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The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages
The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages
The complement inhibitor CD55/DAF is expressed on many cell types. Dysregulation of CD55 expression is associated with inc...
The Structural Features of Skeletal Muscle Titin Aggregates
The Structural Features of Skeletal Muscle Titin Aggregates
Abstract—Titin is a multidomain protein of striated and smooth muscles of vertebrates. The protein consists of repea...
Changes in the Genome of the Tick-Borne Encephalitis Virus during Cultivation
Changes in the Genome of the Tick-Borne Encephalitis Virus during Cultivation
The tick-borne encephalitis virus (TBEV) strain C11-13 (GenBank acc. no. OQ565596) of the Siberian genotype was previously...
The Expression of TP53TG1, LINC00342, MALAT1, H19, and MEG3 Long Noncoding RNAs in Type 2 diabetes mellitus
The Expression of TP53TG1, LINC00342, MALAT1, H19, and MEG3 Long Noncoding RNAs in Type 2 diabetes mellitus
Abstract—Type 2 diabetes is a complex and multifactorial metabolic disorder. The frequency of type 2 diabetes has dr...
The Oral Microbiome in the Development of Oral Cancer
The Oral Microbiome in the Development of Oral Cancer
Abstract—Oral cancer is an aggressive and rapidly progressive disease. The oral cavity is home to over 700 species o...
Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells
Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells
Abstract—Multiple exogenous or endogenous factors alter gene expression patterns by different mechanisms that are po...
The Molecular and Genetic Mechanisms of Sex Determination in Poplar
The Molecular and Genetic Mechanisms of Sex Determination in Poplar
Abstract—The study of molecular and genetic mechanisms of sex determination in the poplar is of interest not only in...
Regulation of Transcription by RNA Polymerase III Promotors in the Norm and Pathology
Regulation of Transcription by RNA Polymerase III Promotors in the Norm and Pathology
Abstract—RNA polymerase III synthesizes a wide range of noncoding RNAs shorter than 400 nucleotides in length. These...
Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches
Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches
Uveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, ...
A Bioinformatics Method for Identification of Human Proteases Active against Viral Envelope Glycoproteins: A Case Study on the SARS-CoV-2 Spike Protein
A Bioinformatics Method for Identification of Human Proteases Active against Viral Envelope Glycoproteins: A Case Study on the SARS-CoV-2 Spike Protein
Abstract—Many viruses, including SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, enter host cells...
Knockout of Hsp70 Genes Modulates Age-Related Transcriptomic Changes in Leg Muscles and Reduces the Locomotion Speed and Lifespan of Drosophila melanogaster
Knockout of Hsp70 Genes Modulates Age-Related Transcriptomic Changes in Leg Muscles and Reduces the Locomotion Speed and Lifespan of Drosophila melanogaster
This study investigated the effect of knockout of six Hsp70 genes (orthologues of the mammalian genes Hspa1a, Hspa1b, Hspa...
Cytotoxicity Studies of 5-Arylaminouracil Derivatives
Cytotoxicity Studies of 5-Arylaminouracil Derivatives
We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other path...
Method of Inducible Knockdown of Essential Genes in OSC Cell Culture of Drosophila melanogaster
Method of Inducible Knockdown of Essential Genes in OSC Cell Culture of Drosophila melanogaster
An RNA interference-based method was proposed to achieve an inducible knockdown of genes essential for cell viability. In ...
Verification of CRISPR/Cas9 Activity In Vitro via SSA-Based Dual-Luciferase Reporter System
Verification of CRISPR/Cas9 Activity In Vitro via SSA-Based Dual-Luciferase Reporter System
The CRISPR/Cas9 technique has emerged as a powerful and promising tool for precise genomic integration, which applied to v...
Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Flowering time plays an important role in crop regional adaptation, yield and reproductive success. ABRE BINDING FACTORs (...
Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
The cadherin superfamily molecules, functioning as cell adhesion molecules, are recognized to play roles in both physiolog...
Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
Microglia phagocytosis plays an important role in the pathogenesis of neurodegeneration. Defects or dysfunction of microgl...
Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs
Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs
Long non-coding RNAs (lncRNAs) are involved in many cellular processes while displaying high tissue specificity. In contra...
What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins
What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins
The functions of actin and its motor proteins myosins in the cytoplasm have been the subject of research for more than 100...
Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
Calcitonin is a 32-amino acid peptide, which causes a decrease in blood calcium levels and bone resorption in the human bo...
Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
Current data on the molecular mechanisms of liver fibrosis and cirrhosis fail to fully explain all stages of their develop...
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
Abstract—Breast cancer is the most common type of cancer among women. The study of the mechanisms of metastasis, the...
Structure and Evolution of DNA Transposons of the L31 Superfamily in Bivalves
Structure and Evolution of DNA Transposons of the L31 Superfamily in Bivalves
The mobile genetic elements IS630/Tc1/mariner (ITm) are widespread DNA transposons that make a significant contribution to...
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical reactions in cell DNA are induced in various organisms by solar UV radiation and may lead to a series of bio...
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone synthesized by the pineal gland. Due to its oncostatic effect, ...
Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Abstract—Regulation of retrotransposon activity in somatic tissues is a complex mechanism that has still not been st...
The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19
The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19
Abstract—Production of extracellular membrane vesicles plays an important role in communication in bacterial populat...
Stochastic Packaging of Cas Proteins into Exosomes
Stochastic Packaging of Cas Proteins into Exosomes
Abstract—CRISPR/Cas systems are perspective molecular tools for targeted manipulation with genetic materials, such a...
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Abstract—Spore-forming bacteria have a unique resistance to negative environmental conditions, including aggressive ...
Prime-Editing Methods and pegRNA Design Programs
Prime-Editing Methods and pegRNA Design Programs
Abstract—It has been 10 years since CRISPR/Cas technology was applied to edit the genomes of various organisms. Its ...
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