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Bismuth radical catalysis in the activation and coupling of redox-active electrophiles
Bismuth radical catalysis in the activation and coupling of redox-active electrophiles
Radical cross-coupling reactions represent a revolutionary tool to make C(sp3)–C and C(sp3)–heteroatom bonds b...
D3+ formation through photoionization of the molecular D2–D2 dimer
D3+ formation through photoionization of the molecular D2–D2 dimer
The H2–H2 molecular dimer is of fundamental importance in the study of chemical interactions because of its unique b...
Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers
Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers
Although the principles of noncovalent bonding are well understood and form the basis for the syntheses of many intricate ...
Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo
Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo
The absence of orthogonal aminoacyl-transfer RNA (tRNA) synthetases that accept non-l-α-amino acids is a primary bott...
Why charging Li–air batteries with current low-voltage mediators is slow and singlet oxygen does not explain degradation
Why charging Li–air batteries with current low-voltage mediators is slow and singlet oxygen does not explain degradation
Although Li–air rechargeable batteries offer higher energy densities than lithium-ion batteries, the insulating Li2O...
Ultrafast formation dynamics of D3+ from the light-driven bimolecular reaction of the D2–D2 dimer
Ultrafast formation dynamics of D3+ from the light-driven bimolecular reaction of the D2–D2 dimer
The light-driven formation of trihydrogen cation has been attracting considerable attention because of its important role ...
Opportunities and challenges with hyperpolarized bioresponsive probes for functional imaging using magnetic resonance
Opportunities and challenges with hyperpolarized bioresponsive probes for functional imaging using magnetic resonance
The development of hyperpolarized bioresponsive probes for magnetic resonance imaging (MRI) applications is an emerging an...
Polymeric protagonists for biological processes
Polymeric protagonists for biological processes
Complexity is a hallmark of biological systems, but scientific experiments are typically conducted in simplified condition...
Selecting aptamers with programmed affinities
Selecting aptamers with programmed affinities
Constructing aptamers with desired target-binding affinities may lead to new applications but is challenging. Now, a new m...
Illuminating enzyme design using deep learning
Illuminating enzyme design using deep learning
From humans designing machines, to machines designing biology, deep learning is turning the tables for assisted exploratio...
Fragmentation and [4 + 3] cycloaddition in sodorifen biosynthesis
Fragmentation and [4 + 3] cycloaddition in sodorifen biosynthesis
Terpenes constitute the largest class of natural products. Their skeletons are formed by terpene cyclases (TCs) from acycl...
Route to complex colloidal crystals through entropy compartmentalization
Route to complex colloidal crystals through entropy compartmentalization
Colloidal clathrate crystals self-assembled from hard polyhedral shapes in computer simulations are stabilized by entropy ...
Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions
Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions
Biomolecular condensates, protein-rich and dynamic membrane-less organelles, play critical roles in a range of subcellular...
Entropy compartmentalization stabilizes open host–guest colloidal clathrates
Entropy compartmentalization stabilizes open host–guest colloidal clathrates
Clathrates are open crystals in which molecules are arranged in a hierarchy of polyhedral cages that encapsulate guest mol...
A trivalent 4f complex with two bis-silylamide ligands displaying slow magnetic relaxation
A trivalent 4f complex with two bis-silylamide ligands displaying slow magnetic relaxation
The best-performing single-molecule magnets (SMMs) have historically relied on pseudoaxial ligands delocalized across seve...
Arene additions
Arene additions
Dipolar cycloadditions are excellent processes for generating heterocyclic systems from simple starting materials, but are...
Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes
Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes
The venerable 1,3-dipolar cycloaddition has been widely used in organic synthesis for the construction of various heterocy...
Activity-based directed evolution of a membrane editor in mammalian cells
Activity-based directed evolution of a membrane editor in mammalian cells
Cellular membranes contain numerous lipid species, and efforts to understand the biological functions of individual lipids...
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
γ-Amino acids can play important roles in the biological activities of natural products; however, the ribosomal incor...
Spin-dependent reactivity and spin-flipping dynamics in oxygen atom scattering from graphite
Spin-dependent reactivity and spin-flipping dynamics in oxygen atom scattering from graphite
The formation of two-electron chemical bonds requires the alignment of spins. Hence, it is well established for gas-phase ...
Making a start on the tenure track
Making a start on the tenure track
Getting started at a new institution and building a research programme can be an exciting period, but there is much to do ...
Multi-site programmable functionalization of alkenes via controllable alkene isomerization
Multi-site programmable functionalization of alkenes via controllable alkene isomerization
Direct and selective functionalization of hydrocarbon chains is a fundamental problem in synthetic chemistry. Conventional...
Not all catenanes with oriented rings are topologically chiral
Not all catenanes with oriented rings are topologically chiral
Catenanes that are chiral owing to the relative orientation of their rings have always been referred to as ‘topologi...
A catenane that is topologically achiral despite being composed of oriented rings
A catenane that is topologically achiral despite being composed of oriented rings
Catenanes—molecules comprising two interlocking rings held together like links in a chain—are topologically no...
In vivo metallophilic self-assembly of a light-activated anticancer drug
In vivo metallophilic self-assembly of a light-activated anticancer drug
Self-assembling molecular drugs combine the easy preparation typical of small-molecule chemotherapy and the tumour-targeti...
Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity
Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity
Stereochemistry has an essential role in organic synthesis, biological catalysis and physical processes. In situ chirality...
Chloride in the battery pool
Chloride in the battery pool
The researchers synthesized Li3TiCl6 from LiCl and TiCl3 and, with electrochemical testing, found room-temperature ionic c...
Looking into luciferin
Looking into luciferin
Organisms that glow are perhaps eerie. Vadim Viviani ponders on the luciferin–luciferase systems responsible for the...
Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters
Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters
Molecules that contain a stereogenic phosphorus atom are crucial to medicine, agrochemistry and catalysis. While methods a...
Precision native polysaccharides from living polymerization of anhydrosugars
Precision native polysaccharides from living polymerization of anhydrosugars
The composition, sequence, length and type of glycosidic linkage of polysaccharides profoundly affect their biological and...
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