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Bladder cancer variants — one disease with many faces
Bladder cancer progression to microscopically distinct variants such as sarcomatoid, small cell, micropapillary and plasma...
EAU à la mode
Urologists from around the world congregated at the 39th Annual Congress of the European Association of Urology (EAU), whi...
The evolving landscape of monogenic nephrolithiasis and therapeutic innovations
Monogenic causes account for up to 20% of nephrolithiasis instances and are crucial for developing targeted treatments. Wh...
A CAF subpopulation promotes LVI in early-stage bladder cancer
In a new article published in Cancer Cell, a subset of cancer-associated fibroblasts (CAFs) was shown to have a crucial ro...
The case for centralization of care in penile cancer — respecting geographical needs
Centralization of care for penile cancer has been underscored in the 2023 updated EAU–ASCO guidelines. Expertise con...
Patient-reported toxic effects of hypofractionated versus conventional RT
Post-prostatectomy radiotherapy (RT) is a common second-line treatment for patients with prostate cancer. In the phase III...
Safe delivery of ICI therapy through sub-urothelial injection
Systemic treatment with the human monoclonal anti-PDL1 antibody durvalumab showed benefit in several cancers. In a phase I...
HRQoL in patients receiving EV versus chemotherapy
In the phase III EV-301 trial, enfortumab vedotin (EV) has been shown to increase overall survival compared with chemother...
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Ferroptosis is a distinct form of regulated cell death that is predominantly driven by the build-up of intracellular iron ...
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Diets leading to caloric overload are linked to metabolic disorders and reproductive function impairment. Metabolic and ho...
Robots learning to imitate surgeons — challenges and possibilities
Robots learning to imitate surgeons — challenges and possibilities
Autonomous surgical robots have the potential to transform surgery and increase access to quality health care. Advances in...
Overcoming antibiotic resistance in complicated UTI
Complicated urinary tract infection (UTI) is a debilitating condition often resulting in patient hospitalization and conse...
The ins and outs of penile erection
New discoveries concerning the function of fibroblasts in penile erection have improved our understanding of this physiolo...
Robotic kidney transplantation
Robotic kidney transplantation
Kidney transplantation is the best treatment option for patients with end-stage renal disease owing to improved survival a...
Diversifying editorial boards to mitigate the global burden of genitourinary cancers
The growing global burden of genitourinary cancers is disproportionately shouldered by low- and middle-income countries. M...
Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Bladder cancer in the most advanced, muscle-invasive stage is lethal, and very limited therapeutic advances have been repo...
The evolving management of small renal masses
The evolving management of small renal masses
Small renal masses (SRMs) are a heterogeneous group of tumours with varying metastatic potential. The increasing use and i...
Sun, sea, sex and spaghetti as the ESSM hits Bari
Sun, sea, sex and spaghetti as the ESSM hits Bari
Delegates were treated to a fantastic menu of both science and gastronomy as the European Society for Sexual Medicine (ESS...
ADT intensification to treat biochemically recurrent prostate cancer
In the randomized phase III, open-label trial PRESTO, the effect of potentiating androgen deprivation therapy (ADT) on imp...
A new rapid point-of-care test for N. gonorrhoeae
The lack of a rapid, cheap point-of-care test to diagnose infection with Neisseria gonorrhoeae has led to overuse of antib...
Mellow yellow: BilR reduces bilirubin to urobilinogen
Researchers have identified the enzyme, now called bilirubin reductase (BilR), that converts bilirubin to urobilinogen, gi...
First-morning urine samples to study the urobiome
The urinary microbiome (urobiome) is emerging as a new contributing factor in determining bladder cancer risk, but data fr...
RNA N6-methyladenosine modifications in urological cancers: from mechanism to application
RNA N6-methyladenosine modifications in urological cancers: from mechanism to application
The N6‐methyladenosine (m6A) modification is the most common modification of messenger RNAs in eukaryotes and has cr...
Molecular profile of bladder cancer progression to clinically aggressive subtypes
Molecular profile of bladder cancer progression to clinically aggressive subtypes
Bladder cancer is a histologically and clinically heterogenous disease. Most bladder cancers are urothelial carcinomas, wh...
Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome
Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by bladder and/or pelvic pain, increased urinary urg...
Supplementary selenium and vitamin E in non-muscle-invasive bladder cancer
In the SELENIB trial, selenium and vitamin E were compared with placebo as chemoprevention for non-muscle-invasive bladder...
Management of patients with muscle-invasive bladder cancer with clinical evidence of pelvic lymph node metastases
Management of patients with muscle-invasive bladder cancer with clinical evidence of pelvic lymph node metastases
Identification of clinically positive pelvic lymph node metastases (cN+) in patients with muscle-invasive bladder cancer i...
The yin and yang of chromosomal instability in prostate cancer
The yin and yang of chromosomal instability in prostate cancer
Metastatic prostate cancer remains an incurable lethal disease. Studies indicate that prostate cancer accumulates genomic ...
The complex interplay of modifiable risk factors affecting prostate cancer disparities in African American men
The complex interplay of modifiable risk factors affecting prostate cancer disparities in African American men
Prostate cancer is the second most commonly diagnosed non-skin malignancy and the second leading cause of cancer death amo...
Pembrolizumab plus enfortumab vedotin in urothelial cancer
The combination of pembrolizumab and enfortumab vedotin shows promise as a first-line therapy for advanced urothelial carc...
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