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Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain
1 Introduction Neuropathic pain (NP) refers to pain that arises as a direct consequence of a lesion or disease affecting...
Editorial: Glial cells in health and disease: impacts on neural circuits and plasticity
This research topic has markedly enhanced the current understanding of the role of glial cells on pathological conditions ...
Enhancing autophagy mitigates LPS-induced neuroinflammation by inhibiting microglial M1 polarization and neuronophagocytosis
1 Introduction Autophagy has multitiered immunological functions and can regulate infection, inflammation, and immunity ...
Neuron identity switches in response to the gradient gene expression pathway
Nonstatic Neuron identity emerges from the complementary synaptic transcriptional architecture shaped by neuron signaling ...
Multiscale brain modeling: bridging microscopic and macroscopic brain dynamics for clinical and technological applications
1 Introduction The brain is an extraordinary organ, orchestrating dynamic processes that span multiple scales—from the mo...
Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
Introduction Metabolic hormones, including insulin, leptin, and glucagon-like peptide-1 (GLP-1), regulate glucose homeost...
Glymphatic system: a self-purification circulation in brain
1 CSF-ISF circulation and glymphatic system in brain Cerebrospinal fluid is a kind of clear, colorless fluid, substantial...
Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting
Introduction Relapse is a key challenge for treating methamphetamine (Meth) addiction, for which no pharmacotherapy appro...
Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures
1 Introduction Following recovery from acute SARS-CoV-2 infection, many patients report lingering symptoms including fat...
Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases
1 Introduction Neurodegenerative diseases are characterized by progressive neuronal loss in the central nervous system (C...
Editorial: 15 years of Frontiers in Cellular Neuroscience: the dual role of microglia in (neuro)inflammation
Interest in microglial cells as agents involved in neuroinflammation is recent but growing rapidly, although we still do n...
Editorial: Cellular and molecular mechanisms that govern assembly, plasticity, and function of GABAergic inhibitory circuits in the mammalian brain
Inhibitory regulations by GABAergic interneurons (INs) play an essential role in intricate neural computations in normal b...
Editorial: Function and regulation of non-neuronal cells in the nervous system
Traditionally, the nervous system has been perceived primarily as a complex network predominantly composed of neurons. Nev...
Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions
Introduction The pupillary light reflex (PLR) is elicited upon illumination of the eyes, protecting the retina from exces...
miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery
1 Introduction Stroke is one of the leading causes of mortality and disability worldwide. In Latin America, one in ten p...
Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury
Introduction Spinal cord injury (SCI) is a severe systemic condition of the central nervous system (CNS), leading to sign...
Editorial: New insights into intracellular pathways and therapeutic targets in CNS diseases
The future of therapy in the realm of central nervous system (CNS) disorders unquestionably lies in the development of tar...
Tight junction proteins in glial tumors development and progression
1 Introduction 1.1 Definition of the tight junction (TJ) and the discovery of its structure and function 1.1.1 TJs struc...
N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1
1 Introduction Age-related hearing loss (ARHL) is a multifactorial condition resulting from genetic predisposition, aging...
Enhancing sleep quality in synucleinopathies through physical exercise
1 Introduction Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (LBD), and multiple syst...
The spatial buildup of nonlinear compression in the cochlea
1 Introduction In the mammalian ear, the huge (>100-dB) dynamic range of audible sounds is compressed to less than 40...
The role of neurotrophic factors in retinal ganglion cell resiliency
1 Introduction The retina is a multi-layered tissue containing various cell types that create circuits which detect ligh...
Long-term live-cell imaging of GFAP+ astroglia and laminin+ vessels in organotypic mouse brain slices using microcontact printing
Introduction Organotypic brain slices Organotypic brain slice cultures provide a cytoarchitecturally intact, three-dimen...
Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons
Introduction The founding member of the Synapse Differentiation Induced Gene (SynDIG) family of AMPA receptor (AMPAR) au...
Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease
Introduction The mammalian brain’s ability to adapt to varying cognitive states and environmental demands is crucial for...
Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes
Variants in genes encoding for voltage-gated K+ (Kv) channels are frequent cause of drug-resistant pediatric epilepsies. O...
Electrophysiological properties of melanin-concentrating hormone neuron subpopulations defined by anatomical localization and CART expression
Introduction Melanin-concentrating hormone (MCH) is a 17-amino acid peptide that is expressed in the hypothalamus of the...
Exploring the impact of the stargazin V143L mutation on the dynamics of the AMPA receptor: stargazin complex
1 Introduction Glutamate is a key excitatory neurotransmitter in the Central Nervous System (CNS), and glutamatergic syn...
Developmental regression of novel space preference in an autism spectrum disorder model is unlinked to GABAergic and social circuitry
Introduction Autism spectrum disorder (ASD) is characterized by social communication deficits and restricted, repetitive...
Bibliometric insights into astrocytic roles in depression and treatment
1 Introduction Depression is a widespread mental health disorder characterized by persistent sadness, loss of interest o...
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