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Mammalian Sterile 20-Like Kinase 1 Suppresses Atherosclerosis
Mammalian Sterile 20-Like Kinase 1 Suppresses Atherosclerosis
BACKGROUND: Atherosclerosis occurs mainly at arterial branching points exposed to disturbed blood flow. How MST1 (mammalia...
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal pulmonary artery (PA) obstruction...
Faecalibacterium Prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis
Faecalibacterium Prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis
Background: Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbi...
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage
Rationale: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell prol...
LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin
LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin
Rationale: Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a patholog...
Leveraging the Metabolome: Translating Social Risk Into Biological Pathways
Leveraging the Metabolome: Translating Social Risk Into Biological Pathways
Sadiya S. Khan Correspondence to: Sadiya S. Khan, MD, MSc, Department of Medicine, Northwestern University Feinberg School...
Functions Beyond the Editor’s I in Regulating Cardiac Innate Immunity and Heart Failure
Functions Beyond the Editor’s I in Regulating Cardiac Innate Immunity and Heart Failure
Farah Sheikh Correspondence to: Farah Sheikh, PhD, Department of Medicine (Cardiology Division), University of California ...
Transcriptional and Immune Landscape of Cardiac Sarcoidosis
Transcriptional and Immune Landscape of Cardiac Sarcoidosis
Background: Cardiac involvement is an important determinant of mortality among sarcoidosis patients. Although granulomatou...
Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure
Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure
BACKGROUND: Chronic heart failure (CHF) is associated with redox imbalance. Downregulation of Nrf2 (nuclear factor [erythr...
The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function
The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function
Background: Amino acid metabolism is crucial for inflammatory processes during atherogenesis. The endogenous amino acid ho...
Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2
Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal cardiac arrhythmia syndro...
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart
BACKGROUND: Heart failure is the leading cause of mortality, morbidity, and health care expenditures worldwide. Numerous s...
Targeted Mito- and Cardioprotection by Malonate
Targeted Mito- and Cardioprotection by Malonate
Rainer Schulz Correspondence to: Rainer Schulz, MD, Institute of Physiology, Justus-Liebig University, Aulweg 129, Giessen...
Dysbiosis in Preeclampsia and Treatment With Short Chain Fatty Acids
Charles R. Mackay Correspondence to: Charles R. Mackay, PhD, Department of Microbiology, Biomedicine Discovery Institute, ...
Metabolic Endotoxemia and Arterial Stiffness in Diabetes
Metabolic Endotoxemia and Arterial Stiffness in Diabetes
Lorenzo Loffredo Correspondence to: Lorenzo Loffredo, MD, Department of Clinical, Internal Medicine, Anesthesiologic and C...
L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling
L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling
Background: L-2-hydroxyglutarate (L2HG) couples mitochondrial and cytoplasmic energy metabolism to support cellular redox ...
Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk
Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk
Background: Despite mechanistic studies linking retinol and RBP4 (retinol binding protein 4) to the pathogenesis of cardio...
ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7
ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7
BACKGROUND: ADAR1 (adenosine deaminase acting on RNA-1)-mediated adenosine to inosine (A-to-I) RNA editing plays an essent...
Beyond Diagnosis: a Novel Microbiota Dependent Biomarker and Target for Atherosclerosis
Beyond Diagnosis: a Novel Microbiota Dependent Biomarker and Target for Atherosclerosis
Di Lang Correspondence to: Di Lang, PhD, 555 Mission Bay Blvd South, San Francisco, CA 94158. Email E-mail Address: [emai...
Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels
Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels
BACKGROUND: Experimental evidence suggests a key role of SIRT1 (silent information regulator 1) in age- and metabolic-rela...
Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart
Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart
BACKGROUND: An ancient family of arrestin-fold proteins, termed alpha-arrestins, may have conserved roles in regulating nu...
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts
BACKGROUND: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hyperten...
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury
Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in amelio...
Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank
Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank
Background: Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic, and skeletal muscles may affect...
Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes
Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes
Background: Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lys...
LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction
LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction
Rationale: Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular events. Our previous study found...
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction
Rationale: Jacobsen syndrome is a rare chromosomal disorder caused by deletions in the long arm of human chromosome 11, re...
Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation
Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation
Background: Timely and complete restoration of blood flow is the most effective intervention for patients with acute myoca...