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Synaptic connectivity of the TRPV1-positive trigeminal afferents in the rat lateral parabrachial nucleus
Synaptic connectivity of the TRPV1-positive trigeminal afferents in the rat lateral parabrachial nucleus
Recent studies have shown a direct projection of nociceptive trigeminal afferents into the lateral parabrachial nucleus (L...
Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model
Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model
BackgroundCreatine supplementation during pregnancy is a promising prophylactic treatment for perinatal hypoxic brain inju...
Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent
Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent
Field potential (FP) recording is an accessible means to capture the shifts in the activity of neuron populations. However...
Cerebellum and neurodevelopmental disorders: RORα is a unifying force
Cerebellum and neurodevelopmental disorders: RORα is a unifying force
Errors of cerebellar development are increasingly acknowledged as risk factors for neuro-developmental disorders (NDDs), s...
Posttranslational modifications of proteins in diseased retina
Posttranslational modifications of proteins in diseased retina
Posttranslational modifications (PTMs) are known to constitute a key step in protein biosynthesis and in the regulation of...
pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity
pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity
pH-sensitive fluorescent proteins are widely used to study synaptic vesicle (SV) fusion and recycling. When targeted to th...
Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone
Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone
N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute adm...
Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy
Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy
Selective loss of inhibitory interneurons (INs) that promotes a shift toward an excitatory predominance may have a critica...
Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro
Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro
Introduction:In vitro models of traumatic brain injury (TBI) commonly use neurons isolated from the central nervous system...
Comparative assessment of the effects of DREADDs and endogenously expressed GPCRs in hippocampal astrocytes on synaptic activity and memory
Comparative assessment of the effects of DREADDs and endogenously expressed GPCRs in hippocampal astrocytes on synaptic activity and memory
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have proven themselves as one of the key in vivo tech...
Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes
Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes
2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum ...
Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague–Dawley rats via the P38 MAPK signaling pathway
Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague–Dawley rats via the P38 MAPK signaling pathway
BackgroundPeriodontitis is one of the most common oral diseases and has been shown to be a risk factor for systemic diseas...
Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
1 Introduction: identification of UCH-L1 (PGP9.5)High-resolution two-dimensional electrophoresis was employed to detect so...
Exploiting volume electron microscopy to investigate structural plasticity and stability of the postsynaptic compartment of central synapses
Exploiting volume electron microscopy to investigate structural plasticity and stability of the postsynaptic compartment of central synapses
Volume reconstruction from electron microscopy datasets is a tool increasingly used to study the ultrastructure of the syn...
Microgeometrical dendritic factors predict electrical decoupling between somatic and dendritic compartments in magnocellular neurosecretory neurons
Microgeometrical dendritic factors predict electrical decoupling between somatic and dendritic compartments in magnocellular neurosecretory neurons
It is generally assumed that dendritic release of neuropeptides from magnocellular neurosecretory neurons (MNNs), a critic...
Editorial: Kinase/phosphatase signaling and axonal function in health and disease
Editorial: Kinase/phosphatase signaling and axonal function in health and disease
The axonal initial segment (AIS), nodes of Ranvier, and presynaptic terminals are primary examples of discrete axonal subc...
Defining the role of TRPM4 in broadly responsive taste receptor cells
Defining the role of TRPM4 in broadly responsive taste receptor cells
Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are se...
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis
BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demye...
A new method to quantify the human visual threshold from melanopsin sensitive ganglion cells
A new method to quantify the human visual threshold from melanopsin sensitive ganglion cells
Traditional photoreceptors utilize the chromophore retinal to absorb light coupled with a unique opsin protein to specify ...
Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia
Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia
Hypoinsulinemia is a pathological consequence of diabetes mellitus that can cause a number of complications of the central...
Effects of bilirubin on the development and electrical activity of neural circuits
Effects of bilirubin on the development and electrical activity of neural circuits
In the past several decades, bilirubin has attracted great attention for central nervous system (CNS) toxicity in some pat...
Elevated IL-6 plasma levels are associated with GAD antibodies-associated autoimmune epilepsy
Elevated IL-6 plasma levels are associated with GAD antibodies-associated autoimmune epilepsy
BackgroundAntibodies against glutamic acid decarboxylase (GADA) are present in multiple neurological manifestations, such ...
Microglia-mediated inflammatory destruction of neuro-cardiovascular dysfunction after stroke
Microglia-mediated inflammatory destruction of neuro-cardiovascular dysfunction after stroke
Stroke, a serious systemic inflammatory disease, features neurological deficits and cardiovascular dysfunction. Neuroinfla...
Locus coeruleus noradrenergic neurons phase-lock to prefrontal and hippocampal infra-slow rhythms that synchronize to behavioral events
Locus coeruleus noradrenergic neurons phase-lock to prefrontal and hippocampal infra-slow rhythms that synchronize to behavioral events
The locus coeruleus (LC) is the primary source of noradrenergic projections to the forebrain, and, in prefrontal cortex, i...
Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels
Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels
Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced Ca2+ release in response to activity-...
Modularity and neuronal heterogeneity: Two properties that influence in vitro neuropharmacological experiments
Modularity and neuronal heterogeneity: Two properties that influence in vitro neuropharmacological experiments
IntroductionThe goal of this work is to prove the relevance of the experimental model (in vitro neuronal networks in this ...
Synergies between synaptic and HCN channel plasticity dictates firing rate homeostasis and mutual information transfer in hippocampal model neuron
Synergies between synaptic and HCN channel plasticity dictates firing rate homeostasis and mutual information transfer in hippocampal model neuron
Homeostasis is a precondition for any physiological system of any living organism. Nonetheless, models of learning and mem...
Brain vitamin D3-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity
Brain vitamin D3-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity
IntroductionVitamin D3 (VD3) is a potent para/autocrine regulator and neurosteroid that can strongly influence nerve cell ...
Ion channels as molecular targets of glioblastoma electrotherapy
Ion channels as molecular targets of glioblastoma electrotherapy
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (T...
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer’s disease mouse model
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer’s disease mouse model
Introduction: Increasing evidence indicates that neurodegenerative diseases, including Alzheimer’s disease (AD), are a pro...
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