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Functional analysis of NLRP3 variants provides insight into inflammasome regulation
Functional analysis of NLRP3 variants provides insight into inflammasome regulation
Automated functional profiling of all natural NLRP3 variants accelerates the diagnosis of NLRP3-associated inflammatory di...
Functional signatures and activation mechanisms of effector γδ T cell subsets
Functional signatures and activation mechanisms of effector γδ T cell subsets
Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals...
Systems neuroimmunology: current bottlenecks, research priorities and future directions
Systems neuroimmunology: current bottlenecks, research priorities and future directions
Strategies to advance the field of neuroimmunology by embracing its complexity via inclusion of its multidisciplinary prop...
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors
Metabolite-sensing G protein-coupled receptors act as critical signaling hubs that connect metabolism to immunity in cance...
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
The NLRP3 inflammasome is a multiprotein complex that mediates caspase-1 activation and the release of proinflammatory cyt...
Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
These authors contributed equally: Nargis Khan, Kim A. Tran.Department of Medicine, Department of Pathology, Department of...
Insights into autoimmunity and cancer
Insights into autoimmunity and cancer
In December 2024, the NIH Office of Autoimmune Disease Research in the Office of Research on Women’s Health (OADR-OR...
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existen...
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
Regulatory T (Treg) cells are a specialized CD4+ T cell lineage with essential anti-inflammatory functions. Analysis...
Human versus mouse PD-1
Engagement of the immune checkpoint receptor PD-1 by its ligand PD-L1 triggers recruitment and activation of the phosphata...
Exhaustion is planned
CD8+ T cell exhaustion has been thought to occur only in the context of chronic antigen persistence, such as in cancer or ...
Recruiting lymphocytes
Circulating naive lymphocytes are recruited from the blood to homeostatic lymph nodes (LNs) by the chemokines CCL19 and CC...
Tolerance during infection
Antigen-presenting cells (APCs) in the intestine maintain the delicate balance between the induction of immunity against i...
A symphony of immunity to SARS-CoV-2 in the adenoids
A symphony of immunity to SARS-CoV-2 in the adenoids
Lymphoid tissues in the upper respiratory tract contain immune cells that are crucial for local immunity. An analysis of a...
Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge
Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge
Adaptive immunity is generated in lymphoid organs, but how these structures defend themselves during infection in humans i...
Nutrient metabolism shapes epigenetic landscape of T cells
Nutrient metabolism shapes epigenetic landscape of T cells
CD8+ T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for t...
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses
Allergic diseases are common and affect a large proportion of the population. Interleukin-13 (IL-13)-expressing follicular...
Evasion of T cell responses by newly emerging SARS-CoV-2 variants
Evasion of T cell responses by newly emerging SARS-CoV-2 variants
We describe how newly emerging mutations in the SARS-CoV-2 variant BA.2.86 sub-variant JN.1 contribute to evasion of CD8+ ...
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots
Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, ...
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs
Mucosal antigen-specific T cells are pivotal for pathogen clearance and immune modulation in respiratory infections. Dysre...
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa
Cell-type-specific SARS-CoV-2-induced responses in nasal mucosa differ largely between ancestral, Delta and Omicron cases,...
Single-cell profiling of the immune landscape across the human lifespan
Single-cell profiling of the immune landscape across the human lifespan
Using a combination of single-cell RNA sequencing, T cell and B cell receptor sequencing, and mass cytometry analyses, we ...
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
A comprehensive understanding of the evolution of the immune landscape in humans across the entire lifespan at single-cell...
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) ...
Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity
Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity
Using a novel human tonsil immune organoid system, Chen et al. demonstrate that by controlling autoreactive humoral and ce...
ImmunOctoberfest reloaded
ImmunOctoberfest reloaded
On 23–26 September 2024, the second ImmunOctoberfest conference took place in Raitenhaslach, Germany, and brought to...
NIAID workshop on infections and autoimmune diseases
NIAID workshop on infections and autoimmune diseases
On 11–12 September 2024, the National Institute of Allergy and Infectious Diseases (NIAID) convened experts to discu...
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity ...
Intestinal microbiome metabolites control sepsis outcome
Intestinal microbiome metabolites control sepsis outcome
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites...
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