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Benign Prostatic Hyperplasia/Obstruction Ameliorated Using a Soluble Guanylate Cyclase Activator
Benign Prostatic Hyperplasia/Obstruction Ameliorated Using a Soluble Guanylate Cyclase Activator
Abstract Benign prostatic hyperplasia (BPH) is a feature of ageing males. Up to half demonstrate bladder outlet obstructio...
Quantitative features to assist in the diagnostic assessment of Chronic Lymphocytic Leukemia progression†
Quantitative features to assist in the diagnostic assessment of Chronic Lymphocytic Leukemia progression†
Abstract The use of artificial intelligence methods in the image-based diagnostic assessment of hematological diseases is ...
5‐alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
5‐alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
Abstract Benign prostatic hyperplasia (BPH) is a progressive expansion of peri-urethral prostate tissue common in aging me...
Immune‐related gene expression signatures: A step forward in the stratification of patients with ovarian clear cell carcinoma†
Immune‐related gene expression signatures: A step forward in the stratification of patients with ovarian clear cell carcinoma†
Abstract Clear cell carcinoma of the ovary (CCC) is one of the five major histological types of ovarian cancer and present...
Machine Learning Models Predict the Primary Sites of Head and Neck Squamous Cell Carcinoma Metastases Based on DNA Methylation
Machine Learning Models Predict the Primary Sites of Head and Neck Squamous Cell Carcinoma Metastases Based on DNA Methylation
Abstract In head and neck squamous cell cancers (HNSCs) that present as metastases with an unknown primary (HNSC-CUPs), th...
NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions
NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions
Abstract Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are emerging tissue-agnostic drug targets in maligna...
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19
Abstract COVID-19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID-19 patients, we found ext...
Pancancer cytotoxic T cell trapping: Are neutrophil extracellular traps a viable biomarker for immunotherapy response?†
Pancancer cytotoxic T cell trapping: Are neutrophil extracellular traps a viable biomarker for immunotherapy response?†
Abstract In a recent issue of The Journal of Pathology, a study by de Andrea et al demonstrates the presence of neutrophil...
Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα‐dependent mechanism
Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα‐dependent mechanism
Abstract Granulosa cell tumor (GCT) is a form of ovarian tumor characterized by its tendency to recur years after surgical...
Splicing predictions, minigene analyses and ACMG/AMP clinical classification of 42 germline PALB2 splice‐site variants
Splicing predictions, minigene analyses and ACMG/AMP clinical classification of 42 germline PALB2 splice‐site variants
Abstract PALB2 loss-of-function variants confer high risk of developing breast cancer. Here, we present a systematic funct...
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis
Abstract MUTYH encodes a glycosylase involved in the base excision repair of DNA. Biallelic pathogenic germline variants i...
Clinical implications of cell‐of‐origin epigenetic characteristics in non‐functional pancreatic neuroendocrine tumors
Clinical implications of cell‐of‐origin epigenetic characteristics in non‐functional pancreatic neuroendocrine tumors
Abstract Primary non-functional pancreatic neuroendocrine tumors (NF-PanNETs) are a heterogeneous group of neuroendocrine ...
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas
Abstract Immunotherapy is a new anti-cancer treatment option, showing promising results in clinical trials. To investigate...
Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth
Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth
Abstract A common limitation of cancer treatments is chemotherapy resistance. We have identified previously that endotheli...
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer
Abstract Radiation and Bacillus Calmette-Guérin (BCG) instillations are used clinically for treatment of urothelial c...
Mitochondria govern histone acetylation in colorectal cancer
Mitochondria govern histone acetylation in colorectal cancer
Abstract Cancer cells have an altered metabolic state that supports their growth; for example, aerobic glycolysis, known a...
A digital score of tumour‐associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma
A digital score of tumour‐associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma
Abstract The infiltration of T-lymphocytes in the stroma and tumour is an indication of an effective immune response again...
Immune Cell Infiltrates and Prognosis in Localized Prostate Cancer†
Immune Cell Infiltrates and Prognosis in Localized Prostate Cancer†
Abstract Multiple lines of evidence indicate that quantification of immune cell infiltrates in primary prostate cancer can...
Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer
Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer
Abstract Basal/Squamous (Ba/Sq) subtype represents an intrinsic and robust group in the consensus molecular classification...
Stroma Areactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes
Stroma Areactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes
Abstract Compared to other malignancies, there is a lack of easy-to-evaluate biomarkers for gastric cancer, which is assoc...
Untangling the complexities of micropapillary cancer†
Untangling the complexities of micropapillary cancer†
Abstract Distinct morphological subtypes of colorectal cancer (CRC) confer a bleak clinical outlook. In a recent issue of ...
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alterations
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alterations
Abstract Cutaneous, ocular, and mucosal melanomas are histologically indistinguishable tumors that are driven by a differe...
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors
Abstract Germ cell tumors (GCTs) originate during the histogenesis of primordial germ cells to mature gametes. Previous st...
Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology
Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology
Abstract Deep Learning is a powerful tool in computational pathology: it can be used for tumor detection and for predictin...
Weakly supervised learning on unannotated H&E‐stained slides predicts BRAF mutation in thyroid cancer with high accuracy
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Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer
Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer
Abstract Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of prostate cancer that respond...
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases
Abstract Insulin-degrading enzyme (IDE) function goes far beyond its known proteolytic role as a regulator of insulin leve...
Mutation‐ and methylation‐profiles of ectopic and eutopic endometrial epithelium
Mutation‐ and methylation‐profiles of ectopic and eutopic endometrial epithelium
Abstract Adenomyosis and peritoneal endometriosis are common gynecologic lesions; they are characterized by aberrant locat...
The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet‐induced non‐alcoholic steatohepatitis
The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet‐induced non‐alcoholic steatohepatitis
Abstract Epigenetic regulation in macrophages plays a crucial role in the inflammatory response of cells. We investigated ...
Calcyphosine promotes the proliferation of glioma cells and serves as a potential therapeutic target
Calcyphosine promotes the proliferation of glioma cells and serves as a potential therapeutic target
Abstract Calcyphosine (CAPS) was initially identified from the canine thyroid. It also exists in many types of tumors, but...
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