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Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity ...
Intestinal microbiome metabolites control sepsis outcome
Intestinal microbiome metabolites control sepsis outcome
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites...
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independ...
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
These authors contributed equally: Susan Pereira Ribeiro, Zachary Strongin.Deceased: Timothy Hoang.These authors jointly s...
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increas...
Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses
Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses
Here we analyzed the relative contributions of CD4+ regulatory T cells expressing Forkhead box protein P3 (FOXP3) and CD8+...
Low-avidity T cells drive endogenous tumor immunity in mice and humans
Low-avidity T cells drive endogenous tumor immunity in mice and humans
T cells recognize neoepitope peptide-major histocompatibility complex class I on cancer cells. The strength (or avidity) o...
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs
Hematopoietic stem cells must mitigate myriad stressors throughout their lifetime to ensure normal blood cell generation. ...
Retraction Note: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ
These authors contributed equally: Hanh Chi Do-Umehara, Cong Chen.Division of Pulmonary and Critical Care Medicine, Feinbe...
Author Correction: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19
These authors contributed equally: Joseph I. Bailey, Connor H. Puritz, Karolina J. Senkow.These authors jointly supervised...
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology with...
A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells
A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells
Chimeric antigen receptor T cells (CAR T cells) with T stem (TSCM) cell-like phenotypic characteristics promote sustained ...
The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity
The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity
T cell-based immunotherapies have revolutionized cancer treatment, yet durable responses remain elusive. Here we show that...
Sex differences in demyelination
Demyelination is associated with aging and age-related neurodegenerative disorders, including Alzheimer’s disease, and has...
Latent HIV-1 induction
HIV-1 persistence in the latently infected cell reservoir even during treatment with antiretroviral therapy (ART) eludes t...
IGF2 drives CAF evasion
Tumors with higher frequencies of infiltrating CD8+ T cells correlate with better patient prognosis than tumors with fewer...
KEAP1 maintains stemness
Oxidation of cysteine residues in the cellular redox sensor KEAP1 releases its suppression of the transcription factor NRF...
Innate immune barrier against oncogenic transformation
Innate immune barrier against oncogenic transformation
In a mouse model of lymphoma, inflammasome dysfunction increases hematopoietic stem cell turnover and accelerates lymphoma...
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73
A healthy immune system is tolerant to self-antigens while maintaining responsiveness to foreign threats. Co-expression of...
Past interactions of T cells with antigens shape CAR T cell responses
Past interactions of T cells with antigens shape CAR T cell responses
CAR T cells are engineered from a heterogeneous pool of T cells. This study shows that CAR T cells are epigenetically impr...
The Creation Game: of AI and human creativity
The Creation Game: of AI and human creativity
Here I propose the ‘Creation Game’, inspired by the Turing test, to assess the capacity of artificial intellig...
SLE B cells take an extrafollicular detour after mRNA vaccination
SLE B cells take an extrafollicular detour after mRNA vaccination
Systemic lupus erythematosus (SLE) is an autoimmune disease with considerable clinical heterogeneity and diverse treatment...
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells
The mechanisms underlying the efficacy of anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-asso...
Pyroptotic corpses are flagged by filopodia to alert dendritic cells
Pyroptotic corpses are flagged by filopodia to alert dendritic cells
Inflammasomes induce pyroptosis and, through poorly defined mechanisms, promote adaptive immune responses. High-resolution...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
While apoptosis dismantles the cell to enforce immunological silence, pyroptotic cell death provokes inflammation. Little ...
Publisher Correction: Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USAC...
Author Correction: Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
These authors contributed equally: Ruoyan Li, Johanna Strobl, Elizabeth F. M. Poyner, Aya Balbaa.Wellcome Sanger Institute...
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Effective anti-tumor immunity is driven by cytotoxic CD8+ T cells with specificity for tumor antigens. However, the ...
Pregnancy stress
Retrotransposons are transposable DNA elements that in hematopoietic stem cells (HSC) can be activated by aging, irradiati...
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