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Regenerating the academic pipeline
Regenerating the academic pipeline
Kara McKinley is an assistant professor of stem-cell and regenerative biology at Harvard University. In addition to advanc...
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression
Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodell...
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro
The glandular stomach is composed of two regenerative compartments termed corpus and antrum, and our understanding of the ...
Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression
Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression
Substantial follicle remodelling during the regression phase of the hair growth cycle is coordinated by the contraction of...
P5-ATPases: Structure, substrate specificities, and transport mechanisms
P5A- and P5B- ATPases, or collectively P5-ATPases, are eukaryotic-specific ATP-dependent transporters that are important f...
Deep learning for protein complex structure prediction
Recent developments in the structure prediction of protein complexes have resulted in accuracies rivalling experimental me...
Suppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice
Hemophilia A (affecting 1 in 5000 male births) is inherited as an X-linked recessive genetic disorder, resulting in a defi...
The dual role of microRNA (miR)-20b in cancers: Friend or foe?
The dual role of microRNA (miR)-20b in cancers: Friend or foe?
MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions...
Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation
Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation
Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range o...
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps ...
MicroRNA let-7d attenuates hypertrophic scar fibrosis through modulation of iron metabolism by reducing DMT1 expression
MicroRNA let-7d attenuates hypertrophic scar fibrosis through modulation of iron metabolism by reducing DMT1 expression
Hypertrophic scar is an unavoidable result of wound healing following burns and trauma, which remains a challenging proble...
Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice
Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice
MET is a high-affinity receptor tyrosine kinase of HGF (hepatocyte growth factor). HGF is secreted as an inactive single-c...
A prognostic cuproptosis-related lncRNA predictive signature for bladder cancer patients
A prognostic cuproptosis-related lncRNA predictive signature for bladder cancer patients
Cuproptosis is a novel form of cell death in tumours. However, the clinical impact and mechanism of cuproptosis in bladder...
ARHGAP6 inhibits bladder cancer cell viability, migration, and invasion via β-catenin signaling and enhances mitomycin C sensitivity
ARHGAP6 inhibits bladder cancer cell viability, migration, and invasion via β-catenin signaling and enhances mitomycin C sensitivity
The Rho/ROCK pathway regulates diverse cellular processes and contributes to the development and advancement of several ty...
A network map of GDNF/RET signaling pathway in physiological and pathological conditions
A network map of GDNF/RET signaling pathway in physiological and pathological conditions
Glial cell line-derived neurotrophic factor (GDNF) signals through a multi-component receptor system predominantly consist...
Chronic stress in solid tumor development: from mechanisms to interventions
Chronic stress in solid tumor development: from mechanisms to interventions
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experienc...
Greater than the sum of parts: Mechanisms of metabolic regulation by enzyme filaments
Large assemblies of purified enzymes from across intermediary metabolism have been documented since their initial purifica...
Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
Mutations in the leucine-rich repeat kinase 2 (LRRK2) that increase kinase activity are associated with some forms of Park...
Niche formation and function in developing tissue: studies from the Drosophila ovary
Niche formation and function in developing tissue: studies from the Drosophila ovary
Adult stem cells have a unique ability to self-renew and to generate differentiated daughter cells that are required in th...
miR-7-5p Antagomir Protects Against Inflammation-Mediated Apoptosis and Lung Injury via Targeting Raf-1 In Vitro and In Vivo
miR-7-5p Antagomir Protects Against Inflammation-Mediated Apoptosis and Lung Injury via Targeting Raf-1 In Vitro and In Vivo
Exacerbated inflammation and apoptosis are considered upstream events associated with acute lung injury (ALI). microRNAs a...
The potential role of N6-methyladenosine modification of LncRNAs in contributing to the pathogenesis of chronic glomerulonephritis
The potential role of N6-methyladenosine modification of LncRNAs in contributing to the pathogenesis of chronic glomerulonephritis
Increasing evidence indicates that N6-methyladenosine (m6A) modification of mRNAs has been shown to play a critical role i...
Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated bl...
Correction: Akt: a key transducer in cancer
Correction: Akt: a key transducer in cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
A novel tool for the unbiased characterization of epithelial monolayer development in culture
A novel tool for the unbiased characterization of epithelial monolayer development in culture
The function of an epithelial tissue is intertwined with its architecture. Epithelial tissues are often described as pseud...
Targeting of Hmo1 to subcompartments of the budding yeast nucleolus
Targeting of Hmo1 to subcompartments of the budding yeast nucleolus
The nucleolus is a multi-layered, membrane-less organelle made up of liquid-like biogenesis compartments surrounding an ar...
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice
To survive poor nutritional conditions, tumor cells activate the unfolded protein response, which is composed of the IRE1,...
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
Cells sense and migrate across mechanically dissimilar environments throughout development and disease progression. Howeve...
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Clathrin-mediated endocytosis is a conserved eukaryotic membrane trafficking pathway that is driven by a sequentially asse...
Developmental programming: Adipose depot-specific regulation of non-coding RNAs and their relation to coding RNA expression in prenatal testosterone and prenatal bisphenol-A -treated female sheep
Developmental insults contribute to increases in non-communicable diseases, including cardiovascular diseases (CVD), diabe...
Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection
Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, the virus ha...
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