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Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats
Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats
Opioid misuse is a prominent public health concern, although patterns of use may confer different vulnerability to relapse...
Pace of alcohol drinking during in natural-environment drinking is associated with heightened alcohol-related reward and negative consequences in risky drinkers
Pace of alcohol drinking during in natural-environment drinking is associated with heightened alcohol-related reward and negative consequences in risky drinkers
Sensitivity to alcohol’s stimulating and rewarding properties is associated with increased risk for future heavy dri...
Preventive and therapeutic impact of probiotic supplementation on behavior and inflammatory responses in the PTZ-induced chemical kindling in rats
Preventive and therapeutic impact of probiotic supplementation on behavior and inflammatory responses in the PTZ-induced chemical kindling in rats
Epilepsy is a common neurological disorder that affects the quality of life globally. Its pathophysiology involves disrupt...
Involvement of the GABAergic and the serotonergic systems in the anxiolytic effects expressed by the nitric oxide (NO) donor sodium nitroprusside (SNP) in the male rat
Involvement of the GABAergic and the serotonergic systems in the anxiolytic effects expressed by the nitric oxide (NO) donor sodium nitroprusside (SNP) in the male rat
Anxiety is a chronic severe psychiatric disorder. In a series of studies, the implication of the gaseous molecule nitric o...
Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder
Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder
Two prominent neurobiological models of addiction, the allostatic and incentive-sensitization models, have guided clinical...
Value signals guiding choices for cannabis versus non-drug rewards in people who use cannabis near-daily
Value signals guiding choices for cannabis versus non-drug rewards in people who use cannabis near-daily
Despite the critical role of choice processes in substance use disorders, the neurobehavioral mechanisms guiding human dec...
Time to choose: impact of intertrial interval on selecting between methamphetamine and food reinforcement in male and female rats
Time to choose: impact of intertrial interval on selecting between methamphetamine and food reinforcement in male and female rats
A central component of substance use disorder is the maladaptive choice of the drug over natural reinforcers. Compared to ...
A humanized monoclonal antibody attenuates fentanyl self-administration and reverses and prevents fentanyl-induced ventilatory depression in rhesus monkeys
A humanized monoclonal antibody attenuates fentanyl self-administration and reverses and prevents fentanyl-induced ventilatory depression in rhesus monkeys
Medications for opioid use disorder (OUD) and overdose have been available for decades, yet nearly 70% of fatal drug overd...
Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors
Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors
Alcohol is one of the most frequently used drugs of abuse and has a major impact on human health worldwide. People assigne...
Acute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner
Acute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner
Current treatment options for PTSD have unreliable efficacy, with many individuals unable to achieve complete remission. C...
Acute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis
Acute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis
Psilocybin shows promise for treating neuropsychiatric disorders. However, insight into its acute effects on cognition is ...
Increased risky choice during forced abstinence from fentanyl on the cued rat gambling task
Increased risky choice during forced abstinence from fentanyl on the cued rat gambling task
The use of illicit opioids has arguably never been more risky; street drug potency can be dangerously high, is often unkno...
Captopril attenuates oxidative stress and neuroinflammation implicated in cisplatin-induced cognitive deficits in rats
Captopril attenuates oxidative stress and neuroinflammation implicated in cisplatin-induced cognitive deficits in rats
One of the most debilitating drawbacks of cisplatin chemotherapy is neurotoxicity which elicits memory impairment and cogn...
Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice
Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice
Clinical literature indicates there may be a therapeutic use of cannabidiol (CBD) for stress-related disorders. Preclinica...
Safety and efficacy of dasotraline for patients with attention deficit/hyperactivity disorder: a systematic review and meta-analysis of 1594 patients including GRADE qualifications
Safety and efficacy of dasotraline for patients with attention deficit/hyperactivity disorder: a systematic review and meta-analysis of 1594 patients including GRADE qualifications
Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder. It is one of the most common men...
Substance use disorder severity is associated with sensitivity to effort-related decision-making constraints
Substance use disorder severity is associated with sensitivity to effort-related decision-making constraints
Several studies have reported associations between substance use and effort-related decision making, or the degree to whic...
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling
Prenatal maternal immune activation (MIA) is an etiological risk factor for schizophrenia in offspring. Recently, parvalbu...
Depression-like effects induced by chronic unpredictable mild stress in mice are rapidly reversed by a partial negative allosteric modulator of mGlu5 receptor, M-5MPEP
Depression-like effects induced by chronic unpredictable mild stress in mice are rapidly reversed by a partial negative allosteric modulator of mGlu5 receptor, M-5MPEP
Due to the numerous limitations of ketamine as a rapid-acting antidepressant drug (RAAD), research is still being conducte...
Ketamine differentially affects implicit and explicit memory processes in rats
Ketamine differentially affects implicit and explicit memory processes in rats
Ketamine, a non-competitive NMDA receptor antagonist, produces antidepressant effects at subanesthetic doses. The therapeu...
Characterization of the nicotine uptake and safety of Nordic spirit tobacco-free oral nicotine pouches: A randomized cross-over study
Characterization of the nicotine uptake and safety of Nordic spirit tobacco-free oral nicotine pouches: A randomized cross-over study
Given the nascency of tobacco-free oral nicotine pouches (NPs) and the heterogeneity of commercially available NP brands, ...
The effect of mixed tobacco monoamine oxidase inhibitors in animal models relevant to tobacco dependence
The effect of mixed tobacco monoamine oxidase inhibitors in animal models relevant to tobacco dependence
Tobacco monoamine oxidase (MAO) inhibitors have long been suspected of influencing tobacco dependence, but direct evidence...
Efficacy and safety of prophylactic use of benzhexol after risperidone treatment in MK-801-induced mouse model of schizophrenia
Efficacy and safety of prophylactic use of benzhexol after risperidone treatment in MK-801-induced mouse model of schizophrenia
There is a debate about whether doctors should prophylactically use benzhexol in schizophrenic patients to reduce the occu...
Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype
Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype
The endocannabinoid system, which regulates fear- and anxiety-related behaviors, is dysregulated in adults with posttrauma...
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex has a strong influence on the prevalence and course of brain conditions, including autism spectrum disorders. The mech...
The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats
The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats
The literature indicates that nicotine exposure or its discontinuation impair adult hippocampal neurogenesis in rats, thou...
A potential role of gut microbiota in stroke: mechanisms, therapeutic strategies and future prospective
A potential role of gut microbiota in stroke: mechanisms, therapeutic strategies and future prospective
Neurological conditions like Stroke and Alzheimer’s disease (AD) often include inflammatory responses in the nervous...
Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains
Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains
Anticipation is a critical antecedent to drug use, in which the prospect of imminent drug availability can potently motiva...
Efficacy of Nigella sativa seed oil against psychophysical stress induced irritable bowel syndrome and anxiety-like symptoms in Wistar rats
Efficacy of Nigella sativa seed oil against psychophysical stress induced irritable bowel syndrome and anxiety-like symptoms in Wistar rats
Stressors play a critical role in the progression of irritable bowel syndrome (IBS). Heterogenous stress causes alteration...
Multimodal examination of daily stress rhythms in chronic Cannabis users
Multimodal examination of daily stress rhythms in chronic Cannabis users
Chronic cannabis users frequently report stress relief as their primary reason for use. The endocannabinoid system is invo...
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Alcohol consumption despite negative consequences is a core symptom of Alcohol Use Disorder. In animal models, this is stu...
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