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H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
Bivalent genes, of which promoters are marked by both H3K4me3 (trimethylation of histone H3 on lysine 4) and H3K27me3 (tri...
TMED3 promotes the development of malignant melanoma by targeting CDCA8 and regulating PI3K/Akt pathway
TMED3 promotes the development of malignant melanoma by targeting CDCA8 and regulating PI3K/Akt pathway
Transmembrane emp24 domain containing (TMED) proteins are known to play pivotal roles in normal development, but have been...
N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo
N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo
N-methyl-d-aspartate receptors (NMDARs) are considered to be involved in several physiological and pathophysiological proc...
The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands
The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands
The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in mammals. They are variably expres...
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression
The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to aden...
Aging aggravates acetaminophen-induced acute liver injury and inflammation through inordinate C/EBPα-BMP9 crosstalk
Aging aggravates acetaminophen-induced acute liver injury and inflammation through inordinate C/EBPα-BMP9 crosstalk
Previous studies have shown that bone morphogenetic protein 9 (BMP9) is almost exclusively produced in the liver and reach...
Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes
Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes
Endoplasmic reticulum (ER) stress plays an important role in the occurrence and development of various liver diseases. How...
SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival
SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival
Hepatocellular carcinoma (HCC) metastasis and recurrence lead to therapy failure, which are closely associated with the pr...
Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia–reper...
Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction
Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction
Sphincter dysfunction often occurs at the end of tubule organs such as the urethra, anus, or gastroesophageal sphincters. ...
Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes
Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes
Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases t...
Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel
Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel
Breast cancer (BC) metastasis is the leading cause of poor prognosis and therapeutic failure. However, the mechanisms unde...
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression
About 10–20% of patients with bladder cancer (BC) progress to muscle-invasive diseases, of which the underlying key ...
Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease ...
Sexual dimorphism in chronic respiratory diseases
Sexual dimorphism in chronic respiratory diseases
Sex differences in susceptibility, severity, and progression are prevalent for various diseases in multiple organ systems....
Macrophage-derived exosomes mediate glomerular endothelial cell dysfunction in sepsis-associated acute kidney injury
Macrophage-derived exosomes mediate glomerular endothelial cell dysfunction in sepsis-associated acute kidney injury
Sepsis-associated AKI has been shown to be related to sepsis mortality. Macrophage activation and endothelial cell damage ...
Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways
Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways
Itaconate, a crucial immunometabolite, plays a critical role in linking immune and metabolic functions to influence host d...
Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax
Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax
Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even e...
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glio...
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy
Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise sp...
RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, frequently accompanied by metastasis and ae...
Cell cycle regulators and bone: development and regeneration
Cell cycle regulators and bone: development and regeneration
Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they ca...
ARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes
ARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes
This study aimed to identify potential biomarkers for prostate cancer (PCa) progression and metastasis, and to discern the...
HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA
HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA
Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation fact...
Neurocircuitry underlying the antidepressant effect of retrograde facial botulinum toxin in mice
Neurocircuitry underlying the antidepressant effect of retrograde facial botulinum toxin in mice
Botulinum toxin type A (BoNT/A) is extensively applied in spasticity and dystonia as it cleaves synaptosome-associated pro...
Echocardiographic assessment of Xenopus tropicalis heart regeneration
Echocardiographic assessment of Xenopus tropicalis heart regeneration
Recently, it was reported that the adult X. tropicalis heart can regenerate in a nearly scar-free manner after injury via ...
Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagna...
GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors
GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors
Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and m...
Retraction Note: The suppressing role of miR-622 in renal cell carcinoma progression by down-regulation of CCL18/MAPK signal pathway
Retraction Note: The suppressing role of miR-622 in renal cell carcinoma progression by down-regulation of CCL18/MAPK signal pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function
Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function
Impaired metabolic functions of gut microbiota have been demonstrated in alcohol-related liver disease (ALD), but little i...
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