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A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction
To investigate physiological function of α-synuclein is important for understanding its pathophysiological mechanism ...
Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2
Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2
Increasingly studies highlight the crucial role of the ancestral retrovirus envelope protein ERVWE1 in the pathogenic mech...
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice
In understanding the pathophysiology of pulmonary fibrosis (PF), macrophage plasticity has been implicated with a crucial ...
Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells
Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells
Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascad...
Potassium channels in depression: emerging roles and potential targets
Potassium channels in depression: emerging roles and potential targets
Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and sh...
Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice
Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice
Mitochondrial calcium uniporter (MCU) plays pleiotropic roles in cellular physiology and pathology that contributes to a v...
Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques
Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques
Drug-induced liver injury (DILI) refers to drug-mediated damage to the structure and function of the liver, ranging from m...
Ribosomal proteins in hepatocellular carcinoma: mysterious but promising
Ribosomal proteins in hepatocellular carcinoma: mysterious but promising
Ribosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also...
Golgiphagy: a novel selective autophagy to the fore
Golgiphagy: a novel selective autophagy to the fore
The Golgi apparatus is the central hub of the cellular endocrine pathway and plays a crucial role in processing, transport...
Revisiting Virchow’s triad: exploring the cellular and molecular alterations in cerebral venous congestion
Revisiting Virchow’s triad: exploring the cellular and molecular alterations in cerebral venous congestion
Cerebral venous thrombosis (CVT) is a rare but serious condition that can lead to significant morbidity and mortality. Vir...
Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits
Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits
Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons in the nigrostriatal pathway, lea...
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice
In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells w...
HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis
HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis
Ferroptosis, a newly identified form of regulated cell death triggered by small molecules or specific conditions, plays a ...
CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma
CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma
Lung cancer, a leading global cause of cancer-related mortality, necessitates enhanced prognostic markers for improved tre...
Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes
Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes
Occludin, a crucial component of tight junctions, has emerged as a promising biomarker for the diagnosis of acute ischemic...
Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles
Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles
Neural stem cells (NSCs) play a crucial role in the progress of ischemic stroke. Research on zebrafish embryonic demonstra...
Research progress and challenges of the PD-1/PD-L1 axis in gliomas
Research progress and challenges of the PD-1/PD-L1 axis in gliomas
The emergence of programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) immunosuppressants provides new therapeut...
Reading the m6A-encoded epitranscriptomic information in development and diseases
Reading the m6A-encoded epitranscriptomic information in development and diseases
N6-methyladenosine (m6A) represents the most prevalent internal and reversible modification on RNAs. Different cell types ...
Astaxanthin attenuates glucose-induced liver injury in largemouth bass: role of p38MAPK and PI3K/Akt signaling pathways
Astaxanthin attenuates glucose-induced liver injury in largemouth bass: role of p38MAPK and PI3K/Akt signaling pathways
Astaxanthin (ASX) has been documented to exert beneficial influence on various processes in fish. Largemouth bass (Micropt...
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer’s disease
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer’s disease
Amyloid toxicity and glucose metabolic disorders are key pathological features during the progression of Alzheimer’s...
The roles of OGT and its mechanisms in cancer
The roles of OGT and its mechanisms in cancer
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linki...
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma
Hepatitis B virus (HBV) infection can exacerbate liver disease progression through multiple mechanisms, eventually leading...
Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development
Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development
The cell development atlas of transition stage from late Carnegie to fetal development (7–9 weeks) remain u...
Advances in predictive biomarkers associated with immunotherapy in extensive-stage small cell lung cancer
Advances in predictive biomarkers associated with immunotherapy in extensive-stage small cell lung cancer
Small cell lung cancer (SCLC) is a highly malignant and poor-prognosis cancer, with most cases diagnosed at the extensive ...
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment
Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-prolongation even curable in some cancer patie...
YIPF2 regulates genome integrity
YIPF2 regulates genome integrity
Understanding of the mechanisms for genome integrity maintenance can help in developing effective intervention strategies ...
Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19
Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19
Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose...
Role of extracellular vesicle-associated proteins in the progression, diagnosis, and treatment of hepatocellular carcinoma
Role of extracellular vesicle-associated proteins in the progression, diagnosis, and treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, characterized by difficulties in early dia...
Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas
Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngioma (ACP) is a clinically aggressive tumor without effective treatment method. Previous stu...
Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis
Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis
Deubiquitinating enzymes (DUBs) are pivotal in maintaining cell homeostasis by regulating substrate protein ubiquitination...
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