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Chronic pain in Alzheimer's disease: Endocannabinoid system
Chronic pain, one of the most common reasons adults seek medical care, has been linked to restrictions in mobility and dai...
Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex
Ischemic stroke is the most common clinical type of stroke, a cerebrovascular disease caused by stenosis or obstruction of...
Cannabidiol reveals a disruptive strategy for 21st century epilepsy drug discovery
Epilepsy is distinct among neurological conditions in that it has enjoyed a relatively high degree of translational succes...
Adaptation of a cervical bilateral contusive spinal cord injury for study of skilled forelimb function
We present an updated, clinically relevant model of moderately severe bilateral cervical level 6 contusive spinal cord inj...
Knock-in mouse models for CMTX1 show a loss of function phenotype in the peripheral nervous system
Charcot-Marie-Tooth (CMT) disease is common, affecting ∼1:2500 people, and CMTX1 is the second most common form (Fridman e...
Secukinumab attenuates neuroinflammation and neurobehavior defect via PKCβ/ERK/NF-κB pathway in a rat model of GMH
Germinal matrix hemorrhage (GMH) is a devastating clinical event for neonates, especially for preterm or low-birth weight ...
Role of tubulin post-translational modifications in peripheral neuropathy
The structure of the peripheral nervous system (PNS) is extremely complex due to the myriad connections it establishes wit...
Downregulation of miR-26b attenuates early brain injury induced by subarachnoid hemorrhage via mediating the KLF4/STAT3/HMGB1 axis
Subarachnoid hemorrhage (SAH), a common manifestation of ruptured brain aneurysm, is one of the most devastating cerebrova...
Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury
Spinal cord injury (SCI) disrupts communication within the nervous system, leading to the loss of the motor/sensory functi...
The pericontused cortex can support function early after TBI but it remains functionally isolated from normal afferent input
Traumatically injured brain functional connectivity (FC) is altered in a region-dependent manner with some regions functio...
Cis-p-tau plays crucial role in lysolecithin-induced demyelination and subsequent axonopathy in mouse optic chiasm
Multiple sclerosis (MS) is an autoimmune demyelinating disease that leads to axon degeneration as the major cause of everl...
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy
Stroke patients are often complicated by cerebral ischemia-reperfusion injury (CIRI) after the restoration of cerebral per...
BDNF guides neural stem cell-derived axons to ventral interneurons and motor neurons after spinal cord injury
Neural stem cells (NSCs) implanted into sites of spinal cord injury (SCI) extend very large numbers of new axons over very...
Movement decoding using spatio-spectral features of cortical and subcortical local field potentials
The first commercially sensing enabled deep brain stimulation (DBS) devices for the treatment of movement disorders have r...
Cross-talk between α-synuclein and the microtubule cytoskeleton in neurodegeneration
Looking at the puzzle that depicts the molecular determinants in neurodegeneration, many pieces are lacking and multiple i...
Towards a mechanistic understanding of axon transport and endocytic changes underlying paclitaxel-induced peripheral neuropathy
Paclitaxel is a common chemotherapeutic agent widely used to treat solid cancer. However, it frequently causes peripheral ...
Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage
Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity and mortality in preterm infants in the United ...
Efficacy of the FDA-approved cannabidiol on the development and persistence of temporal lobe epilepsy and complex focal onset seizures
Presently there is no drug therapy for curing epilepsy. Despite many advancements in epilepsy research, nearly 30% of peop...