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Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior
Diabetes mellitus (DM) is a chronic, metabolic disease characterized by elevated blood glucose levels; it is a widespread ...
Glypican-2 defines age-dependent axonal response to chondroitin sulfate
Most neurons have one or two long processes called axons that conduct electrical information to their targets, including o...
X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease
Hydrocephalus is one of the most frequently encountered brain diseases, characterized by excessive accumulation of cerebro...
The relationship between long non-coding RNAs and Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer’s disease
Alois Alzheimer primarily defined Alzheimer’s disease (AD) in 1906(Dong et al., 2012) as a challenging brain disorder that...
Microglial priming induced by loss of Mef2C contributes to postoperative cognitive dysfunction in aged mice
Postoperative cognitive dysfunction (POCD) is a central nervous system (CNS) complication that adversely affects attention...
POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia
The datasets generated and analyzed during the study are included with the Supplemental Information. The RNA sequencing re...
Response of terminal Schwann cells following volumetric muscle loss injury
Recent work suggests denervation of surviving muscle fibers is a contributing factor to the overall pathophysiology follow...
Impairment of Connexin 43 may initiate cilia decline in syringomyelia
Syringomyelia is characterized by the formation of a fluid-filled cyst within the spinal cord(Greitz, 2006; Milhorat, 2000...
Ketolysis is required for the proper development and function of the somatosensory nervous system
Ketolysis—the catabolism of β-hydroxybutyrate (β-HB) and acetoacetate for fuel—is known to contribute to the development a...
Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-κB/MAPK signaling pathway in microglia
Major depressive disorder (MDD) is a common psychiatric disorder that severely affects human life and health. However, the...
Human brain microphysiological systems in the study of neuroinfectious disorders
Neurological infections leading to encephalitis, meningitis, and myelitis are frequently severe and prolonged neurological...
Bone marrow stromal cells-derived exosomes reduce neurological damage in traumatic brain injury through the miR-124-3p/p38 MAPK/GLT-1 axis
BackgroundMounting evidence indicates that stem cell-derived exosomal miRNAs have therapeutic effects on traumatic brain i...
Higher untrained fitness exerts a neuroprotection in Independence to caloric restriction or exercise in high-fat diet-induced obesity
Obesity is one of the major public health problems because it substantially increases the risk of many diseases, including...
Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis
Diabetes mellitus (DM) is a common metabolic disease of aging around the world, leading to many chronic complications, inc...
Chaperone-mediated autophagy (CMA) alleviates cognitive impairment by reducing neuronal death in sepsis-associated encephalopathy (SAE)
Available online 19 April 2023, 114417Author links open overlay panel, , , , , , , , , , AbstractSepsis-associated encepha...
Role of galectin-3 in cardiac dysfunction induced by subarachnoid hemorrhage
Available online 19 April 2023, 114418Author links open overlay panel, , , , , , , , AbstractSubarachnoid hemorrhage (SAH)...
Hearing loss and impaired short-term memory in an Alzheimer's disease mouse model of amyloid-beta pathology
Available online 17 April 2023, 114413Author links open overlay panel, , , AbstractCurrent evidence supports the link betw...
Modulating chronic outcomes after pediatric traumatic brain injury: Distinct effects of social and environmental enrichment
Impairments in social and cognitive function are a common consequence of pediatric traumatic brain injury (TBI). Rehabilit...
Hippocampal demyelination is associated with increased magnetic susceptibility in a mouse model of concussion
Concussion, also known as mild traumatic brain injury (mTBI), is the most common form of TBI, with an estimated incidence ...