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Macrophage plasticity in Duchenne muscular dystrophy: a nexus of pathological remodelling with therapeutic implications
Macrophage plasticity in Duchenne muscular dystrophy: a nexus of pathological remodelling with therapeutic implications
Abstract Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle necrosis, leading to muscle regener...
Mixed SYGnals in potassium channels: A mechanism for alternate ion conduction in human Kir3.2 channel mutations
Mixed SYGnals in potassium channels: A mechanism for alternate ion conduction in human Kir3.2 channel mutations
Corresponding Author Peter E. Light Alberta Diabetes Insti...
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents
Key points Evidence suggests insulin centrally activates the sympathetic nervous system, and a chemical stimulus to tissue...
Nitric oxide contributes to cerebrovascular shear‐mediated dilatation but not steady‐state cerebrovascular reactivity to carbon dioxide
Nitric oxide contributes to cerebrovascular shear‐mediated dilatation but not steady‐state cerebrovascular reactivity to carbon dioxide
Abstract Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular endothelial function. We r...
The Endocrine Kidney: Tampering with oxygen sensors may change your character
The Endocrine Kidney: Tampering with oxygen sensors may change your character
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Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm
Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm
Abstract Progressive improvements in perinatal care and respiratory management of preterm infants has resulted in increase...
Reply from Jumes Leopoldino Oliveira Lira, Carlos Ugrinowitsch, Daniel Boari Coelho, Luis Augusto Teixeira, Andrea Cristina de Lima‐Pardini, Fernando Henrique Magalhães, Egberto Reis Barbosa, Fay B. Horak, and Carla Silva‐Batista
Reply from Jumes Leopoldino Oliveira Lira, Carlos Ugrinowitsch, Daniel Boari Coelho, Luis Augusto Teixeira, Andrea Cristina de Lima‐Pardini, Fernando Henrique Magalhães, Egberto Reis Barbosa, Fay B. Horak, and Carla Silva‐Batista
Early View Response to the Letter to the Editor Jumes Leopoldino Oliveira Lira, Jumes...
All‐optical monitoring of excitation‐secretion coupling demonstrates that SV2A functions downstream of evoked Ca2+ entry
All‐optical monitoring of excitation‐secretion coupling demonstrates that SV2A functions downstream of evoked Ca2+ entry
Key points One of the most prescribed antiepileptic medications, levetiracetam, acts by binding a protein of uncertain mol...
A revised mechanism of action of hyperaldosteronism‐linked mutations in cytosolic domains of GIRK4 (KCNJ5)
A revised mechanism of action of hyperaldosteronism‐linked mutations in cytosolic domains of GIRK4 (KCNJ5)
Key points Mutations in GIRK4 (KCNJ5) G-protein gated channels cause primary aldosteronism, a major cause of secondary hyp...
Physiological control of fetal heart rate variability during labour: Implications and controversies
Physiological control of fetal heart rate variability during labour: Implications and controversies
Abstract The interpretation of fetal heart rate (FHR) patterns is the only available method to continuously monitor fetal ...
Something's fishy: Cardiovascular ATP‐sensitive K+ channels in zebrafish
Something's fishy: Cardiovascular ATP‐sensitive K+ channels in zebrafish
Abstract Mammalian adenosine-triphosphate-sensitive K+ (KATP) channels help couple cellular metabolism to electrical excit...
High altitude vascular dysfunction‐ can we ‘C’ our way to a remedy?
High altitude vascular dysfunction‐ can we ‘C’ our way to a remedy?
This article has been accepted for publication and undergone full peer review but has not been through the co...
Short term exercise‐induced protection of cardiovascular function and health: Why and how fast does the heart benefit from exercise?
Short term exercise‐induced protection of cardiovascular function and health: Why and how fast does the heart benefit from exercise?
Key points Single or Short-term Exercise-induced Protection (SEP) attenuates the magnitude of cardiac and/or vascular dama...
The influence of maturation on exercise‐induced cardiac remodelling and haematological adaptation
The influence of maturation on exercise‐induced cardiac remodelling and haematological adaptation
Key points It has long been hypothesised that cardiovascular adaptation to endurance training is augmented following puber...
