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The many phases of biomolecular condensates
In this issue we feature several articles that explore advances in the study of phase separation. They highlight some rece...
Hydrogen splitting at a single phosphorus centre and its use for hydrogenation
Hydrogen splitting at a single phosphorus centre and its use for hydrogenation
Catalytic processes are largely dominated by transition-metal complexes. Main-group compounds that can mimic the behaviour...
Direct visualization of ligands on gold nanoparticles in a liquid environment
Direct visualization of ligands on gold nanoparticles in a liquid environment
The interactions between gold nanoparticles, their surface ligands and the solvent critically influence the properties of ...
Modular assembly of arenes, ethylene and heteroarenes for the synthesis of 1,2-arylheteroaryl ethanes
Modular assembly of arenes, ethylene and heteroarenes for the synthesis of 1,2-arylheteroaryl ethanes
The 1,2-arylheteroaryl ethane motif stands as a privileged scaffold with promising implications in drug discovery. Convent...
Free carbenes from complementarily paired alkynes
Free carbenes from complementarily paired alkynes
Carbenes (R1R2C:) like radicals, arynes and nitrenes constitute an important family of neutral, high-energy, reactive inte...
High-pressure synthesis of Ruddlesden–Popper nitrides
High-pressure synthesis of Ruddlesden–Popper nitrides
Layered perovskites with Ruddlesden–Popper-type structures are fundamentally important for low-dimensional propertie...
Atomically dispersed low-valent Au boosts photocatalytic hydroxyl radical production
Atomically dispersed low-valent Au boosts photocatalytic hydroxyl radical production
Providing affordable, safe drinking water and universal sanitation poses a grand societal challenge. Here we developed ato...
De novo DNA-based catch bonds
De novo DNA-based catch bonds
All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the mater...
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria
Bacteria have evolved resistance to nearly all known antibacterials, emphasizing the need to identify antibiotics that ope...
Coherent photoexcitation of entangled triplet pair states
Coherent photoexcitation of entangled triplet pair states
The functional properties of organic semiconductors are defined by the interplay between optically bright and dark states....
Polarizing the Be–Be bond
Polarizing the Be–Be bond
The Be–Be bond has long represented a ‘missing link’ between the H–H bond of dihydrogen and the B&...
A crystalline stannyne
A crystalline stannyne
The synthesis of heteronuclear alkyne analogues incorporating heavier group 14 elements (R1–C≡E–R2, E...
Encoding signal propagation on topology-programmed DNA origami
Encoding signal propagation on topology-programmed DNA origami
Biological systems often rely on topological transformation to reconfigure connectivity between nodes to guide the flux of...
A folding motif formed with an expanded genetic alphabet
A folding motif formed with an expanded genetic alphabet
Adding synthetic nucleotides to DNA increases the linear information density of DNA molecules. Here we report that it also...
Harnessing Maxwell’s demon to establish a macroscale concentration gradient
Harnessing Maxwell’s demon to establish a macroscale concentration gradient
Maxwell’s demon describes a thought experiment in which a ‘demon’ regulates the flow of particles betwee...
A physically encoded Bayesian assistant for the optimization of multicomponent reactions
A physically encoded Bayesian assistant for the optimization of multicomponent reactions
The optimization of chemical reactions can be laborious, particularly in the case of complex, multicomponent catalytic cyc...
Sequential closed-loop Bayesian optimization as a guide for organic molecular metallophotocatalyst formulation discovery
Sequential closed-loop Bayesian optimization as a guide for organic molecular metallophotocatalyst formulation discovery
Conjugated organic photoredox catalysts (OPCs) can promote a wide range of chemical transformations. It is challenging to ...
Chemo-enzymatic synthesis is spot on for ganglioside glycan libraries
Chemo-enzymatic synthesis is spot on for ganglioside glycan libraries
By employing chemo-enzymatic techniques, a diverse 65-member ganglioside glycan library has been generated that provides a...
The genetic engineering Swiss army knife
The genetic engineering Swiss army knife
In molecular biology, few molecules have had as profound an impact as Cas9. Madeleine King, Kayla Perry, Mitchell McAndrew...
Repurposing of halogenated organic pollutants via alkyl bromide-catalysed transfer chlorination
Repurposing of halogenated organic pollutants via alkyl bromide-catalysed transfer chlorination
Halogenated organic pollutants (HOPs) are causing a significant environmental and human health crisis due to their high le...
Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
Recent advances in chemical proteomics have focused on developing chemical probes that react with nucleophilic amino acid ...
How we talk about harmful chemicals in the environment
How we talk about harmful chemicals in the environment
Environmental contamination is in the news more than ever. Shira Joudan introduces key concepts to talk about what happens...
Reversing the charge of lysine by genetic code expansion
Reversing the charge of lysine by genetic code expansion
Posttranslational modifications alter the structure and function of proteins. Now, genetic code expansion enables encoding...
Metal-free catalysts for hydrogenation
Metal-free catalysts for hydrogenation
Ethylene feedstocks must be ultrapure for plastics production, but metal-based catalysts used for acetylene removal are li...
Layered self-pillared zeolites convert polyethylene to gasoline
Layered self-pillared zeolites convert polyethylene to gasoline
State-of-the-art plastic deconstruction technologies typically require noble metals, consume hydrogen gas, and generate wa...
Repurposing a plant peptide cyclase for targeted lysine acylation
Repurposing a plant peptide cyclase for targeted lysine acylation
Transpeptidases are powerful tools for protein engineering but are largely restricted to acting at protein backbone termin...
Copper sulfide mineral performs non-enzymatic anaerobic ammonium oxidation through a hydrazine intermediate
Copper sulfide mineral performs non-enzymatic anaerobic ammonium oxidation through a hydrazine intermediate
Anaerobic ammonium oxidation (anammox)—the biological process that activates ammonium with nitrite—is responsi...
Cyclopropenium functionalization
Cyclopropenium functionalization
Although functionalized cyclopropenes have found uses in many applications, their synthesis has been severely limited. Now...
Accessing elusive σ-type cyclopropenium cation equivalents through redox gold catalysis
Accessing elusive σ-type cyclopropenium cation equivalents through redox gold catalysis
Cyclopropenes are the smallest unsaturated carbocycles. Removing one substituent from cyclopropenes leads to cyclopropeniu...