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Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics
IntroductionCell-free DNA (cfDNA) is DNA circulating freely in the bloodstream, unbound by cell nuclei. Released from cell...
LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China
Background: Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OS...
Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk
IntroductionCoronary artery disease (CAD) is the most common type of heart disease and a leading cause of morbidity and mo...
Editorial: Integrative genetics and multi-omics of complex human disorders
Over the past two decades, genome-wide association studies (GWASs) have reported numerous susceptibility loci that provide...
Calculating maternal polygenic risk scores from prenatal screening by cell-free DNA data
1 IntroductionPolygenic risk scores (PRS) are numerically weighted summarizations of genotypic alleles of an individual th...
EDN1 and NTF3 in keloid pathogenesis: computational and experimental evidence as novel diagnostic biomarkers for fibrosis and inflammation
1 IntroductionKeloid is a typical fibroproliferative skin disorder characterized by excessive scar tissue formation that e...
Deciphering the role of CNIH4 in pan-cancer landscapes and its significance in breast cancer progression
1 IntroductionThe burgeoning global cancer burden is a critical health concern (Bray et al., 2024). Projections from the A...
High-throughput microRNA sequencing in the developing branchial arches suggests miR-92b-3p regulation of a cardiovascular gene network
1 IntroductionVertebrate branchial arches (BAs) represent a principal developmental model that incorporates segmented desi...
Corrigendum: Integrated network analysis to identify key modules and potential hub genes involved in bovine respiratory disease: a systems biology approach
Corrigendum: Integrated Network Analysis to Identify Key Modules and Potential Hub Genes Involved in Bovine Respiratory Di...
Correlation and clinical significance of GSTP1 hypermethylation in hepatocellular carcinoma: a systematic review and meta-analysis
1 BackgroundHepatocellular carcinoma (HCC) represents one of the most prevalent and deadly forms of cancer globally, contr...
Comprehensive systematic review and meta-analysis of the TGF-β1 T869C gene polymorphism and autoimmune disease susceptibility
1 IntroductionAutoimmune diseases (ADs) are a class of conditions characterized by immune system dysfunction leading to ti...
Corrigendum: Construction of a circRNA–lincRNA–lncRNA–miRNA–mRNA ceRNA regulatory network identifies genes and pathways linked to goat fertility
1 INTRODUCTIONImprovement of reproductive performance is a priority in the goat industry, as it is one of the most importa...
Editorial: Recent advances in causes, diagnosis, and therapeutics for congenital heart defects
Congenital heart disease (CHD) is one of the most prevalent major birth defects, yet its causes remain largely unknown. Bo...
Editorial: Challenges and prospects for conservation genetics at XXI century
A molecular tool that has been developed in recent years is metabarcoding, which enables the identification of species&...
Identification of cancer-associated fibroblast signature genes for prognostic prediction in colorectal cancer
InstructionColorectal cancer (CRC) ranks as the third most common malignancy worldwide and the second leading cause of can...
Editorial: Advancements and prospects of genome-wide association studies
Since the very first Genome-Wide association study was published in 2005 followed by the pivotal manuscript by the Wellcom...
Corrigendum: Zearalenone exposure enhanced the expression of tumorigenesis genes in donkey granulosa cells via the PTEN/PI3K/AKT signaling pathway
We hope this Corrigendum finds you well. l am writing to bring to your attention an error that we have identified in our p...
Case report: A novel intronic JMJD6 likely pathogenic variant (c.941+75G > T) associated with congenital eyelid coloboma in one of the identical twin sisters
IntroductionCongenital eyelid coloboma (CEC) is a rare congenital malformation first reported by the French physician Jacq...
Role of PD-L1 in mediating the effect of lipid on ulcerative colitis: a mediation Mendelian randomization study
1 IntroductionUlcerative colitis (UC) is a chronic inflammatory disease characterized by persistent inflammation of the mu...
Exploration and verification of circulating diagnostic biomarkers in osteoarthritis based on machine learning
IntroductionOsteoarthritis (OA) is a prevalent joint disorder, particularly among older adults, affecting more than 500 mi...
Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses
1 IntroductionCOVID-19 is an extreme and clinically homogeneous disease phenotype (Gao et al., 2021; Oran and Topol, 2020)...
Alteration of chromatin states perturb the transcription regulation of gene during hydronephrosis
BackgroundHydronephrosis, accompany with ureteral stricture, is a common disease may happen in any age. Usually, the urina...
WCSGNet: a graph neural network approach using weighted cell-specific networks for cell-type annotation in scRNA-seq
1 IntroductionSingle-cell RNA sequencing (scRNA-seq) is a high-throughput and highly sensitive technology that allows for ...
A comparison of design algorithms for choosing the training population in genomic models
1 IntroductionPlant breeding has been done by humans for centuries and has only grown in importance in recent history due ...
Genetic and metabolic characterization of individual differences in liver fat accumulation in Atlantic salmon
1 IntroductionThe liver is the central organ for metabolism and transport of lipids in Atlantic salmon. It is an important...
Editorial: Advances and trends in gene expression, regulation, and phenotypic variation in livestock science: a comprehensive review of methods and technologies
Breeding for efficient animals has been a major focus for producers, aiming not only to increase profitability but also to...
Distinct gene signatures define the epithelial cell features of mucinous appendiceal neoplasms and pseudomyxoma metastases
IntroductionAppendiceal mucinous neoplasms (AMN) are a rare, indolent malignancy that originates in the appendix epitheliu...
ADAM-multi: software to simulate complex breeding programs for animals and plants with different ploidy levels and generalized genotypic effect models to account for multiple alleles
1 IntroductionStochastic simulation is a cost-effective and powerful tool to optimize breeding programs with reduced exper...
Exploring the taxonomical and functional profiles of marine microorganisms in Submarine Groundwater Discharge vent water from Mabini, Batangas, Philippines through metagenome-assembled genomes
I. IntroductionSubmarine groundwater discharge (SGD) refers to the movement of water from land to coastal waters, flowing ...
Dual graph-embedded fusion network for predicting potential microbe-disease associations with sequence learning
1 IntroductionMicroorganisms play an important and far-reaching role in human life and greatly impact our health (Liang et...
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