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Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as ...
Rapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Rapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological proce...
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
Neural progenitor cells (NPCs) can be cultivated from developing brains, reproducing many of the processes that occur duri...
ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration
ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration
N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in ...
Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression
Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression
The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated t...
Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders
Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders
Chronic inflammatory musculoskeletal disorders characterized by prolonged muscle inflammation, resulting in enduring pain ...
CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells
CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells
Paraptosis is a programmed cell death characterized by cytoplasmic vacuolation, which has been explored as an alternative ...
Role of NLRP3 inflammasome in central nervous system diseases
Role of NLRP3 inflammasome in central nervous system diseases
The central nervous system (CNS) is the most delicate system in human body, with the most complex structure and function. ...
Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis
Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis
The adult intestinal epithelium is a complex, self-renewing tissue composed of specialized cell types with diverse functio...
Endothelial progenitor cell-derived extracellular vesicles: the world of potential prospects for the treatment of cardiovascular diseases
Endothelial progenitor cell-derived extracellular vesicles: the world of potential prospects for the treatment of cardiovascular diseases
Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortalit...
Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway
Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway
Ototoxicity is a major side effect of many broadly used aminoglycoside antibiotics (AGs) and no FDA-approved otoprotective...
Pivotal role of intestinal cholesterol and nuclear receptor LXR in metabolic liver steatohepatitis and hepatocarcinoma
Pivotal role of intestinal cholesterol and nuclear receptor LXR in metabolic liver steatohepatitis and hepatocarcinoma
Hepatocellular carcinoma (HCC) incidence is continuously increasing worldwide, due to the rise of metabolic dysfunction-as...
TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors
TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors
Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is an effective therapeutic target for diseases such as ca...
Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study
Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study
Observational studies have reported that gut microbiota composition is associated with metabolic syndrome. However, the ca...
Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss d...
Employment of diverse in vitro systems for analyzing multiple aspects of disease, hereditary hemorrhagic telangiectasia (HHT)
Employment of diverse in vitro systems for analyzing multiple aspects of disease, hereditary hemorrhagic telangiectasia (HHT)
In vitro disease modeling enables translational research by providing insight into disease pathophysiology and molecular m...
Agrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling
Agrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling
Human patients often experience an episode of serious seizure activity, such as status epilepticus (SE), prior to the onse...
Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions
Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions
Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial met...
Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker
Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker
Enolase, a multifunctional protein with diverse isoforms, has generally been recognized for its primary roles in glycolysi...
Microbiota-derived 3-phenylpropionic acid promotes myotube hypertrophy by Foxo3/NAD+ signaling pathway
Microbiota-derived 3-phenylpropionic acid promotes myotube hypertrophy by Foxo3/NAD+ signaling pathway
Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth and development, which be known as g...
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING...
Unveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies
Unveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Th...
TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor
TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor
Transcriptional coactivator with PDZ-biding motif (TAZ) is widely expressed in most tissues and interacts with several tra...
Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1β/CXCL2/neutrophil axis
Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1β/CXCL2/neutrophil axis
Psoriasis is an inflammatory skin disease characterized by the hyperproliferative epidermal keratinocytes and significant ...
The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury
The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury
Acute lung injury (ALI) is strongly associated with hospitalization and mortality in patients with sepsis. Recent evidence...
Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation
Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation
Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable pro...
Structural properties of immune complexes formed by viral antigens and specific antibodies shape the inflammatory response of macrophages
Structural properties of immune complexes formed by viral antigens and specific antibodies shape the inflammatory response of macrophages
Data on the course of viral infections revealed severe inflammation as a consequence of antiviral immune response. Despite...