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Astaxanthin attenuates cognitive deficits in Alzheimer’s disease models by reducing oxidative stress via the SIRT1/PGC-1α signaling pathway
Astaxanthin attenuates cognitive deficits in Alzheimer’s disease models by reducing oxidative stress via the SIRT1/PGC-1α signaling pathway
Oxidative stress plays a pivotal role in neurodegenerative diseases. Astaxanthin (AST) can play a neuroprotective role owi...
Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Sleep disorders (SDs) are a symptom of the prodromal phase of neurodegenerative disorders that are mechanistically linked ...
Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studi...
Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis
Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic hepatic disease and results in non-alcoho...
A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS
A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS
Numerous genes, including SOD1, mutated in familial and sporadic amyotrophic lateral sclerosis (f/sALS) share a role in DN...
Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis
Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis
PI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. Protein phosphorylation is crucial for s...
The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance
The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance
Aberrant interplay between epigenetic reprogramming and hypoxia signaling contributes to renal cell carcinoma progression ...
Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen
Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen
Gene-environment interactions contribute to metabolic disorders such as diabetes and dyslipidemia. In addition to affectin...
A novel 3D bilayer hydrogel tri-culture system for studying functional motor units
A novel 3D bilayer hydrogel tri-culture system for studying functional motor units
A motor unit (MU) is formed by a single alpha motor neuron (MN) and the muscle fibers it innervates. The MU is essential f...
A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection
A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection
Varicella zoster virus (VZV), which is a human restricted alpha-herpesvirus, causes varicella (chickenpox) and zoster (shi...
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
The human placenta, a tissue with a lifespan limited to the period of pregnancy, is exposed to varying shear rates by mate...
Cardiac-to-adipose axis in metabolic homeostasis and diseases: special instructions from the heart
Cardiac-to-adipose axis in metabolic homeostasis and diseases: special instructions from the heart
Adipose tissue is essential for maintaining systemic metabolic homeostasis through traditional metabolic regulation, endoc...
Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications
Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications
Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver dysfunctions are classified int...
Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by widespread intranucle...
Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function
Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function
Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it ...
Impaired mitophagy induces antimicrobial responses in macrophages infected with Mycobacterium tuberculosis
Impaired mitophagy induces antimicrobial responses in macrophages infected with Mycobacterium tuberculosis
Mitophagy, mitochondrial selective autophagy, plays a pivotal role in the maintenance of cellular homeostasis in response ...
Engineered clinical-grade mesenchymal stromal cells combating SARS-CoV-2 omicron variants by secreting effective neutralizing antibodies
Engineered clinical-grade mesenchymal stromal cells combating SARS-CoV-2 omicron variants by secreting effective neutralizing antibodies
The emergence of SARS-CoV-2 becomes life-threatening for the older and immunocompromised individuals, whereas limited trea...
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species
Pain in early life may impact on development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of...
Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes
Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes
Type 1 diabetes (T1D) is a chronic, progressive autoinflammatory disorder resulting from the breakdown of self-tolerance a...
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice
Phosphoglycerate mutase 5 (PGAM5), a phosphatase involved in mitochondrial homeostasis, is reported to be closely related ...
HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
Renal cell carcinoma (RCC) is characterized by a high rate of distant metastasis, which leads to poor prognosis in patient...
l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway
l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway
Chronic obstructive pulmonary disease (COPD) is a frequent and common disease in clinical respiratory medicine and its mec...
Fibroblast-to-cardiomyocyte lactate shuttle modulates hypertensive cardiac remodelling
Fibroblast-to-cardiomyocyte lactate shuttle modulates hypertensive cardiac remodelling
Cardiac fibroblasts (CFs) and cardiomyocytes are the major cell populations in the heart. CFs not only support cardiomyocy...
New insights into the important roles of phase seperation in the targeted therapy of lung cancer
New insights into the important roles of phase seperation in the targeted therapy of lung cancer
Lung cancer is a complex and heterogeneous disease characterized by abnormal growth and proliferation of lung cells. It is...
Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer
Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer
N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is re...
Retraction Note: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p
Retraction Note: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer
Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresp...
Retraction Note: SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis
Retraction Note: SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer
KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer
The oncoprotein KAI1 C-terminal interacting tetraspanin (KITENIN; vang-like 1) promotes cell metastasis, invasion, and ang...
Rhox6 regulates the expression of distinct target genes to mediate mouse PGCLC formation and ESC self-renewal
Rhox6 regulates the expression of distinct target genes to mediate mouse PGCLC formation and ESC self-renewal
Mouse embryonic stem cells (mESCs) not only retain the property of self-renewal but also have the ability to develop into ...
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