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The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear ...
Exploring the relationship between glycemic variability and muscle dysfunction in adults with diabetes: A systematic review
Exploring the relationship between glycemic variability and muscle dysfunction in adults with diabetes: A systematic review
This review is to systematically explore the relationship between muscle dysfunction and diabetes in adults, and to examin...
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone (GH)-releasing hormone (GHRH), a hypothalamic peptide initially characterized for its role in GH regulation...
Pituitary adenomas: biology, nomenclature and clinical classification
Pituitary adenomas: biology, nomenclature and clinical classification
An ‘adenoma’ is a benign neoplasm composed of epithelial tissue, and has been standard nomenclature for primar...
Update on regulation of GHRH and its actions on GH secretion in health and disease
Update on regulation of GHRH and its actions on GH secretion in health and disease
This review focuses on our current understanding of how growth hormone releasing hormone (GHRH): 1) stimulates GH release ...
Poor muscle quality: A hidden and detrimental health condition in obesity
Poor muscle quality: A hidden and detrimental health condition in obesity
Poor muscle quality (MQ) is a hidden health condition in obesity, commonly disregarded and underdiagnosed, associated with...
The radiologic spectrum of neuroendocrine tumors in emergent care
The radiologic spectrum of neuroendocrine tumors in emergent care
Neuroendocrine tumors (NETs) are a diverse group of neoplasms whose prevalence is increasing globally, primarily due to ad...
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peri...
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
Growth hormone (GH) secretion is pulsatile, entropic, and nycthemeral and is mainly controlled by the hypothalamus through...
No longer to be ignored: Hypophosphatemia following intravenous iron administration
No longer to be ignored: Hypophosphatemia following intravenous iron administration
Intravenous iron supplementation is increasingly used to safely and effectively correct iron deficiency anemia, but some f...
GHRH and reproductive systems: Mechanisms, functions, and clinical implications
GHRH and reproductive systems: Mechanisms, functions, and clinical implications
Growth hormone-releasing hormone (GHRH) has classically been considered a regulatory neuropeptide of the hypothalamic-pitu...
Correction: Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis
Correction: Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
Association of maternal blood metabolomics and gestational diabetes mellitus risk: a systematic review and meta-analysis
Association of maternal blood metabolomics and gestational diabetes mellitus risk: a systematic review and meta-analysis
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that has short- and long-term adverse effects. T...
Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond
Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond
The regulation of growth hormone (GH) synthesis and secretion by somatotroph cells of the anterior pituitary is a highly c...
Reference intervals for serum prolactin concentrations: analytical and clinical considerations
Reference intervals for serum prolactin concentrations: analytical and clinical considerations
Prolactin is a 23 kDa protein synthesised and released by lactotrophs located in the anterior pituitary gland. Th...
GHRH in diabetes and metabolism
GHRH in diabetes and metabolism
Despite over a century of insulin therapy and recent advances in glucose monitoring, diabetes and its complications remain...
Effects of GHRH and its analogues on the Vascular System
Effects of GHRH and its analogues on the Vascular System
Growth hormone-releasing hormone (GHRH) is a crucial endocrine hormone that exerts its biological effects by binding to sp...
Meal replacement therapy for obesity and diabetes remission: efficacy assessment and considerations of barriers and facilitators to adherence among U.S. individuals with low economic resources
Meal replacement therapy for obesity and diabetes remission: efficacy assessment and considerations of barriers and facilitators to adherence among U.S. individuals with low economic resources
Individuals in the United States with lower economic resources face a disproportionate burden of obesity and co-morbid con...
Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis
Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis
Pasireotide long-acting release (PAS-LAR) is a second-generation somatostatin receptor ligand (SRL) approved for acromegal...
Role of HOXA10 in pathologies of the endometrium
Role of HOXA10 in pathologies of the endometrium
HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implan...
GHRH and the prostate
GHRH and the prostate
In the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it ...
Prolactin: structure, receptors, and functions
Prolactin: structure, receptors, and functions
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also ...
GHRH and its analogues in central nervous system diseases
GHRH and its analogues in central nervous system diseases
Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus and stimulates the release of growth hor...
Meal replacements on obesity and leptin: a systematic review and meta-analysis
Meal replacements on obesity and leptin: a systematic review and meta-analysis
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous intervent...
Growth hormone-releasing hormone and cancer
Growth hormone-releasing hormone and cancer
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of gr...
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602
Acute myeloid leukemia (AML) is the most aggressive and prevalent form of leukemia in adults. The gold-standard interventi...
The molecular basis of hypoprolactinaemia
The molecular basis of hypoprolactinaemia
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a combined pituitary hormone deficiency ...
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has ...
Growth hormone – releasing hormone in the immune system
Growth hormone – releasing hormone in the immune system
GHRH is a neuropeptide associated with a diverse variety of activities in human physiology and immune responses. The prese...
Replacement with sex steroids in hypopituitary men and women: implications for gender differences in morbidities and mortality
Replacement with sex steroids in hypopituitary men and women: implications for gender differences in morbidities and mortality
Hypopituitarism is a heterogenous disorder characterised by a deficiency in one or more anterior pituitary hormones. There...
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