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MiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury
MiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury
Sulfur mustard (SM) is a highly toxic chemical warfare agent that has caused numerous casualties during wars and conflicts...
Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway
Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway
Exosomes play important roles in intercellular communication by delivering microRNAs (miRNAs) that mediate tumor initiatio...
Intravenous injection of human umbilical cord-derived mesenchymal stem cells ameliorates not only blood glucose but also nephrotic complication of diabetic rats through autophagy-mediated anti-senescent mechanism
Intravenous injection of human umbilical cord-derived mesenchymal stem cells ameliorates not only blood glucose but also nephrotic complication of diabetic rats through autophagy-mediated anti-senescent mechanism
Diabetic nephropathy (DN) is one of the most severe complications of diabetes mellitus, which is characterized by early oc...
Human umbilical cord mesenchymal stem cell treatment alleviates symptoms in an atopic dermatitis-like mouse model
Human umbilical cord mesenchymal stem cell treatment alleviates symptoms in an atopic dermatitis-like mouse model
Atopic dermatitis (AD) is one of the most common immune and inflammatory skin disorders, leading to insufferable itching a...
Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status
Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status
Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of t...
Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells
Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells
Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potent...
MSCs’ conditioned media cytokine and growth factor profiles and their impact on macrophage polarization
MSCs’ conditioned media cytokine and growth factor profiles and their impact on macrophage polarization
There is a growing body of evidence that multipotent mesenchymal stromal cells’ (MSCs’) remarkable therapeutic...
Cell therapy in end-stage liver disease: replace and remodel
Cell therapy in end-stage liver disease: replace and remodel
Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50% or more. Although liver transp...
Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation
Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation
Metformin as a first-line clinical anti-diabetic agent prolongs the lifespan of model animals and promotes cell proliferat...
An optimized force-triggered density gradient sedimentation method for isolation of pelage follicle dermal papilla cells from neonatal mouse skin
An optimized force-triggered density gradient sedimentation method for isolation of pelage follicle dermal papilla cells from neonatal mouse skin
The dermal papilla cells are a specialized population of mesenchymal cells located at the base of the hair follicle (HF), ...
Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases
Potential advantages of genetically modified mesenchymal stem cells in the treatment of acute and chronic liver diseases
Liver damage caused by toxicity can lead to various severe conditions, such as acute liver failure (ALF), fibrogenesis, an...
Immortalized erythroid cells as a novel frontier for in vitro blood production: current approaches and potential clinical application
Immortalized erythroid cells as a novel frontier for in vitro blood production: current approaches and potential clinical application
Blood transfusions represent common medical procedures, which provide essential supportive therapy. However, these procedu...
Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model
Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model
Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying...
Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation
Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation
Intrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is ...
Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway
Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway
Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied by cerebral edema, inflammation, and subseque...
Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration
Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration
Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3), a secreted multifunctional glycoprotein whose transcript expr...
CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration
CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration
Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat live...
Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
Electromagnetic fields (EMF) are increasing in popularity as a safe and non-invasive therapy. On the one hand, it is widel...
Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model
Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model
Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very ...
Correction: Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
Correction: Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Comparison of therapeutic effects of mesenchymal stem cells derived from superficial and deep subcutaneous adipose tissues
Comparison of therapeutic effects of mesenchymal stem cells derived from superficial and deep subcutaneous adipose tissues
Fibrosis is a common histological feature in the process from chronic organ injury to organ failure. Chronic tissue injury...
Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury
Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury
Considering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the sear...
Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells
Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells
In vertebrates, hematopoietic stem and progenitor cells (HSPCs) emerge from hemogenic endothelium in the floor of the dors...
Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida
Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida
To evaluate the safety and efficacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neuro...
PDGFBB improved the biological function of menstrual blood-derived stromal cells and the anti-fibrotic properties of exosomes
PDGFBB improved the biological function of menstrual blood-derived stromal cells and the anti-fibrotic properties of exosomes
Intrauterine adhesion (IUA) is a reproductive dysfunction disease characterized by endometrial fibrosis, with limited ther...
The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, le...
In vitro erythrocyte production using human-induced pluripotent stem cells: determining the best hematopoietic stem cell sources
In vitro erythrocyte production using human-induced pluripotent stem cells: determining the best hematopoietic stem cell sources
Blood transfusion is an essential part of medicine. However, many countries have been facing a national blood crisis. To a...
Effects of hormones on intestinal stem cells
Effects of hormones on intestinal stem cells
The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs), which can also contribute...
Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones
Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones
CRISPR/Cas9 editing systems are currently used to generate mutations in a particular gene to mimic a genetic disorder in v...
Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy
Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an incurable genetic disease characterized by degeneration and necrosis of myofibers,...
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