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PRMT7 can prevent neurovascular uncoupling, blood-brain barrier permeability, and mitochondrial dysfunction in repetitive and mild traumatic brain injury
Traumatic brain injury (TBI) can be caused by a penetrating force, hit to the head, or rotating injury from high impact sp...
Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior
Diabetes mellitus (DM) is a chronic, metabolic disease characterized by elevated blood glucose levels; it is a widespread ...
Esketamine is neuroprotective against traumatic brain injury through its modulation of autophagy and oxidative stress via AMPK/mTOR-dependent TFEB nuclear translocation
Traumatic brain injury (TBI) is caused by trauma to the head, often leading to a variety of functional disorders (Capizzi ...
Glypican-2 defines age-dependent axonal response to chondroitin sulfate
Most neurons have one or two long processes called axons that conduct electrical information to their targets, including o...
Corrigendum to “HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects” [Experimental Neurology,Volume 361, March 2023, 114301]
Volume 365, July 2023, 114419Author links open overlay panelXuegang He a b c, Xudong Guo a b c, Bo Deng a b, Jihe Kang a b...
X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease
Hydrocephalus is one of the most frequently encountered brain diseases, characterized by excessive accumulation of cerebro...
The relationship between long non-coding RNAs and Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer’s disease
Alois Alzheimer primarily defined Alzheimer’s disease (AD) in 1906(Dong et al., 2012) as a challenging brain disorder that...
Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling
Identifying disease-modifying therapies to slow nigrostriatal neuron loss is an unmet need in Parkinson's disease (PD) the...
Microglial priming induced by loss of Mef2C contributes to postoperative cognitive dysfunction in aged mice
Postoperative cognitive dysfunction (POCD) is a central nervous system (CNS) complication that adversely affects attention...
POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia
The datasets generated and analyzed during the study are included with the Supplemental Information. The RNA sequencing re...
Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice
Autism Spectrum Disorder (ASD) is one of the most complex neurodevelopmental syndromes having an enormous impact during th...
Response of terminal Schwann cells following volumetric muscle loss injury
Recent work suggests denervation of surviving muscle fibers is a contributing factor to the overall pathophysiology follow...
Impairment of Connexin 43 may initiate cilia decline in syringomyelia
Syringomyelia is characterized by the formation of a fluid-filled cyst within the spinal cord(Greitz, 2006; Milhorat, 2000...
Ketolysis is required for the proper development and function of the somatosensory nervous system
Ketolysis—the catabolism of β-hydroxybutyrate (β-HB) and acetoacetate for fuel—is known to contribute to the development a...
Retinotectal plasticity induced by monocular enucleation during the critical period is dependent of A2a adenosine receptor: A possible role of astrocytes
The mammalian visual system has been a valuable model to study the development of topographical order as well as neuronal ...
Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: a systematic review and meta-analysis of preclinical studies
Cerebral palsy (CP) is a neurodevelopmental disorder with a number of functional repercussions in the organism (Pereira et...
Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-κB/MAPK signaling pathway in microglia
Major depressive disorder (MDD) is a common psychiatric disorder that severely affects human life and health. However, the...
Human brain microphysiological systems in the study of neuroinfectious disorders
Neurological infections leading to encephalitis, meningitis, and myelitis are frequently severe and prolonged neurological...
Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur
Myelin formation requires a process of proliferation and differentiation of oligodendrocyte precursor cells (OPCs) into ma...
Bone marrow stromal cells-derived exosomes reduce neurological damage in traumatic brain injury through the miR-124-3p/p38 MAPK/GLT-1 axis
BackgroundMounting evidence indicates that stem cell-derived exosomal miRNAs have therapeutic effects on traumatic brain i...
Higher untrained fitness exerts a neuroprotection in Independence to caloric restriction or exercise in high-fat diet-induced obesity
Obesity is one of the major public health problems because it substantially increases the risk of many diseases, including...
Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis
Diabetes mellitus (DM) is a common metabolic disease of aging around the world, leading to many chronic complications, inc...
Chaperone-mediated autophagy (CMA) alleviates cognitive impairment by reducing neuronal death in sepsis-associated encephalopathy (SAE)
Available online 19 April 2023, 114417Author links open overlay panel, , , , , , , , , , AbstractSepsis-associated encepha...
Role of galectin-3 in cardiac dysfunction induced by subarachnoid hemorrhage
Available online 19 April 2023, 114418Author links open overlay panel, , , , , , , , AbstractSubarachnoid hemorrhage (SAH)...
Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood–brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP
Available online 17 April 2023, 114410Author links open overlay panel, , , , AbstractEnolase-phosphatase 1 (ENOPH1) is a n...
Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats
Available online 17 April 2023, 114415Author links open overlay panel, , , , AbstractMild traumatic brain injuries (mild T...
Hearing loss and impaired short-term memory in an Alzheimer's disease mouse model of amyloid-beta pathology
Available online 17 April 2023, 114413Author links open overlay panel, , , AbstractCurrent evidence supports the link betw...
Modulating chronic outcomes after pediatric traumatic brain injury: Distinct effects of social and environmental enrichment
Impairments in social and cognitive function are a common consequence of pediatric traumatic brain injury (TBI). Rehabilit...
Hippocampal demyelination is associated with increased magnetic susceptibility in a mouse model of concussion
Concussion, also known as mild traumatic brain injury (mTBI), is the most common form of TBI, with an estimated incidence ...
24-hydroxycholesterol replacement rate measured in blood is a non-invasive biomarker of brain demyelination and remyelination in cuprizone-treated mice
In mice, dietary cuprizone causes brain demyelination with subsequent spontaneous remyelination upon return to normal chow...
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