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In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder
In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder
Single nucleotide polymorphism (SNP) is called changes in a single base sequence in DNA between individuals. Micro-RNAs (m...
An association study of polymorphisms in the P2RX7 gene in an Iranian population with the risk of type 2 diabetes mellitus
An association study of polymorphisms in the P2RX7 gene in an Iranian population with the risk of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) showed a broad etiology that both environmental and genetic factors play a role in its pre...
Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients
Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients
Acute lymphoblastic leukemia (ALL) is the most common malignancy affecting children. The ABO blood group system and von Wi...
A comprehensive in silico analysis of structural and functional impacts of natural nonsynonymous SNPs in the ALDH2_HUMAN gene
A comprehensive in silico analysis of structural and functional impacts of natural nonsynonymous SNPs in the ALDH2_HUMAN gene
nsSNPs result in amino acid substitutions in coding regions that contribute significantly to the structural diversity of p...
Pyrogallol acts as a novel anticancer factor to enhance the sensitivity to cisplatin in ovarian cancer cells through inducing miR-15a upregulation
Pyrogallol acts as a novel anticancer factor to enhance the sensitivity to cisplatin in ovarian cancer cells through inducing miR-15a upregulation
Pyrogallol is a catechin compound, as an active ingredient extracted from Emblica officinalis, has antiproliferative and a...
Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach
Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach
Amyotrophic lateral sclerosis (ALS), an alarming neurodegenerative disorder, induces muscle atrophy and motor deterioratio...
Association of VEGF promoter polymorphisms with gastrointestinal tract cancer risk and therapy response: a systematic review
Association of VEGF promoter polymorphisms with gastrointestinal tract cancer risk and therapy response: a systematic review
Gastrointestinal tract (GIT) cancers are the most lethal cancers with a high incidence and poor prognosis. Vascular endoth...
In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders
In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders
Parkinson’s disease (PD) is a neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons...
A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis
A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis
Sepsis is a multi-organ dysfunction due to an uncontrolled host-response to pathogens, a leading cause of mortality in int...
Microcephalic osteodysplastic primordial dwarfism type II in four Indian children with PCNT variants
Microcephalic osteodysplastic primordial dwarfism type II in four Indian children with PCNT variants
Microcephalic Osteodysplastic Primordial Dwarfism Type II (MOPD II) is an autosomal recessive rare genetic condition marke...
Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer
Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer
Apoptosis-signaling kinase 1 is a MAPKKK (mitogen-activated protein kinase) overexpressed in various types of human cancer...
Awareness and attitudes of pregnant women concerning genetic disorders and pregnancy termination in northeastern Iran
Awareness and attitudes of pregnant women concerning genetic disorders and pregnancy termination in northeastern Iran
Genetic disorders are common in the Eastern Mediterranean region due to the high prevalence of consanguineous marriages. T...
Implications of cytokine genes polymorphisms in Jordanian patients with obsessive compulsive disorder
Implications of cytokine genes polymorphisms in Jordanian patients with obsessive compulsive disorder
Obsessive–compulsive disorder (OCD) is a common and often highly debilitating chronic neuropsychiatric condition. Th...
MIRAGE syndrome: a case report of de novo SAMD9 c.884del p.(Pro295GlnfsTer104) variant and a novel phenotype of pyloric stenosis
MIRAGE syndrome: a case report of de novo SAMD9 c.884del p.(Pro295GlnfsTer104) variant and a novel phenotype of pyloric stenosis
MIRAGE syndrome is a rare multisystem disorder characterized by myelodysplasia, infection, growth restriction, adrenal hyp...
Analysis of genetic and pathologic association between diabetes mellitus and cervical cancer
Analysis of genetic and pathologic association between diabetes mellitus and cervical cancer
Cervical cancer is the fourth most common cancer among women globally and second most common in India. As per WHO, almost ...
INI1 (SMARCB1) deletion of lung cancer: a case report and literature review
INI1 (SMARCB1) deletion of lung cancer: a case report and literature review
Integrase interaction factor 1 (INI1), also known as switch/sucrose non-fermentable (SWI/SNF)-related matrix-associated ac...
