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Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis
Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis
This study aimed to investigate the expression of protein regulator of cytokinesis 1 (PRC1) in cholangiocarcinoma (CHOL) a...
Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation
Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation
Lethal graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem-cell transplantation (A...
Editorial overview: Folding and Binding (2024)
Editorial overview: Folding and Binding (2024)
Jane Dyson is a Professor at The Scripps Research Institute. Her research interests are in the conformation of peptides, p...
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of en...
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the in...
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such...
Quercetin Regulates Microglia M1/M2 Polarization and Alleviates Retinal Inflammation via ERK/STAT3 Pathway
Quercetin Regulates Microglia M1/M2 Polarization and Alleviates Retinal Inflammation via ERK/STAT3 Pathway
Retinal inflammation is a pivotal characteristic observed in various retinal degenerative disorders, notably age-related m...
The Protective Effects of Vitamin B Complex on Diclofenac Sodium-Induced Nephrotoxicity: The Role of NOX4/RhoA/ROCK
The Protective Effects of Vitamin B Complex on Diclofenac Sodium-Induced Nephrotoxicity: The Role of NOX4/RhoA/ROCK
Diclofenac sodium (DIC) is a widely used non-steroidal anti-inflammatory drug. Unfortunately, its prolonged use is associa...
A concise review on the bioactive potential of the genus Gracilaria (Rhodophyta)
A concise review on the bioactive potential of the genus Gracilaria (Rhodophyta)
The Genus Gracilaria (Gracilariales, Rhodophyta) has compressed, cylindrical, fleshy, or succulent thallus that contains a...
Regulatory role of N-myc downregulated genes in amelogenesis in rats
Regulatory role of N-myc downregulated genes in amelogenesis in rats
Cytodifferentiation of odontogenic cells, a late stage event in odontogenesis is based on gene regulation. However, studie...
LINC00665 promotes glycolysis in lung adenocarcinoma cells via the let-7c-5p/HMMR axis
LINC00665 promotes glycolysis in lung adenocarcinoma cells via the let-7c-5p/HMMR axis
Lung adenocarcinoma (LUAD) is one of the most lethal and common malignancies. The energy metabolism of LUAD is a critical ...
MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
MYCN (master regulator of cell cycle entry and proliferative metabolism) gene amplification defines a molecular subgroup o...
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
Neuroinflammation is crucial in the development of postoperative cognitive dysfunction (POCD), and microglial activation i...
METTL3 restrains autoimmunity in β-cells
METTL3 restrains autoimmunity in β-cells
Activation of innate immunity has been linked to the progression of type 1 diabetes. A study now shows that overexpression...
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed th...
Revisiting the evolution of family B1 GPCRs and ligands: Insights from mollusca
Revisiting the evolution of family B1 GPCRs and ligands: Insights from mollusca
Family B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they p...
MALT1 inhibition suppresses antigen-specific T cell responses
MALT1 inhibition suppresses antigen-specific T cell responses
AbbreviationsMALT1mucosa-associated lymphoid tissue lymphoma translocation1PBMCperipheral blood mononuclear cellCTLA4cytot...
Prime editing and its application in beta-hemoglobinopathies
Prime editing and its application in beta-hemoglobinopathies
Genome-editing technologies have provided researchers with the ability to edit DNA mutations associated with various genet...
Deep learning in modeling protein complex structures: From contact prediction to end-to-end approaches
Deep learning in modeling protein complex structures: From contact prediction to end-to-end approaches
Protein–protein interactions (PPI) play crucial roles in many biological processes in cells. Therefore, determining the st...
Helical reconstruction, again
Helical reconstruction, again
Volume 85, April 2024, 102788Author links open overlay panelAbstractMany protein and nucleoprotein complexes exist as heli...
Neurofilaments: Novel findings and future challenges
Neurofilaments: Novel findings and future challenges
Neurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. ...
GFAP-isoforms in the nervous system: Understanding the need for diversity
GFAP-isoforms in the nervous system: Understanding the need for diversity
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells...
Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses
Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses
Apoptosis plays a pivotal role in pathogen elimination and maintaining homeostasis. However, viruses have evolved strategi...