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Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers
Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers
Over the past two decades, the study of sperm-borne small non-coding RNAs (sncRNAs) has garnered substantial growth. Once ...
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation
Epicardium, the most outer mesothelium, exerts crucial functions in fetal heart development and adult heart regeneration. ...
DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma
DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma
Altered metabolism has become an important characteristic of cancer, and acyl-CoA dehydrogenase short-chain (ACADS), a reg...
Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury
Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury
Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptor...
Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes
Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes
Spontaneous preterm birth (sPTB) poses significant challenges, affecting neonatal health and neurodevelopmental outcomes w...
Unraveling the protein kinase C/NDRG1 signaling network in breast cancer
Unraveling the protein kinase C/NDRG1 signaling network in breast cancer
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central rol...
CCN3: lactational bone booster
CCN3: lactational bone booster
Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. Me...
PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation
PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation
Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biall...
Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases
Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases
macrophage-targeting therapy of ischemic disease has made progress in clinic trial. However, the role and underlying mecha...
SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer
SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer
Aberrant interplay between epigenetic reprogramming and metabolic rewiring events contributes to bladder cancer progressio...
Impact of c-JUN deficiency on thalamus development in mice and human neural models
Impact of c-JUN deficiency on thalamus development in mice and human neural models
c-Jun is a key regulator of gene expression. Through the formation of homo- or heterodimers, c-JUN binds to DNA and regula...
Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis
Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis
Diabetic polyneuropathy (DPN) is a common diabetes complication with limited treatment options. We aimed to identify circu...
Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice
Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice
L-DOPA has been considered the first-line therapy for treating Parkinson’s disease (PD) via restoring striatal dopam...
CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC
CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC
Cancer-associated fibroblasts (CAFs), a predominant stromal cell type in the tumor microenvironment, significantly affect ...
Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery
Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery
The increasing incidence of childhood obesity annually has led to a surge in physical and mental health risks, making it a...
Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12
Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12
Aberrant alternative splicing (AS) events, triggered by the alterations in serine/arginine splicing factor 1 (SRSF1), a me...
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma
B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of lymphoma and is significantly heterogeneous among various s...
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction
To investigate physiological function of α-synuclein is important for understanding its pathophysiological mechanism ...
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice
In understanding the pathophysiology of pulmonary fibrosis (PF), macrophage plasticity has been implicated with a crucial ...
Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells
Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells
Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascad...
Potassium channels in depression: emerging roles and potential targets
Potassium channels in depression: emerging roles and potential targets
Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and sh...
Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice
Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice
Mitochondrial calcium uniporter (MCU) plays pleiotropic roles in cellular physiology and pathology that contributes to a v...
Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques
Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques
Drug-induced liver injury (DILI) refers to drug-mediated damage to the structure and function of the liver, ranging from m...
Ribosomal proteins in hepatocellular carcinoma: mysterious but promising
Ribosomal proteins in hepatocellular carcinoma: mysterious but promising
Ribosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also...
Golgiphagy: a novel selective autophagy to the fore
Golgiphagy: a novel selective autophagy to the fore
The Golgi apparatus is the central hub of the cellular endocrine pathway and plays a crucial role in processing, transport...
Revisiting Virchow’s triad: exploring the cellular and molecular alterations in cerebral venous congestion
Revisiting Virchow’s triad: exploring the cellular and molecular alterations in cerebral venous congestion
Cerebral venous thrombosis (CVT) is a rare but serious condition that can lead to significant morbidity and mortality. Vir...