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Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV
Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV
Based on emerging evidence on the role for specific single-nucleotide variants (SNVs) in EIF2AK3 encoding the integrated s...
Cornuside ameliorates cognitive impairments via RAGE/TXNIP/NF-κB signaling in Aβ1-42 induced Alzheimer’s disease mice
Cornuside ameliorates cognitive impairments via RAGE/TXNIP/NF-κB signaling in Aβ1-42 induced Alzheimer’s disease mice
Cornuside has been discovered to improve learning and memory in AD mice, however, its underlying mechanism was not fully u...
Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins
Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins
SARS-CoV-2 spike proteins have been shown to cross the blood–brain barrier (BBB) in mice and affect the integrity of...
Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression
Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression
Neuroinflammation has emerged as a crucial factor in the development of depression. Despite the well-known anti-inflammato...
The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke
The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke
Ischemic stroke is the leading cause of death and disability worldwide. Nevertheless, there still lacks the effective ther...
The Effects of Fingolimod (FTY720) on Leukocyte Subset Circulation cannot be Behaviourally Conditioned in Rats
The Effects of Fingolimod (FTY720) on Leukocyte Subset Circulation cannot be Behaviourally Conditioned in Rats
Suppression of immune functions can be elicited by behavioural conditioning using drugs such as cyclosporin A or rapamycin...
Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke
Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke
Acute ischemic stroke (AIS), commonly known as stroke, is a debilitating condition characterized by the interruption of bl...
JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia
JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia
Microglia, the resident immune cells of the brain, regulate neuroinflammation which can lead to secondary neuronal damage ...
IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice
IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice
Autism spectrum disorder (ASD) is a neurological disorder associated with brain inflammation. The underlying mechanisms co...
Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala
Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala
Primarily regarded as immune proteins, chemokines are emerging as a family of molecules serving neuromodulatory functions ...
New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
Inflammasomes are important modulators of inflammation. Dysregulation of inflammasomes can enhance vulnerability to condit...
Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease
Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease
Melanocortin 1 receptor (MC1R) is a key pigmentation gene, and loss-of-function of MC1R variants that produce red hair may...
β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway
β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway
The etiology of neuropathic pain is mostly caused by mechanical deformation and neuroinflammation, of which neuroinflammat...
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Recent research on placental, embryo, and brain organoids suggests that the COVID-19 virus may potentially affect embryoni...
GPNMB Ameliorates Neuroinflammation Via the Modulation of AMPK/NFκB Signaling Pathway After SAH in Mice
GPNMB Ameliorates Neuroinflammation Via the Modulation of AMPK/NFκB Signaling Pathway After SAH in Mice
Glycoprotein non-metastatic melanoma protein B (GPNMB) got its name from the first discovery in a cell line of non-metasta...
Elucidating the Therapeutic Utility of Olaparib in Sulfatide-Induced Human Astrocyte Toxicity and Neuroinflammation
Elucidating the Therapeutic Utility of Olaparib in Sulfatide-Induced Human Astrocyte Toxicity and Neuroinflammation
Metachromatic leukodystrophy (MLD) is a severe demyelinating, autosomal recessive genetic leukodystrophy, with no curative...