SCI时时刷

search
+
Mitochondria are midfield players in steroid synthesis
Available online 18 May 2023, 106431Author links open overlay panel, ABSTRACTSteroids are important membrane components an...
Three-dimensional spheroid culture of dental pulp-derived stromal cells enhance their biological and regenerative properties for potential therapeutic applications
Dental pulp derived stromal cells or dental pulp stem cells (DPSCs) are of ectomesenchyme origin and exhibit enormous in v...
The role of monocyte-derived macrophages in the lung: it’s all about context
Macrophages are present in every tissue of the body where they play crucial roles in maintaining tissue homeostasis and pr...
Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice
The increasing prevalence of metabolic syndrome (MetS) and type 2 diabetes (T2D) is a global issue (Zafar et al., 2018). I...
Melatonin protects Leydig cells from HT-2 toxin-induced ferroptosis and apoptosis via glucose-6-phosphate dehydrogenase/glutathione -dependent pathway
HT-2 toxin, a type A trichothecene mycotoxins produced by Fusarium, is a widespread contaminant of animal feed and food pr...
Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells
Iron chelators, such as deferoxamine, exert an anticancer effect by altering the activity of biomolecules critical for reg...
Melatonin protects Leydig cells from HT-2 toxin-induced ferroptosis and apoptosis via glucose-6-phosphate dehydrogenase/glutathione -dependent pathway
Available online 4 April 2023, 106410Author links open overlay panel, , , , , AbstractHT-2 toxin is a mycotoxin commonly f...
The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer
Colorectal cancer (CRC) is one of the three leading causes of cancer-related death in the world (Dienstmann et al., 2017, ...
ECM2, a prognostic biomarker for lower grade glioma, serves as a potential novel target for immunotherapy
Extracellular matrix protein 2 (ECM2), which regulates cell proliferation and differentiation, has recently been reported ...
ALDOC regulated the biological function and immune infiltration of gastric cancer cells
As of 2020, gastric cancer (GC) is fatal disease worldwide, with more than 1,000,000 new cases in 2020, and its mortality ...
Retraction notice to “Gastrodin protects rat cardiomyocytes H9c2 from hypoxia-induced injury by up-regulation of microRNA-21” [Int. J. Biochem. Cell Biol. 109 (2019) 8–16]
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms
There is mounting experimental evidence supporting the notion that α7 nicotinic acetylcholine receptors (nAChRs) expressed...
Pathological implications of cellular stress in cardiovascular diseases
Cell degeneration and dysfunction are among the primary causes of numerous cardiovascular diseases, leading to tissue and ...
Inhibition of histone lysine demethylase 6A promotes chondrocytic activity and attenuates osteoarthritis development through repressing H3K27me3 enhancement of Wnt10a
Articular cartilage microstructure destruction causes joint integrity loss, enhancing the development of osteoarthritis (O...
Chidamide, a novel histone deacetylase inhibitor, inhibits laryngeal cancer progression in vitro and in vivo
Although surgery is an important treatment for laryngeal cancer, surgery has a significant negative impact on the quality ...
Anti-cancer effect of Rumex obtusifolius in combination with arginase/nitric oxide synthase inhibitors via downregulation of oxidative stress, inflammation, and polyamine synthesis
Cancer remains a leading cause of death worldwide, with an estimated 10 million cases and a total economic medical treatme...
The endocytosis receptor megalin: From bench to bedside
Volume 157, April 2023, 106393Author links open overlay panel, , , AbstractThe large (∼600 kDa) endocytosis receptor megal...
A platinum(II) complex HY1-Pt overcomes cisplatin-induced resistance and attenuates metastasis of epithelial ovarian cancer by cancer cell stemness inhibition
Ovarian cancer, one of the most common and lethal gynecologic cancers, is often called as a “silent killer” of women (Mome...
Inhibition of Histone Lysine Demethylase 6 A Promotes Chondrocytic Activity and Attenuates Osteoarthritis Development through Repressing H3K27me3 Enhancement of Wnt10a
Articular cartilage microstructure destruction causes joint integrity loss, enhancing the development of osteoarthritis (O...
Long non-coding RNAs: The growth controller of vascular smooth muscle cells in cardiovascular diseases
Medial vascular smooth muscle cells (VSMCs) in normal adults are lowly proliferative, synthetic, and secretory but rich in...
From Mitochondria to Cells to Humans: Targeting Bioenergetics in Aging and Disease
Available online 17 February 2023, 106391Author links open overlay panel, , ABSTRACTIn vivo control over metabolism is at ...
E2F1-mediated ectopic expression of PP1A promotes breast cancer progression via activation of YAP1
Breast cancer has become the most common malignant tumor worldwide with 70% of breast cancer being hormone receptor-positi...
Secretoglobin 3A2 protects lung from developing cigarette smoke-induced pulmonary emphysema
Chronic obstructive pulmonary disease (COPD) is mainly caused by chronic inflammation secondary to long-term inhalation ex...
G-protein signaling modulator 1 promotes colorectal cancer metastasis by PI3K/AKT/mTOR signaling and autophagy
Colorectal cancer (CRC) is one of the most common cancer types and the second leading cause of cancer-related death worldw...
Nicotinic acetylcholine receptors: key targets for attenuating neurodegenerative diseases
Organisms have developed defences against pathogens via physical, chemical, and cellular mechanisms that underlie the inna...
Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway
Neuroinflammation is a common response that accompanies various disorders including infectious and noninfectious neurologi...
Calcium/calmodulin-dependent serine protein kinase exacerbates mitochondrial calcium uniporter-related mitochondrial calcium overload by phosphorylating α-synuclein in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by dopaminergic neurodeg...
Histone H2A deubiquitinases in the transcriptional programs of development and hematopoiesis: a consolidated analysis
Monoubiquitinated lysine 119 of histone H2A (H2AK119ub) is a highly abundant epigenetic mark, associated with gene repress...
Molecular profiling in desmoplastic small round cell tumours
Desmoplastic small round cell tumour (DSRCT) is an ultra-rare soft tissue sarcoma that is characterised by aggressive dise...
Investigating and imaging platelets in inflammation
Volume 157, April 2023, 106373Author links open overlay panelAbstractBlood platelets are best known for their roles in hem...
阅读更多
format_indent_increase