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PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
Neurocognitive disorders and psychosocial difficulties are common in patients with Turner syndrome and multiple neurodegen...
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channel...
MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis
MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis
Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxic...
A synthetic pregnenolone analog promotes microtubule dynamics and neural development
A synthetic pregnenolone analog promotes microtubule dynamics and neural development
Pregnenolone (P5) is a neurosteroid that promotes microtubule polymerization. It also reduces stress and negative symptoms...
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspec...
Defb19 regulates the migration of germ cell and is involved in male fertility
Defb19 regulates the migration of germ cell and is involved in male fertility
β-defensins are small antimicrobial peptides that play essential roles in male fertility. Although several members of...
The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
Acute liver failure caused by drug overdose is a significant clinical problem in developed countries. Acetaminophen (APAP)...
DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets
DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets
Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes, is a major cause of vision loss among midd...
Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis
Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis
Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasi...
Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis
Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis
There are hundreds of central nervous system (CNS) diseases, but there are few diseases for which the etiology or pathogen...
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A
Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefit...
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate
Human primordial germ cells (hPGCs) initiate from the early post-implantation embryo at week 2–3 and undergo epigene...
Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway
Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway
Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite pr...
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake
Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Gluca...
Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation
Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation
DNMT1 has been shown to be highly expressed in a variety of cancers, including breast cancer. However, the mechanism is no...
Wasteosomes (corpora amylacea) of human brain can be phagocytosed and digested by macrophages
Wasteosomes (corpora amylacea) of human brain can be phagocytosed and digested by macrophages
Corpora amylacea of human brain, recently renamed as wasteosomes, are granular structures that appear during aging and als...
Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion
Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion
The human endometrium is a highly regenerative tissue that is believed to have two main types of stem cells: endometrial m...
RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression
RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression
NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an imp...
Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype
Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype
Huntington’s disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) prot...
A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease
A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease
Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune ho...
Revisiting potential value of antitumor drugs in the treatment of COVID-19
Revisiting potential value of antitumor drugs in the treatment of COVID-19
Since an outbreak started in China in 2019, coronavirus disease 2019 (COVID-19) has rapidly become a worldwide epidemic wi...
YAP1 protects against septic liver injury via ferroptosis resistance
YAP1 protects against septic liver injury via ferroptosis resistance
The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly ...
Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation
Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation
Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigene...
Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
Specific gene fusions and their fusion products (chimeric RNA and protein) have served as ideal diagnostic markers and the...