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Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia
Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia
This study focuses on understanding the role of c-Myc, a cancer-associated transcription factor, in the penumbra following...
An Emerging Role for Enhancer RNAs in Brain Disorders
An Emerging Role for Enhancer RNAs in Brain Disorders
Noncoding DNA undergoes widespread context-dependent transcription to produce noncoding RNAs. In recent decades, tremendou...
Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease
Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease
Familial Alzheimer’s disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid pr...
MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients
MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease with a wide disease progression. Despite several effor...
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
Background: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors li...
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
Neuromuscular disorders (NMD) are a class of progressive disorders that are characterized by wasting of the muscles. Some ...
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
Orexin and its receptors are closely related to the pathogenesis of Alzheimer’s disease (AD). Although the expressio...
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SA...
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a long-known complex neurodevelopmental disorder, and over the past decades, with the en...
Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Expression levels of activated inflammasome components, pro-inflammatory cytokine maturation and markers of cell death in ...
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Medulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with dist...
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
Activated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated ...
The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease
The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-aged people and elderly people...
Dysregulated COMT Expression in Fragile X Syndrome
Dysregulated COMT Expression in Fragile X Syndrome
Transcriptional and proteomics analyses in human fragile X syndrome (FXS) neurons identified markedly reduced expression o...
Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellu...
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency
AIFM1 is a mitochondrial flavoprotein involved in caspase-independent cell death and regulation of respiratory chain compl...
PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance
PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance
Glioblastoma (GBM) is the most frequent tumor of the central nervous system, and its heterogeneity is a challenge in treat...
Targeting Pericytes for Functional Recovery in Ischemic Stroke
Targeting Pericytes for Functional Recovery in Ischemic Stroke
Pericytes surrounding endothelial cells in the capillaries are emerging as an attractive cell resource, which can show a l...
Pathophysiological Links Between Obesity and Dementia
Pathophysiological Links Between Obesity and Dementia
Obesity is a major global health concern, with prevalence rates rapidly rising due to increased availability of highly pro...
Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease?
Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease?
Alzheimer's disease (AD) is a neurodegenerative disease leading to dementia for which no effective medicine exists. Cu...