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Single-cell transcriptomics and Mendelian randomization reveal LUCAT1’s role in right-sided colorectal cancer risk
Single-cell transcriptomics and Mendelian randomization reveal LUCAT1’s role in right-sided colorectal cancer risk
Background: Colorectal cancer (CRC) is a malignancy with high incidence and mortality rates globally, categorized into lef...
Current phenotypic and genetic spectrum of syndromic deafness in Tunisia: paving the way for precision auditory health
Current phenotypic and genetic spectrum of syndromic deafness in Tunisia: paving the way for precision auditory health
Hearing impairment (HI) is a prevalent neurosensory condition globally, impacting 5% of the population, with over 50% of c...
Identification of Dof transcription factors in Dendrobium huoshanense and expression pattern under abiotic stresses
Identification of Dof transcription factors in Dendrobium huoshanense and expression pattern under abiotic stresses
Introduction: DNA-binding with one finger (Dof) transcription factors (TFs) are a unique family of TFs found in higher pla...
Editorial: Co-occurrence of numerical and structural aberration—small supernumerary marker chromosomes and B-chromosomes
Editorial: Co-occurrence of numerical and structural aberration—small supernumerary marker chromosomes and B-chromosomes
This Editorial is for the Research Topic dedicated to small supernumerary marker chromosomes (sSMCs) and B-chromosomes (Bs...
Circulating VEGF and inflammatory bowel disease: a bidirectional mendelian randomization
Circulating VEGF and inflammatory bowel disease: a bidirectional mendelian randomization
Introduction: Prior observational studies have suggested an association between circulating vascular endothelial growth fa...
The occurrence and development of induced pluripotent stem cells
The occurrence and development of induced pluripotent stem cells
The ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc (OSKM), known as “Yamanaka factors,” c...
A comparative genomics study of the microbiome and freshwater resistome in Southern Pantanal
A comparative genomics study of the microbiome and freshwater resistome in Southern Pantanal
This study explores the resistome and bacterial diversity of two small lakes in the Southern Pantanal, one in Aquidauana s...
Editorial: The impact of the human genome on interindividual variability in drug response
Editorial: The impact of the human genome on interindividual variability in drug response
The genetic background of patients contributes to the variability in drug metabolism and response. Several genetic variant...
Methylation-driven mechanisms of allergic rhinitis during pollen and non-pollen seasons using integrated bioinformatics analysis
Methylation-driven mechanisms of allergic rhinitis during pollen and non-pollen seasons using integrated bioinformatics analysis
Background:Allergic rhinitis (AR) is a widespread allergic airway disease that results from a complex interplay between ge...
Endoplasmic reticulum stress-related gene expression causes the progression of dilated cardiomyopathy by inducing apoptosis
Endoplasmic reticulum stress-related gene expression causes the progression of dilated cardiomyopathy by inducing apoptosis
Background: Previous studies have shown that endoplasmic reticulum stress (ERS) -induced apoptosis is involved in the path...
Identification of common genes and pathways between type 2 diabetes and COVID-19
Identification of common genes and pathways between type 2 diabetes and COVID-19
Background:Numerous studies have reported a high incidence and risk of severe illness due to coronavirus disease 2019 (COV...
Single-cell and bulk RNAseq unveils the immune infiltration landscape and targeted therapeutic biomarkers of psoriasis
Single-cell and bulk RNAseq unveils the immune infiltration landscape and targeted therapeutic biomarkers of psoriasis
Background:Psoriasis represents a multifaceted and debilitating immune-mediated systemic ailment afflicting millions globa...
Codon decoding by orthogonal tRNAs interrogates the in vivo preferences of unmodified adenosine in the wobble position
Codon decoding by orthogonal tRNAs interrogates the in vivo preferences of unmodified adenosine in the wobble position
The in vivo codon decoding preferences of tRNAs with an authentic adenosine residue at position 34 of the anticodon, the w...
Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC)
Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC)
Leigh syndrome French Canadian type (LSFC) is a recessive neurodegenerative disease characterized by tissue-specific defic...
Advances in genomics and genome editing for improving strawberry (Fragaria ×ananassa)
Advances in genomics and genome editing for improving strawberry (Fragaria ×ananassa)
The cultivated strawberry, Fragaria ×ananassa, is a recently domesticated fruit species of economic interest worldwide. As...
Phenotypic and genomic characterisation of performance of tropically adapted chickens raised in smallholder farm conditions in Ethiopia
Phenotypic and genomic characterisation of performance of tropically adapted chickens raised in smallholder farm conditions in Ethiopia
Background:In sub-Saharan Africa, 80% of poultry production is on smallholder village farms, where chickens are typically ...
