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Synaptic connectivity of the TRPV1-positive trigeminal afferents in the rat lateral parabrachial nucleus
Synaptic connectivity of the TRPV1-positive trigeminal afferents in the rat lateral parabrachial nucleus
Recent studies have shown a direct projection of nociceptive trigeminal afferents into the lateral parabrachial nucleus (L...
Cerebellum and neurodevelopmental disorders: RORα is a unifying force
Cerebellum and neurodevelopmental disorders: RORα is a unifying force
Errors of cerebellar development are increasingly acknowledged as risk factors for neuro-developmental disorders (NDDs), s...
Posttranslational modifications of proteins in diseased retina
Posttranslational modifications of proteins in diseased retina
Posttranslational modifications (PTMs) are known to constitute a key step in protein biosynthesis and in the regulation of...
Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy
Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy
Selective loss of inhibitory interneurons (INs) that promotes a shift toward an excitatory predominance may have a critica...
Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro
Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro
Introduction:In vitro models of traumatic brain injury (TBI) commonly use neurons isolated from the central nervous system...
Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
1 Introduction: identification of UCH-L1 (PGP9.5)High-resolution two-dimensional electrophoresis was employed to detect so...
Editorial: Kinase/phosphatase signaling and axonal function in health and disease
Editorial: Kinase/phosphatase signaling and axonal function in health and disease
The axonal initial segment (AIS), nodes of Ranvier, and presynaptic terminals are primary examples of discrete axonal subc...
Defining the role of TRPM4 in broadly responsive taste receptor cells
Defining the role of TRPM4 in broadly responsive taste receptor cells
Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are se...
A new method to quantify the human visual threshold from melanopsin sensitive ganglion cells
A new method to quantify the human visual threshold from melanopsin sensitive ganglion cells
Traditional photoreceptors utilize the chromophore retinal to absorb light coupled with a unique opsin protein to specify ...
Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia
Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia
Hypoinsulinemia is a pathological consequence of diabetes mellitus that can cause a number of complications of the central...
Effects of bilirubin on the development and electrical activity of neural circuits
Effects of bilirubin on the development and electrical activity of neural circuits
In the past several decades, bilirubin has attracted great attention for central nervous system (CNS) toxicity in some pat...
Elevated IL-6 plasma levels are associated with GAD antibodies-associated autoimmune epilepsy
Elevated IL-6 plasma levels are associated with GAD antibodies-associated autoimmune epilepsy
BackgroundAntibodies against glutamic acid decarboxylase (GADA) are present in multiple neurological manifestations, such ...
Microglia-mediated inflammatory destruction of neuro-cardiovascular dysfunction after stroke
Microglia-mediated inflammatory destruction of neuro-cardiovascular dysfunction after stroke
Stroke, a serious systemic inflammatory disease, features neurological deficits and cardiovascular dysfunction. Neuroinfla...
Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels
Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels
Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced Ca2+ release in response to activity-...
Modularity and neuronal heterogeneity: Two properties that influence in vitro neuropharmacological experiments
Modularity and neuronal heterogeneity: Two properties that influence in vitro neuropharmacological experiments
IntroductionThe goal of this work is to prove the relevance of the experimental model (in vitro neuronal networks in this ...
Ion channels as molecular targets of glioblastoma electrotherapy
Ion channels as molecular targets of glioblastoma electrotherapy
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (T...