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Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis
Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis
IntroductionExposure to heavy metal lead can cause serious health effects such as developmental neurotoxicity in infants, ...
Electrophysiological activity pattern of mouse hippocampal CA1 and dentate gyrus under isoflurane anesthesia
Electrophysiological activity pattern of mouse hippocampal CA1 and dentate gyrus under isoflurane anesthesia
General anesthesia can impact a patient’s memory and cognition by influencing hippocampal function. The CA1 and dentate gy...
A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells
A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells
The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the...
Ectopic burst induced by blockade of axonal potassium channels on the mouse hippocampal mossy fiber
Ectopic burst induced by blockade of axonal potassium channels on the mouse hippocampal mossy fiber
A potassium channel blocker 4-AP has been shown to exert pronounced convulsive action to generate burst firings when appli...
Sex differences in the distribution and density of regulatory interneurons in the striatum
Sex differences in the distribution and density of regulatory interneurons in the striatum
IntroductionDysfunction of the cortico-basal circuitry – including its primary input nucleus, the striatum – contributes t...
Limitations of human brain organoids to study neurodegenerative diseases: a manual to survive
Limitations of human brain organoids to study neurodegenerative diseases: a manual to survive
In 2013, M. Lancaster described the first protocol to obtain human brain organoids. These organoids, usually generated fro...
Reflective imaging of myelin integrity in the human and mouse central nervous systems
Reflective imaging of myelin integrity in the human and mouse central nervous systems
The structural integrity of myelin sheaths in the central nervous system (CNS) is crucial for the maintenance of its funct...
Extracellular vesicles released by LPS-stimulated spinal organotypic slices spread neuroinflammation into naïve slices through connexin43 hemichannel opening and astrocyte aberrant calcium dynamics
Extracellular vesicles released by LPS-stimulated spinal organotypic slices spread neuroinflammation into naïve slices through connexin43 hemichannel opening and astrocyte aberrant calcium dynamics
IntroductionNeuroinflammation is a hallmark of multiple neurodegenerative diseases, shared by all pathological processes w...
Functionally linked amygdala and prefrontal cortical regions are innervated by both single and double projecting cholinergic neurons
Functionally linked amygdala and prefrontal cortical regions are innervated by both single and double projecting cholinergic neurons
Cholinergic cells have been proposed to innervate simultaneously those cortical areas that are mutually interconnected wit...
Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington’s disease
Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington’s disease
Huntington’s disease (HD) is caused by an expansion of CAG trinucleotide repeat in the HTT gene; the exact pathogenesis of...
Microglia as potential key regulators in viral-induced neuroinflammation
Microglia as potential key regulators in viral-induced neuroinflammation
1 Introduction 1.1 Types of viruses involved in CNS infections Viruses are the most frequently identified cause of centra...
Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging
Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging
IntroductionDamage to the corneal nerves can result in discomfort and chronic pain, profoundly impacting the quality of li...
Glial cells in the mammalian olfactory bulb
Glial cells in the mammalian olfactory bulb
The mammalian olfactory bulb (OB), an essential part of the olfactory system, plays a critical role in odor detection and ...
GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis
GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis
GABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic co...
Editorial: 15 years of Frontiers in Cellular Neuroscience: super-resolution microscopy in the healthy and the injured brain
The continuous evolution of light microscopy technologies has led to the development of several superresolution methods ...
Editorial: Space and neural cell: the impact of space environment on neurological function and their molecular mechanistic insights
As manned space explorations continues to grow in many nations, it is crucial to research how the space environment affe...
Editorial: The outcomes of pollutants on glia
The global environment is experiencing profound challenges, with pollution being the largest environmental cause of disa...
Corrigendum: Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders
In the published article, there was an error in section 3.1 Impaired cerebral blood supply in autism spectrum disorders,...
Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery
Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery
General anesthesia, as a commonly used medical intervention, has been widely applied during surgical procedures to ensure ...
Synaptic cell adhesion molecules contribute to the pathogenesis and progression of fragile X syndrome
Synaptic cell adhesion molecules contribute to the pathogenesis and progression of fragile X syndrome
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a monogenic cause of autism spec...
Necrostatin-1: a promising compound for neurological disorders
Necrostatin-1: a promising compound for neurological disorders
Necrostatin-1, a small molecular alkaloid, was identified as an inhibitor of necroptosis in 2005. Investigating the fundam...
Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety
Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety
The basolateral amygdala plays pivotal roles in the regulation of fear and anxiety and these processes are profoundly modu...
Unusual morphology of foveal Müller glia in an adult human born pre-term
Unusual morphology of foveal Müller glia in an adult human born pre-term
The fovea of the human retina, a specialization for acute and color vision, features a high concentration of cone photorec...
Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer’s disease
Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer’s disease
Brain degenerations in sporadic Alzheimer’s disease (AD) are observed earliest in the locus coeruleus (LC), a population o...
A long journey to treat epilepsy with the gut microbiota
A long journey to treat epilepsy with the gut microbiota
Epilepsy is a common neurological disorder that affects approximately 10.5 million children worldwide. Approximately 33% o...
Astrocyte regulation of extracellular space parameters across the sleep-wake cycle
Astrocyte regulation of extracellular space parameters across the sleep-wake cycle
Multiple subfields of neuroscience research are beginning to incorporate astrocytes into current frameworks of understandi...
Modeling demyelination and endogenous remyelination in spinal cord ex vivo rat organotypic slice cultures
Modeling demyelination and endogenous remyelination in spinal cord ex vivo rat organotypic slice cultures
IntroductionDemyelination of the spinal cord is a prominent feature of multiple sclerosis (MS) and spinal cord injuries (S...
Understanding electrical and chemical transmission in the brain
Understanding electrical and chemical transmission in the brain
The histochemical Falck-Hillarp method for the localization of dopamine (DA), noradrenaline (NA) and serotonin in the cent...
Age-related alterations in efferent medial olivocochlear-outer hair cell and primary auditory ribbon synapses in CBA/J mice
Age-related alterations in efferent medial olivocochlear-outer hair cell and primary auditory ribbon synapses in CBA/J mice
IntroductionHearing decline stands as the most prevalent single sensory deficit associated with the aging process. Giving ...
Brain organoid as a model to study the role of mitochondria in neurodevelopmental disorders: achievements and weaknesses
Brain organoid as a model to study the role of mitochondria in neurodevelopmental disorders: achievements and weaknesses
Mitochondrial diseases are a group of severe pathologies that cause complex neurodegenerative disorders for which, in most...
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