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A comprehensive analysis of the expression and prognostic significance of signal transducers and activators of transcription family in gastric cancer patients
A comprehensive analysis of the expression and prognostic significance of signal transducers and activators of transcription family in gastric cancer patients
Understanding the role of the STAT family in gastric cancer (GC) is essential for developing targeted therapies and improv...
Unravelling variants in Farber disease: diagnostic and prenatal challenges in atypical presentations
Unravelling variants in Farber disease: diagnostic and prenatal challenges in atypical presentations
Farber disease (FD; OMIM #228000), also known as Farber's lipogranulomatosis, is a rare lysosomal storage disease caus...
Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction
Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction
Studies have suggested that Guizhi Jia Longgu Muli decoction (GuiZhiJiaLongGuMuLiTang) has a therapeutic effect on erectil...
Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
Myocardial ischemia is a significant problem in cardiovascular health caused by the obstruction or constriction of coronar...
Alterations in the metabolic signature of full-term infants of diabetic mothers
Alterations in the metabolic signature of full-term infants of diabetic mothers
Maternal diabetes during pregnancy may alter the metabolomic profile of the offspring, increasing the risk of perinatal co...
Inhibition of JAK2 and MDM2 to treat secondary acute myeloid leukemia evolving from myelofibrosis
Inhibition of JAK2 and MDM2 to treat secondary acute myeloid leukemia evolving from myelofibrosis
Myelofibrosis (MF) is characterized by splenomegaly, extramedullary hematopoiesis, bone marrow fibrosis, anemia, constitut...
Double trouble: how c-MET and HER2 fuel bladder cancer progression
Double trouble: how c-MET and HER2 fuel bladder cancer progression
Bladder cancer is still a prevalent, heterogeneous, and challenging disease. Most cases are non-muscle invasive and carry ...
A perspective on the genesis, diagnostics, and management of sickle cell disease
A perspective on the genesis, diagnostics, and management of sickle cell disease
Hemoglobinopathies, including sickle cell disease (SCD), have been recognized as a major health problem globally. SCD is c...
UCP2 45-bp insertion/deletion polymorphism and obesity phenotype in the Lebanese population: a preliminary study
UCP2 45-bp insertion/deletion polymorphism and obesity phenotype in the Lebanese population: a preliminary study
Obesity is a significant health concern in Lebanon, contributing to various chronic diseases. Uncoupling Protein 2 (UCP2) ...
Transcriptomic analysis delineates potential regulatory network as therapeutic alternatives in chronic myeloid leukemia
Transcriptomic analysis delineates potential regulatory network as therapeutic alternatives in chronic myeloid leukemia
Chronic myeloid leukemia (CML) relapse and progression after discontinuation of tyrosine kinase inhibitors (TKI) therapy i...
Decoding the role of NOS3 rs1799983 and PON1 rs662 variants in cardiovascular diseases
Decoding the role of NOS3 rs1799983 and PON1 rs662 variants in cardiovascular diseases
Cardiovascular diseases (CVDs) are complex diseases determined by various environmental risk factors and genetic susceptib...
A case of double aneuploidy of Down and Klinefelter syndrome in an Indian infant: a detailed case report
A case of double aneuploidy of Down and Klinefelter syndrome in an Indian infant: a detailed case report
A variation in the number of chromosomes can lead to chromosomal disorders. These chromosomal aberrations might be related...
Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article
Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article
Serum and glucocorticoid-regulated kinase 1 (SGK1) plays a multifaceted role in cancer progression and treatment resistanc...
Investigating the association of exon variant rs1800470 of TGF-β1 gene with the risk of stroke using a meta-analysis approach
Investigating the association of exon variant rs1800470 of TGF-β1 gene with the risk of stroke using a meta-analysis approach
Ischemic stroke is a type of stroke in which blood vessel blockage prevents blood supply to the brain. Transforming growth...
A novel USP51 variant in a patient with autism spectrum disorder and epilepsy
A novel USP51 variant in a patient with autism spectrum disorder and epilepsy
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder characterized by impaired social communic...
Assessment of liver x receptor messenger RNA beta and microRNA-146a in a group of Egyptian patients with Behçet’s disease
Assessment of liver x receptor messenger RNA beta and microRNA-146a in a group of Egyptian patients with Behçet’s disease
Behçet’s disease (BD) is an ongoing systemic vasculitis with mouth and genital ulceration and eye, skin, and sy...
Exploring SLC30A6 as a potential prognostic, immunomodulatory, and therapeutic biomarker in various cancers with a focus on pancreatic cancer: a pan-cancer analysis
Exploring SLC30A6 as a potential prognostic, immunomodulatory, and therapeutic biomarker in various cancers with a focus on pancreatic cancer: a pan-cancer analysis
Our study investigates the multifaceted role of the gene SLC30A6 across 33 distinct cancer types. Understanding the functi...
