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Understanding the roles of the WFDC cluster in sperm development and function
A study in Proceedings of the National Academy of Sciences has elucidated the roles of the whey acidic protein four-disulf...
The burden of kidney transplant evaluation — an older adults’ perspective
Kidney transplantation is a crucial treatment option for older adults (defined as ≥65 years old) with kidney failure, but ...
Particulate matter leaves a bitter taste in testes
New data show that bitter taste transduction has an essential role maintaining male reproductive health. This process is k...
Turning down the heat in NEPC
Heat shock protein 60 (HSP60), the main chaperone of the mitochondrial unfolded protein response, could be a potential the...
Efficacy of the Revi system in treating urgency urinary incontinence
The 2-year follow-up results of the OASIS trial, assessing the efficacy of the novel implantable tibial neuromodulation de...
A distinct TAM subset mediates immunotherapy resistance in prostate cancer
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Prostate cancer epigenetics — from pathophysiology to clinical application
Prostate cancer epigenetics — from pathophysiology to clinical application
Prostate cancer is a multifactorial disease influenced by various molecular features. Over the past decades, epigenetics, ...
Pain management in percutaneous nephrolithotomy — an approach rooted in pathophysiology
Pain management in percutaneous nephrolithotomy — an approach rooted in pathophysiology
Pain related to percutaneous nephrolithotomy (PCNL) is multifactorial and poorly elucidated. However, understanding the pa...
Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma
Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma
Spatial transcriptomics has emerged as a powerful tool for discerning the heterogeneity of the tumour microenvironment acr...
Pathophysiological effects of hypoxia on testis function and spermatogenesis
Pathophysiological effects of hypoxia on testis function and spermatogenesis
Multiple conditions can cause hypoxia in the testis, including exposure to high altitude, sleep apnoea, testicular torsion...
Antibiotic therapy for treating overactive bladder is not supported by clinical evidence
Antibiotic therapy for treating overactive bladder is not supported by clinical evidence
A number of reports have suggested that the use of prolonged antibiotic treatment could be an effective therapy for patien...
Predicting surgical outcome for renal tumours
A new 3D method of calculating contact surface area (CSA) for renal tumours is reported in Urologic Oncology. This method ...
Diagnosis of ccRCC
Diagnosis of clear cell renal cell carcinoma (ccRCC) is challenging, particularly as [18F]FDG PET–CT is not routinely reco...
Virtual reality for nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is the main surgical option for the management of large or complex renal stones. A stu...
Personalized 3D models for prostate cancer surgery
Nerve-sparing surgery is the standard approach used in radical prostatectomy to enhance functional outcomes, but secondary...
Neoadjuvant therapy in MIBC
Efficacious neoadjuvant therapy is an unmet need in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIB...
Serial ctDNA to understand PARPi resistance
Poly(ADP-ribose) polymerase inhibition (PARPi) is an effective therapy for castration-resistant prostate cancer (CRPC) wit...
The mechanism of action of neuromodulation in the treatment of overactive bladder
The mechanism of action of neuromodulation in the treatment of overactive bladder
Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placeb...
PEACEing together prostate cancer therapy
Results of the PEACE-1 open-label, randomized, controlled, phase III trial have been published in The Lancet. In this stud...
PFOA affects androgen metabolism
A novel, endocrine-disrupting property of the perfluoroalkyl substance perfluorooctanoic acid (PFOA) affecting androgen me...
JAK–STAT signalling and prostate basal cell fate
A rare intermediate population of basal cells expressing luminal markers has been identified. Markers of this cell populat...
Better PrEParation for HIV prevention in minority groups
In a phase III, double-blind, randomized, active-controlled trial, receipt of twice-yearly subcutaneous lenacapavir every ...
Robot-assisted radical prostatectomy haemostasis techniques and outcomes
The robot-assisted approach to radical prostatectomy has enabled same-day discharge. A substantial concern associated with...
Advancing the state of the art in congenital obstructive uropathy
In March 2024, we convened a symposium to consider the state of the art regarding the mechanisms and management of congeni...
Opening up about cancer and mental health
Opening up about cancer and mental health
Everyone understands the tragedy of cancer; however, the severity of its effects are only known to those who have first-ha...
Time is on our side — rethinking the concept of time to treatment for prostate cancer
Prostate cancer is often an indolent disease, and delays in treatment up to 6 months do not seem to affect cancer-free sur...
Tomorrow’s patient management: LLMs empowered by external tools
Tomorrow’s patient management: LLMs empowered by external tools
Large language models are gaining increasing interest in the medical community; however, an important but overlooked aspec...
Metastasis development in non-muscle-invasive bladder cancer
Metastasis development in non-muscle-invasive bladder cancer
Non-muscle-invasive bladder cancer (NMIBC) is the most common type of bladder cancer presentation and is characterized by ...
Metabolism, mitochondria and metastasis in kidney cancer
A study published in Nature investigating tumour metabolism in kidney cancers provides insight into the influence of mitoc...
Disruption of circadian rhythm as a potential pathogenesis of nocturia
Disruption of circadian rhythm as a potential pathogenesis of nocturia
Increasing evidence suggested the multifactorial nature of nocturia, but the true pathogenesis of this condition still rem...
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