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Overall survival with adjuvant pembrolizumab in renal cell carcinoma — the shock of the lightning
Overall survival with adjuvant pembrolizumab in renal cell carcinoma — the shock of the lightning
In the KEYNOTE-564 trial, patients with resected clear cell renal cell carcinoma at a high risk of relapse experienced dis...
Preclinical models of bladder cancer: BBN and beyond
Preclinical models of bladder cancer: BBN and beyond
Preclinical modelling is a crucial component of advancing the understanding of cancer biology and therapeutic development....
AUA24 — pioneering shared decision-making and patient engagement strategies
AUA24 — pioneering shared decision-making and patient engagement strategies
Urologists, scientists and other professionals in the urology field converged in San Antonio, Texas, to attend the 119th e...
Promoting the health of men of all backgrounds: educating ourselves to build trust and improve care
Specific issues affect the treatment of urological cancer and survivorship in gay and bisexual men. Creating an accepting ...
Overcoming barriers in cancer care for gender minorities
As the population of gender minorities grows in the setting of rising incidence of cancers globally, health-care professio...
Chromosome segregation in SCNT oocytes
The possibility of men in same-sex relationships and people who do not have their own eggs having biological children has ...
Asexuality: the invisible orientation
Asexuality is often neglected in education and conversations around sexuality, making it essentially an ‘invisible o...
Elevated periprostatic androgens, sneaky testosterone and its implications
Elevated periprostatic androgens, sneaky testosterone and its implications
A subset of men with prostate cancer have elevated periprostatic androgens compared with levels in peripheral blood (terme...
Current and emerging strategies to curb antibiotic-resistant urinary tract infections
Current and emerging strategies to curb antibiotic-resistant urinary tract infections
Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes and prolong hospital stays. Co...
We all get erections — de-gendering sexual arousal dysfunction in the ICD
We all get erections — de-gendering sexual arousal dysfunction in the ICD
Definitions of sexual arousal dysfunction in the International Classification of Diseases use sex-specific binaries that o...
Breaking the silence: normalizing receptive anal intercourse for patients, for people and for myself
Breaking the silence: normalizing receptive anal intercourse for patients, for people and for myself
The lack of information and discussion on receptive anal intercourse (RAI) perpetuates the stigma. Normalizing RAI and emp...
Centralization of care for rare genetic syndromes associated with cancer: improving outcomes and advancing research on VHL disease
Centralization of care for rare genetic syndromes associated with cancer: improving outcomes and advancing research on VHL disease
Von Hippel–Lindau (VHL) disease is a rare genetic syndrome caused by a germline pathogenic variant in one VHL allele...
The evolving treatment landscape of metastatic urothelial cancer
The evolving treatment landscape of metastatic urothelial cancer
Cisplatin-based chemotherapy is currently the first-line standard of care for patients with metastatic urothelial cancer (...
Strengthening preclinical testing to increase safety in surgical mesh
Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress u...
Von Hippel–Lindau protein signalling in clear cell renal cell carcinoma
Von Hippel–Lindau protein signalling in clear cell renal cell carcinoma
The distinct pathological and molecular features of kidney cancer in adaptation to oxygen homeostasis render this malignan...
From biology to the clinic — exploring liver metastasis in prostate cancer
From biology to the clinic — exploring liver metastasis in prostate cancer
Liver metastases from prostate cancer are associated with an aggressive disease course and poor prognosis. Results from au...
Influence of substance use on male reproductive health and offspring outcomes
Influence of substance use on male reproductive health and offspring outcomes
The prevalence of substance use globally is rising and is highest among men of reproductive age. In Africa, and South and ...
Bladder cancer variants — one disease with many faces
Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasma...
EAU à la mode
Urologists from around the world congregated at the 39th Annual Congress of the European Association of Urology (EAU), whi...
The evolving landscape of monogenic nephrolithiasis and therapeutic innovations
Monogenic causes account for up to 20% of nephrolithiasis instances and are crucial for developing targeted treatments. Wh...
A CAF subpopulation promotes LVI in early-stage bladder cancer
In a new article published in Cancer Cell, a subset of cancer-associated fibroblasts (CAFs) was shown to have a crucial ro...
The case for centralization of care in penile cancer — respecting geographical needs
Centralization of care for penile cancer has been underscored in the 2023 updated EAU–ASCO guidelines. Expertise con...
Patient-reported toxic effects of hypofractionated versus conventional RT
Post-prostatectomy radiotherapy (RT) is a common second-line treatment for patients with prostate cancer. In the phase III...
Safe delivery of ICI therapy through sub-urothelial injection
Systemic treatment with the human monoclonal anti-PDL1 antibody durvalumab showed benefit in several cancers. In a phase I...
HRQoL in patients receiving EV versus chemotherapy
In the phase III EV-301 trial, enfortumab vedotin (EV) has been shown to increase overall survival compared with chemother...
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Ferroptosis is a distinct form of regulated cell death that is predominantly driven by the build-up of intracellular iron ...
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Diets leading to caloric overload are linked to metabolic disorders and reproductive function impairment. Metabolic and ho...
Robots learning to imitate surgeons — challenges and possibilities
Robots learning to imitate surgeons — challenges and possibilities
Autonomous surgical robots have the potential to transform surgery and increase access to quality health care. Advances in...
Overcoming antibiotic resistance in complicated UTI
Complicated urinary tract infection (UTI) is a debilitating condition often resulting in patient hospitalization and conse...
The ins and outs of penile erection
New discoveries concerning the function of fibroblasts in penile erection have improved our understanding of this physiolo...