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Sclerostin inhibition in rare bone diseases: Molecular understanding and therapeutic perspectives
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Wnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review
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Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis
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Comparative effect of skeletal stem cells versus bone marrow mesenchymal stem cells on rotator cuff tendon-bone healing
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Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head
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XAF1 promotes osteoclast apoptosis by antagonizing the XIAP-caspase axis
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Aging and musculoskeletal health
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SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathway
SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathway
Volume 46, May 2024, Pages 116-128Author links open overlay panel, , , , , , , , AbstractObjectivesSPARCL1 is a matricellu...
Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review
Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review
The neuromuscular junction (NMJ) is a specialized chemical synapse that converts neural impulses into muscle action. Age-a...
YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritis
YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritis
BackgroundThe cartilage stem/progenitor cells (CSPC) play a critical role in maintaining cartilage homeostasis. However, t...
l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy
l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy
Volume 46, May 2024, Pages 53-64Author links open overlay panel, , , , , , , , , , , AbstractBackgroundOsteoporosis is one...
Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis
Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis
Volume 46, May 2024, Pages 33-45Author links open overlay panel, , , , , , , , , AbstractSmoking continues to pose a globa...
Basic research is the foundation and driving force for clinical translation
Basic research is the foundation and driving force for clinical translation
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Knee osteoarthritis pendulum therapy: In vivo evaluation and a randomised, single-blind feasibility clinical trial
Knee osteoarthritis pendulum therapy: In vivo evaluation and a randomised, single-blind feasibility clinical trial
BackgroundExercise is recommended as the first-line management for knee osteoarthritis (KOA); however, it is difficult to ...
Time trends in the burden of low back pain and its associated risk factors in China from 1990 to 2019
Time trends in the burden of low back pain and its associated risk factors in China from 1990 to 2019
BackgroundFrom 1990 to 2019, low back pain (LBP) was the leading cause of years lived with disability (YLDs) in China. How...
Therapeutic potential of a prominent dihydroxyflavanone pinocembrin for osteolytic bone disease: In vitro and in vivo evidence
Therapeutic potential of a prominent dihydroxyflavanone pinocembrin for osteolytic bone disease: In vitro and in vivo evidence
Background/objectiveAs the pivotal cellular mediators of bone resorption and pathological bone remodeling, osteoclasts hav...
IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis
IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis
BackgroundOsteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of joint cartilage and underl...
Salivary nitrate prevents osteoporosis via regulating bone marrow mesenchymal stem cells proliferation and differentiation
Salivary nitrate prevents osteoporosis via regulating bone marrow mesenchymal stem cells proliferation and differentiation
BackgroundNitrate, a key component of saliva, has been shown widely physiological functions in the human body. But its fun...