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An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice
An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice
Cell death occurs after traumatic brain injury (TBI) as a consequence of primary brain injury resulting from mechanical in...
Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats
Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats
Intrauterine growth restriction (IUGR), defined as fetal weight less than the 10th percentile of the range determined by g...
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function
Subarachnoid hemorrhage (SAH) is a type of stroke associated with high morbidity and mortality, and survivors often experi...
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) accounts for 5–10% of all strokes, of which about 80% are caused by ruptured aneurysms, with...
An improved method for generating human spinal cord neural stem cells
An improved method for generating human spinal cord neural stem cells
Human neural stem cells and neural progenitor cells have been tested in a variety of CNS disorders, including spinal cord ...
Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice
Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice
Arrhythmia is the leading cause of cardiac arrest and sudden cardiac death, with 50 to 100 cases per 100,000 people worldw...
Mice harboring the T316N variant in the GABAAR γ2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway
Mice harboring the T316N variant in the GABAAR γ2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway
Sleep-related hypermotor epilepsy (SHE), also known as nocturnal frontal lobe epilepsy, is a type of focal epilepsy. Seizu...
Type selective ablation of postnatal slow and fast fatigue-resistant motor neurons in mice induces late onset kinetic and postural tremor following fiber-type transition and myopathy
Type selective ablation of postnatal slow and fast fatigue-resistant motor neurons in mice induces late onset kinetic and postural tremor following fiber-type transition and myopathy
Animals on Earth need to hold postures and execute a series of movements under gravity and atmospheric pressure. VAChT-Cre...
Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activity
Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activity
The pathogenesis involved in age-related cognitive impairment is somewhat complex and remains unclear. Though progressive ...
Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation
Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation
Peripheral nerve injury (PNI) resulting from limb trauma (Noble et al., 1998; Simske et al., 2019), or entrapment syndrome...
Ampakines increase diaphragm activation following mid-cervical contusion injury in rats
Ampakines increase diaphragm activation following mid-cervical contusion injury in rats
Trauma to the mid-cervical spinal cord causes disruption of bulbospinal pathways innervating the phrenic nucleus and direc...
Aging accelerates locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression
Aging accelerates locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression
Parkinson's disease (PD) is a multifactorial neurodegenerative disease with aging as the leading risk factor (Gelders et a...
DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD
DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD
GGGGCC(G4C2) repeat expansion in C9ORF72 (C9) is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy
Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy
Mesial temporal lobe epilepsy (MTLE) is the most common form of adult-onset focal epilepsy. Current standard of care inclu...
Early developmental changes in a rat model of malformations of cortical development: Abnormal neuronal migration and altered response to NMDA-induced excitotoxic injury
Early developmental changes in a rat model of malformations of cortical development: Abnormal neuronal migration and altered response to NMDA-induced excitotoxic injury
Malformations of cortical development (MCDs) are caused by abnormal neuronal migration processes during the fetal period a...
Hydrogen sulfide mitigates memory impairments via the restoration of glutamatergic neurons in a mouse model of hemorrhage shock and resuscitation
Hydrogen sulfide mitigates memory impairments via the restoration of glutamatergic neurons in a mouse model of hemorrhage shock and resuscitation
Numerous investigations have demonstrated that hemorrhagic shock and resuscitation (HSR) causes long-term neurological dis...
MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived extracellular vesicles promotes axon regeneration by targeting Tgif1
MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived extracellular vesicles promotes axon regeneration by targeting Tgif1
The etiological factors for peripheral nerve injury (PNI), a frequent clinical disorder, are accidents, natural disasters,...
Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases
Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases
The intricate functional interactions between mitochondria and lysosomes play a pivotal role in maintaining cellular homeo...
The role of glia in the dysregulation of neuronal spinogenesis in Ube3a-dependent ASD
The role of glia in the dysregulation of neuronal spinogenesis in Ube3a-dependent ASD
Overexpression of the Ube3a gene and the resulting increase in Ube3a protein are linked to autism spectrum disorder (ASD)....
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Spasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI)...
Pharmacological and stem cell therapy of stroke in animal models: Do they accurately reflect the response of humans?
Pharmacological and stem cell therapy of stroke in animal models: Do they accurately reflect the response of humans?
Available online 14 March 2024, 114753Author links open overlay panel, , , , , , , AbstractCerebrovascular diseases are th...
MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo
MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo
Available online 12 March 2024, 114752Author links open overlay panel, , , , Highlights•Loss of MARK1 causes a decrease in...
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
KeywordsDeep brain stimulationIschemiaMotor recoveryLateral cerebellar nucleusCorticostriatalCerebellumAbbreviationsDTCden...
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were ...
Corrigendum to ‘Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats’ [Experimental Neurology 371 (2024) 114585]
Corrigendum to ‘Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats’ [Experimental Neurology 371 (2024) 114585]
Available online 6 March 2024, 114747Author links open overlay panelChengmei Sun a b, Muhammad Saif Ur Rahman a b, Budbaza...
Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia
Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia
Available online 7 March 2024, 114748Author links open overlay panel, , , , , , , , Highlights•Floralozone has been found ...
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
BackgroundThe complex pathophysiological changes following cerebral ischemia-reperfusion injury (CIRI) include the accumul...
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
Cerebral small vessel disease (CSVD) is a cerebral vascular disease with insidious onset and poor clinical treatment effec...
Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity
Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity
Cancer survivors often experience neuropsychological changes, including cognitive impairment, anxiety, and depression duri...
State-dependent alteration of respiration in a rat model of Parkinson's disease
State-dependent alteration of respiration in a rat model of Parkinson's disease
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Besides major deficits in motor coordinat...
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