Association between estrogen repctor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis
Association between estrogen repctor-1 gene polymorphisms (rs1801132, rs2228480, rs2234693) and migraine susceptibility: an unveiling association through a comprehensive meta-analysis
This meta-analysis aims to find the relationship of ESR-1 gene polymorphisms (rs1801132, rs2228480, and rs2234693) with mi...
Innate immunodeficiencies: a group of primary immunodeficiencies predisposing exclusively to common diseases
Innate immunodeficiencies: a group of primary immunodeficiencies predisposing exclusively to common diseases
Innate immune deficiencies can impair both cellular and humoral immune responses. In contrast, other immune functions may ...
Autosomal recessive polycystic kidney disease: late-onset renal enlargement and proteinuria with rare PKHD1 mutation—a case report
Autosomal recessive polycystic kidney disease: late-onset renal enlargement and proteinuria with rare PKHD1 mutation—a case report
Autosomal recessive polycystic kidney disease (ARPKD) is a genetically inherited pediatric disorder. It is caused by a mut...
Molecular characterization of Ebola virus, immune response, and therapeutic challenges: a narrative review
Molecular characterization of Ebola virus, immune response, and therapeutic challenges: a narrative review
The Ebola virus (EBOV) remains a major public health challenge due to its complex structure and the lack of appropriate an...
The IFIH1 gene variants rs1990760 and rs2111485 are associated with COVID-19 susceptibility and affect IFIH1 protein levels in Iraqis
The IFIH1 gene variants rs1990760 and rs2111485 are associated with COVID-19 susceptibility and affect IFIH1 protein levels in Iraqis
Interferon-induced helicase C domain-containing protein 1 (IFIH1) is one of the main pattern recognition receptors that se...
An integrative analysis of functional consequences of PKD2 missense variants on RNA and protein structures: a computational approach
An integrative analysis of functional consequences of PKD2 missense variants on RNA and protein structures: a computational approach
The PKD2, encoding polycystin-2 (PC2) protein, is second major genetic determinant of autosomal dominant polycystic kidney...
Genetic predisposition to thyroid dysfunction: a case–control study investigating TSHR gene polymorphism (rs2268458) in Indians
Genetic predisposition to thyroid dysfunction: a case–control study investigating TSHR gene polymorphism (rs2268458) in Indians
Variations in the TSHR gene have been implicated in a spectrum of thyroid diseases. Previous studies have implicated varia...
Association of MnSOD (rs4880) and GPx1 (rs1050450) with diabetic nephropathy: a meta-analysis
Association of MnSOD (rs4880) and GPx1 (rs1050450) with diabetic nephropathy: a meta-analysis
Microvascular complications of diabetes including retinopathy, nephropathy, and neuropathy are those long-term complicatio...
Characterization of mitochondrial DNA mutations in colorectal cancer progression by in silico approach and use as potential biomarkers for diagnosis and prognosis
Characterization of mitochondrial DNA mutations in colorectal cancer progression by in silico approach and use as potential biomarkers for diagnosis and prognosis
Mitochondrial DNA variants are significant contributors to cancer progression, as evidenced by numerous findings. This stu...
The role of AGAP2-AS1, DLEU2, HMBOX1_1, and UGDH-AS1 in the progression of esophageal squamous cell carcinoma
The role of AGAP2-AS1, DLEU2, HMBOX1_1, and UGDH-AS1 in the progression of esophageal squamous cell carcinoma
Long noncoding RNAs (lncRNAs) have been recognized as viable prognostic and therapeutic indicators for numerous human mali...
In silico identification and characterisation of pathogenic genetic variants (nsSNPs) in the eukaryotic initiation factors eIF2 and eIF2B affecting miRNA binding sites
In silico identification and characterisation of pathogenic genetic variants (nsSNPs) in the eukaryotic initiation factors eIF2 and eIF2B affecting miRNA binding sites
The eukaryotic translation initiation factors (eIF2 and eIF2B) are known to play a regulatory role in translation initiati...
FSHB and FSHR genes variants in combination with hormones levels predict low and high ovarian response to controlled ovarian stimulation: a logistic regressive model
FSHB and FSHR genes variants in combination with hormones levels predict low and high ovarian response to controlled ovarian stimulation: a logistic regressive model
Predicting the number of follicles obtained after controlled ovarian stimulation (COS) is challenging, especially consider...
Mechanism of metabolic memory: progression in diabetic nephropathy—a descriptive review
Mechanism of metabolic memory: progression in diabetic nephropathy—a descriptive review
Diabetes mellitus and its complications exploit significantly impact global human well-being and economic burden. Previous...
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