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The need for smart microalgal bioprospecting
The need for smart microalgal bioprospecting
Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic mic...
Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation
Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation
Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. Howev...
New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
Chemically engineered extracts represent a promising source of new bioactive semi-synthetic molecules. Prepared through di...
Discovery of a parallel family of euglenatide analogs in Euglena gracilis
Discovery of a parallel family of euglenatide analogs in Euglena gracilis
The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracili...
Novel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect
Novel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect
Teucrifarides A–D (1–4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen kno...
Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.
Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.
A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb...
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
In the twenty-first century, we have witnessed multiple coronavirus pandemics. Despite declining SARS-CoV-2 cases, continu...
Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia
Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia
Fifteen novel carbazole alkaloids, euchrestifolines A–O (1–15), were obtained from Murraya euchrestifolia. The...
Diterpene chemical space of Aeollanthus buchnerianus Briq. aerial part
Diterpene chemical space of Aeollanthus buchnerianus Briq. aerial part
The Plectranthinae clade, which includes genera such as Plectranthus, Ocimum, and Aeollanthus, is well known for its diver...
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species
Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies h...
Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science
Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science
The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented ...
Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities
Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities
Thirty-six structurally diverse sesquiterpenoids, including caryolanes (1–12), germacranes (13–16), isodaucane...
Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway
Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway
This study aimed to evaluate the therapeutic properties of the traditional Chinese medicine Xuesanqi (XSQ, from the rhizom...
Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity
Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity
Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A − I (1–7, 9 and 10...
Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway
Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway
Viral pneumonia is characterized by inflammation in the lungs triggered by respiratory viruses. Dayuan Yin (DYY), a tradit...
Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.
Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.
Four new isoquinoline alkaloids, hypecotumines A-D (1–4), were isolated and identified from the whole herbs of Hypec...
Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways
Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways
Insulin-like growth factor-1 (IGF-1) is considered as a pathogenic factor contributing to sebaceous gland dysfunction, whi...
Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
Iminosugars, a class of polyhydroxylated cyclic alkaloids with intriguing properties, hold promising therapeutic potential...
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Dictyophora rubrovalvata is a valuable fungus homologous to food and medicine, and its polysaccharide have been gaining in...
Recent advances in pharmaceutical cocrystals of theophylline
Recent advances in pharmaceutical cocrystals of theophylline
Currently, cocrystallization is a promising strategy for tailoring the physicochemical properties of active pharmaceutical...
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
Eleven novel clerodane-type diterpenoids, grewiifopenes A–K (1–4 and 12–18), along with nine known compo...
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These...
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Functionalized mesoporous materials have become a promising carrier for enzyme immobilization. In this study, Santa Barbar...
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Triplostegia glandulifera Wall (T. glandulifera) is an ethnomedicine commonly used by ethnic minorities in Yunnan, China, ...
Natural and revolutionary tumor-specific T-cell therapy
Natural and revolutionary tumor-specific T-cell therapy
Recently the FDA conducted a risk investigation and labeled the Boxed Warning for all BCMA- and CD19-directed CAR-T cell t...
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation is a process in which molecules are modified in the presence of a biocatalyst or enzymes, as well as the...
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Arctium lappa, widely recognized as burdock, is a perennial plant that is employed in the realm of traditional Chinese med...
Silvaticusins A–D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus
Silvaticusins A–D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus
Three new ent-kaurane diterpenoids, silvaticusins A–C (1–3), along with a new ent-kaurane dimer silvaticusin D...
Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Xiaoyankangjun tablet (XYKJP) is a traditional Chinese medicine formulation used to treat intestinal disorders in clinical...
Correction: Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Correction: Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Following publication of the original article [1], the authors reported that the original version of this article unfortun...
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