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5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
Alzheimer’s disease (AD) is a complex neurodegenerative condition. 5α-epoxyalantolactone (5α-EAL), a eudes...
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Plants and microbes are closely associated with each other in their ecological niches. Much has been studied about plant&#...
Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo
Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo
In this study, the effects of sea buckthorn oil (SBO), fish oil (FO) and an enzymatically synthesized structured lipid (SL...
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
The marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA, ITS re...
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and i...
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
Adenosma buchneroides Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of C...
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration
The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thio...
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferropt...
Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
N-Hydroxyapiosporamide (N-hydap), a marine product derived from a sponge-associated fungus, has shown promising inhibitory...
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy
Four extracts of the marine-derived fungus Penicillium velutinum J.F.H. Beyma were obtained via metal ions stress conditio...
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subt...
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successful...
Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)
Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)
Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most v...
Natural-derived acetophenones: chemistry and pharmacological activities
Natural-derived acetophenones: chemistry and pharmacological activities
Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains...
Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbo...
Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Until recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-...
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz...
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalenc...
Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata
Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata
Based on the research progress and traditional usage with whole herbal of the TCM "Tianma", chemical studies her...
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two othe...
Which is the optimal choice for neonates’ formula or breast milk?
Which is the optimal choice for neonates’ formula or breast milk?
The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerab...
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological p...
Current advances on the therapeutic potential of scutellarin: an updated review
Current advances on the therapeutic potential of scutellarin: an updated review
Scutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteracea...
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various ...
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, ...
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 mi...
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
A type of high molecular weight bioactive polymers called exopolysaccharides (EPS) are produced by thermophiles, the extre...
Chemistry and biology of marine-derived Trichoderma metabolites
Chemistry and biology of marine-derived Trichoderma metabolites
Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with va...
Natural and engineered xylosyl products from microbial source
Natural and engineered xylosyl products from microbial source
Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural di...
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake...
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