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Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
Lung fibrosis is a chronic lung disease with a high mortality rate with only two approved drugs (pirfenidone and nintedani...
Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
The response to glucocorticoids is hampered in many COPD patients by a yet unknown mechanism. Earlier we reported that sho...
Commentary: Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: A Two‑Sample Mendelian Randomization Study
Commentary: Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: A Two‑Sample Mendelian Randomization Study
Author notesQiong Wen and Li Li are co-corresponding authors.Authors and AffiliationsDepartment of Oncology, The First Aff...
Genetic Spectrum and Clinical Characteristics of Patients with Primary Ciliary Dyskinesia: a Belgian Single Center Study
Genetic Spectrum and Clinical Characteristics of Patients with Primary Ciliary Dyskinesia: a Belgian Single Center Study
We aimed to examine the correlation between clinical characteristics and the pathogenic gene variants in patients with Pri...
Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia
Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia
Postoperative pneumonia remains a common complication of surgery, despite increased attention. The purpose of our study wa...
First Exploration of the Altered Microbial Gut–Lung Axis in the Pathogenesis of Human Refractory Chronic Cough
First Exploration of the Altered Microbial Gut–Lung Axis in the Pathogenesis of Human Refractory Chronic Cough
Cough represents a natural mechanism that plays an important defensive role in the respiratory tract, but in some conditio...
Outcomes of Extracorporeal Life Support (ECLS) in Acute Severe Asthma: A Narrative Review
Outcomes of Extracorporeal Life Support (ECLS) in Acute Severe Asthma: A Narrative Review
In this narrative review we aimed to explore outcomes of extracorporeal life support (extracorporeal membrane oxygenation ...
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
To investigate the transcriptome of human bronchial epithelial cells (HBEC) in response to serum from patients with differ...
Asymptomatic Dysphagia and Aspiration in Patients with Idiopathic Bronchiectasis
Asymptomatic Dysphagia and Aspiration in Patients with Idiopathic Bronchiectasis
Although considered contributors to idiopathic bronchiectasis (IB), neither dysphagia nor silent aspiration have been syst...
Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways
Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways
The respiratory syncytial virus (RSV) is a common respiratory virus that causes acute lower respiratory tract infectious d...
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Weaning patients with COPD from mechanical ventilation (MV) presents a challenge, as literature on this topic is limited. ...
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Pembrolizumab-based regimens are conditioned by the expression of PD-L1, but durable response rate is limited by innate an...
Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
Lung biopsy remains the gold standard in the diagnosis of fibrotic interstitial lung disease (F-ILD), but there is a growi...
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Codeine is a narcotic antitussive often considered for managing patients with refractory or unexplained chronic cough. Thi...
Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
Diagnosis of idiopathic pulmonary fibrosis (IPF) typically relies on high-resolution computed tomography imaging (HRCT) or...
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
IKS is supported in part by the National Institutes of Health NIH R01HL142543, the National Institute of General Medical S...
Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
This study aimed to examine reports of cardiovascular adverse events (CV AEs) observed in the real-world during treatment ...
Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)
Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)
This study investigated the safety and efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)...
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asth...
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Non-cystic fibrosis bronchiectasis is a chronic respiratory disease characterized by bronchial dilation. However, the sign...
Transbronchial Lung Cryobiopsy Performed with Cone Beam Computed Tomography Guidance Versus Fluoroscopy: A Retrospective Cohort Review
Transbronchial Lung Cryobiopsy Performed with Cone Beam Computed Tomography Guidance Versus Fluoroscopy: A Retrospective Cohort Review
Determining the cause of interstitial lung disease (ILD) remains challenging. While surgical lung biopsy remains the gold ...
The Therapeutic Landscape in Chronic Cough
The Therapeutic Landscape in Chronic Cough
In recent years, there has been a substantial increase in the development of antitussive therapies and the first new&n...
Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Chronic cough is characterized by a state of cough hypersensitivity. We analyze the process of transpiration, by which wat...
Osteopontin: A Novel Therapeutic Target for Respiratory Diseases
Osteopontin: A Novel Therapeutic Target for Respiratory Diseases
Osteopontin (OPN) is a multifunctional phosphorylated protein that is involved in physiological and pathological events. E...
Diaphragm Ultrasonography: Reference Values and Influencing Factors for Thickness, Thickening Fraction, and Excursion in the Seated Position
Diaphragm Ultrasonography: Reference Values and Influencing Factors for Thickness, Thickening Fraction, and Excursion in the Seated Position
Measurements of diaphragm function by ultrasonography are affected by body position, but reference values in the seated po...
Predictors of Initial CPAP Prescription and Subsequent Course with CPAP in Patients with Central Sleep Apneas at a Single Center
Predictors of Initial CPAP Prescription and Subsequent Course with CPAP in Patients with Central Sleep Apneas at a Single Center
Guidelines recommend considering an initial trial of continuous positive airway pressure (CPAP) to treat central sleep apn...
Illuminating Airway Nerve Structure and Function in Chronic Cough
Illuminating Airway Nerve Structure and Function in Chronic Cough
Airway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulat...
Chronic Cough as a Genetic Neurological Disorder? Insights from Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)
Chronic Cough as a Genetic Neurological Disorder? Insights from Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)
Chronic cough is common, and in many cases unexplained or refractory to otherwise effective treatment of associated medica...
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
Gene variants have been identified in patients with familial or sporadic idiopathic pulmonary fibrosis (IPF). These varian...
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis
People living with cystic fibrosis (CF) experience impaired quality of life, but the extent to which pulmonary function is...
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