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Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus
Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus
In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tolerance to RNA and DNA, respectively. Yet, TLR7 promotes ...
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
Naive T cells undergo radical changes during the transition from dormant to hyperactive states upon activation, which nece...
Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination
Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination
Understanding immune responses to SARS-CoV-2 messenger RNA (mRNA) vaccines is of great interest, principally because of th...
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress
Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally diverse; however, the extent and de...
A guide to systems-level immunomics
A guide to systems-level immunomics
The immune system is highly complex and distributed throughout an organism, with hundreds to thousands of cell states exis...
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
B cell progenitor acute lymphoblastic leukemia (B-ALL) treatment has been revolutionized by T cell-based immunotherapies&#...
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
The heterogeneous cellular microenvironment of human airway chronic inflammatory diseases, including chronic rhinosinusiti...
ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination
ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination
A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond onl...
Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination
Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination
T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens. According to the kinetic pro...
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Innate lymphoid cells (ILCs) are well-characterized immune cells that play key roles in host defense and tissue homeostasi...
SARS-CoV-2-cross-reactive T cells identified in pre-pandemic lower airway samples
SARS-CoV-2-cross-reactive T cells identified in pre-pandemic lower airway samples
Through access to healthy donors’ bronchoalveolar lavage (BAL) samples cryopreserved before the COVID-19 pandemic, w...
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2
T cells can contribute to clearance of respiratory viruses that cause acute-resolving infections such as SARS-CoV-2, helpi...
Patrolling ILC3 cells monitor intestinal tissue in response to inflammation
Patrolling ILC3 cells monitor intestinal tissue in response to inflammation
Intestinal group 3 innate lymphoid (ILC3) cells exhibit increased mobility in response to flagellin-mediated inflammation....
Immuno-epigenetic escape of cancer stem cells
Immuno-epigenetic escape of cancer stem cells
The net effect of type I interferon (IFN-I) signaling on tumor control depends on various factors, including the potential...
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high tumorigenic, chemoresistant and metastatic ...
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy
Eosinophils are important effector cells and therapeutic targets in allergic diseases. Emerging data indicate that eosinop...
A common activator of tissue-remodeling fibroblasts across tissues
A common activator of tissue-remodeling fibroblasts across tissues
ETS1 regulates tissue-remodeling properties of specific fibroblast subtypes in the synovium, gut and cancer and thus emerg...
Ketogenesis and COVID-19
In response to acute infection, there is a metabolic switch toward ketogenesis and the production of ketone bodies, includ...
Isotype matters
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δγ T cells in tumorigenesis
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Leaky mitochondria
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PD-1 blockade unblocks immune responses to vaccination
PD-1 blockade unblocks immune responses to vaccination
Wherry and colleagues describe how anti-PD-1 immunotherapy impacts outcomes of influenza vaccination in patients with canc...
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is a...
Super-enhancing mutations
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IL-17A heals wounds
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Meningeal functional specialization
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Thymus mimetic cells
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Mechanics drive lymph node expansion
Mechanics drive lymph node expansion
Multistep mechanosensing of lymphocyte infiltration and proliferation by the remodeling stroma and matrix underlies the im...