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Identification of Stigma Specific Expression Fragment in the Promoter of a Soybean Chitinase Class I Gene
Identification of Stigma Specific Expression Fragment in the Promoter of a Soybean Chitinase Class I Gene
The expression level of heterologous genes in transgenic plants serves as an important indicator of gene efficiency. The s...
Insulator Protein CP190 Regulates Expression оf Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline
Insulator Protein CP190 Regulates Expression оf Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline
CP190 protein is one of the key components of Drosophila insulator complexes, and its study is important for understanding...
Unusual Dependence between Gene Expression and Negative Selection in Euplotes
Unusual Dependence between Gene Expression and Negative Selection in Euplotes
In most of the studied organisms, gene expression is associated with a number of evolutionary features pertaining to the p...
Phase Separation of Purified Human LSM4 Protein
Phase Separation of Purified Human LSM4 Protein
Liquid–liquid phase separation of proteins occur in a number of biological processes, such as regulation of transcri...
Methylophiopogonanone a Inhibits LPS/ATP-Induced Macrophage Pyroptosis via ROS/NLRP3 Pathway
Methylophiopogonanone a Inhibits LPS/ATP-Induced Macrophage Pyroptosis via ROS/NLRP3 Pathway
As a byproduct of mitochondrial respiration or metabolism, reactive oxygen species (ROS) can act as a signaling molecule t...
Dormancy: There and Back Again
Dormancy: There and Back Again
Many cells are capable of maintaining viability in a non-dividing state with minimal metabolism under unfavorable conditio...
HBx Protein Potentiates Hepatitis B Virus Reactivation
HBx Protein Potentiates Hepatitis B Virus Reactivation
Hepatitis B virus (HBV) can cause chronic hepatitis B, one of the most prevalent infectious diseases in the world. Global ...
Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that ...
Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2
Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2
One of the most important steps in the development of drugs and vaccines against a new coronavirus infection is their test...
Oncolytic Viruses in the Therapy of Lymphoproliferative Diseases
Oncolytic Viruses in the Therapy of Lymphoproliferative Diseases
Cancer is a leading causes of death. Despite significant success in the treatment of lymphatic system tumors, the problems...
Murine Models of Chronic Viral Infections and Associated Cancers
Murine Models of Chronic Viral Infections and Associated Cancers
Viruses are now recognized as bona fide etiologic factors of human cancer. Carcinogenic viruses include Epstein– Bar...
Physiological Media in Studies of Cell Metabolism
Physiological Media in Studies of Cell Metabolism
Changes in cell metabolism accompany the development of a wide spectrum of pathologies including cancer, autoimmune, and i...
Enhancement of the Bactericidal Effect of Antibiotics by Inhibition of Enzymes Involved in Production of Hydrogen Sulfide in Bacteria
Enhancement of the Bactericidal Effect of Antibiotics by Inhibition of Enzymes Involved in Production of Hydrogen Sulfide in Bacteria
Counteraction of the origin and distribution of multidrug-resistant pathogens responsible for intra-hospital infections is...
Enhanced Natural Killers with CISH and B2M Gene Knockouts Reveal Increased Cytotoxicity in Glioblastoma Primary Cultures
Enhanced Natural Killers with CISH and B2M Gene Knockouts Reveal Increased Cytotoxicity in Glioblastoma Primary Cultures
In an experimental study using the CRISPR/Cas9 system, “enhanced” NK cell lines with knockout of CISH, the gen...
Expression of HIV-1 Reverse Transcriptase in Murine Cancer Cells Increases Mitochondrial Respiration
Expression of HIV-1 Reverse Transcriptase in Murine Cancer Cells Increases Mitochondrial Respiration
Changes in metabolic pathways are often associated with the development of a wide range of pathologies. Increased glycolys...
Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways
Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways
Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is inv...
Full and D-BOX-Deficient PTTG1 Isoforms: Effects on Cell Proliferation
Full and D-BOX-Deficient PTTG1 Isoforms: Effects on Cell Proliferation
Human securin (PTTG1) is a protooncogene whose expression is elevated in many types of malignant cells. We previously disc...
