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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis
Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis
The regenerative potential of mesenchymal stromal/stem cells (MSCs) has been extensively studied in clinical trials in the...
Transdifferentiation of rat keratinocyte progenitors to corneal epithelial cells by limbal niche via the STAT3/PI3K/AKT signaling pathway
Transdifferentiation of rat keratinocyte progenitors to corneal epithelial cells by limbal niche via the STAT3/PI3K/AKT signaling pathway
To develop a method for enriching keratinocyte progenitor cells (KPCs) and establish a limbal niche (LN)-mediated transdif...
Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials
Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials
Chronic liver diseases, including cirrhosis and liver failure, remain formidable challenges due to their complex progressi...
Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis
Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis
As cell-free nanotherapeutics, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown potential t...
Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2
Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2
Patient-derived lung cancer organoids (PD-LCOs) demonstrate exceptional potential in preclinical testing and serve as a pr...
Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies
Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies
Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist of lipid bilaye...
Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model
Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model
Inflammatory bowel disease (IBD) is a persistent inflammation of the digestive system, and Mesenchymal Stem Cells (MSCs) a...
hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1
hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1
Pulmonary fibrosis (PF) is a common and multidimensional devastating interstitial lung disease. The development of novel a...
The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy
The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy
Neural stem cells from the subventricular zone (SVZ) neurogenic niche provide neurons that integrate in the olfactory bulb...
A chitosan/acellular matrix-based neural graft carrying mesenchymal stem cells to promote peripheral nerve repair
A chitosan/acellular matrix-based neural graft carrying mesenchymal stem cells to promote peripheral nerve repair
Treatment of peripheral nerve defects is a major concern in regenerative medicine. This study therefore aimed to explore t...
Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies
Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies
Sickle cell disease (SCD) and β-thalassemia patients with elevated gamma globin (HBG1/G2) levels exhibit mild or no s...
Research advances in the construction of stem cell-derived ovarian organoids
Research advances in the construction of stem cell-derived ovarian organoids
Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and impro...
Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats
Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats
Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may caus...
Long-term therapeutic effects of allogeneic mesenchymal stem cell transplantation for intrauterine adhesions
Long-term therapeutic effects of allogeneic mesenchymal stem cell transplantation for intrauterine adhesions
Intrauterine adhesion (IUA), resulting from uterine trauma, is one of the major causes of female infertility. Previous stu...
Correction: Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species
Correction: Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Preclinical study of novel human allogeneic adipose tissue-derived mesenchymal stem cell sheets toward a first-in-human clinical trial for myopic chorioretinal atrophy
Preclinical study of novel human allogeneic adipose tissue-derived mesenchymal stem cell sheets toward a first-in-human clinical trial for myopic chorioretinal atrophy
Mesenchymal stem cells may have neuroprotective and tissue regenerative capabilities and the potential to rescue retinal d...
Generation of vascularized pancreatic progenitors through co-differentiation of endoderm and mesoderm from human pluripotent stem cells
Generation of vascularized pancreatic progenitors through co-differentiation of endoderm and mesoderm from human pluripotent stem cells
The simultaneous differentiation of human pluripotent stem cells (hPSCs) into both endodermal and mesodermal lineages is c...
Effect of traction therapy on muscle satellite cell proliferation and differentiation in a rat model of knee stiffness
Effect of traction therapy on muscle satellite cell proliferation and differentiation in a rat model of knee stiffness
In the rat knee stiffness model, the duration of traction treatment is mostly 20–40 min; however, relativel...
Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain
Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain
Transplantation of induced pluripotent stem cell-derived neural cells represents a promising strategy for treating neurode...
Exosomes derived from hypoxic mesenchymal stem cells restore ovarian function by enhancing angiogenesis
Exosomes derived from hypoxic mesenchymal stem cells restore ovarian function by enhancing angiogenesis
hucMSC-exosomes can be engineered to strengthen their therapeutic potential, and the present study aimed to explore whethe...
A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia
A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia
Allo-HSCT is a curative therapy for patients with transfusion-dependent thalassemia (TDT). The high incidence of transplan...
Multiomics analyses reveal adipose-derived stem cells inhibit the inflammatory response of M1-like macrophages through secreting lactate
Multiomics analyses reveal adipose-derived stem cells inhibit the inflammatory response of M1-like macrophages through secreting lactate
Adipose-derived stem cells (ADSCs) are widely used in the field of regenerative medicine because of their various function...
Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases
Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases
Neural stem cells (NSCs) have increasingly been recognized as the most promising candidates for cell-based therapies for t...
Time-efficient strategies in human iPS cell-derived pancreatic progenitor differentiation and cryopreservation: advancing towards practical applications
Time-efficient strategies in human iPS cell-derived pancreatic progenitor differentiation and cryopreservation: advancing towards practical applications
Differentiation of patient-specific induced pluripotent stem cells (iPS) helps researchers to study the individual sensibi...
Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis
Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a type of interstitial lung disease characterized by chronic inflammation due to pe...
Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes
Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes
Mesenchymal stem cells (MSCs) have shown a great potential role in treating liver injury. MSCs can promote liver regenerat...
Dynamic three dimensional environment for efficient and large scale generation of smooth muscle cells from hiPSCs
Dynamic three dimensional environment for efficient and large scale generation of smooth muscle cells from hiPSCs
Chronic ischemic limb disease often leads to amputation, which remains a significant clinical problem. Smooth-muscle cells...
Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced-intensity conditioning: a double-blind randomized study and literature review
Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced-intensity conditioning: a double-blind randomized study and literature review
Mesenchymal stromal cells (MSC) have immunomodulatory and hematopoiesis-supporting properties that could potentially benef...
Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations
Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations
Mesenchymal stem cells (MSCs) derived from gestational tissues offer a promising avenue for prenatal intervention in conge...
Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model
Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model
Patient-derived induced pluripotent stem cell (iPSCs) represents a powerful tool for elucidating the underlying disease me...
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