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Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Currently, empirical therapy regimens are often used in the treatment of infectious diseases that are not based on data on...
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Dysregulation of microRNAs (miRs) plays an essential role in tumor progression of oral squamous cell carcinoma (OSCC) thro...
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Considerable research...
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
RNA Recognition Motifs (RRMs) are the most common type of protein domain found in eukaryotic RNA-binding proteins (RBPs). ...
Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs
Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs
Abstract—Solving the problem of multidrug resistance currently requires the development of nonstandard approaches, s...
Antibiotic Resistance: Threats and Search for Solution
Antibiotic Resistance: Threats and Search for Solution
Antibiotic and, more broadly, antimicrobial resistance is a naturally occurring biological phenomenon and a major public h...
Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin
Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin
Acute and subchronic toxicity of the pharmacological pair based on encapsulated Citrobacter freundii C115H methionine ^...
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
Increased resistance to polycyclic glycopeptide antibiotics has become a serious problem for chemotherapy of infections ca...
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Resistance to antimicrobial drugs is an urgent problem not only in public health, but also in animal husbandry. The widesp...
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
Cancer-multidrug resistance (MDR) is recognized as one of the barriers to the treatment of advanced hepatocellular carcino...
Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Despite nearly a century of therapy for gonococcal infection with a variety of antimicrobials, more than 80 million cases ...
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Diallyl thiosulfinate (allicin) effectively inhibits the growth of various microorganisms, including antibiotic-resistant ...
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Proteasome inhibitors (PIs) are effective in the treatment of multiple myeloma (MM), which is a plasma cell malignancy. Di...
Distribution of β-Lactamase-Producing Enterobacterales among Patients in Surgical and Therapeutic Departments of a Multidisciplinary Hospital
Distribution of β-Lactamase-Producing Enterobacterales among Patients in Surgical and Therapeutic Departments of a Multidisciplinary Hospital
Adequate empiric therapy is difficult to choose without monitoring the local distribution of antibiotic-resistant bacteria...
Development of a New Inhibitor of Bacterial Cystathionine γ-Lyase Based on 6-Bromoindole and Aminothiophene
Development of a New Inhibitor of Bacterial Cystathionine γ-Lyase Based on 6-Bromoindole and Aminothiophene
Cystathionine-γ-lyase (CSE) is a key enzyme for H2S generation in the pathogenic bacteria Sta-phylococcus aureus, Pse...
Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells
Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells
Ras-related protein Rab-7a (RAB7A) is a member of the RAS oncogene superfamily; it plays an important role in vesicle tran...
CpG Traffic Lights Are Involved in Active DNA Demethylation
CpG Traffic Lights Are Involved in Active DNA Demethylation
DNA methylation is one of the most important mechanisms closely involved in the epigenetic regulation of gene expression. ...
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Transglutaminases are enzymes that carry out post-translational modifications of proteins and participate in the regulatio...
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Pancreatic Ductal AdenoCarcinoma (PDAC) is characterized by a poor prognosis and is poorly amenable to modern therapies. A...
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
Vimentin intermediate filaments are dynamic structures that are able to move in cytoplasm owing to activity of the motor p...
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Serine/threonine protein kinase ATM (ataxia-telangiectasia mutated) performs a number of aging-related functions in the ce...
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Various age-related disorders accumulate during aging, causing a decline in tissue and organ function, raising the risk of...
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Klebsiella oxytoca is a causative agent of various community-acquired and nosocomial infections, including urinary tract i...
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
The human primase-polymerase PrimPol is a key participant of the mechanism of DNA synthesis restart during replication for...
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Human papillomavirus type 16 (HPV16) belongs to viruses of the high-risk type and is associated by overexpression of E6 an...
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Transposable elements (TEs) increase the frequency of spontaneous mutations in the genome and are capable of altering the ...
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflammatory respiratory disease. T...
Methylation of Selected CpG-Sites of the Gene CSF1 as a Factor in Regulation of Its Expression and a Marker of Human Biological Aging
Methylation of Selected CpG-Sites of the Gene CSF1 as a Factor in Regulation of Its Expression and a Marker of Human Biological Aging
Abstract—Age-associated transformation of methylation patterns is considered to be an important predictor of human b...
p62: Intersection of Antioxidant Defense and Autophagy Pathways
p62: Intersection of Antioxidant Defense and Autophagy Pathways
Numerous regulatory cascades link the cell response to oxidative stress and the mechanisms that maintain homeostasis and c...
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Breast cancer cells undergo a process of reprogramming their metabolism for rapid growth and proliferation. One of the mos...
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