunological characterizations of BZW1/2 in pancreatic adenocarcinoma
Background: Despite the progress in early diagnosis and treatment, prognosis of pancreatic adenocarcinoma (PAAD) is still ...
Genome-wide identification, characterization and expression of HSP 20 gene family in dove
Genome-wide identification, characterization and expression of HSP 20 gene family in dove
Davidia involucrata is a significant living fossil with high abiotic stress tolerance. Although heat shock protein 20 (HSP...
Progress in research on the role of exosomal miRNAs in the diagnosis and treatment of cardiovascular diseases
Progress in research on the role of exosomal miRNAs in the diagnosis and treatment of cardiovascular diseases
Cardiovascular diseases are the most common diseases threatening the health of the elderly, and the incidence and mortalit...
LncRNA TP53TG1 plays an anti-oncogenic role in cervical cancer by synthetically regulating transcriptome profile in HeLa cells
LncRNA TP53TG1 plays an anti-oncogenic role in cervical cancer by synthetically regulating transcriptome profile in HeLa cells
Long non-coding RNAs (lncRNAs) have been extensively studied as important regulators of tumor development in various cance...
Comment on three papers about Hardy–Weinberg equilibrium tests in autopolyploids
Comment on three papers about Hardy–Weinberg equilibrium tests in autopolyploids
This comment pertains to the genotype frequencies of autopolyploids, organisms with more than two sets of homologous chrom...
CircRNA-regulated immune responses of asian honey bee workers to microsporidian infection
CircRNA-regulated immune responses of asian honey bee workers to microsporidian infection
Nosema ceranae is a widespread fungal parasite for honey bees, causing bee nosemosis. Based on deep sequencing and bioinfo...
Ferroptosis regulator FANCD2 is associated with immune infiltration and predicts worse prognosis in lung adenocarcinoma
Ferroptosis regulator FANCD2 is associated with immune infiltration and predicts worse prognosis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) remains one of the leading causes of cancer-related death. Although immunotherapy has been show...
Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis
Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis
Purpose: Observational research has indicated the presence of a causal relationship between sleep disturbances and low bac...
Genetic regulation of newborn telomere length is mediated and modified by DNA methylation
Genetic regulation of newborn telomere length is mediated and modified by DNA methylation
Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, ...
Development and verification of the glycolysis-associated and immune-related prognosis signature for hepatocellular carcinoma
Development and verification of the glycolysis-associated and immune-related prognosis signature for hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) refers to the malignant tumor associated with a high mortality rate. This work ...
The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs
The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs
Osteoarthritis (OA) is a slowly progressing and irreversible joint disease. The existing non-surgical treatment can only d...
A novel necroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma
A novel necroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the malignant tumors with high mortality and a worse prognosis globally. Necropto...
Population genomic screening: Ethical considerations to guide age at implementation
Population genomic screening: Ethical considerations to guide age at implementation
Currently, most genetic testing involves next generation sequencing or panel testing, indicating future population-based s...
The future regulation of artificial intelligence systems in healthcare services and medical research in the European Union
The future regulation of artificial intelligence systems in healthcare services and medical research in the European Union
Despite its promising future, the application of artificial intelligence (AI) and automated decision-making in healthcare ...
Identification of CD161 expression as a novel prognostic biomarker in breast cancer correlated with immune infiltration
Identification of CD161 expression as a novel prognostic biomarker in breast cancer correlated with immune infiltration
Background:CD161 has been identified as a prognostic biomarker in many neoplasms, but its role in breast cancer (BC) has n...
Advances and challenges of immunocheckpoint inhibitors in the treatment of primary liver cancer
Advances and challenges of immunocheckpoint inhibitors in the treatment of primary liver cancer
Primary liver cancer (PLC) is one of the most common malignant tumors, which clinically characterized by occult onset, rap...
Genetic heterogeneity in corpus callosum agenesis
Genetic heterogeneity in corpus callosum agenesis
The corpus callosum is the largest white matter structure connecting the two cerebral hemispheres. Agenesis of the corpus ...
Identification and characterization of extrachromosomal circular DNA in alcohol induced osteonecrosis of femoral head
Identification and characterization of extrachromosomal circular DNA in alcohol induced osteonecrosis of femoral head
Alcohol-induced osteonecrosis of the femoral head (AIONFH) is a complicated refractory bone disease seen in the clinic. Th...
Low expression of the metabolism-related gene SLC25A21 predicts unfavourable prognosis in patients with acute myeloid leukaemia
Low expression of the metabolism-related gene SLC25A21 predicts unfavourable prognosis in patients with acute myeloid leukaemia
Acute myeloid leukaemia (AML) is a heterogeneous disease associated with poor outcomes. To identify AML-specific genes wit...
Expanded newborn screening for inherited metabolic disorders by tandem mass spectrometry in a northern Chinese population
Expanded newborn screening for inherited metabolic disorders by tandem mass spectrometry in a northern Chinese population
Tandem mass spectrometry (MS/MS) has been developed as one of the most important diagnostic platforms for the early detect...
Development and validation of a combined glycolysis and immune prognostic signature for lung squamous cell carcinoma
Development and validation of a combined glycolysis and immune prognostic signature for lung squamous cell carcinoma
Background: The involvement of glycolysis in the regulation of the tumor immune microenvironment has become a novel resear...
Diverse selection pressures shaping the genetic architecture of behçet disease susceptibility
Diverse selection pressures shaping the genetic architecture of behçet disease susceptibility
Behçet disease (BD) is a polygenic, multifactorial, multisystem inflammatory condition with unknown etiology. Global ...
Identification and validation of an inflammation-related lncRNAs signature for improving outcomes of patients in colorectal cancer
Identification and validation of an inflammation-related lncRNAs signature for improving outcomes of patients in colorectal cancer
Background: Colorectal cancer is the fourth most deadly cancer worldwide. Although current treatment regimens have prolong...