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Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Corticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in t...
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI
Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide (Adams et al., 2017). Epidemiological ...
Mild traumatic brain injury in Drosophila melanogaster alters reactive oxygen and nitrogen species in a sex-dependent manner
Mild traumatic brain injury in Drosophila melanogaster alters reactive oxygen and nitrogen species in a sex-dependent manner
Traumatic brain injury (TBI) is an outside force causing a modification in brain function and/or structural brain patholog...
Azithromycin reduces hemoglobin-induced innate neuroimmune activation
Azithromycin reduces hemoglobin-induced innate neuroimmune activation
Neonatal intraventricular hemorrhage (IVH) releases blood products into the lateral ventricles and brain parenchyma. There...
Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disease with a prevalence of 1.37% in people aged ove...
Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
Chronic cerebral ischemia (CCI) is a condition of chronic cerebral hypoperfusion from various causes that can lead to vasc...
Repetitive, non-invasive imaging of neurodegeneration, and prevention of it with gene replacement, in mice with Sanfilippo syndrome.
Repetitive, non-invasive imaging of neurodegeneration, and prevention of it with gene replacement, in mice with Sanfilippo syndrome.
Sanfilippo syndrome or mucopolysaccharidosis type III (MPS III) is a childhood-onset dementia in which a normal infancy is...
GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPARβ/δ/CD300a/SHP1 pathway after GMH in neonatal rats
GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPARβ/δ/CD300a/SHP1 pathway after GMH in neonatal rats
BackgroundActivation of mast cells plays an important role in brain inflammation. CD300a, an inhibitory receptor located o...
Combined effect of trifluoperazine and sodium cromoglycate on reducing acute edema and limiting lasting functional impairments after spinal cord injury in rats
Combined effect of trifluoperazine and sodium cromoglycate on reducing acute edema and limiting lasting functional impairments after spinal cord injury in rats
Spinal cord injury (SCI) is a devastating event that causes serious physical disability for both sensory, motor, and auton...
Altered T cell development in an animal model of multiple sclerosis
Altered T cell development in an animal model of multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disorder that affects the central nervous system (CNS), leading to immune-...
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice
Ischemic stroke, a subtype of stroke that occurs when a blood vessel supplying a specific brain region is occluded, is the...
Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination
Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination
Cuprizone (CPZ)-induced alterations in axonal myelination are associated with a period of neuronal hyperexcitability and i...
Neuronal aerobic glycolysis exacerbates synapse loss in aging mice
Neuronal aerobic glycolysis exacerbates synapse loss in aging mice
The human brain constitutes approximately a quarter of the body's glucose consumption, relying on both oxidative phosphory...
Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus
Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus
Cerebral infarction is a major cause of death worldwide. The incidence of ischemic stroke in patients with abnormal glucos...
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice
Epidemiological investigation has showed that anxiety is increasing prevalent and becoming one of major public health prob...
Dynamic electrical stimulation enhances the recruitment of spinal interneurons by corticospinal input
Dynamic electrical stimulation enhances the recruitment of spinal interneurons by corticospinal input
Dynamic Stimulation (DS) is a highly varying biomimetic protocol of spinal electrical stimulation sampled from an EMG trac...
Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in autophagy activation following subarachnoid hemorrhage
Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in autophagy activation following subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a common catastrophic clinical event, typically affects a younger population when compare...
Neddylation in the chronically hypoperfused corpus callosum: MLN4924 reduces blood-brain barrier injury via ERK5/KLF2 signaling
Neddylation in the chronically hypoperfused corpus callosum: MLN4924 reduces blood-brain barrier injury via ERK5/KLF2 signaling
Chronic cerebral hypoperfusion resulting from cerebral small vessel pathology, is a leading cause of vascular dementia (Go...
Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats
Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats
Subarachnoid hemorrhage (SAH), a neurologic emergency usually caused by ruptured aneurysms, is responsible for 5–10% of al...
Chemogenetic stimulation of intact corticospinal tract during rehabilitative training promotes circuit rewiring and functional recovery after stroke
Chemogenetic stimulation of intact corticospinal tract during rehabilitative training promotes circuit rewiring and functional recovery after stroke
Globally, stroke is a leading cause of persistent neurological disability and death in the elderly population worldwide (B...
Subclinical respiratory dysfunction and impaired ventilatory adaptation in degenerative cervical myelopathy
Subclinical respiratory dysfunction and impaired ventilatory adaptation in degenerative cervical myelopathy
KeywordsDegenerative cervical myelopathyRespiratory plasticityHypercapniaAdaptive breathingSpinal cord injurySpinal decomp...
LIPUS-induced neurogenesis:A potential therapeutic strategy for cognitive dysfunction in traumatic brain injury
LIPUS-induced neurogenesis:A potential therapeutic strategy for cognitive dysfunction in traumatic brain injury
Traumatic brain injury (TBI), also known as craniocerebral injury or head trauma, refers to brain tissue damage caused by ...
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy
Today, dietary intake is characterized by high fat content in most developed and many developing countries (Haddad et al.,...
Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats
Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats
Acute ischemic stroke (AIS) is one of the leading causes of global mortality and long-term disability (Gorelick, 2019). Th...
The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype
The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype
KeywordsApoEApolipoprotein EAlzheimer's diseaseCancer chemotherapy-induced cognitive impairmentSenescenceAbbreviationsANOV...
Blockade of connexin hemichannels with tonabersat protects against mild hypoxic ischemic brain injury in neonatal rats
Blockade of connexin hemichannels with tonabersat protects against mild hypoxic ischemic brain injury in neonatal rats
Background and purposeThere is growing evidence that infants with mild hypoxic-ischemic (HI) encephalopathy have increased...
NTS-105 decreased cell death and preserved long-term potentiation in an in vitro model of moderate traumatic brain injury
NTS-105 decreased cell death and preserved long-term potentiation in an in vitro model of moderate traumatic brain injury
Traumatic brain injury (TBI) was responsible for >223,000 hospitalizations in 2019 (“Centers for Disease Control and Pr...
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
Stroke is a leading cause of disability and death worldwide (Campbell and Khatri, 2020). It affects approximately 14 milli...
Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats
Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats
Neuropathic pain is a common and debilitating comorbidity after spinal cord injury (SCI). Not only did the patients with n...
Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
KeywordsNon invasive neuromodulationDravetEpilepsyMagnetic stimulationData availabilityAll data and materials used in the ...
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