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A novel lysosome-related gene signature coupled with gleason score for prognosis prediction in prostate cancer
A novel lysosome-related gene signature coupled with gleason score for prognosis prediction in prostate cancer
Background: Prostate cancer (PCa) is highly heterogeneous, which makes it difficult to precisely distinguish the clinical ...
Prognostic value of autophagy-related genes based on single-cell RNA-sequencing in colorectal cancer
Prognostic value of autophagy-related genes based on single-cell RNA-sequencing in colorectal cancer
Background: Colorectal cancer (CRC) is the second most common cancer in China. Autophagy plays an important role in the in...
Analysis of cerebral infarction caused by dysplasminogenemia in three pedigrees
Analysis of cerebral infarction caused by dysplasminogenemia in three pedigrees
Background and aims: Dysplasminogenemia is a rare heritable disease caused by plasminogen (PLG) gene defects resulting in ...
Integration analysis based on fatty acid metabolism robustly predicts prognosis, dissecting immunity microenvironment and aiding immunotherapy for soft tissue sarcoma
Integration analysis based on fatty acid metabolism robustly predicts prognosis, dissecting immunity microenvironment and aiding immunotherapy for soft tissue sarcoma
Background: Soft tissue sarcoma (STS) is a highly malignant tumor with a dismal prognosis. Presently, the dysregulation of...
Genome-wide analysis emancipates genomic diversity and signature of selection in Altay white-headed cattle of Xinjiang, China
Genome-wide analysis emancipates genomic diversity and signature of selection in Altay white-headed cattle of Xinjiang, China
Altay white-headed cattle have not received enough attention for several reasons. Due to irrational breeding and selection...
Predicting late-stage age-related macular degeneration by integrating marginally weak SNPs in GWA studies
Predicting late-stage age-related macular degeneration by integrating marginally weak SNPs in GWA studies
Introduction: Age-related macular degeneration (AMD) is a progressive neurodegenerative disease and the leading cause of b...
Clustering and machine learning-based integration identify cancer associated fibroblasts genes’ signature in head and neck squamous cell carcinoma
Clustering and machine learning-based integration identify cancer associated fibroblasts genes’ signature in head and neck squamous cell carcinoma
Background: A hallmark signature of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) is abundan...
Frequencies of variants in genes associated with dyslipidemias identified in Costa Rican genomes
Frequencies of variants in genes associated with dyslipidemias identified in Costa Rican genomes
Dyslipidemias are risk factors in diseases of significant importance to public health, such as atherosclerosis, a conditio...
A novel cuproptosis-related lncRNAs signature predicts prognostic and immune of bladder urothelial carcinoma
A novel cuproptosis-related lncRNAs signature predicts prognostic and immune of bladder urothelial carcinoma
Bladder Urothelial Carcinoma (BLCA) remains the most common urinary system tumor, and its prognosis is poor. Cuproptosis i...
Maximizing the utility of public data
Maximizing the utility of public data
The human genome project galvanized the scientific community around an ambitious goal. Upon completion, the project delive...
Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma
Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma
Introduction: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy. The patients’ survival outcomes vary...
Case report: Optical genome mapping revealed double rearrangements in a male undergoing preimplantation genetic testing
Case report: Optical genome mapping revealed double rearrangements in a male undergoing preimplantation genetic testing
Chromosome rearrangement is one of the main causes of abortion. In individuals with double chromosomal rearrangements, the...
Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum
Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum
High-throughput genomic and phenomic data have enhanced the ability to detect genotype-to-phenotype associations that can ...
Genotyping of Haliotis discus hannai and machine learning models to predict the heat resistant phenotype based on genotype
Genotyping of Haliotis discus hannai and machine learning models to predict the heat resistant phenotype based on genotype
Abalone (Haliotis discus hannai) is an expensive seafood in Asian countries and an important species in fishery and maricu...