Association between BAFF gene polymorphism and systemic lupus erythematosus: a meta-analysis
Association between BAFF gene polymorphism and systemic lupus erythematosus: a meta-analysis
To inquire into the association from BAFF gene promoter -871C > T single nucleotide polymorphisms (SNP)...
First African case report of hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome due to inverted duplication and deletion of chromosome 10p
First African case report of hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome due to inverted duplication and deletion of chromosome 10p
Hypoparathyroidism, sensorineural deafness and renal disease (HDR) syndrome, also known as Barakat syndrome, is a rare aut...
An Egyptian child with Wolman disease presenting with hemophagocytic lymphohistiocytosis
An Egyptian child with Wolman disease presenting with hemophagocytic lymphohistiocytosis
Lysosomal acid lipase (LAL) deficiency is hyperinflammatory disease caused by the deficiency of the enzyme which hydrolyze...
A comprehensive analysis of the expression and prognostic significance of signal transducers and activators of transcription family in gastric cancer patients
A comprehensive analysis of the expression and prognostic significance of signal transducers and activators of transcription family in gastric cancer patients
Understanding the role of the STAT family in gastric cancer (GC) is essential for developing targeted therapies and improv...
Unravelling variants in Farber disease: diagnostic and prenatal challenges in atypical presentations
Unravelling variants in Farber disease: diagnostic and prenatal challenges in atypical presentations
Farber disease (FD; OMIM #228000), also known as Farber's lipogranulomatosis, is a rare lysosomal storage disease caus...
Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction
Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction
Studies have suggested that Guizhi Jia Longgu Muli decoction (GuiZhiJiaLongGuMuLiTang) has a therapeutic effect on erectil...
Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
Myocardial ischemia is a significant problem in cardiovascular health caused by the obstruction or constriction of coronar...
Alterations in the metabolic signature of full-term infants of diabetic mothers
Alterations in the metabolic signature of full-term infants of diabetic mothers
Maternal diabetes during pregnancy may alter the metabolomic profile of the offspring, increasing the risk of perinatal co...
Inhibition of JAK2 and MDM2 to treat secondary acute myeloid leukemia evolving from myelofibrosis
Inhibition of JAK2 and MDM2 to treat secondary acute myeloid leukemia evolving from myelofibrosis
Myelofibrosis (MF) is characterized by splenomegaly, extramedullary hematopoiesis, bone marrow fibrosis, anemia, constitut...
Double trouble: how c-MET and HER2 fuel bladder cancer progression
Double trouble: how c-MET and HER2 fuel bladder cancer progression
Bladder cancer is still a prevalent, heterogeneous, and challenging disease. Most cases are non-muscle invasive and carry ...
A perspective on the genesis, diagnostics, and management of sickle cell disease
A perspective on the genesis, diagnostics, and management of sickle cell disease
Hemoglobinopathies, including sickle cell disease (SCD), have been recognized as a major health problem globally. SCD is c...
UCP2 45-bp insertion/deletion polymorphism and obesity phenotype in the Lebanese population: a preliminary study
UCP2 45-bp insertion/deletion polymorphism and obesity phenotype in the Lebanese population: a preliminary study
Obesity is a significant health concern in Lebanon, contributing to various chronic diseases. Uncoupling Protein 2 (UCP2) ...
Transcriptomic analysis delineates potential regulatory network as therapeutic alternatives in chronic myeloid leukemia
Transcriptomic analysis delineates potential regulatory network as therapeutic alternatives in chronic myeloid leukemia
Chronic myeloid leukemia (CML) relapse and progression after discontinuation of tyrosine kinase inhibitors (TKI) therapy i...
Decoding the role of NOS3 rs1799983 and PON1 rs662 variants in cardiovascular diseases
Decoding the role of NOS3 rs1799983 and PON1 rs662 variants in cardiovascular diseases
Cardiovascular diseases (CVDs) are complex diseases determined by various environmental risk factors and genetic susceptib...
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