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Factors Affecting the Stability of the Trimer of 2'-Deoxyuridine 5'-Triphosphate Nucleotide Hydrolase from Escherichia coli
Factors Affecting the Stability of the Trimer of 2'-Deoxyuridine 5'-Triphosphate Nucleotide Hydrolase from Escherichia coli
2′-Deoxyuridine 5′-triphosphate nucleotide hhydrolase (Dut) hydrolyzes dUTP to dUMP and pyrophosphate to preve...
Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2
Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2
This study provides an overview of scientific results on the feasibility of using type III interferons against SARS-CoV-2....
Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells
Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells
Base excision repair (BER) is aimed at repair of damaged bases, which are the largest group of DNA lesions. The main steps...
Geometric Approach to Phylogeographic Analysis Molecular Genetic Sequences: Principal Components and Dendrograms
Geometric Approach to Phylogeographic Analysis Molecular Genetic Sequences: Principal Components and Dendrograms
Currently, the search for manifestations of selection under the influence of the environment in molecular sequences is usu...
Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo
Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that removes various adducts from the 3' end of DNA. Suc...
Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration
Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration
Tryptophan hydroxylases 1 and 2 (TPH1 and TPH2) play a key role in the synthesis of serotonin (5-HT), a hormone and neurot...
Genotype-Specific Features of Cold-Induced Sweetening Process Regulation in Potato Varieties Nikulinsky, Symfonia, and Nevsky
Genotype-Specific Features of Cold-Induced Sweetening Process Regulation in Potato Varieties Nikulinsky, Symfonia, and Nevsky
Abstract—In this study, we performed expression analysis of genes associated with cold-induced sweetening in potato ...
DNA Probes for Analysis of the Activity of Key Enzymes of the Base Excision DNA Repair Pathway in Human Cells
DNA Probes for Analysis of the Activity of Key Enzymes of the Base Excision DNA Repair Pathway in Human Cells
Abstract—The important role of DNA damage in the occurrence of various diseases, including cancer, has led to study ...
Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma
Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma
Abstract—One of the most common malignant liver diseases is hepatocellular carcinoma, which has a high recurrence ra...
Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1
Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1
Poly(ADP-ribose) (PAR) is a negatively charged polymer, linear or branched, that consists of ADP-ribose monomers. PAR is s...
On Immunological Studies at Sirius University of Science and Technology
On Immunological Studies at Sirius University of Science and Technology
This short report summarizes the results of recent immunological studies performed at new Sirius University of Science and...
Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats
Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats
Inherited stress-induced arterial hypertension (ISIAH) rats are characterized by increased stress reactivity of the hypoth...
Modern Approaches to Protein Engineering to Create Enzymes with New Catalytic Properties
Modern Approaches to Protein Engineering to Create Enzymes with New Catalytic Properties
Adenine-DNA-glycosylase MutY is a monofunctional enzyme and catalyzes hydrolysis of N-glycosidic bonds with adenine residu...
Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy
Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy
Autism spectrum disorder (ASD) is a developmental disorder characterized by the early onset of problems with communication...
Molecular Mechanisms to Optimize Gene Translation Elongation Differ Significantly in Bacteria with and without Nonribosomal Peptides
Molecular Mechanisms to Optimize Gene Translation Elongation Differ Significantly in Bacteria with and without Nonribosomal Peptides
Nonribosomal peptides play an important role in the vital activity of bacteria and have an extremely broad field of biolog...
Comparative Analysis of Family A DNA-Polymerases as a Searching Tool for Enzymes with New Properties
Comparative Analysis of Family A DNA-Polymerases as a Searching Tool for Enzymes with New Properties
Abstract—DNA polymerases catalyze DNA synthesis during DNA replication, repair, and recombination. A number...
New Zwitter-Ionic Oligonucleotides: Preparation and Complementary Binding
New Zwitter-Ionic Oligonucleotides: Preparation and Complementary Binding
New zwitter-ionic oligonucleotide derivatives containing 1,2,3,4-tetrahydroisoquinoline-7-sulfonyl phosphoramidate group a...
