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Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19
Coronavirus disease (COVID-19) begins with upper airway symptoms but proceeds in a significant proportion of patients to l...
Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development
Pulmonary hypertension (PH) is a multifaceted condition characterized by elevated pulmonary arterial pressure, which can r...
CXCL14 Protects against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages
Rapid and effective control of bacterial infection is critical for the treatment of bacterial sepsis. CXCL14 (CXC motif li...
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice
Ozone (O3)-induced respiratory toxicity varies considerably within the human population and across inbred mouse strains, i...
PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells
G protein–coupled receptors (GPCRs) not only are turned on or off to control canonical G protein signaling but also may be...
m6A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling induced by human pulmonary arteria...
Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma
Activation of IL-4R (IL-4 receptor) signaling in airway epithelial cells leads to airway hyperresponsiveness and mucus ove...
The Role of Glutathione Reductase in Influenza Infection
Influenza infection induces lung epithelial cell injury via programmed cell death. Glutathione, a potent antioxidant, has ...
New Insights Relating Gasdermin B to the Onset of Childhood Asthma
Chromosome 17q12-q21 is the most replicated genetic locus for childhood-onset asthma. Polymorphisms in this locus containi...
Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization
Asthma is a common respiratory disease characterized, in part, by excessive airway smooth muscle (ASM) contraction (airway...
A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH
"A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH." American Journal of Respiratory Cell and Molecular Bio...
Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury
CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, con...
BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts
Fibroblasts play a central role in the lung fibrotic process. Our recent study identified a novel subpopulation of lung fi...
WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia
In cystic fibrosis (CF), reduced HCO3− secretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts hos...
A Deep Intronic, Pathogenic Variant in DNAH11 Causes Primary Ciliary Dyskinesia
"A Deep Intronic, Pathogenic Variant in DNAH11 Causes Primary Ciliary Dyskinesia." American Journal of Respiratory Cell an...
Cardiac and Pulmonary Vascular Dysfunction in Vitamin D–Deficient Bmpr2-Mutant Rats
"Cardiac and Pulmonary Vascular Dysfunction in Vitamin D–Deficient Bmpr2-Mutant Rats." American Journal of Respiratory Cel...
COVID-19 and Long-Term Outcomes: Lessons from Other Critical Care Illnesses and Potential Mechanisms
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that is currently causing a pandemic a...
Kasugamycin Is a Novel Chitinase 1 Inhibitor with Strong Antifibrotic Effects on Pulmonary Fibrosis
Pulmonary fibrosis is a devastating lung disease with few therapeutic options. CHIT1 (chitinase 1), an 18 glycosyl hydrola...
Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection
The lung epithelium forms the first barrier against respiratory pathogens and noxious chemicals; however, little is known ...
Suppression of Allergic Asthma by Loss of Function of Miz1-mediated Th1 Skewing
Asthma is the most prevalent chronic respiratory disease worldwide. There is currently no cure, and it remains an importan...
Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis
As shown in our previous studies, the intratracheal-administration of STC1 (stanniocalcin-1) ameliorates pulmonary fibrosi...
Recessive Mutations in CFAP74 Cause Primary Ciliary Dyskinesia with Normal Ciliary Ultrastructure
Supported by grants from the Deutsche Forschungsgemeinschaft (DFG OM6/7, OM6/8, OM6/10, OM6/14, OM6/16, and CRU 326 [subpr...
TLR7 Mediates Acute Respiratory Distress Syndrome in Sepsis by Sensing Extracellular miR-146a
TLR7 (Toll-like receptor 7), the sensor for single-stranded RNA, contributes to systemic inflammation and mortality in mur...