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Landscape of mast cell populations across organs in mice and humans
Combining whole-tissue imaging and single-cell RNA sequencing datasets, Tauber et al. present a pan-organ analysis of mast...
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
Petersone et al. investigate IL-21–dependent germinal center (GC) regulation and reveal key roles for IL-21 in promoting l...
Type I interferons drive MAIT cell functions against bacterial pneumonia
This report identifies a central role for type I interferons in governing the activation and effector functions of murine ...
Thymic mimicry: The art of imitation
Michelson and colleagues continue to advance our understanding of self-antigen representation by medullary thymic epitheli...
An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment
Oncolytic viruses induce tumor lysis and inflame the tumor microenvironment but do not relieve immunosuppressive signals. ...
Targeting helminths: The expanding world of type 2 immune effector mechanisms
Maizels and Gause review advances in type 2 immunity in the setting of helminth worm infections, in the skin, lung, and in...
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1
In this issue of JEM, companion articles from Pinilla et al. and Robinson et al. demonstrate that ribotoxic stress induced...
EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption
Here, Pinilla and colleagues address the ability of the human NLRP1 inflammasome-forming sensor to detect translation inac...
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path
Nina Cabezas Wallscheid is a group leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, German...
Women in STEM becoming independent: Great mentors make all the difference
In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and th...
PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer
The authors use single-cell RNA-sequencing and TCR tracking to analyze blood and tumors from breast and ovarian cancer pat...
Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
Petkova et al. identify a new Ptx3-positive immune-interacting subtype of lymphatic endothelial cells, iLECs, that drive o...
Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection
Collaboration between myeloid and lymphoid lineages on hematopoiesis has not been fully elucidated. Here, we showed that d...
Macrophages promote anti-androgen resistance in prostate cancer bone disease
New mechanism of macrophage-driven therapy resistance of metastatic prostate cancer with high ECM expression and SRC activ...
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression
Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice ...
Macrophages and bone metastasis
Macrophages activate a cascade to drive anti-androgen therapy resistance in the prostate bone metastasis microenvironment.
Targeting type 2 immunity and the future of food allergy treatment
There is growing appreciation of the heterogeneity of type 2 immunity in food allergy and how type 2 cytokines from distin...
Tingible body macrophages: Gargantuan chameleons of the germinal center
Tingible body macrophages in lymph node clear apoptotic B cell debris. Gurwisz et al. and Grootveld et al. report how ting...
The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination
Studies of novel RAG1 N-terminal region mutants reveal a role for the first 215 amino acids in establishing the balance be...
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Mantle cell lymphoma (MCL) is an incurable aggressive B cell lymphoma for which mouse models are currently lacking. Pieter...
Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation
In response to bacterial inflammation, hepatic fibroblast growth factor 21 (FGF21), an endocrine hormone that mediates ada...
CD4 + T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope
We identify a peptide derived from Aspergillus nidulans recognized by CD4+ T cells derived from the lungs of Löfgren’s syn...
Correction: Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs
Vol. 218, No. 10 | 10.1084/jem.20211211 | August 6, 2021
Single-cell imaging of T cell immunotherapy responses in vivo
Xenograft cancer studies using rag2Δ/Δ, il2rga−/− zebrafish allow facile, single-cell imaging of T cell–mediated tumor kil...
MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites
MERTK signaling in mononuclear phagocytes drives T cell regulation at inflammatory disease sites in peripheral tissues. ME...
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
Remyelination requires the clearance of cholesterol-rich myelin debris within demyelinating lesions by phagocytes. Gouna e...
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells
Single-cell RNA sequencing of human follicular dendritic cells (FDCs) provides insights in germinal center biology and enh...
The early interferon catches the SARS-CoV-2
Interferon responses in the nasopharyngeal epithelium are critical to prevent severe COVID-19. Epithelial cells alone are ...
JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy
This work shows that JAML–CXADR interactions promote γδ T cell activation and limit CD8 T cell dysfunction within the tumo...
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth
This study identifies AT2s as the relevant source of GM-CSF for the development and maintenance of alveolar macrophages. D...
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