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Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells
The mechanisms underlying the efficacy of anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-asso...
Pyroptotic corpses are flagged by filopodia to alert dendritic cells
Pyroptotic corpses are flagged by filopodia to alert dendritic cells
Inflammasomes induce pyroptosis and, through poorly defined mechanisms, promote adaptive immune responses. High-resolution...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
While apoptosis dismantles the cell to enforce immunological silence, pyroptotic cell death provokes inflammation. Little ...
Publisher Correction: Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USAC...
Author Correction: Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
These authors contributed equally: Ruoyan Li, Johanna Strobl, Elizabeth F. M. Poyner, Aya Balbaa.Wellcome Sanger Institute...
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Effective anti-tumor immunity is driven by cytotoxic CD8+ T cells with specificity for tumor antigens. However, the ...
Pregnancy stress
Retrotransposons are transposable DNA elements that in hematopoietic stem cells (HSC) can be activated by aging, irradiati...
IL-4 promotes immunotherapy resistance
Ovarian cancer has high clonal heterogeneity and an immunosuppressed tumor microenvironment (TME) that contribute to resis...
TH1 responses in type 2 diabetes
Type 2 diabetes (T2D) increases the risk of complications during respiratory viral infections and individuals with T2D fai...
The brain tames autoimmunity
The blood–brain barrier was once thought to prevent the peripheral immune system interacting with the central nervous syst...
3D imaging of the synovium defines an immune defense system at the blood–joint barrier
3D imaging of the synovium defines an immune defense system at the blood–joint barrier
Circulating immune stimuli access the joint through fenestrated capillaries that are located at the outer edge of the syno...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inf...
Next-generation combination approaches for immune checkpoint therapy
Next-generation combination approaches for immune checkpoint therapy
Immune checkpoint therapy has revolutionized cancer treatment, leading to dramatic clinical outcomes for a subset of patie...
The diverse roles of neutrophils from protection to pathogenesis
The diverse roles of neutrophils from protection to pathogenesis
Neutrophil granulocytes are the most abundant leukocytes in the blood and constitute a critical arm of innate immunity. Th...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also...
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
The type 2 cytokines, interleukin (IL)-4, IL-13 and IL-5 reside within a multigene cluster. Both innate (ILC2) and adaptiv...
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an o...
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
Vaccination with self- and foreign peptides induces weak and strong expansion of antigen-specific CD4+ T cells, respective...
Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Author notesThese authors contributed equally: Marko Šestan, Inga Kavazović.Authors and AffiliationsDepartment of Histolog...
B cells infiltrate cutaneous T cell lymphomas
B cells infiltrate cutaneous T cell lymphomas
Cutaneous T cell lymphoma is a rare, difficult to diagnose malignancy of T cells. Malignant T cells, together with populat...
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The mos...
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised in...
Immune drivers of pain resolution and protection
Immune drivers of pain resolution and protection
Immune cells are involved in the pathogenesis of pain by directly activating or sensitizing nociceptor sensory neurons. Ho...
Nanotech unveils cytokine traces in post-COVID cardiovascular complications
Nanotech unveils cytokine traces in post-COVID cardiovascular complications
Trace levels of circulating cytokines correlate with the prevalence of cardiovascular symptoms following COVID-19.
Lactate fermentation intoxicates TILs
Lactate fermentation intoxicates TILs
Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunctio...
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
CD8+ T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell ex...
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovati...
Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
We generated a mouse model to investigate the mechanistic basis of inborn errors of immunity caused by heterozygous BCL11B...
COQ6 defies immune and metabolic expectations
COQ6 defies immune and metabolic expectations
A COQ6 variant increases susceptibility to pneumococcal infection via non-bone marrow-derived cells without affecting ubiq...
Involuted TLS as a harbinger of HCC regression
Involuted TLS as a harbinger of HCC regression
Tertiary lymphoid structures (TLS) have different stages and cellular compositions in human tumors. New data are showing t...
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