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Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Author notesThese authors contributed equally: Marko Šestan, Inga Kavazović.Authors and AffiliationsDepartment of Histolog...
B cells infiltrate cutaneous T cell lymphomas
B cells infiltrate cutaneous T cell lymphomas
Cutaneous T cell lymphoma is a rare, difficult to diagnose malignancy of T cells. Malignant T cells, together with populat...
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The mos...
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised in...
Immune drivers of pain resolution and protection
Immune drivers of pain resolution and protection
Immune cells are involved in the pathogenesis of pain by directly activating or sensitizing nociceptor sensory neurons. Ho...
Nanotech unveils cytokine traces in post-COVID cardiovascular complications
Nanotech unveils cytokine traces in post-COVID cardiovascular complications
Trace levels of circulating cytokines correlate with the prevalence of cardiovascular symptoms following COVID-19.
Lactate fermentation intoxicates TILs
Lactate fermentation intoxicates TILs
Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunctio...
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
CD8+ T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell ex...
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovati...
Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
We generated a mouse model to investigate the mechanistic basis of inborn errors of immunity caused by heterozygous BCL11B...
COQ6 defies immune and metabolic expectations
COQ6 defies immune and metabolic expectations
A COQ6 variant increases susceptibility to pneumococcal infection via non-bone marrow-derived cells without affecting ubiq...
Involuted TLS as a harbinger of HCC regression
Involuted TLS as a harbinger of HCC regression
Tertiary lymphoid structures (TLS) have different stages and cellular compositions in human tumors. New data are showing t...
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma
Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint bl...
Dosage compensation in T cells
X chromosome inactivation (XCI) occurs in female mammals to normalize gene expression of sex chromosomes. This process is ...
How to feed mitochondria to T cells
Exhaustion and mitochondrial dysfunction can limit the effector function of T cells and their ability to kill solid tumors...
IL-1α in aging tumors
Aging is a risk factor for cancer but the mechanisms by which aging affects tumor control remain unclear. In Science, Park...
Innate memory against viruses
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Post-translational control of B lineage commitment
Post-translational control of B lineage commitment
PAX5 controls the gene regulatory circuit that leads to B cell lineage commitment. A detailed study shows that the stabili...
A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development
A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development
Genetic studies in mice have shown that the zinc finger transcription factor BCL11B has an essential role in regulating ea...
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment respons...
Spatial cytokine microniches direct T helper cell pathways that drive allergic asthma
Spatial cytokine microniches direct T helper cell pathways that drive allergic asthma
Using temporal and spatial tracking of allergen-specific T cells, we describe the gene regulatory networks that drive T he...
A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5
A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5
B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell progenitors, lineage commitment is me...
Metabolic–epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation
Metabolic–epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation
The interplay of metabolites with epigenetic programs influences CD8+ T cell fate decisions. Here, Raychaudhuri et al. sho...
Pathogenic T cells in post-viral lung disease in mice
Pathogenic T cells in post-viral lung disease in mice
A hallmark of post-viral lung disease, including post-acute sequelae of COVID-19, is dysplastic lung repair. CD8+ T cells ...
Inflammasome protein scaffolds the DNA damage complex during tumor development
Inflammasome protein scaffolds the DNA damage complex during tumor development
Inflammasome sensors activate cellular signaling machineries to drive inflammation and cell death processes. Inflammasomes...
Targeting systemic IL-2 to BCMA CAR-T cells
Targeting systemic IL-2 to BCMA CAR-T cells
CAR-T cells are revolutionizing the treatment of cancer and other diseases. A latest iteration in development involves fus...
Weak enhancer allows autoactivation of Irf8 to control cDC1 versus cDC2 lineage commitment
Weak enhancer allows autoactivation of Irf8 to control cDC1 versus cDC2 lineage commitment
The Irf8 +32-kb enhancer controls transcriptional autoactivation to generate ‘IRF8 on’ and ‘IRF8 offR...
Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen
Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen
The mechanisms that guide T helper 2 (TH2) cell differentiation in barrier tissues are unclear. Here we describe the molec...
Reply to: LRRK2 is not required for lysozyme expression in Paneth cells
Reply to: LRRK2 is not required for lysozyme expression in Paneth cells
We thank L. Wu and Y. Jia at Tsinghua University for sharing mice with us. Z.L. is supported by Tsinghua-Peking Center for...
LRRK2 is not required for lysozyme expression in Paneth cells
LRRK2 is not required for lysozyme expression in Paneth cells
Russo, I., Bubacco, L. & Greggio, E. LRRK2 as a target for modulating immune system responses. Neurobiol. Dis. 169, 10...
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