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Identification of immune-related biomarkers in peripheral blood of schizophrenia using bioinformatic methods and machine learning algorithms
Identification of immune-related biomarkers in peripheral blood of schizophrenia using bioinformatic methods and machine learning algorithms
Schizophrenia is a group of severe neurodevelopmental disorders. Identification of peripheral diagnostic biomarkers is an ...
Mild hypoxia-induced structural and functional changes of the hippocampal network
Mild hypoxia-induced structural and functional changes of the hippocampal network
Hypoxia causes structural and functional changes in several brain regions, including the oxygen-concentration-sensitive hi...
12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes
12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes
IntroductionLipoxygenases (LOXs) have essential roles in stroke, atherosclerosis, diabetes, and hypertension. 12/15-LOX in...
A homozygous missense variant in the YG box domain in an individual with severe spinal muscular atrophy: a case report and variant characterization
A homozygous missense variant in the YG box domain in an individual with severe spinal muscular atrophy: a case report and variant characterization
The vast majority of severe (Type 0) spinal muscular atrophy (SMA) cases are caused by homozygous deletions of survival mo...
Neuron populations across layer 2-6 in the mouse visual cortex exhibit different coding abilities in the awake mice
Neuron populations across layer 2-6 in the mouse visual cortex exhibit different coding abilities in the awake mice
IntroductionThe visual cortex is a key region in the mouse brain, responsible for processing visual information. Comprised...
Cell-type expression and activation by light of neuropsins in the developing and mature Xenopus retina
Cell-type expression and activation by light of neuropsins in the developing and mature Xenopus retina
Photosensitive opsins detect light and perform image- or nonimage-forming tasks. Opsins such as the “classical” visual ops...
Pathogenic role of autoantibodies at the ependyma in autoimmune disorders of the central nervous system
Pathogenic role of autoantibodies at the ependyma in autoimmune disorders of the central nervous system
Ependymal cells make up the epithelial monolayer that lines the brain ventricles and the spinal cord central canal that ar...
Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke
Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke
Pericytes play an indispensable role in various organs and biological processes, such as promoting angiogenesis, regulatin...
Synaptic input and temperature influence sensory coding in a mechanoreceptor
Synaptic input and temperature influence sensory coding in a mechanoreceptor
Many neurons possess more than one spike initiation zone (SIZ), which adds to their computational power and functional fle...
Replenished microglia partially rescue schizophrenia-related stress response
Replenished microglia partially rescue schizophrenia-related stress response
BackgroundMicroglia play an important role in the maintenance of brain and behavioral homeostasis. The protective effect o...
HSP27 induced glaucomatous damage in mice of young and advanced age
HSP27 induced glaucomatous damage in mice of young and advanced age
IntroductionAge-related diseases such as glaucoma, a leading cause of blindness, are having an upward trend due to an agin...
EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
BackgroundTransient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrow...
Postconditioning promotes recovery in the neurovascular unit after stroke
Postconditioning promotes recovery in the neurovascular unit after stroke
Background and purposeExperimental studies suggest that ischemic postconditioning interferes with cell death mechanisms an...
CUT homeobox genes: transcriptional regulation of neuronal specification and beyond
CUT homeobox genes: transcriptional regulation of neuronal specification and beyond
CUT homeobox genes represent a captivating gene class fulfilling critical functions in the development and maintenance of ...
Fear learning and aversive stimuli differentially change excitatory synaptic transmission in perisomatic inhibitory cells of the basal amygdala
Fear learning and aversive stimuli differentially change excitatory synaptic transmission in perisomatic inhibitory cells of the basal amygdala
Inhibitory circuits in the basal amygdala (BA) have been shown to play a crucial role in associative fear learning. How th...
Structure and function of neocortical layer 6b
Structure and function of neocortical layer 6b
Cortical layer 6b is considered by many to be a remnant of the subplate that forms during early stages of neocortical deve...
Morphological screens using aged primary adult neuronal, microglial, and astrocytic cultures to find novel neurotherapeutics
Morphological screens using aged primary adult neuronal, microglial, and astrocytic cultures to find novel neurotherapeutics
The average age of a patient with neurotraumatic injuries or neurodegenerative diseases has been increasing worldwide. The...
Biomolecular alterations detected in multiple sclerosis skin fibroblasts using Fourier transform infrared spectroscopy
Biomolecular alterations detected in multiple sclerosis skin fibroblasts using Fourier transform infrared spectroscopy
Multiple sclerosis (MS) is the leading cause of non-traumatic disability in young adults. New avenues are needed to help p...
Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea
Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea
Obstructive sleep apnea (OSA) is a severe sleep disorder associated with intermittent hypoxia and sleep fragmentation. Cog...
The role and potential therapeutic targets of astrocytes in central nervous system demyelinating diseases
The role and potential therapeutic targets of astrocytes in central nervous system demyelinating diseases
Astrocytes play vital roles in the central nervous system, contributing significantly to both its normal functioning and p...
A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation
A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation
Spinal cord injury causes varying degrees of motor and sensory function loss. However, there are no effective treatments f...
Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice
Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that progressively affects motoneurons, causing muscle ...
The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species
The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species
The bed nucleus of the stria terminalis (BNST), as part of the extended amygdala, has become a region of increasing intere...
Lamin B1 as a key modulator of the developing and aging brain
Lamin B1 as a key modulator of the developing and aging brain
Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It ...
Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS
Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that ...
Linking temporal coordination of hippocampal activity to memory function
Linking temporal coordination of hippocampal activity to memory function
Oscillations in neural activity are widespread throughout the brain and can be observed at the population level through th...
Thinking about the action potential: the nerve signal as a window to the physical principles guiding neuronal excitability
Thinking about the action potential: the nerve signal as a window to the physical principles guiding neuronal excitability
Ever since the work of Edgar Adrian, the neuronal action potential has been considered as an electric signal, modeled and ...
Heterogeneity in macrophages along the cochlear spiral in mice: insights from SEM and functional analyses
Heterogeneity in macrophages along the cochlear spiral in mice: insights from SEM and functional analyses
The susceptibility of sensory cells to pathological conditions differs between the apical and basal regions of the cochlea...
Corrigendum: Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization
Corrigendum: Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization
Corrigendum on: Schröder L-J, Thiesler H, Gretenkort L, Möllenkamp TM, Stangel S, Gudi V, Hildebrandt H (2023). ...
Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders
Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders
Normal brain development, function, and aging critically depend on unique characteristics of the cerebrovascular system. G...
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