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The endoplasmic reticulum stress response in prostate cancer
The endoplasmic reticulum stress response in prostate cancer
In order to proliferate in unfavourable conditions, cancer cells can take advantage of the naturally occurring endoplasmic...
Quality checkpoints in the MRI-directed prostate cancer diagnostic pathway
Quality checkpoints in the MRI-directed prostate cancer diagnostic pathway
Multiparametric MRI of the prostate is now recommended as the initial diagnostic test for men presenting with suspected pr...
Mechanisms of the intestinal and urinary microbiome in kidney stone disease
Mechanisms of the intestinal and urinary microbiome in kidney stone disease
Kidney stone disease affects ~10% of the global population and the incidence continues to rise owing to the associated glo...
What is fuelling the monkeypox outbreak?
In July 2022, the WHO declared a public health emergency of international concern regarding monkeypox — a...
Male infertility and somatic health — insights into lipid damage as a mechanistic link
Male infertility and somatic health — insights into lipid damage as a mechanistic link
Over the past decade, mounting evidence has shown an alarming association between male subfertility and poor somatic healt...
Nature versus nurture contribution to prostate cancer risk
Genetics has a role in predisposition towards prostate cancer, and an accurate prediction of prostate cancer risk can be m...
The shifting treatment paradigm of metastatic renal cell carcinoma
The shifting treatment paradigm of metastatic renal cell carcinoma
The treatment landscape of renal cell carcinoma is rapidly evolving, especially with the introduction and approval of immu...
Transitional care in urology: the road to independence
Transition from child-centred to adult-centred care is a crucial step for patients with a congenital urological disease. T...
Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction
Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction
The lower urinary tract (LUT), including the bladder, urethra and external striated muscle, becomes dysfunctional with age...
Secondary kidney stones — remove or leave?
Small, asymptomatic kidney stones (≤6 mm) are often observed during removal of symptomatic stones, and no clear indication...
Time for women-centred gynaecology
Although gynaecology is a specialty responsible for women’s health, the field was historically male-dominated and it...
Current and emerging treatment options for premature ejaculation
Current and emerging treatment options for premature ejaculation
Premature ejaculation (PE) is a prevalent male sexual dysfunction. Current standard treatment regimens include behavioural...
Mapping gonadogenesis in time and space
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Biomarkers of disease recurrence in stage I testicular germ cell tumours
Biomarkers of disease recurrence in stage I testicular germ cell tumours
Stage I testicular cancer is a disease restricted to the testicle. After orchiectomy, patients are considered to be withou...
Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction
Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction
Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global public health. Treating systemic ...
Spatiotemporal trends in human semen quality
Spatiotemporal trends in human semen quality
Over the past four decades, studies of various designs have reported spatial and temporal trends in human semen quality. S...
Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future
Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future
In the pre-PSA-detection era, a large proportion of men were diagnosed with metastatic prostate cancer and died of the dis...
Race and prostate cancer: genomic landscape
Race and prostate cancer: genomic landscape
In the past 20 years, new insights into the genomic pathogenesis of prostate cancer have been provided. Large-scale integr...
Mapping immune cell chromatin landscapes in ccRCC
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
MDPs and racial differences in prostate cancer
Mitochondrial DNA encodes small peptides (mitochondria-derived peptides (MDPs)), high serum levels of which have been asso...
Treating cancer in kidney transplant recipients
The efficacy of immune checkpoint inhibitors (ICIs) in kidney transplant recipients is not well understood, as the results...
Vaccination to prevent untreatable gonorrhoea
Antibiotic resistance is a major challenge in gonorrhoea treatment and might lead to untreatable gonorrhoea in the future;...
Novel intravesical gemcitabine delivery system (TAR-200) for neoadjuvant treatment of MIBC: context is everything
Muscle-invasive bladder cancer (MIBC) remains a deadly disease, despite aggressive surgical and systemic chemotherapeutic ...
The future of pelvic lymph node dissection for urological malignancies
Controversies over how, why and when pelvic lymph node dissection (PLND) should be performed persist. Available data sugge...
Mutagenic effect of chemotherapy on sperm DNA and implications for family planning
Some chemotherapeutic agents can induce distinct mutational signatures in healthy cells in patients with cancer. The effec...
The unclear role of PET–CT in localized radiorecurrent prostate cancer
Prostate cancer recurrence is common after radical radiotherapy and the increasing use of novel, minimally invasive salvag...
Immune-based therapies in penile cancer
Immune-based therapies in penile cancer
Penile cancer is a rare genitourinary malignancy that is associated with poor outcomes and severely limited therapeutic op...