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CIDP: Analysis of Immunomarkers During COVID-19 mRNA-Vaccination and IVIg-Immunomodulation: An Exploratory Study
CIDP: Analysis of Immunomarkers During COVID-19 mRNA-Vaccination and IVIg-Immunomodulation: An Exploratory Study
Availability of COVID-19 mRNA vaccine for patients with chronic inflammatory demyelinating polyneuropathy (CIDP) treated w...
Inflammatory Cytokines Associated with Multiple Sclerosis Directly Induce Alterations of Neuronal Cytoarchitecture in Human Neurons
Inflammatory Cytokines Associated with Multiple Sclerosis Directly Induce Alterations of Neuronal Cytoarchitecture in Human Neurons
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) coined by inflammation and n...
PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1
PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1
Ample evidence has pointed to a close link between cardiovascular diseases (CVD) and depression. Inflammatory pathways inc...
Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson’s Disease
Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson’s Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. The standard treatments for PD...
Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis
Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis
A hallmark of the inflammatory response in multiple sclerosis (MS) is the presence of intrathecal Immunoglobulin G (IgG) a...
miR-146a Dysregulates Energy Metabolism During Neuroinflammation
miR-146a Dysregulates Energy Metabolism During Neuroinflammation
Alzheimer’s disease (AD) and other neurodegenerative diseases are characterized by chronic neuroinflammation and a r...
Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status
Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status
Deoxycytidine kinase (dCK) and 5’ deoxynucleotidase (NT5C2) are involved in metabolism of cladribine (2CdA), the imm...
Chronic Opioid Administration is Associated with Prevotella-dominated Dysbiosis in SIVmac251 Infected, cART-treated Macaques
Chronic Opioid Administration is Associated with Prevotella-dominated Dysbiosis in SIVmac251 Infected, cART-treated Macaques
People living with the human immunodeficiency virus (HIV) have an elevated risk of opioid misuse due to both prescriptions...
Synergistic Effect and Mechanism of Apoptosis Induction by Morphine and the HIV-1gp120V3 Loop in Hippocampal Neurons
Synergistic Effect and Mechanism of Apoptosis Induction by Morphine and the HIV-1gp120V3 Loop in Hippocampal Neurons
HIV-associated neurocognitive disorders (HAND) are a collective name for neurological disorders associated with HIV-1 infe...
Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture
Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture
Oligodendrocytes produce the myelin that is critical for rapid neuronal transmission in the central nervous system (CNS). ...
Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines
Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines
Mechanically ventilated patients suffering critical illness are at high risk of developing neurocognitive impairm...
The Role of CD4+ T Cells in the Immunotherapy of Brain Disease by Secreting Different Cytokines
The Role of CD4+ T Cells in the Immunotherapy of Brain Disease by Secreting Different Cytokines
Upon different stimulation, naïve CD4+ T cells differentiate into various subsets of T helper (Th) cells, including T...
Oral GSH Exerts a Therapeutic Effect on Experimental Salmonella Meningitis by Protecting BBB Integrity and Inhibiting Salmonella-induced Apoptosis
Oral GSH Exerts a Therapeutic Effect on Experimental Salmonella Meningitis by Protecting BBB Integrity and Inhibiting Salmonella-induced Apoptosis
Bacterial meningitis (BM) is the main cause of the central nervous system (CNS) infection and continues to be an important...
TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages
TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages
Trace amine-associated receptor 1 (TAAR1) is an established neuroregulatory G protein-coupled receptor with recent studies...
Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway
Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway
Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher ...
Integrase Inhibitors are Associated with Neuropsychiatric Symptoms in Women with HIV
Integrase Inhibitors are Associated with Neuropsychiatric Symptoms in Women with HIV
Women with HIV(WWH) are more likely to discontinue/change antiretroviral therapy(ART) due to side effects including neurop...
Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons
Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons
The gastrointestinal epithelium is critical for maintaining a symbiotic relationship with commensal microbiota. Chronic mo...
Vancomycin Pretreatment on MPTP-Induced Parkinson’s Disease Mice Exerts Neuroprotection by Suppressing Inflammation Both in Brain and Gut
Vancomycin Pretreatment on MPTP-Induced Parkinson’s Disease Mice Exerts Neuroprotection by Suppressing Inflammation Both in Brain and Gut
A growing body of evidence implies that gut microbiota was involved in pathogenesis of Parkinson’s disease (PD), but...
A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia
A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia
RhoGDIα is an inhibitor of RhoGDP dissociation that involves in Aβ metabolism and NFTs production in Alzheimer&#...
From Initiation to Maintenance: HIV-1 Gp120-induced Neuropathic Pain Exhibits Different Molecular Mechanisms in the Mouse Spinal Cord Via Bioinformatics Analysis Based on RNA Sequencing
From Initiation to Maintenance: HIV-1 Gp120-induced Neuropathic Pain Exhibits Different Molecular Mechanisms in the Mouse Spinal Cord Via Bioinformatics Analysis Based on RNA Sequencing
Human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS), remains one of the most divers...
Effects of Morphine on Gp120-induced Neuroinflammation Under Immunocompetent Vs. Immunodeficient Conditions
Effects of Morphine on Gp120-induced Neuroinflammation Under Immunocompetent Vs. Immunodeficient Conditions
HIV-associated neurocognitive disorder (HAND) is a common complication of HIV infection, whose development is known to be ...
Oligosaccharide and Flavanoid Mediated Prebiotic Interventions to Treat Gut Dysbiosis Associated Cognitive Decline
Oligosaccharide and Flavanoid Mediated Prebiotic Interventions to Treat Gut Dysbiosis Associated Cognitive Decline
Oligosaccharides are potential prebiotic which maintains gut microbiota and improves gut health. The association of gut an...
Aging Accelerates Postural Instability in HIV Infection: Contributing Sensory Biomarkers
Aging Accelerates Postural Instability in HIV Infection: Contributing Sensory Biomarkers
People living with HIV infection (PWH) who are adequately treated pharmacologically are now likely to have a near normal l...
Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System
Opioid Use, Gut Dysbiosis, Inflammation, and the Nervous System
Opioid use disorder (OUD) is defined as the chronic use or misuse of prescribed or illicitly obtained opioids and is chara...
Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders
Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders
Increased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple sclerosis (MS). Although no such di...
Cognitive Phenotypes of HIV Defined Using a Novel Data-driven Approach
Cognitive Phenotypes of HIV Defined Using a Novel Data-driven Approach
The current study applied data-driven methods to identify and explain novel cognitive phenotypes of HIV. Methods: 388 peop...
Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice
Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice
Major depressive disorder is characterized by the deficiencies of monoamine neurotransmitters, neurotrophic factors and pe...
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke
Increasing studies showed that several anti-platelet drugs turned out to be a promising strategy for inflammatory response...
Intrathecal Administration of an Anti‐nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization
Intrathecal Administration of an Anti‐nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization
Inflammatory pain associates with spinal glial activation and central sensitization. Systemic administration of IMT504, a ...
Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat‐inhibited Dopamine Transport
Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat‐inhibited Dopamine Transport
HIV-1 transactivator of transcription (Tat) has a great impact on the development of HIV-1 associated neurocognitive disor...
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