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Learning from cancer mutations
T cell lymphomas acquire mutations that endow them with advantages to endure the immunosuppressive tumor microenvironment....
Complement profile
Severe COVID-19 has been associated with complement activation, hypercoagulation and vascular injury. In Science, Cervia-H...
Surface RNAs move neutrophils
RNAs have been detected on the outer surface of mammalian cells, including some with glycan modifications known as glycoRN...
What Jane Jacobs has taught me about neuroimmunology
What Jane Jacobs has taught me about neuroimmunology
In acknowledgment of Women’s History Month, I have drawn upon timeless concepts from Jane Jacobs’ seminal 1961...
Opening the doors of opportunity
Opening the doors of opportunity
Breakdown barriers that make you hesitate from challenging yourself, and jump into new fields that interest you.
Neuroimmunology, women scientists and dogma
Neuroimmunology, women scientists and dogma
Reflecting on the decision to become a neuroimmunologist, and the women mentors who taught me how to challenge dogma in al...
Marching forward in neuroimmunology
As part of Women’s History Month, we are celebrating the contributions of women who stand at the crossroads of immun...
Alterations of iron homeostasis as a potential druggable driver of long COVID
Alterations of iron homeostasis as a potential druggable driver of long COVID
Drivers of persistent symptoms after acute COVID-19 remain largely unknown. Alterations in immune function, iron homeostas...
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
The immune system comprises diverse specialized cell types that cooperate to defend the host against a wide range of patho...
A repair pathway lost in multiple sclerosis provides a new drug opportunity
A repair pathway lost in multiple sclerosis provides a new drug opportunity
A study identifies an increase in the tissue-protective factor HB-EGF during the initial stage of multiple sclerosis (MS),...
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing atte...
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflam...
A mechanism for BCG vaccine cross-protection against pulmonary viral infections
A mechanism for BCG vaccine cross-protection against pulmonary viral infections
Bacillus Calmette–Guérin (BCG) is the only available vaccine against tuberculosis. As well as being an effectiv...
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus
In this study, we developed an adenoviral-vectored vaccine that targets the spike protein of BA.5 Omicron SARS-CoV-2. When...
Reactivating antitumor immunity by inhibiting JMJD1C
Reactivating antitumor immunity by inhibiting JMJD1C
Intratumoral regulatory T (Treg) cells can suppress antitumor immunity. Unlike in splenic Treg cells, the H3K9me2 demethyl...
Adipose Treg cells in charge of metabolism
Adipose Treg cells in charge of metabolism
Visceral adipose tissue hosts at least two populations of mature FOXP3+ regulatory T cells, which together can preserve sy...
IL-23 stabilizes an effector Treg cell program in the tumor microenvironment
IL-23 stabilizes an effector Treg cell program in the tumor microenvironment
Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in variou...
Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity
Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity
Regulatory T (Treg) cells are critical for immune tolerance but also form a barrier to antitumor immunity. As therapeutic ...
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism
Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (Tre...
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Susanna S. Ng & Dillon CorvinoPresent address: Institute of Experimental Oncology, Medical Faculty, University Hospita...
Publisher Correction: The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+T cell fates
These authors contributed equally: Xin Zhao, Wei Hu, Sung Rye Park, Shaoqi Zhu.Center for Discovery and Innovation, Hacken...
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and...
A new step in understanding mouse cDC ontogeny
A new step in understanding mouse cDC ontogeny
Understanding the ontogeny of conventional dendritic cells (cDCs) is a major aim in the field. The fate of progenitors of ...
Distinct ontogenetic lineages dictate cDC2 heterogeneity
Distinct ontogenetic lineages dictate cDC2 heterogeneity
Conventional dendritic cells (cDCs) include functionally and phenotypically diverse populations, such as cDC1s and cDC2s. ...
Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection
Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection
A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (C...
Working towards diversity in the immunology research community
Many immunologists strongly support the drive for inclusion and diversity in the workplace, but factors beyond their contr...
Mapping brain–immune interactions in ischemic stroke
Mapping brain–immune interactions in ischemic stroke
The development of therapies for ischemic stroke requires a deep understanding of the immune response to injury. Analysis ...
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a...