What gets on the nerves of cardiac patients? pathophysiological changes in cardiac innervation
What gets on the nerves of cardiac patients? pathophysiological changes in cardiac innervation
Abstract The autonomic nervous system regulates cardiac function by balancing the actions of sympathetic and parasympathet...
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation
Key points Cortical integration of sensory inputs is crucial for dexterous movement. Short-latency somatosensory afferent ...
Notch1 promotes revascularization through modulation of downstream vascular patterning signaling
Notch1 promotes revascularization through modulation of downstream vascular patterning signaling
Notch signaling is a critical mediator of re-vascularization. Yet the cellular processes activated during recovery post-va...
Expiratory oscillator recruitment: balance between inhibitory and excitatory synaptic inputs?
Expiratory oscillator recruitment: balance between inhibitory and excitatory synaptic inputs?
This article has been accepted for publication and undergone full peer review but has not been through the co...
Nitric oxide contributes to cerebrovascular shear‐mediated dilation but not steady‐state cerebrovascular reactivity to carbon dioxide
Nitric oxide contributes to cerebrovascular shear‐mediated dilation but not steady‐state cerebrovascular reactivity to carbon dioxide
Key points Emerging evidence indicates that a transient carbon dioxide stimulus elicits shear-mediated dilation of the int...
Macrophage plasticity in Duchenne muscular dystrophy: A nexus of pathological remodeling with therapeutic implications
Macrophage plasticity in Duchenne muscular dystrophy: A nexus of pathological remodeling with therapeutic implications
Abstract Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle necrosis, leading to muscle regener...
The Hodgkin and Huxley papers: still inspiring after all these years
The Hodgkin and Huxley papers: still inspiring after all these years
This article has been accepted for publication and undergone full peer review but has not been through the co...
Neurotransmitter regulation rather than cell‐intrinsic properties shapes the high‐pass filtering properties of olfactory bulb glomeruli
Neurotransmitter regulation rather than cell‐intrinsic properties shapes the high‐pass filtering properties of olfactory bulb glomeruli
Key points GABAergic periglomerular (PG) cells in the olfactory bulb are proposed to mediate a “high-pass” f...
The effect of 8 weeks of physical training on muscle performance and maximal fat oxidation rates in patients treated with simvastatin and coenzyme Q10 supplementation
The effect of 8 weeks of physical training on muscle performance and maximal fat oxidation rates in patients treated with simvastatin and coenzyme Q10 supplementation
Key points Simvastatins are prescribed for treatment of elevated cholesterol, but they may negatively impact metabolism, m...
Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness
Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness
Abstract Psychophysical data indicate that humans can discriminate visual scenes based on their skewness, i.e. the ratio o...
A novel ion conducting route besides the central pore in an inherited mutant of G‐protein‐gated inwardly rectifying K+ channel
A novel ion conducting route besides the central pore in an inherited mutant of G‐protein‐gated inwardly rectifying K+ channel
Key points G-protein-gated inwardly rectifying K+ (GIRK; Kir3.x) channels play important roles in controlling excitation o...
Orai1‐ and Orai2‐, but not Orai3‐mediated ICRAC is regulated by intracellular pH
Orai1‐ and Orai2‐, but not Orai3‐mediated ICRAC is regulated by intracellular pH
Key points It has been shown previously that Orai1/STIM1 (stromal interaction molecule 1)-mediated Ca2+ release activated ...
A ‘virtual’ revolution: non‐invasive methods to probe skeletal muscle metabolism in Duchenne muscular dystrophy
A ‘virtual’ revolution: non‐invasive methods to probe skeletal muscle metabolism in Duchenne muscular dystrophy
This article has been accepted for publication and undergone full peer review but has not been through the co...
Prolyl‐4‐hydroxylases 2 and 3 control erythropoietin production in renin expressing cells of mouse kidneys
Prolyl‐4‐hydroxylases 2 and 3 control erythropoietin production in renin expressing cells of mouse kidneys
Key points Renal renin expressing cells can be clearly distinguished into two subgroups, the typical juxtaglomerular renin...
Brain blood flow: The more you N.O
Brain blood flow: The more you N.O
This article has been accepted for publication and undergone full peer review but has not been through the co...
Metformin in pregnancy: a re‐examination of its safety
Metformin in pregnancy: a re‐examination of its safety
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