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Activation of cell adhesion and migration is an early event of platelet-rich plasma (PRP)-dependent stimulation of human adipose-derived stem/stromal cells
Activation of cell adhesion and migration is an early event of platelet-rich plasma (PRP)-dependent stimulation of human adipose-derived stem/stromal cells
Stem cell therapy is a promising treatment in regenerative medicine. Human adipose-derived stem/stromal cells (hASCs), a t...
Phase separation in chemical and mechanical signal transduction
Phase separation in chemical and mechanical signal transduction
Signal transduction enables cells to sense and respond to information in the extracellular environment. Cells sense chemic...
A diffusion barrier limits nuclear leaks
A diffusion barrier limits nuclear leaks
ESCRT-III seals holes in the nuclear envelope (NE). A study now shows that the Cmp7-directed ESCRT-III cascade that gromme...
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mec...
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
The molecular mechanisms by which the endosomal sorting complexes required for transport (ESCRT) proteins contribute to th...
ZDHHC17 participates in the pathogenesis of polycystic ovary syndrome by affecting androgen conversion to estrogen in granulosa cells
ZDHHC17 participates in the pathogenesis of polycystic ovary syndrome by affecting androgen conversion to estrogen in granulosa cells
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age and is a significan...
The development of proximity labeling technology and its applications in mammals, plants, and microorganisms
The development of proximity labeling technology and its applications in mammals, plants, and microorganisms
Protein‒protein, protein‒RNA, and protein‒DNA interaction networks form the basis of cellular regulation...
Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis
Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis
Due to the complexity and incomplete understanding of the crosstalk between liver and adipose tissue, especially the proce...
SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression
SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression
Classically activated M1 macrophages, characterized by aberrant glycolysis and secretion of inflammatory cytokines, play p...
Protein disorder and autoinhibition: The role of multivalency and effective concentration
Protein disorder and autoinhibition: The role of multivalency and effective concentration
Autoinhibition is a common method of self-regulation in proteins, where two or more domains interact to modulate the equil...
Folding and functions of knotted proteins
Folding and functions of knotted proteins
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ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway
Endoplasmic reticulum oxidoreductin 1α (ERO1α) is an oxidase that exists in the endoplasmic reticulum and plays ...
Vimentin takes a hike – Emerging roles of extracellular vimentin in cancer and wound healing
Vimentin takes a hike – Emerging roles of extracellular vimentin in cancer and wound healing
Vimentin belongs to the intermediate filament (IFs) protein family, which is a large group of cytoskeletal elements expres...
Mechanical regulation of the Notch signaling pathway
Mechanical regulation of the Notch signaling pathway
The mechanical regulation of Notch signaling is an emerging area of interest in cell biology. Notch is essential in many p...
Tug-of-war via ERK signaling pathway for tissue organization – ERK activation to force generation
Tug-of-war via ERK signaling pathway for tissue organization – ERK activation to force generation
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell behaviors observed in diver...
PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder
PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder
Monocyte dysfunction is critical to sepsis-induced immunosuppression. Programmed death ligand-1 (PD-L1) has shown a close ...
Single-Cell Sequencing Reveals the Expression of Immune-Related Genes in Macrophages of Diabetic Kidney Disease
Single-Cell Sequencing Reveals the Expression of Immune-Related Genes in Macrophages of Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by macrophage infiltration, which requires further investigation. This stud...
Early-immune development in asthma: a review of the literature
Early-immune development in asthma: a review of the literature
Asthma is the most common chronic disease in childhood, and according to the Global Asthma report, 14% of children worldwi...
ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer
ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer
LAG3Lymphocyte-activation gene 3CTLA4Cytotoxic T-lymphocyte-associated protein 4TIGITT cell Ig and ITIM domainTIM-3T cell ...
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Available online 30 September 2023, 104772Author links open overlay panel, , Section snippetsTo the Editor2We read with gr...
Advances of autoimmune rheumatic diseases related to malignant tumors
Advances of autoimmune rheumatic diseases related to malignant tumors
Malignant neoplasms are a well-recognized global public health concern, with significant impacts on human health and quali...
Representing structures of the multiple conformational states of proteins
Representing structures of the multiple conformational states of proteins
Biomolecules exhibit dynamic behavior that single-state models of their structures cannot fully capture. We review some re...
Three-dimensional visualization of the lymphatic, vascular and neural network in rat lung by confocal microscopy
Three-dimensional visualization of the lymphatic, vascular and neural network in rat lung by confocal microscopy
In order to demonstrate the intricate interconnection of pulmonary lymphatic vessels, blood vessels, and nerve fibers, the...
Copper in Cancer: from transition metal to potential target
Copper in Cancer: from transition metal to potential target
In recent years, with the continuous in-depth exploration of the molecular mechanisms of tumorigenesis, numerous potential...
Isolation of tumor stem-like cells from primary laryngeal squamous cell carcinoma cells (FD-LS-6)
Isolation of tumor stem-like cells from primary laryngeal squamous cell carcinoma cells (FD-LS-6)
The development of efficient treatments for laryngeal squamous cell carcinoma (LSCC) is hindered by the lack of applicable...
MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer
MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer
Ovarian cancer is the common cause of cancer-related death in women and is considered the most deadly gynecological cancer...
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitocho...
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions
Integrin-mediated focal adhesions are the primary architectures that transmit forces between the extracellular matrix (ECM...
Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes
Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes
Hormones often coevolve with the enzymes that synthesize and/or metabolism them and with the receptors that mediate their ...
Alterations in GLP-1 and PYY release with aging and body mass in the human gut
Alterations in GLP-1 and PYY release with aging and body mass in the human gut
The lining of our intestinal surface contains an array of hormone-producing cells that are collectively our bodies’ larges...
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