A novel cis-regulatory element regulates αD and αA-globin gene expression in chicken erythroid cells
A novel cis-regulatory element regulates αD and αA-globin gene expression in chicken erythroid cells
BackgroundCis-regulatory elements (CREs) play crucial roles in regulating gene expression during erythroid cell differenti...
Use of whole-genome sequence data for fine mapping and genomic prediction of sea louse resistance in Atlantic salmon
Use of whole-genome sequence data for fine mapping and genomic prediction of sea louse resistance in Atlantic salmon
Sea louse (Lepeophtheirus salmonis) infestation of Atlantic salmon (Salmo salar) is a significant challenge in aquaculture...
Dissecting the shared genetic architecture between Alzheimer’s disease and frailty: a cross-trait meta-analyses of genome-wide association studies
Dissecting the shared genetic architecture between Alzheimer’s disease and frailty: a cross-trait meta-analyses of genome-wide association studies
Introduction: Frailty is the most common medical condition affecting the aging population, and its prevalence increases in...
Detection and characterization of copy number variation in three differentially-selected Nellore cattle populations
Detection and characterization of copy number variation in three differentially-selected Nellore cattle populations
Introduction: Nellore cattle (Bos taurus indicus) is the main beef cattle breed raised in Brazil. This breed is well adapt...
Disulfidptosis-related signature elucidates the prognostic, immunologic, and therapeutic characteristics in ovarian cancer
Disulfidptosis-related signature elucidates the prognostic, immunologic, and therapeutic characteristics in ovarian cancer
Introduction:Ovarian cancer (OC) is the deadliest malignancy in gynecology, but the mechanism of its initiation and progre...
Identification of immune-related biomarkers for glaucoma using gene expression profiling
Identification of immune-related biomarkers for glaucoma using gene expression profiling
Introduction: Glaucoma, a principal cause of irreversible vision loss, is characterized by intricate optic neuropathy invo...
Editorial: Current progress in genomic and genetic research on human viral diseases
Editorial: Current progress in genomic and genetic research on human viral diseases
Viral diseases pose a global public health threat, demanding a deeper understanding of the intricate interplay between vir...
CRF transcription factors in the trade-off between abiotic stress response and plant developmental processes
CRF transcription factors in the trade-off between abiotic stress response and plant developmental processes
Climate change-induced environmental stress significantly affects crop yield and quality. In response to environmental str...
Polymorphism rs3733591 of the SLC2A9 gene and metabolic syndrome affect gout risk in Taiwan Biobank subjects
Polymorphism rs3733591 of the SLC2A9 gene and metabolic syndrome affect gout risk in Taiwan Biobank subjects
Background:Over the past few decades, gout and diseases like metabolic syndrome (MetS) have become more prevalent. Attempt...
Transcriptomic atlas for hypoxia and following re-oxygenation in Ancherythroculter nigrocauda heart and brain tissues: insights into gene expression, alternative splicing, and signaling pathways
Transcriptomic atlas for hypoxia and following re-oxygenation in Ancherythroculter nigrocauda heart and brain tissues: insights into gene expression, alternative splicing, and signaling pathways
Hypoxia is a mounting problem that affects the world’s freshwaters, with severe consequence for many species, including de...
Meta-analysis of differential gene expression in lower motor neurons isolated by laser capture microdissection from post-mortem ALS spinal cords
Meta-analysis of differential gene expression in lower motor neurons isolated by laser capture microdissection from post-mortem ALS spinal cords
IntroductionALS is a fatal neurodegenerative disease for which underlying mechanisms are incompletely understood. The moto...
Comparative genomics analysis of pheophorbide a oxygenase (PAO) genes in eight pyrus genomes and their regulatory role in multiple stress responses in Chinese pear (Pyrus bretschneideri)
Comparative genomics analysis of pheophorbide a oxygenase (PAO) genes in eight pyrus genomes and their regulatory role in multiple stress responses in Chinese pear (Pyrus bretschneideri)
Pyrus (pear) is among the most nutritious fruits and contains fibers that have great health benefits to humans. It is most...
Identification and functional analysis of lactic acid metabolism-related differentially expressed genes in hepatocellular carcinoma
Identification and functional analysis of lactic acid metabolism-related differentially expressed genes in hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality rate that seriously thre...
OGNNMDA: a computational model for microbe-drug association prediction based on ordered message-passing graph neural networks
OGNNMDA: a computational model for microbe-drug association prediction based on ordered message-passing graph neural networks
In recent years, many excellent computational models have emerged in microbe-drug association prediction, but their perfor...
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