Repair of Double-Stranded DNA Breaks Generated by CRISPR–Cas9 in Pseudomonas putida KT2440
Repair of Double-Stranded DNA Breaks Generated by CRISPR–Cas9 in Pseudomonas putida KT2440
Pseudomonas putida KT2440 is a metabolically versatile bacterium with considerable promise as a chassis strain for product...
Editing of Phage Genomes—Recombineering-assisted SpCas9 Modification of Model Coliphages T7, T5, and T3
Editing of Phage Genomes—Recombineering-assisted SpCas9 Modification of Model Coliphages T7, T5, and T3
Bacteriophages—viruses that infect bacterial cells—are the most abundant biological entities on Earth. The use...
Protein Homeostasis Dysregulation in Pathogenesis of Neurodegenerative Diseases
Protein Homeostasis Dysregulation in Pathogenesis of Neurodegenerative Diseases
The formation and accumulation of unfolded, misfolded, or damaged cellular proteins leads to development of endoplasmic re...
Mechanism of Leakage in Phosphatidylserine-Containing Membranes by Melittin
Mechanism of Leakage in Phosphatidylserine-Containing Membranes by Melittin
Phosphatidylserine (PS) is an important apoptotic-cell surface signal that exists in bacterial and cancer cells. The mecha...
Genetic and Molecular Characterization of a Dash Cryptochrome Homologous Gene from Antarctic Diatom Phaeodactylum tricornutum ICE-H
Genetic and Molecular Characterization of a Dash Cryptochrome Homologous Gene from Antarctic Diatom Phaeodactylum tricornutum ICE-H
DASH-type cryptochromes (cry-DASH) belong to cryptochrome/photolyase family (CPF), that includes photolyases with the capa...
Prokaryotic Argonaute Proteins as a Tool for Biotechnology
Prokaryotic Argonaute Proteins as a Tool for Biotechnology
Programmable nucleases are the most important tool for manipulating the genes and genomes of both prokaryotes and eukaryot...
HIV Restriction Factor APOBEC3G and Prospects for Its Use in Gene Therapy for HIV
HIV Restriction Factor APOBEC3G and Prospects for Its Use in Gene Therapy for HIV
The mechanisms for the protection of the human body from viral or bacterial agents are extremely diverse. In one such mech...
Plant Genome Sequencing: Modern Technologies and Novel Opportunities for Breeding
Plant Genome Sequencing: Modern Technologies and Novel Opportunities for Breeding
The investigation of plant genomes is of great importance for basic research and practical breeding. In 1977, F. Sanger pr...
Single-Domain Antibodies Used to Pretreat the Human Urinary Proteome in Cancer Biomarker Testing
Single-Domain Antibodies Used to Pretreat the Human Urinary Proteome in Cancer Biomarker Testing
A number of single-domain antibodies (nanobodies) obtained previously to major marker blood proteins were tested as tools ...
Reduced Expression of the Tissue-Specific Oct-1L Isoform Exerts an Antitumor Effect on Namalwa Burkitt’s Lymphoma Cells
Reduced Expression of the Tissue-Specific Oct-1L Isoform Exerts an Antitumor Effect on Namalwa Burkitt’s Lymphoma Cells
Increased expression levels of the Oct-1 transcription factor is considered to be one of the key markers of poor cancer pr...
Analysis of Multiple Protein Alignments Using 3D-Structural Information on the Orientation of Amino Acid Side-Chains
Analysis of Multiple Protein Alignments Using 3D-Structural Information on the Orientation of Amino Acid Side-Chains
Multiple alignment of amino acid sequences of homologous proteins is a key tool in state-of-the-art bioinformatics and evo...
Rpn4p without the DNA-Binding Domain Provides Saccharomyces cerevisiae Resistance to Oxidative Stress and Cycloheximide
Rpn4p without the DNA-Binding Domain Provides Saccharomyces cerevisiae Resistance to Oxidative Stress and Cycloheximide
The ubiquitin-proteasome system is involved in the control of all essential molecular processes under normal conditions an...