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Advancements in pathogen immunity and signaling
Advancements in pathogen immunity and signaling
The EMBO workshop ‘Pathogen Immunity and Signaling’, held in San Servolo, Italy, from 8 to 12 April 2024, aime...
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Interleukin-17 (IL-17)-producing helper T (TH17) cells are heterogenous and consist of nonpathogenic TH17 (npTH17) cells t...
A humanized mouse that mounts specific and mature antibody and autoantibody responses
A humanized mouse that mounts specific and mature antibody and autoantibody responses
We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse n...
T cell dysfunction and therapeutic intervention in cancer
T cell dysfunction and therapeutic intervention in cancer
Recent advances in immunotherapy have affirmed the curative potential of T cell-based approaches for treating relapsed and...
Gα13 restricts nutrient driven proliferation in mucosal germinal centers
Gα13 restricts nutrient driven proliferation in mucosal germinal centers
Germinal centers (GCs) that form in mucosal sites are exposed to gut-derived factors that have the potential to influence ...
Immunological imprinting and risks of influenza B virus infection
Immunological imprinting and risks of influenza B virus infection
Immunological imprinting early in life has been proposed to influence the risk of infection by influenza viruses later on ...
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated re...
Chromatin state and BACH2 control TH17 cell functional heterogeneity
Chromatin state and BACH2 control TH17 cell functional heterogeneity
We performed transcriptional and chromatin accessibility profiling of TH17 cells to distinguish the pathways that regulate...
Author Correction: Distinct developmental pathways generate functionally distinct populations of natural killer cells
T Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute...
Blocking EBV-driven lymphomageneis metabolism
Infection of B cells by Epstein Barr virus (EBV) leads to proliferation and transformation of these cells via the EBV prot...
Nociceptors enhance humoral immunity
Increasing evidence indicates direct communication channels exist between the nervous and immune systems. In Cell, Wu et a...
PD-L1 senses fungi
Inflammatory conditions upregulate the expression of PD-L1 on phagocytes. In Nature, Li et al. used proximity labeling of ...
The balance of STING signaling orchestrates immunity in cancer
The balance of STING signaling orchestrates immunity in cancer
Over the past decade, it has become clear that the stimulator of interferon genes (STING) pathway is critical for a variet...
Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2
Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2
IL-1R1 signaling in neural stem cells reduces hippocampal neurogenesis in adult mice, potentially affecting learning and m...
Lymphoid TCF1+CD39+CD8+ T cells maintain stem-like features and contribute to viral control
Lymphoid TCF1+CD39+CD8+ T cells maintain stem-like features and contribute to viral control
Improved understanding of CD8+ T cell function during HIV infection is vital to designing an HIV cure. We have identified ...
A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we c...
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development
The immunological mechanisms underlying chronic colitis are poorly understood. T follicular helper (TFH) cells are critica...
Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease
Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease
Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten pe...
Nuclear squeezing wakes up dendritic cells
Nuclear squeezing wakes up dendritic cells
Dendritic cells migrate to and from lymph nodes in response to chemokine gradients.Data now show that steady-state migrati...
Genetics determines how environmental change alters immune phenotypes
Genetics determines how environmental change alters immune phenotypes
Variation in inter-individual immune phenotypes can be influenced by both genetics and environmental factors. Using a rang...
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans
To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated fro...
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice
Up to 25% of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit postacute cogn...
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8+ T cell functions, which requir...
Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USATorben Schiffner, Olivia Swans...
Genetic and environmental interactions contribute to immune variation in rewilded mice
Genetic and environmental interactions contribute to immune variation in rewilded mice
The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain...
Mycobacterial d-serine impairs TB control
Mycobacterial d-serine impairs TB control
Adaptation to hypoxia and immune escape are two hallmarks of Mycobacterium tuberculosis infection. The d-serine isomer has...
Elusive early NK cell progenitor identified
Elusive early NK cell progenitor identified
The developmental relationship between natural killer (NK) cells and other innate lymphoid cells (ILCs) has been a subject...
Eomes expression identifies the early bone marrow precursor to classical NK cells
Eomes expression identifies the early bone marrow precursor to classical NK cells
Natural killer (NK) cells traffic through the blood and mount cytolytic and interferon-γ (IFNγ)-focused response...
Distinct developmental pathways generate functionally distinct populations of natural killer cells
Distinct developmental pathways generate functionally distinct populations of natural killer cells
Natural killer (NK) cells function by eliminating virus-infected or tumor cells. Here we identified an NK-lineage-biased p...
IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses
IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses
While some infections elicit germinal centers, others produce only extrafollicular responses. The mechanisms controlling t...
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