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Effects of growth hormone-releasing hormone deficiency in mice beyond growth
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peri...
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
Growth hormone (GH) secretion is pulsatile, entropic, and nycthemeral and is mainly controlled by the hypothalamus through...
No longer to be ignored: Hypophosphatemia following intravenous iron administration
No longer to be ignored: Hypophosphatemia following intravenous iron administration
Intravenous iron supplementation is increasingly used to safely and effectively correct iron deficiency anemia, but some f...
GHRH and reproductive systems: Mechanisms, functions, and clinical implications
GHRH and reproductive systems: Mechanisms, functions, and clinical implications
Growth hormone-releasing hormone (GHRH) has classically been considered a regulatory neuropeptide of the hypothalamic-pitu...
Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond
Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond
The regulation of growth hormone (GH) synthesis and secretion by somatotroph cells of the anterior pituitary is a highly c...
Reference intervals for serum prolactin concentrations: analytical and clinical considerations
Reference intervals for serum prolactin concentrations: analytical and clinical considerations
Prolactin is a 23 kDa protein synthesised and released by lactotrophs located in the anterior pituitary gland. Th...
GHRH in diabetes and metabolism
GHRH in diabetes and metabolism
Despite over a century of insulin therapy and recent advances in glucose monitoring, diabetes and its complications remain...
Effects of GHRH and its analogues on the Vascular System
Effects of GHRH and its analogues on the Vascular System
Growth hormone-releasing hormone (GHRH) is a crucial endocrine hormone that exerts its biological effects by binding to sp...
Role of HOXA10 in pathologies of the endometrium
Role of HOXA10 in pathologies of the endometrium
HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implan...
GHRH and the prostate
GHRH and the prostate
In the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it ...
Prolactin: structure, receptors, and functions
Prolactin: structure, receptors, and functions
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also ...
GHRH and its analogues in central nervous system diseases
GHRH and its analogues in central nervous system diseases
Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus and stimulates the release of growth hor...
Meal replacements on obesity and leptin: a systematic review and meta-analysis
Meal replacements on obesity and leptin: a systematic review and meta-analysis
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous intervent...
Growth hormone-releasing hormone and cancer
Growth hormone-releasing hormone and cancer
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of gr...
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
Acute myeloid leukemia (AML) is the most aggressive and prevalent form of leukemia in adults. The gold-standard interventi...
The molecular basis of hypoprolactinaemia
The molecular basis of hypoprolactinaemia
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a combined pituitary hormone deficiency ...
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has ...
Growth hormone – releasing hormone in the immune system
Growth hormone – releasing hormone in the immune system
GHRH is a neuropeptide associated with a diverse variety of activities in human physiology and immune responses. The prese...
Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach
Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach
Osteosarcopenia is an emerging clinical condition highly prevalent in the older people. Affected subjects due to their int...
Drug induced hypoprolactinemia
Drug induced hypoprolactinemia
Prolactin levels can be influenced by multiple medications primarily through the interaction with dopamine receptors which...
The role of tissue oxygenation in obesity-related cardiometabolic complications
The role of tissue oxygenation in obesity-related cardiometabolic complications
Obesity is a complex, multifactorial, chronic disease that acts as a gateway to a range of other diseases. Evidence from r...
Iron homeostasis and insulin sensitivity: unraveling the complex interactions
Iron homeostasis and insulin sensitivity: unraveling the complex interactions
Diabetes has arisen as a noteworthy global health issue, marked by escalating incidence and mortality rates. Insulin, cruc...
Isolated hypoprolactinemia: The rarest of the rare?
Isolated hypoprolactinemia: The rarest of the rare?
Isolated hypoprolactinemia (IHP) can be defined as the presence of consistently low serum levels of prolactin in the absen...
Traumatic brain injury and prolactin
Traumatic brain injury and prolactin
Traumatic brain injury (TBI) is a well-known etiologic factor for pituitary dysfunctions, with a prevalence of 15% during ...