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Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small non-coding RNAs (sRNAs, also called sncRNAs) known as gene expression regulatory factors are capable of modulating m...
Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles
Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles
ENY2 is an evolutionarily conserved multifunctional protein and is a member of several complexes that regulate various sta...
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
As a result of molecular domestication of the gag gene of errantiviruses, the Gagr gene was formed in the genome of Drosop...
Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs
Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs
SINEs are mobile genetic elements of multicellular eukaryotes that arose during evolution from various tRNAs, as well as f...
Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand
Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand
Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a com...
Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins
Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins
The process of mRNA localization in the cytoplasm involves the directed transport of mRNP particles using the microtubule ...
Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer
Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a h...
Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects
Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects
The development and creation of a new generation vaccines based on recombinant proteins that assemble into virus-like part...
Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers
Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers
A method has been developed for manufacturing biological microchips on an aluminum substrate with hydrophilic cells from b...
ArdA Protein Specificity against Type I Restriction–Modification Systems
ArdA Protein Specificity against Type I Restriction–Modification Systems
The ArdA DNA-mimic antirestriction proteins inhibit type I restriction−modification (RMI) systems by binding instead...
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
Atherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a lon...
Exploring the Potential Mechanism of Apoptosis Induced by MFSD8 in Endothelial Cells: an RNA Sequencing and Bioinformatics Analysis
Exploring the Potential Mechanism of Apoptosis Induced by MFSD8 in Endothelial Cells: an RNA Sequencing and Bioinformatics Analysis
Neuronal ceroid lipofuscinoses (NCLs) belong to a group of inherited neurodegenerative disorders without effective treatme...
Microtubule-Associated Protein 9 Is a Potential Tumor Suppressor That Is Inactivated by Methylation in Cervical Cancer
Microtubule-Associated Protein 9 Is a Potential Tumor Suppressor That Is Inactivated by Methylation in Cervical Cancer
Cervical cancer is a malignant disease that seriously affects women’s health, and the cause of cervical cancer is co...
P3H4 Regulates Apoptosis and Autophagy of Breast Cancer Cells via BCL-2/BAX/Caspase-3 and AMPK/mTOR/ULK1 Signaling Pathways
P3H4 Regulates Apoptosis and Autophagy of Breast Cancer Cells via BCL-2/BAX/Caspase-3 and AMPK/mTOR/ULK1 Signaling Pathways
The role of prolyl 3-hydroxylase family member 4 (P3H4, or SC65) in breast cancer and the molecular mechanisms in which th...
Global Transcriptome Analysis Reveals Corresponding Genes and Key Pathways Involved in Oxidative Stress in Mouse Small Intestinal Cells
Global Transcriptome Analysis Reveals Corresponding Genes and Key Pathways Involved in Oxidative Stress in Mouse Small Intestinal Cells
Understanding the molecular mechanisms involved in the effects of oxidative stress in humans and animals is important to m...
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and poses a severe threat to human health. Gink...
SMURF1-Interference Effects Autophagy and Pulmonary Fibrosis through SMAD7 and the TGF-β1/SMAD Pathway
SMURF1-Interference Effects Autophagy and Pulmonary Fibrosis through SMAD7 and the TGF-β1/SMAD Pathway
SMAD-specific E3 ubiquitin proten ligase 1 (SMURF1) is involved in transforming growth factor (TGF)-β1/Smad pathway-m...
The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages
The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages
The complement inhibitor CD55/DAF is expressed on many cell types. Dysregulation of CD55 expression is associated with inc...
The Structural Features of Skeletal Muscle Titin Aggregates
The Structural Features of Skeletal Muscle Titin Aggregates
Abstract—Titin is a multidomain protein of striated and smooth muscles of vertebrates. The protein consists of repea...
Changes in the Genome of the Tick-Borne Encephalitis Virus during Cultivation
Changes in the Genome of the Tick-Borne Encephalitis Virus during Cultivation
The tick-borne encephalitis virus (TBEV) strain C11-13 (GenBank acc. no. OQ565596) of the Siberian genotype was previously...
The Expression of TP53TG1, LINC00342, MALAT1, H19, and MEG3 Long Noncoding RNAs in Type 2 diabetes mellitus
The Expression of TP53TG1, LINC00342, MALAT1, H19, and MEG3 Long Noncoding RNAs in Type 2 diabetes mellitus
Abstract—Type 2 diabetes is a complex and multifactorial metabolic disorder. The frequency of type 2 diabetes has dr...
The Oral Microbiome in the Development of Oral Cancer
The Oral Microbiome in the Development of Oral Cancer
Abstract—Oral cancer is an aggressive and rapidly progressive disease. The oral cavity is home to over 700 species o...
Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells
Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells
Abstract—Multiple exogenous or endogenous factors alter gene expression patterns by different mechanisms that are po...
The Molecular and Genetic Mechanisms of Sex Determination in Poplar
The Molecular and Genetic Mechanisms of Sex Determination in Poplar
Abstract—The study of molecular and genetic mechanisms of sex determination in the poplar is of interest not only in...
Regulation of Transcription by RNA Polymerase III Promotors in the Norm and Pathology
Regulation of Transcription by RNA Polymerase III Promotors in the Norm and Pathology
Abstract—RNA polymerase III synthesizes a wide range of noncoding RNAs shorter than 400 nucleotides in length. These...
Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches
Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches
Uveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, ...
A Bioinformatics Method for Identification of Human Proteases Active against Viral Envelope Glycoproteins: A Case Study on the SARS-CoV-2 Spike Protein
A Bioinformatics Method for Identification of Human Proteases Active against Viral Envelope Glycoproteins: A Case Study on the SARS-CoV-2 Spike Protein
Abstract—Many viruses, including SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, enter host cells...
Knockout of Hsp70 Genes Modulates Age-Related Transcriptomic Changes in Leg Muscles and Reduces the Locomotion Speed and Lifespan of Drosophila melanogaster
Knockout of Hsp70 Genes Modulates Age-Related Transcriptomic Changes in Leg Muscles and Reduces the Locomotion Speed and Lifespan of Drosophila melanogaster
This study investigated the effect of knockout of six Hsp70 genes (orthologues of the mammalian genes Hspa1a, Hspa1b, Hspa...
Cytotoxicity Studies of 5-Arylaminouracil Derivatives
Cytotoxicity Studies of 5-Arylaminouracil Derivatives
We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other path...
Method of Inducible Knockdown of Essential Genes in OSC Cell Culture of Drosophila melanogaster
Method of Inducible Knockdown of Essential Genes in OSC Cell Culture of Drosophila melanogaster
An RNA interference-based method was proposed to achieve an inducible knockdown of genes essential for cell viability. In ...
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