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Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Transglutaminases are enzymes that carry out post-translational modifications of proteins and participate in the regulatio...
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Pancreatic Ductal AdenoCarcinoma (PDAC) is characterized by a poor prognosis and is poorly amenable to modern therapies. A...
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
Vimentin intermediate filaments are dynamic structures that are able to move in cytoplasm owing to activity of the motor p...
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Serine/threonine protein kinase ATM (ataxia-telangiectasia mutated) performs a number of aging-related functions in the ce...
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Various age-related disorders accumulate during aging, causing a decline in tissue and organ function, raising the risk of...
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Klebsiella oxytoca is a causative agent of various community-acquired and nosocomial infections, including urinary tract i...
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
The human primase-polymerase PrimPol is a key participant of the mechanism of DNA synthesis restart during replication for...
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Human papillomavirus type 16 (HPV16) belongs to viruses of the high-risk type and is associated by overexpression of E6 an...
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Transposable elements (TEs) increase the frequency of spontaneous mutations in the genome and are capable of altering the ...
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflammatory respiratory disease. T...
Methylation of Selected CpG-Sites of the Gene CSF1 as a Factor in Regulation of Its Expression and a Marker of Human Biological Aging
Methylation of Selected CpG-Sites of the Gene CSF1 as a Factor in Regulation of Its Expression and a Marker of Human Biological Aging
Abstract—Age-associated transformation of methylation patterns is considered to be an important predictor of human b...
p62: Intersection of Antioxidant Defense and Autophagy Pathways
p62: Intersection of Antioxidant Defense and Autophagy Pathways
Numerous regulatory cascades link the cell response to oxidative stress and the mechanisms that maintain homeostasis and c...
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Breast cancer cells undergo a process of reprogramming their metabolism for rapid growth and proliferation. One of the mos...
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
SKP2 gene is an independent prognostic factor in some diseases and a potential oncogene. The molecular mechanism underlyin...
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
Cardiovascular diseases remain a predominant global cause of mortality, with a noteworthy rise in the risk of morbidity wi...
Amino Acid Substitution Patterns in the E6 and E7 Proteins of HPV Type 16: Phylogeography and Evolution
Amino Acid Substitution Patterns in the E6 and E7 Proteins of HPV Type 16: Phylogeography and Evolution
The E6 and E7 proteins of the high risk human papillomaviruses (HR HPVs) play a key role in the oncogenesis associated wit...
Metabolic Profile of Gut Microbiota and Levels of Trefoil Factors in Adults with Different Metabolic Phenotypes of Obesity
Metabolic Profile of Gut Microbiota and Levels of Trefoil Factors in Adults with Different Metabolic Phenotypes of Obesity
Obesity is associated with changes in the gut microbiota, as well as with increased permeability of the intestinal wall. I...
Virus-Like Particles Carrying HIV-1 Env with a Modulated Glycan Composition
Virus-Like Particles Carrying HIV-1 Env with a Modulated Glycan Composition
Previously obtained highly immunogenic Env-VLPs ensure overcoming the natural resistance of HIV-1 surface proteins associa...
The Drosophila Zinc Finger Proteins Aef1 and CG10543 Are Co-Localized with SAGA, SWI/SNF, and ORC Complexes on Gene Promoters and Involved in Transcription Regulation
The Drosophila Zinc Finger Proteins Aef1 and CG10543 Are Co-Localized with SAGA, SWI/SNF, and ORC Complexes on Gene Promoters and Involved in Transcription Regulation
In previous studies, we purified the DUB-module of the Drosophila SAGA complex and showed that a number of zinc proteins i...
Current Knowledge of Base Editing and Prime Editing
Current Knowledge of Base Editing and Prime Editing
Modern genetic engineering technologies, such as base editing and prime editing (PE), have proven to provide the efficient...
Human eRF1 Translation Regulation
Human eRF1 Translation Regulation
Eukaryotic translation release factor eRF1 is an important cellular protein that plays a key role in translation terminati...
How to Shift the Equilibrium of DNA Break Repair in Favor of Homologous Recombination
How to Shift the Equilibrium of DNA Break Repair in Favor of Homologous Recombination
The CRISPR/Cas technology of targeted genome editing made it possible to carry out genetic engineering manipulations with ...
Donor DNA Modification with Cas9 Targeting Sites Improves the Efficiency of MTC34 Knock-in into the CXCR4 Locus
Donor DNA Modification with Cas9 Targeting Sites Improves the Efficiency of MTC34 Knock-in into the CXCR4 Locus
To successfully apply the genome editing technology using the CRISPR/Cas9 system in the clinic, it is necessary to achieve...
Sensitivity of Primary Human Glioblastoma Cell Lines to the Mumps Virus Vaccine Strain
Sensitivity of Primary Human Glioblastoma Cell Lines to the Mumps Virus Vaccine Strain
The sensitivity of human glioblastoma cells to virus-mediated oncolysis was investigated on five patient-derived cell line...
Methods to Increase the Efficiency of Knock-in of a Construct Encoding the HIV-1 Fusion Inhibitor, MT-C34 Peptide, into the CXCR4 Locus in the CEM/R5 T Cell Line
Methods to Increase the Efficiency of Knock-in of a Construct Encoding the HIV-1 Fusion Inhibitor, MT-C34 Peptide, into the CXCR4 Locus in the CEM/R5 T Cell Line
The low knock-in efficiency, especially in primary human cells, limits the use of the genome editing technology for therap...
The Drosophila Zinc Finger Protein CG9609 Interacts with the Deubiquitinating (DUB) Module of the SAGA Complex and Participates in the Regulation of Transcription
The Drosophila Zinc Finger Protein CG9609 Interacts with the Deubiquitinating (DUB) Module of the SAGA Complex and Participates in the Regulation of Transcription
In previous studies, we found that the zinc finger proteins Su(Hw) and CG9890 interact with the Drosophila SAGA complex an...
Molecular Ion Channel Blockers of Influenza A and SARS-CoV-2 Viruses
Molecular Ion Channel Blockers of Influenza A and SARS-CoV-2 Viruses
Molecules were proposed to block the functional cycles of the influenza virus A and SARS-CoV-2. The blocker molecules effi...
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small non-coding RNAs (sRNAs, also called sncRNAs) known as gene expression regulatory factors are capable of modulating m...
Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles
Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles
ENY2 is an evolutionarily conserved multifunctional protein and is a member of several complexes that regulate various sta...
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
As a result of molecular domestication of the gag gene of errantiviruses, the Gagr gene was formed in the genome of Drosop...
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