Exploring the bi-directional relationship and shared genes between depression and stroke via NHANES and bioinformatic analysis
Exploring the bi-directional relationship and shared genes between depression and stroke via NHANES and bioinformatic analysis
Background: Stroke and depression are the two most common causes of disability worldwide. Growing evidence suggests a bi-d...
Comprehensive analysis of epigenetics mechanisms in osteoporosis
Comprehensive analysis of epigenetics mechanisms in osteoporosis
Epigenetic modification pertains to the alteration of genetic-expression, which could be transferred to the next generatio...
Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization study
Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization study
Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with obesity, insulin resistance, type...
Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis
Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis
Background: Hepatocellular carcinoma (HCC) remains notorious for its high malignancy, poor prognosis and high mortality. T...
Use of pain-related gene features to predict depression by support vector machine model in patients with fibromyalgia
Use of pain-related gene features to predict depression by support vector machine model in patients with fibromyalgia
The prevalence rate of depression is higher in patients with fibromyalgia syndrome, but this is often unrecognized in pati...
The regulatory role of microRNAs in common eye diseases: A brief review
The regulatory role of microRNAs in common eye diseases: A brief review
MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biologica...
Identification and immuno-infiltration analysis of cuproptosis regulators in human spermatogenic dysfunction
Identification and immuno-infiltration analysis of cuproptosis regulators in human spermatogenic dysfunction
Introduction: Cuproptosis seems to promote the progression of diverse diseases. Hence, we explored the cuproptosis regulat...
Genomics combined with UAS data enhances prediction of grain yield in winter wheat
Genomics combined with UAS data enhances prediction of grain yield in winter wheat
With the human population continuing to increase worldwide, there is pressure to employ novel technologies to increase gen...
Whole exome sequencing reveals novel variants associated with diminished ovarian reserve in young women
Whole exome sequencing reveals novel variants associated with diminished ovarian reserve in young women
Background: Diminished ovarian reserve is one of the most important causes of female infertility. In the etiology study of...
Exploring immune interactions in triple negative breast cancer: IL-1β inhibition and its therapeutic potential
Exploring immune interactions in triple negative breast cancer: IL-1β inhibition and its therapeutic potential
Triple negative breast cancer (TNBC) has poor prognosis when compared to other breast cancer subtypes. Despite pre-clinica...
Analysis in Proceratophrys boiei genome illuminates the satellite DNA content in a frog from the Brazilian Atlantic forest
Analysis in Proceratophrys boiei genome illuminates the satellite DNA content in a frog from the Brazilian Atlantic forest
Satellite DNAs (satDNAs) are one of the most abundant elements in genomes. Characterized as tandemly organized sequences t...
ACP-GBDT: An improved anticancer peptide identification method with gradient boosting decision tree
ACP-GBDT: An improved anticancer peptide identification method with gradient boosting decision tree
Cancer is one of the most dangerous diseases in the world, killing millions of people every year. Drugs composed of antica...
Regulation of ncRNAs involved with ferroptosis in various cancers
Regulation of ncRNAs involved with ferroptosis in various cancers
As a special pattern of programmed cell death, ferroptosis is reported to participate in several processes of tumor progre...
Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention
Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention
Objective: This paper briefly reviews the structure and function of NLRP3 inflammasomes, signaling pathway, relationship w...
Computational analysis of the flexibility in the disordered linker region connecting LIM domains in cysteine–glycine-rich protein
Computational analysis of the flexibility in the disordered linker region connecting LIM domains in cysteine–glycine-rich protein
One of the key proteins that are present in the Z-disc of cardiac tissues, CSRP3, has been implicated in dilated and hyper...
The regulatory effects of p53 on the typical and atypical ferroptosis in the pathogenesis of osteosarcoma: A systematic review
The regulatory effects of p53 on the typical and atypical ferroptosis in the pathogenesis of osteosarcoma: A systematic review
Study background: As a rare condition, osteosarcoma affects approximately 3% of all cancer patients. Its exact pathogenesi...
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