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The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination
Studies of novel RAG1 N-terminal region mutants reveal a role for the first 215 amino acids in establishing the balance be...
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Mantle cell lymphoma (MCL) is an incurable aggressive B cell lymphoma for which mouse models are currently lacking. Pieter...
Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation
In response to bacterial inflammation, hepatic fibroblast growth factor 21 (FGF21), an endocrine hormone that mediates ada...
CD4 + T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope
We identify a peptide derived from Aspergillus nidulans recognized by CD4+ T cells derived from the lungs of Löfgren’s syn...
Single-cell imaging of T cell immunotherapy responses in vivo
Xenograft cancer studies using rag2Δ/Δ, il2rga−/− zebrafish allow facile, single-cell imaging of T cell–mediated tumor kil...
MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites
MERTK signaling in mononuclear phagocytes drives T cell regulation at inflammatory disease sites in peripheral tissues. ME...
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
Remyelination requires the clearance of cholesterol-rich myelin debris within demyelinating lesions by phagocytes. Gouna e...
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells
Single-cell RNA sequencing of human follicular dendritic cells (FDCs) provides insights in germinal center biology and enh...
The early interferon catches the SARS-CoV-2
Interferon responses in the nasopharyngeal epithelium are critical to prevent severe COVID-19. Epithelial cells alone are ...
JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy
This work shows that JAML–CXADR interactions promote γδ T cell activation and limit CD8 T cell dysfunction within the tumo...
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth
This study identifies AT2s as the relevant source of GM-CSF for the development and maintenance of alveolar macrophages. D...
Imatinib augments standard malaria combination therapy without added toxicity
The coadministration of imatinib with standard of care (dihydroartemisinin plus piperaquine) to P. falciparum malaria pati...
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells
The mechanism controlling lineage commitment in early hematopoiesis is unclear. Cova et al. show that the Helios transcrip...
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome
CAPS is an IL-1β–mediated autoinflammatory disease due to gain-of-function mutations in NLRP3. This work shows that skin-i...
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
TB results in 1.5 million deaths per year, yet a low percentage of M. tuberculosis–infected individuals progress to TB. Kn...
Alveolar macrophages and epithelial cells: The art of living together
In this issue of JEM, Gschwend et al. reveal the indispensable role of alveolar epithelial cells type 2 in controlling the...
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
The present study shows in murine models that autoimmunity, which targets normal cholangiocytes upon primary biliary chola...
A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
A peptide derived from the airborne mold species Aspergillus nidulans that stimulates T cells of Löfgren's syndrome patien...
Takes one to B1a: Dismantling the origin of mantle cell lymphoma
Pieters et al. establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a c...
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma
Vendramin et al. demonstrate that the integrated stress response in melanoma promotes cell plasticity and drives therapy r...
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion
The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully il...
The immunodominant antibody response to Zika virus NS1 protein is characterized by cross-reactivity to self
Using an immunocompetent mouse model of ZIKV infection, Cavazzoni et al. describe an immunodominant anti-NS1 humoral respo...
Functional immune cell–astrocyte interactions
Astrocytes are glial cells of the central nervous system (CNS) that are strategically positioned to control CNS immunity i...
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?
scRNA-seq analyses of microglial responses to AD pathology in patients and mouse models have provided fundamental insights...
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung
Through scRNA-seq and ATAC-seq, Pisu et al. characterize specific lung macrophage subsets that either restrict or promote ...
ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses
hnRNPC prevents release of inverted-repeat Alu double-stranded RNA into the cytosol by masking cryptic splice sites. Herzn...
Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10
Mowat et al. show that anti-tumor immunity in dMMR CRCs relies on recruitment and retention of systemic CD8+ T cells. This...
Epigenetic and transcriptional control of interferon-β
Here, we will summarize the historical and current understanding of the stepwise assembly and function of factors that reg...
Translation from bats to humans beyond infectious diseases
Ahn and Wang discuss the translational potential of the bat model for treating human diseases.