Association of the Level of Serum Prolactin with Polymorphic Variants of the GRIN2A, GPM3, and GPM7 Genes in Patients with Schizophrenia Taking Conventional and Atypical Antipsychotics
Association of the Level of Serum Prolactin with Polymorphic Variants of the GRIN2A, GPM3, and GPM7 Genes in Patients with Schizophrenia Taking Conventional and Atypical Antipsychotics
The dopamine, serotonin and glutamate systems are jointly involved in the pathogenesis and pharmacotherapy of schizophreni...
Regulatory Potential of SNP Markers in Genes of DNA Repair Systems
Regulatory Potential of SNP Markers in Genes of DNA Repair Systems
A broad range of SNP markers associated with diseases and pathogenically significant features were identified in noncoding...
Structure and Evolution of the AqE Gene in Insects
Structure and Evolution of the AqE Gene in Insects
The AqE gene encodes a sulfolactate dehydrogenase-like enzyme of the LDH2/MDG2 oxidoreductase family. The gene is found in...
Anti-Restriction Activity of ArdB Protein against EcoAI Endonuclease
Anti-Restriction Activity of ArdB Protein against EcoAI Endonuclease
ArdB proteins are known to inhibit the activity of the type I restriction-modification (RM-I) system, in particular EcoKI ...
Landscape of KRAS, BRAF, and PIK3CA Mutations and Clinical Features of EBV-Associated and Microsatellite Unstable Gastric Cancer
Landscape of KRAS, BRAF, and PIK3CA Mutations and Clinical Features of EBV-Associated and Microsatellite Unstable Gastric Cancer
Personalization of gastric cancer (GC) treatment is an urgent problem because of the clinical heterogeneity and aggressive...
Method to Generate Complex Predictive Features for Machine Learning-Based Prediction of the Local Structure and Functions of Proteins
Method to Generate Complex Predictive Features for Machine Learning-Based Prediction of the Local Structure and Functions of Proteins
Recently, prediction of the structure and function of a protein from its sequence underwent a rapid increase in performanc...
Interleukin-11 in Pathologies of the Nervous System
Interleukin-11 in Pathologies of the Nervous System
The study of the role of cytokines in various pathological conditions of the body is a topical area in modern biomedicine....
The Effect of the Knockout of Major Transsulfuration Genes on the Pattern of Protein Synthesis in D. melanogaster
The Effect of the Knockout of Major Transsulfuration Genes on the Pattern of Protein Synthesis in D. melanogaster
The enzymes involved in the transsulfuration pathway and hydrogen sulfide production—cystathionine-β-synthase (...
Diversity of MLE Helicase Functions in the Regulation of Gene Expression in Higher Eukaryotes
Diversity of MLE Helicase Functions in the Regulation of Gene Expression in Higher Eukaryotes
The Drosophila melanogaster Maleless (MLE) protein is a conserved helicase involved in a wide range of gene expression reg...
APPswe/PS1dE9/Blg Transgenic Mouse Line for Modeling Cerebral Amyloid Angiopathy Associated with Alzheimer’s Disease
APPswe/PS1dE9/Blg Transgenic Mouse Line for Modeling Cerebral Amyloid Angiopathy Associated with Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common proteinopathy, which is accompanied by a steady decrease in the patient&...
EBF1 Promotes the Sensitivity of Cervical Cancer Cells to Cisplatin via Activating FBN1 Transcription
EBF1 Promotes the Sensitivity of Cervical Cancer Cells to Cisplatin via Activating FBN1 Transcription
Cisplatin (DDP) is widely used in the chemotherapy of cervical cancer (CC), the fourth most common female malignancy world...
Transcriptional Analysis of the Gene Encoding the Putative Myristoylated Membrane Protein (ORF458R) of Invertebrate Iridescent Virus 6 (IIV6)
Transcriptional Analysis of the Gene Encoding the Putative Myristoylated Membrane Protein (ORF458R) of Invertebrate Iridescent Virus 6 (IIV6)
Invertebrate iridescent virus 6 (IIV6) is a member of the genus Iridovirus and belongs to the Iridoviridae family. The ent...
Exploring the Prognostic Features of Hepatocellular Carcinoma via Text Mining and Data Analysis
Exploring the Prognostic Features of Hepatocellular Carcinoma via Text Mining and Data Analysis
Transcatheter arterial chemoembolization is one of the interventional treatments for hepatocellular carcinoma (HCC). This ...
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