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PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to re...
Interruptible demyelination in avian riboflavin deficient neuropathy
Interruptible demyelination in avian riboflavin deficient neuropathy
The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyeli...
Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate i...
Microglia and macrophage metabolism: a regulator of cerebral gliomas
Microglia and macrophage metabolism: a regulator of cerebral gliomas
Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis an...
GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice
GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice
Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation...
Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior
Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior
Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral veno...
Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism
Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism
The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidn...
Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease
Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease
Canavan disease is an autosomal recessive and lethal neurological disorder, characterized by the spongy degeneration of th...
Crosstalk between m6A modification and autophagy in cancer
Crosstalk between m6A modification and autophagy in cancer
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and...
The role of goblet cells in Crohn’ s disease
The role of goblet cells in Crohn’ s disease
The prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The ...
Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of micr...
The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
Steroid receptor coactivator-1 (SRC-1, also known as NCOA1) frequently functions as a transcriptional coactivator by direc...
Unveiling the functional heterogeneity of cytokine-primed human umbilical cord mesenchymal stem cells through single-cell RNA sequencing
Unveiling the functional heterogeneity of cytokine-primed human umbilical cord mesenchymal stem cells through single-cell RNA sequencing
Mesenchymal stem cells (MSCs) hold immense promise for use in immunomodulation and regenerative medicine. However, their i...
The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially ...
Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc
Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc
Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-target...
Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas
Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas
Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1–4 based on it...
Association of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study
Association of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study
Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely re...
RNA editing enzymes: structure, biological functions and applications
RNA editing enzymes: structure, biological functions and applications
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been id...
Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation
Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation
Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiqui...
Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH
Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH
To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH). We profiled s...
A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma
A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma
Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible...
Membrane-associated RING-CH 7 inhibits stem-like capacities of bladder cancer cells by interacting with nucleotide-binding oligomerization domain containing 1
Membrane-associated RING-CH 7 inhibits stem-like capacities of bladder cancer cells by interacting with nucleotide-binding oligomerization domain containing 1
Cancer stem-like capacities are major factors contributing to unfavorable prognosis. However, the associated molecular mec...
Cardiac progenitor cell therapy: mechanisms of action
Cardiac progenitor cell therapy: mechanisms of action
Heart failure (HF) is an end-stage of many cardiac diseases and one of the main causes of death worldwide. The current man...
Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract an...
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2,...
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with l...
Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloi...
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier
Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intes...
Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions
Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions
Vaccination is a valid strategy to prevent and control newly emerging and reemerging infectious diseases in humans and ani...
Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion
Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion
Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection thr...
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