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Matrix-free human pluripotent stem cell manufacturing by seed train approach and intermediate cryopreservation
Matrix-free human pluripotent stem cell manufacturing by seed train approach and intermediate cryopreservation
Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be...
Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3
Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3
Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) in...
Adipose-derived stem cell-based optimization strategies for musculoskeletal regeneration: recent advances and perspectives
Adipose-derived stem cell-based optimization strategies for musculoskeletal regeneration: recent advances and perspectives
Musculoskeletal disorders are the leading causes of physical disabilities worldwide. The poor self-repair capacity of musc...
Identification of potential biomarkers for aging diagnosis of mesenchymal stem cells derived from the aged donors
Identification of potential biomarkers for aging diagnosis of mesenchymal stem cells derived from the aged donors
The clinical application of human bone-marrow derived mesenchymal stem cells (MSCs) for the treatment of refractory diseas...
Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia
Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia
Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of chemotherapy, with an estimated incidence of 65% an...
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
Human corneal endothelial cells lack regenerative capacity through cell division in vivo. Consequently, in the case of tra...
Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for u...
Cholangiocyte organoids to study drug-induced injury
Cholangiocyte organoids to study drug-induced injury
Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. ...
Short cell cycle duration is a phenotype of human epidermal stem cells
Short cell cycle duration is a phenotype of human epidermal stem cells
A traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter...
Pre-clinical evaluation of the efficacy and safety of human induced pluripotent stem cell-derived cardiomyocyte patch
Pre-clinical evaluation of the efficacy and safety of human induced pluripotent stem cell-derived cardiomyocyte patch
Cell- or tissue-based regenerative therapy is an attractive approach to treat heart failure. A tissue patch that can safel...
Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome
Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome
Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing ...
PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties
PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties
Initially discovered for its ability to regenerate ear holes, the Murphy Roth Large (MRL) mouse has been the subject of mu...
Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro
Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro
A significant unmet need in inflammatory bowel disease is the lack of anti-fibrotic agents targeting intestinal fibrosis. ...
Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral ...
Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research
Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research
Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating th...
Oxidized SOD1 accelerates cellular senescence in neural stem cells
Oxidized SOD1 accelerates cellular senescence in neural stem cells
Neural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible pro...
Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection
Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection
Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT ...
Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site
Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site
Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment o...