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Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population
Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population
Glioma is the most common primary intracranial tumor with high mortality and poor prognosis. The purpose of this study was...
A Comprehensive Overview of NF1 Mutations in Iranian Patients
A Comprehensive Overview of NF1 Mutations in Iranian Patients
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in the NF1 gene. This disorder shows nearly compl...
Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus
Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus
Vascular dementia (VaD) is a cognitive disorder characterized by a decline in cognitive function resulting from cerebrovas...
The CD44s Isoform is a Potential Biomarker for Predicting Craniopharyngioma Recurrence in Children
The CD44s Isoform is a Potential Biomarker for Predicting Craniopharyngioma Recurrence in Children
Adamantinomatous craniopharyngioma (ACP) is an intracranial tumor considered partly malignant due to its ability to infilt...
Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway
Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway
Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective ...
Endothelial Progenitor Cells: A Review of Molecular Mechanisms in the Pathogenesis and Endovascular Treatment of Intracranial Aneurysms
Endothelial Progenitor Cells: A Review of Molecular Mechanisms in the Pathogenesis and Endovascular Treatment of Intracranial Aneurysms
This comprehensive review explores the multifaceted role of endothelial progenitor cells (EPCs) in vascular diseases, focu...
FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury
FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury
Depression frequently occurs following traumatic brain injury (TBI). However, the role of Fibromodulin (FMOD) in TBI-relat...
Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells
Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells
Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Pathological forms of T...
p39 Affects Myelin Formation in Cerebral Ischemic Injury
p39 Affects Myelin Formation in Cerebral Ischemic Injury
Stroke is a significant public health issue, and research has consistently focused on studying the mechanisms of injury an...
Influence of SLC40A1 on Cytokine Interactions and Immune Infiltration in Glioblastoma
Influence of SLC40A1 on Cytokine Interactions and Immune Infiltration in Glioblastoma
Numerous studies have explored the various functions of Slc40a1 in cancer development. However, the role of Slc40a1 in pri...
Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder
Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder
The salient features of autism spectrum disorder (ASD) encompass persistent difficulties in social communication, as well ...
Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson’s Disease Pathology: A Pharmacological Investigation
Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson’s Disease Pathology: A Pharmacological Investigation
Parkinson’s disease (PD) is a neurodegenerative disorder associated with mitochondrial dysfunctions and oxidative st...
Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides
Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides
Seipin is a key regulator of lipid metabolism, the deficiency of which leads to severe lipodystrophy. Hypothalamus is the ...
Long-Term Accumulation of T Cytotoxic 1, T Cytotoxic 17, and T Cytotoxic 17/1 Cells in the Brain Contributes to Microglia-Mediated Chronic Neuroinflammation After Ischemic Stroke
Long-Term Accumulation of T Cytotoxic 1, T Cytotoxic 17, and T Cytotoxic 17/1 Cells in the Brain Contributes to Microglia-Mediated Chronic Neuroinflammation After Ischemic Stroke
Post-stroke neuroinflammation affects the damage and recovery of neurological functions. T cells including CD8+ T cells we...
Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells
Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells
Toll-like receptor (TLR) 7 plays an important role in recognizing virus-derived nucleic acids. TLR7 signaling in astrocyte...
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Lycium barbarum polysaccharide (LBP) have a certain curative effect on hypoglycemic and neuroprotective effects, but the s...
The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis
The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic condition affecting the central nervous system (CNS), where the interplay of genetic ...
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma
Normal tension glaucoma (NTG) is a progressive neurodegenerative disease in glaucoma families. Typical glaucoma develops b...
Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway
Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway
The role of circular RNAs (circRNAs) in neuropathic pain is linked to the fundamental physiological mechanisms involved. H...
Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis
Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis
The manifestations of tuberous sclerosis complex (TSC) in humans include epilepsy, autism spectrum disorders (ASD) and int...
Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation
Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation
Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson&...
Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia
Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia
This study focuses on understanding the role of c-Myc, a cancer-associated transcription factor, in the penumbra following...
An Emerging Role for Enhancer RNAs in Brain Disorders
An Emerging Role for Enhancer RNAs in Brain Disorders
Noncoding DNA undergoes widespread context-dependent transcription to produce noncoding RNAs. In recent decades, tremendou...
Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease
Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease
Familial Alzheimer’s disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid pr...
MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients
MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease with a wide disease progression. Despite several effor...
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
Background: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors li...
Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3k9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model
Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3k9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model
Cerebral ischemic stroke is one of the foremost global causes of death and disability. Due to inadequate knowledge in its ...
Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging
Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging
In this study the subcellular modifications undergone by cerebral cortex mitochondrial metabolism in chronic hypertension ...
Amelioration of Astrocyte-Mediated Neuroinflammation by EI-16004 Confers Neuroprotection in an MPTP-induced Parkinson’s Disease Model
Amelioration of Astrocyte-Mediated Neuroinflammation by EI-16004 Confers Neuroprotection in an MPTP-induced Parkinson’s Disease Model
Parkinson’s disease (PD) is a neurodegenerative disorder that results in motor impairment due to dopaminergic neuron...
Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Integrated analysis of iron regulatory biomarkers and inflammatory response could be an important strategy for Japanese en...
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