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The effect of mixed tobacco monoamine oxidase inhibitors in animal models relevant to tobacco dependence
The effect of mixed tobacco monoamine oxidase inhibitors in animal models relevant to tobacco dependence
Tobacco monoamine oxidase (MAO) inhibitors have long been suspected of influencing tobacco dependence, but direct evidence...
Efficacy and safety of prophylactic use of benzhexol after risperidone treatment in MK-801-induced mouse model of schizophrenia
Efficacy and safety of prophylactic use of benzhexol after risperidone treatment in MK-801-induced mouse model of schizophrenia
There is a debate about whether doctors should prophylactically use benzhexol in schizophrenic patients to reduce the occu...
Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype
Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype
The endocannabinoid system, which regulates fear- and anxiety-related behaviors, is dysregulated in adults with posttrauma...
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Sex has a strong influence on the prevalence and course of brain conditions, including autism spectrum disorders. The mech...
The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats
The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats
The literature indicates that nicotine exposure or its discontinuation impair adult hippocampal neurogenesis in rats, thou...
A potential role of gut microbiota in stroke: mechanisms, therapeutic strategies and future prospective
A potential role of gut microbiota in stroke: mechanisms, therapeutic strategies and future prospective
Neurological conditions like Stroke and Alzheimer’s disease (AD) often include inflammatory responses in the nervous...
Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains
Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains
Anticipation is a critical antecedent to drug use, in which the prospect of imminent drug availability can potently motiva...
Efficacy of Nigella sativa seed oil against psychophysical stress induced irritable bowel syndrome and anxiety-like symptoms in Wistar rats
Efficacy of Nigella sativa seed oil against psychophysical stress induced irritable bowel syndrome and anxiety-like symptoms in Wistar rats
Stressors play a critical role in the progression of irritable bowel syndrome (IBS). Heterogenous stress causes alteration...
Multimodal examination of daily stress rhythms in chronic Cannabis users
Multimodal examination of daily stress rhythms in chronic Cannabis users
Chronic cannabis users frequently report stress relief as their primary reason for use. The endocannabinoid system is invo...
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake
Alcohol consumption despite negative consequences is a core symptom of Alcohol Use Disorder. In animal models, this is stu...
Curcumin alleviates arsenic trioxide-induced neural damage in the murine striatal region
Curcumin alleviates arsenic trioxide-induced neural damage in the murine striatal region
Arsenic-induced neurotoxicity, with dose-dependent effects, is well-documented in rodents. Curcumin (CUR), a cost-effectiv...
Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model
Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model
Neuroinflammation may inhibit oligodendrocyte and astrocyte differentiation, which causes demyelination and synaptic degen...
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Morphine withdrawal leads to serious cognitive deficits in which dynorphins are directly involved. Recently, exercise has ...
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression
The intravenous anesthetic propofol is known to induce positive mood effects during routine clinical use, suggesting it mi...
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce e...
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear
Despite the existing anatomical and physiological evidence pointing to the involvement of orexinergic projections from the...
BNST CRF receptor type 1 modulates mechanical hypersensitivity induced by adolescent alcohol exposure in adult female mice
BNST CRF receptor type 1 modulates mechanical hypersensitivity induced by adolescent alcohol exposure in adult female mice
Alcohol exposure during adolescence has been linked to long-lasting behavioral consequences, contributing to the developme...
The ultrasonic vocalization (USV) syllable profile during neonatal opioid withdrawal and a kappa opioid receptor component to increased USV emissions in female mice
The ultrasonic vocalization (USV) syllable profile during neonatal opioid withdrawal and a kappa opioid receptor component to increased USV emissions in female mice
Opioid use during pregnancy can lead to negative infant health outcomes, including neonatal opioid withdrawal syndrome (NO...
Pituitary adenylate cyclase-activating polypeptide (PACAP)+ cells in the paraventricular nucleus of the thalamus: relationship with binge-type eating in male and female mice
Pituitary adenylate cyclase-activating polypeptide (PACAP)+ cells in the paraventricular nucleus of the thalamus: relationship with binge-type eating in male and female mice
Both the paraventricular nucleus of the thalamus (PVT) and the neuropeptide, pituitary adenylate cyclase-activating polype...
Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague–Dawley rats
Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague–Dawley rats
G-protein biased mu-opioid receptor (MOR) agonists have been reported to exhibit superior therapeutic windows compared to ...
Role of vesicular monoamine transporter-2 for treating attention deficit hyperactivity disorder: a review
Role of vesicular monoamine transporter-2 for treating attention deficit hyperactivity disorder: a review
The Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) classifies attention deficit hyperactivity disor...
Emerging roles of cannabinoid receptor CB2 receptor in the central nervous system: therapeutic target for CNS disorders
Emerging roles of cannabinoid receptor CB2 receptor in the central nervous system: therapeutic target for CNS disorders
The endocannabinoid system (ECS) belongs to the G protein-coupled receptor family of cell membranes and is associated with...
Effect of chronic delivery of the NOP/MOR partial agonist AT-201 and NOP antagonist J-113397 on heroin relapse in a rat model of opioid maintenance
Effect of chronic delivery of the NOP/MOR partial agonist AT-201 and NOP antagonist J-113397 on heroin relapse in a rat model of opioid maintenance
The opioid crisis persists despite availability of effective opioid agonist maintenance treatments (methadone and buprenor...
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
The persistent use of opioids leads to profound changes in neuroplasticity of the brain, contributing to the emergence and...
Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats
Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats
Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies su...
Evaluation of (S)-T1 and (S)-T2 ligands targeting α3β4 nAChR as potential nicotine addiction pharmacotherapy
Evaluation of (S)-T1 and (S)-T2 ligands targeting α3β4 nAChR as potential nicotine addiction pharmacotherapy
Substance use disorders (SUDs) represent a significant global health concern, demanding the development of effective pharm...
Late development of OCD-like phenotypes in Dlgap1 knockout mice
Late development of OCD-like phenotypes in Dlgap1 knockout mice
Despite variants in the Dlgap1 gene having the two lowest p-value in a genome-wide association study of obsessive compulsi...
Comparison of pain modulatory effect of the LPGi estragon receptor on inflammatory pain between pro-estrus and estrus phases and OVX rats
Comparison of pain modulatory effect of the LPGi estragon receptor on inflammatory pain between pro-estrus and estrus phases and OVX rats
The present study has investigated whether circulating estrogen level variations in the pro-estrus and estrus phases of th...
Prefrontal cortex—nucleus reuniens—hippocampus network exhibits sex-differentiated responses to stress and antidepressant treatment in rats
Prefrontal cortex—nucleus reuniens—hippocampus network exhibits sex-differentiated responses to stress and antidepressant treatment in rats
Depression is a serious psychiatric disease, which is diagnosed twice as frequently in women than men. We have recently sh...
Repeated exposure to novelty promotes resilience against the amyloid-beta effect through dopaminergic stimulation
Repeated exposure to novelty promotes resilience against the amyloid-beta effect through dopaminergic stimulation
The accumulation of beta-amyloid peptide (Aβ) in the forebrain leads to cognitive dysfunction and neurodegeneration i...
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