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Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus
Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus
Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains ev...
Mapping human hematopoiesis
Mapping human hematopoiesis
Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into h...
cGAS meets its demise in the nucleus
cGAS meets its demise in the nucleus
DNA sensing for the purposes of innate immunity is tricky when the DNA sensor can easily become stuck on chromosomes durin...
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell
These authors contributed equally: Yulong Gao, Fernando Souza-Fonseca-Guimaraes.Immunology in Cancer and Infection, QIMR B...
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cell...
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized mul...
International nomenclature guidelines for the IL-1 family of cytokines and receptors
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USAJoseph M. Gaballa, Jesper Falkesgaa...
A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); howev...
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules
Granulosomes are novel complexes that feature an unexpected partnership between the tetraspanin CD63 and the inflammasome ...
Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components
Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components
The inflammasome components NLRP3 and ASC are cytosolic proteins, which upon sensing endotoxins or danger cues, form multi...
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging v...
Author Correction: The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
Author Correction: The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
Author notesDelphine Galiana-ArnouxPresent address: Institute of Functional Genomics of Lyon–Unités Mixtes de Recherche 52...
The power of memory T cells minus antibodies
The power of memory T cells minus antibodies
T cell- and antibody-based immunological protection are generally considered to function together, but data now show how T...
Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression
Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression
Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus, present in up to 80% of...
Learning from cancer mutations
T cell lymphomas acquire mutations that endow them with advantages to endure the immunosuppressive tumor microenvironment....
Complement profile
Severe COVID-19 has been associated with complement activation, hypercoagulation and vascular injury. In Science, Cervia-H...
Surface RNAs move neutrophils
RNAs have been detected on the outer surface of mammalian cells, including some with glycan modifications known as glycoRN...
What Jane Jacobs has taught me about neuroimmunology
What Jane Jacobs has taught me about neuroimmunology
In acknowledgment of Women’s History Month, I have drawn upon timeless concepts from Jane Jacobs’ seminal 1961...
Opening the doors of opportunity
Opening the doors of opportunity
Breakdown barriers that make you hesitate from challenging yourself, and jump into new fields that interest you.
Neuroimmunology, women scientists and dogma
Neuroimmunology, women scientists and dogma
Reflecting on the decision to become a neuroimmunologist, and the women mentors who taught me how to challenge dogma in al...
Marching forward in neuroimmunology
As part of Women’s History Month, we are celebrating the contributions of women who stand at the crossroads of immun...
Alterations of iron homeostasis as a potential druggable driver of long COVID
Alterations of iron homeostasis as a potential druggable driver of long COVID
Drivers of persistent symptoms after acute COVID-19 remain largely unknown. Alterations in immune function, iron homeostas...
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
The immune system comprises diverse specialized cell types that cooperate to defend the host against a wide range of patho...
A repair pathway lost in multiple sclerosis provides a new drug opportunity
A repair pathway lost in multiple sclerosis provides a new drug opportunity
A study identifies an increase in the tissue-protective factor HB-EGF during the initial stage of multiple sclerosis (MS),...
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing atte...
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflam...
A mechanism for BCG vaccine cross-protection against pulmonary viral infections
A mechanism for BCG vaccine cross-protection against pulmonary viral infections
Bacillus Calmette–Guérin (BCG) is the only available vaccine against tuberculosis. As well as being an effectiv...
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus
In this study, we developed an adenoviral-vectored vaccine that targets the spike protein of BA.5 Omicron SARS-CoV-2. When...