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Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: A Mendelian randomization study
Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: A Mendelian randomization study
IntroductionObservational investigations have examined the impact of glucosamine use on the risk of cancer and non-neoplas...
Lactylation: The emerging frontier in post-translational modification
Lactylation: The emerging frontier in post-translational modification
Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emergin...
Development and evaluation of a chronic kidney disease risk prediction model using random forest
Development and evaluation of a chronic kidney disease risk prediction model using random forest
This research aims to advance the detection of Chronic Kidney Disease (CKD) through a novel gene-based predictive model, l...
Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis
Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis
BackgroundFormer research has emphasized a correlation between lung cancer (LC) and sepsis, but the causative link remains...
Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study
Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study
PurposeMajor depressive disorder (MDD) and venous thromboembolism (VTE) may be linked in observational studies. However, t...
Editorial: Searching for causes of infertility: from pathophysiologic mechanisms to therapeutic strategies
Editorial: Searching for causes of infertility: from pathophysiologic mechanisms to therapeutic strategies
Reproductive disorders are global health problems affecting millions of people worldwide. In humans, infertility is indeed...
Association of ankylosing spondylitis with cardiovascular disease: a bidirectional two-sample mendelian randomization study
Association of ankylosing spondylitis with cardiovascular disease: a bidirectional two-sample mendelian randomization study
BackgroundsCurrent observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascu...
Effects of ankylosing spondylitis on cardiovascular disease: aMendelian randomization study
Effects of ankylosing spondylitis on cardiovascular disease: aMendelian randomization study
ObjectiveAccumulating evidence suggests that patients with ankylosing spondylitis (AS) have an elevated risk for cardiovas...
Corrigendum: Identification of an immune-related gene prognostic index for predicting survival and immunotherapy efficacy in papillary renal cell carcinoma
Corrigendum: Identification of an immune-related gene prognostic index for predicting survival and immunotherapy efficacy in papillary renal cell carcinoma
In the published article, there was an error in the Affiliations. The corrected affiliations and corresponding author attr...
Editorial: Neuronal ceroid lipofuscinosis: molecular genetics and epigenetics
Editorial: Neuronal ceroid lipofuscinosis: molecular genetics and epigenetics
The neuronal ceroid lipofuscinoses (NCLs), also known as Batten disease is a group of inherited neurodegenerative disorder...
Identification of differentially expressed genes of blood leukocytes for Schizophrenia
Identification of differentially expressed genes of blood leukocytes for Schizophrenia
BackgroundSchizophrenia (SCZ) is a severe neurodevelopmental disorder with brain dysfunction. This study aimed to use bioi...
N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma
N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma
IntroductionMiddle ear cholesteatoma is a chronic middle ear disease characterized by severe hearing loss and adjacent bon...
A rare missense p.C125Y mutation in the TNFRSF1A gene identified in a Chinese family with tumor necrosis factor receptor-associated periodic fever syndrome
A rare missense p.C125Y mutation in the TNFRSF1A gene identified in a Chinese family with tumor necrosis factor receptor-associated periodic fever syndrome
BackgroundTumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autosomal dominant disorder with a...
Application of whole exome sequencing in carrier screening for high-risk families without probands
Application of whole exome sequencing in carrier screening for high-risk families without probands
PurposeThis study aimed to screen the genetic etiology for the high-risk families including those with an adverse pregnanc...
Case report: A case of Rabson–Mendenhall syndrome: long-term follow-up and therapeutic management with empagliflozin
Case report: A case of Rabson–Mendenhall syndrome: long-term follow-up and therapeutic management with empagliflozin
Background: Rabson–Mendenhall syndrome (RMS), a rare disorder characterized by severe insulin resistance due to biallelic ...
Inside the genome: understanding genetic influences on oxidative stress
Inside the genome: understanding genetic influences on oxidative stress
Genetics is a key factor that governs the susceptibility to oxidative stress. In the body, oxidative burden is regulated b...
