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Meningitis suppresses macrophages
Meningitis occurs when bacteria enter the lining of the brain and trigger an inflammatory response. In Nature, Pinho-Riber...
Microbiome checkpoint
The integrity of the intestinal microbiome and specific bacterial species are important for responses to immune checkpoint...
Vaccine-induced memory
SARS-CoV-2 breakthrough infections recall spike-specific memory T cells established by vaccination and induce primary T ce...
Modulating bone marrow niches
Bone marrow mesenchymal stem cells (BMSCs) can give rise to osteocytes and adipocytes, which support the development of ly...
Spatial proteomics of tumor microenvironments reveal why location matters
Spatial proteomics of tumor microenvironments reveal why location matters
Capturing cell organization in the tumor microenvironment using spatial proteomics can provide insight into the disease. A...
Plasmacytoid dendritic cells turn red!
Plasmacytoid dendritic cells turn red!
Taking advantage of intersectional genetics, Valente et al. report a novel strategy for tracking plasmacytoid dendritic ce...
Fate-mapping antibodies to study sinful immune dynamics
Fate-mapping antibodies to study sinful immune dynamics
Antibody dynamics resulting from sequential immunization are complex, limiting the study of concepts such as ‘origin...
Tumors evade immune cytotoxicity by altering the surface topology of NK cells
Tumors evade immune cytotoxicity by altering the surface topology of NK cells
The highly variable response rates to immunotherapies underscore our limited knowledge about how tumors can manipulate imm...
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, sugges...
Mitochondrial damage activates the NLRP10 inflammasome
Mitochondrial damage activates the NLRP10 inflammasome
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter AS...
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
The intestinal immune system interacts with commensal microbiota to maintain gut homeostasis. Furthermore, stress alters t...
Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function
Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function
Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor...
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses
Regulatory T (Treg) cells are an immunosuppressive population that are required to maintain peripheral tolerance and preve...
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissu...
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences
Viral infection outcomes are sex biased, with males generally more susceptible than females. Paradoxically, the numbers of...
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells
Plasmacytoid dendritic cells (pDCs) are the main source of type I interferon (IFN-I) during viral infections. Their other ...
Author Correction: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York University Langone Health, New Yor...
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function
Mature T cells must discriminate between brief interactions with self-peptides and prolonged binding to agonists. The kine...
Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants
Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants
The omicron variants of SARS-CoV-2 have substantial ability to escape infection- and vaccine-elicited antibody immunity. H...
The kinetics of chemokine autoantibodies in COVID-19
The kinetics of chemokine autoantibodies in COVID-19
Several panels of naturally arising antibodies against specific chemokines are closely correlated with various favorable C...
Avrion Mitchison (1928–2022)
Avrion Mitchison (1928–2022)
Seventy years after seminal work showing that the transfer of cells (T lymphocytes) rather than antibodie...
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for mon...
T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
Antigen-specific CD8+ T cell accumulation in tumors is a prerequisite for effective immunotherapy, and yet the mechanisms ...
A polarizing answer — microglia in Nasu-Hakola disease
A polarizing answer — microglia in Nasu-Hakola disease
A new study by Zhou et al. identifies a unique microglia state in Nasu-Hakola disease and new potential therapeutic targets.
A protective ACPA
Autoantibodies known as anti-citrullinated protein antibodies (ACPAs) are established markers for the classification and p...
Local complement protection
Circulating complement proteins provide substantial protection against multiple infectious agents, although recent studies...
T cells last longer than mice
In a heroic experiment spanning more than 10 years, now published in Nature, investigators transferred memory CD8+ T cells...
Tissue differences in macrophage metabolism
Oxidative phosphorylation (OXPHOS) is associated with anti-inflammatory macrophages, whereas enhanced glycolysis has been ...
Mechanisms of addiction
Mechanisms of addiction
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
MHC-II heterozygosity limits type 1 diabetes susceptibility through negative selection
MHC-II heterozygosity limits type 1 diabetes susceptibility through negative selection
Homozygous expression of MHC-II alleles that confer susceptibility to type 1 diabetes limits the efficiency of thymic nega...
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