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Metabolic Heterogeneity of Tumors
Metabolic Heterogeneity of Tumors
Abstract—Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates seriou...
Nitric Oxide(II) in the Biology of Chlorophyta
Nitric Oxide(II) in the Biology of Chlorophyta
Abstract—NO is a gaseous signaling redox-active molecule that functions in various eukaryotes. However, its synthesi...
Regulation of Metabolism and the Role of Redox Factors in the Energy Control of Quiescence and Proliferation of Hematopoietic Cells
Regulation of Metabolism and the Role of Redox Factors in the Energy Control of Quiescence and Proliferation of Hematopoietic Cells
Abstract—One of the key regulators of hematopoietic stem cell (HSC) maintenance is cellular metabolism. Resting HSCs...
Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii
Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii
δ-Aminolevulinic acid dehydratase (ALAD) is a key enzyme of the cytoplasmic heme biosynthesis pathway. The primary st...
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Abstract—Low molecular-weight thiols as glutathione and cysteine are an important part of the cell’s redox reg...
The Redox-Catalytic Properties of Cobalamins
The Redox-Catalytic Properties of Cobalamins
Abstract—Vitamin B12, or cobalamin, is essential for normal body function and is used in the therapies of different ...
Changes in the Activity of Antioxidant Systems of Escherichia coli under Phosphate Starvation
Changes in the Activity of Antioxidant Systems of Escherichia coli under Phosphate Starvation
Abstract—Changes in the activity of antioxidant systems in Escherichia coli during phosphate starvation have been st...
The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits
The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits
Abstract—Plant polyphenols are characterized by a wide range of biological activities, including antioxidant propert...
Protein Repeats Show Clade-Specific Volatility in Aves
Protein Repeats Show Clade-Specific Volatility in Aves
Protein repeats are a source of rapid evolutionary and functional novelty. Repeats are crucial in development, neurogenesi...
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract—Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many ...
Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease
Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease
Peripheral blood biomarkers are of particular importance to diagnose certain diseases including coronary artery disease (C...
Dinityrosyl Iron Complexes with Thiol-Containing Ligands as a Functionally Active “Working Form” of Nitric Oxide System in Living Organisms: A Review
Dinityrosyl Iron Complexes with Thiol-Containing Ligands as a Functionally Active “Working Form” of Nitric Oxide System in Living Organisms: A Review
Experimental data were summarized to assume that dinitrosyl iron complexes (DNICs) with thiol-containing ligands are an en...
The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis
The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis
Abstract—Hsp70 and hydrogen sulfide donors reduce inflammatory processes in human and animal cells. The biological a...
Heat Shock Proteins in Plant Protection from Oxidative Stress
Heat Shock Proteins in Plant Protection from Oxidative Stress
Abstract—This review considers the recent progress on the role of heat shock proteins (HSPs), as well as transcripti...
The Thymic Hormone Thymosin-1α Reduces the Pro-Inflammatory Response of Raw 264.7 Cells Induced by Endotoxin
The Thymic Hormone Thymosin-1α Reduces the Pro-Inflammatory Response of Raw 264.7 Cells Induced by Endotoxin
Abstract—The aim of this work was to study the effects of thymosin-1 alpha (Tα1) on the anti-inflammatory respo...
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
Temozolomide resistance is a major cause of recurrence and poor prognosis in neuroglioma. Recently, growing evidence has s...
Metabolic Stress of Red Blood Cells Induces Hemoglobin Glutathionylation
Metabolic Stress of Red Blood Cells Induces Hemoglobin Glutathionylation
Abstract—Metabolic stress caused by a lack of glucose significantly affects the state of red blood cells, where glyc...
The Effects of the Hydrogen Sulfide Donor GYY4137 on the Proteasome Pool of Colorectal Cancer Cells
The Effects of the Hydrogen Sulfide Donor GYY4137 on the Proteasome Pool of Colorectal Cancer Cells
Abstract—Cancer cells are characterized by an increased level of metabolism and are highly dependent on the correct ...
Identification of Melittin-Like Proteins with a Molecular Weight of 67 kDa that Interact with Na+/K+-ATPase
Identification of Melittin-Like Proteins with a Molecular Weight of 67 kDa that Interact with Na+/K+-ATPase
Melittin, a peptide from bee venom, was found to be able to interact with many proteins, including calmodulin target prote...
Latent Macrophage and Immature B Cell Lines Generated with Hygromycin-Resistant Murine Gammaherpesvirus 68 Genome Expresses Modest Levels of Viral miRNAs
Latent Macrophage and Immature B Cell Lines Generated with Hygromycin-Resistant Murine Gammaherpesvirus 68 Genome Expresses Modest Levels of Viral miRNAs
Murine gammaherpesvirus 68 (MHV68) establishes latency mainly in B cells and causes lymphomas reminiscent of human gammahe...
The Development of SpCas9 Variants with High Specificity and Efficiency Based on the HH Theory
The Development of SpCas9 Variants with High Specificity and Efficiency Based on the HH Theory
Streptococcus pyogenes Cas9 (SpCas9) is the most popular tool in gene editing; however, off-target mutagenesis is one of t...
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-1beta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-1beta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
Abstract—The pathology of diseases arising from infections by viruses of Flaviviridae is largely determined by the d...
The Role of the WGR Domain in the Functions of PARP1 and PARP2
The Role of the WGR Domain in the Functions of PARP1 and PARP2
The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repai...
Spatial Models of Piezo Proteins and Protein‒Protein Interaction Networks in Trichoplax Animals (Placozoa)
Spatial Models of Piezo Proteins and Protein‒Protein Interaction Networks in Trichoplax Animals (Placozoa)
The marine free-living organism Trichoplax (phylum Placozoa) resembles a unicellular amoeba in shape and type of movement....
DNA Methylation Profile of CD14+ Monocytes Changes in Primary Progressive Multiple Sclerosis
DNA Methylation Profile of CD14+ Monocytes Changes in Primary Progressive Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune inflammatory and neurodegenerative disease of the central nervous system, ...
Latex Agglutination as an Alternative to the Hemagglutination Reaction of Influenza Viruses
Latex Agglutination as an Alternative to the Hemagglutination Reaction of Influenza Viruses
Abstract—As an alternative to the classical method of erythrocyte hemagglutination, a latex agglutination assay base...
Efficiency of Escherichia coli and Bacillus subtilis Expression Systems for Production of Binase Mutants
Efficiency of Escherichia coli and Bacillus subtilis Expression Systems for Production of Binase Mutants
Bacillus pumilus ribonuclease (binase) exhibits cytotoxic and oncolytic properties, while causing genotoxic effects at hig...
Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis
Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis
Cancer-associated fibroblasts (CAFs) often form a major component of the tumor microenvironment (TMA), providing condition...
Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice
Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice
Abstract—The ubiquitin-proteasome system (UPS) provides hydrolysis of most intracellular proteins in proteasomes. Th...
Digital PCR as a Highly Sensitive Diagnostic Tool: A Review
Digital PCR as a Highly Sensitive Diagnostic Tool: A Review
Abstract—Digital PCR (dPCR) is a nucleic acid quantification method that is widely used in genetic analysis. One of ...
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