The genomic landscape of the immune system in lung cancer: present insights and continuing investigations
The genomic landscape of the immune system in lung cancer: present insights and continuing investigations
Lung cancer is one of the most prevalent malignancies worldwide, contributing to over a million cancer-related deaths annu...
Corrigendum: Current phenotypic and genetic spectrum of syndromic deafness in Tunisia: paving the way for precision auditory health
Corrigendum: Current phenotypic and genetic spectrum of syndromic deafness in Tunisia: paving the way for precision auditory health
In the published article, there was an error in the legend for Figure 4 as published. The gene names corresponding to colo...
Tuning tRNAs for improved translation
Tuning tRNAs for improved translation
Transfer RNAs have been extensively explored as the molecules that translate the genetic code into proteins. At this inter...
Endometriosis is a disease of immune dysfunction, which could be linked to microbiota
Endometriosis is a disease of immune dysfunction, which could be linked to microbiota
Background: Endometriosis, characterized by extrauterine endometrial tissue, leads to irregular bleeding and pelvic pain. ...
DeepSplice: a deep learning approach for accurate prediction of alternative splicing events in the human genome
DeepSplice: a deep learning approach for accurate prediction of alternative splicing events in the human genome
Alternative splicing (AS) is a crucial process in genetic information processing that generates multiple mRNA molecules fr...
Leveraging genetics to investigate causal effects of immune cell phenotypes in periodontitis: a mendelian randomization study
Leveraging genetics to investigate causal effects of immune cell phenotypes in periodontitis: a mendelian randomization study
IntroductionImmune cells are dynamic in the inflammatory environment and play a key role in eradicating periodontal pathog...
A novel variation in DEPDC5 causing familial focal epilepsy with variable foci
A novel variation in DEPDC5 causing familial focal epilepsy with variable foci
BackgroundDisheveled, EGL-10, and pleckstrin (DEP) domain-containing protein 5 (DEPDC5) is a component of GTPase-activatin...
Phylogenomic analysis and molecular identification of true fruit flies
Phylogenomic analysis and molecular identification of true fruit flies
The family Tephritidae in the order Diptera, known as true fruit flies, are agriculturally important insect pests. However...
Robust evidence supports a causal link between higher birthweight and longer telomere length: a mendelian randomization study
Robust evidence supports a causal link between higher birthweight and longer telomere length: a mendelian randomization study
BackgroundObservational studies have suggested a potential relationship between birthweight and telomere length. However, ...
Integrative analysis of cancer multimodality data identifying COPS5 as a novel biomarker of diffuse large B-cell lymphoma
Integrative analysis of cancer multimodality data identifying COPS5 as a novel biomarker of diffuse large B-cell lymphoma
Preventing, diagnosing, and treating diseases requires accurate clinical biomarkers, which remains challenging. Recently, ...
A causal link between circulating leukocytes and three major urologic cancers: a mendelian randomization investigation
A causal link between circulating leukocytes and three major urologic cancers: a mendelian randomization investigation
PurposeThis study aimed to explore the influence of serum leukocytes on urologic cancers (UC) using observation-based inve...
Bridging the gap: exploring the causal relationship between metformin and tumors
Bridging the gap: exploring the causal relationship between metformin and tumors
ObjectiveNumerous studies have reported that metformin can reduce the risk of tumor development. However, some of the resu...
Succinic semialdehyde dehydrogenase deficiency: review of the clinical phenotype and metabolic/genomic approach to diagnosis
Succinic semialdehyde dehydrogenase deficiency: review of the clinical phenotype and metabolic/genomic approach to diagnosis
Genomic sequencing offers an untargeted, data-driven approach to genetic diagnosis; however, variants of uncertain signifi...
Neutrophil in the suppressed immune microenvironment: Critical prognostic factor for lung adenocarcinoma patients with KEAP1 mutation
Neutrophil in the suppressed immune microenvironment: Critical prognostic factor for lung adenocarcinoma patients with KEAP1 mutation
PurposeIt is still unclear whether KEAP1 mutation is detrimental to immunotherapy of lung adenocarcinoma (LUAD) patients, ...
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