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The effect of TLR3 priming conditions on MSC immunosuppressive properties
The effect of TLR3 priming conditions on MSC immunosuppressive properties
Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory properties, making them suitable for cell therapy....
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed ...
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have sho...
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible ...
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable econo...
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease mod...
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new appr...
Bright ferritin for long-term MR imaging of human embryonic stem cells
Bright ferritin for long-term MR imaging of human embryonic stem cells
A non-invasive imaging technology that can monitor cell viability, retention, distribution, and interaction with host tiss...
The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway
The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway
Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylh...
Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of...
Quality management overview for the production of a tissue-engineered human skin substitute in Malaysia
Quality management overview for the production of a tissue-engineered human skin substitute in Malaysia
Treatments for skin injuries have recently advanced tremendously. Such treatments include allogeneic and xenogeneic transp...
Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
Natural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availabilit...
Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics
Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics
Peritoneal fibrosis (PF) is a pathophysiological condition caused by a variety of pathogenic factors. The most important f...