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B cell modulation with anti‐CD79bantibodies ameliorates experimental autoimmune encephalitis in mice
B cell modulation with anti‐CD79bantibodies ameliorates experimental autoimmune encephalitis in mice
Abstract B cells play a major role in the pathogenesis of many autoimmune diseases like multiple sclerosis, rheumatoid art...
Glutamine promotes the generation of B10+ cells via the mTOR/GSK3 pathway
Glutamine promotes the generation of B10+ cells via the mTOR/GSK3 pathway
Abstract Alterations in cell metabolism can shift the differentiation of immune cells towards a regulatory or inflammatory...
Dynamics of IL‐15/IL‐15R‐α expression in response to HSV‐1 infection reveal a novel mode of viral immune evasion counteracted by iNKT cells
Dynamics of IL‐15/IL‐15R‐α expression in response to HSV‐1 infection reveal a novel mode of viral immune evasion counteracted by iNKT cells
Abstract Herpes simplex virus type 1 (HSV-1) infects and persists in most of the human population. Interleukin-15 (IL-15) ...
Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner
Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner
Christine S. Rollier Oxford Vaccine Group, Department of Paediatrics, Universit...
Poly I:C and STING agonist‐primed DC increase lymphoid tissue polyfunctional HIV‐1‐specific CD8+ T cells and limit CD4+ T cell loss in BLT mice
Poly I:C and STING agonist‐primed DC increase lymphoid tissue polyfunctional HIV‐1‐specific CD8+ T cells and limit CD4+ T cell loss in BLT mice
Abstract Effective function of CD8+ T cells and enhanced innate activation of dendritic cells (DC) in response to HIV-1 is...
Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin
Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin
Abstract Human skin is a preferred vaccination site as it harbors multiple dendritic cell (DC) subsets, which display dist...
Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Abstract Psoriasis is a chronic inflammatory skin disease characterised by T helper 17 responses. Recent evidence has iden...
Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol‐associated disease etiology
Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol‐associated disease etiology
Abstract Defective T-cell functions play a role in the persistence of hepatitis C virus (HCV) infection. Activated T-cells...
COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations
COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations
Abstract Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the...
Front cover story: Eur. J. Immunol. 12'21
Front cover story: Eur. J. Immunol. 12'21
Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of majo...
Our latest edition of Flow Cytometry Guidelines for basic and clinical immunologists!
Our latest edition of Flow Cytometry Guidelines for basic and clinical immunologists!
Dear readers, The last issue of 2021 of the European Journal of Immunology (EJI) is special in that it ...
COVID‐19 Vaccine Inequity: High time to calibrate the global moral compass
COVID‐19 Vaccine Inequity: High time to calibrate the global moral compass
As of 28 September 2021, in total, 6.18 billion doses of COVID-19 vaccines have been administered globally and 44.7% of th...
Issue Information: Eur. J. Immunol. 12'21
Issue Information: Eur. J. Immunol. 12'21
Volume 51, Issue 12 PDF ShareShare Please rev...
Contents: Eur. J. Immunol. 12'21
Contents: Eur. J. Immunol. 12'21
Please check your email for instructions on resetting your password. If you do not r...
Dynamics of IL‐15/IL‐15Rα expression in response to HSV‐1 infection reveal a novel mode of viral immune evasion counteracted by iNKT cells
Dynamics of IL‐15/IL‐15Rα expression in response to HSV‐1 infection reveal a novel mode of viral immune evasion counteracted by iNKT cells
Abstract Herpes simplex virus type 1 (HSV-1) infects and persists in most of the human population. Interleukin-15 (IL-15) ...
The unexpected contribution of conventional type 1 dendritic cells in driving antibody responses
The unexpected contribution of conventional type 1 dendritic cells in driving antibody responses
Summary Antibodies are hallmarks of most effective vaccines. For successful T-dependent antibody responses, conventional d...
Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment
Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment
Abstract iNKT cells are CD1d-restricted T cells that play a pro-inflammatory or regulatory role in infectious and autoimmu...
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometr...
BOB.1/OBF.1 is required during B cell ontogeny for B cell differentiation and germinal center function
BOB.1/OBF.1 is required during B cell ontogeny for B cell differentiation and germinal center function
Abstract BOB.1/OBF.1 is a lymphocyte-specific transcriptional co-activator of octamer-dependent transcription. It regulate...
Metabolic reprograming shapes neutrophil functions in severe COVID‐19
Metabolic reprograming shapes neutrophil functions in severe COVID‐19
Abstract To better understand the mechanisms at the basis of neutrophil functions during SARS-CoV-2 we studied patients wi...
Robust induction of neutralizing antibodies against the SARS‐CoV‐2 Delta variant after homologous Spikevax or heterologous Vaxzevria‐Spikevax vaccination
Robust induction of neutralizing antibodies against the SARS‐CoV‐2 Delta variant after homologous Spikevax or heterologous Vaxzevria‐Spikevax vaccination
Abstract Abstract This article is protected by copyright. All rights reserved
Novel approach to monitor intravenous immunoglobulin pharmacokinetics in humans using polymorphic determinants in IgG1 constant domains
Novel approach to monitor intravenous immunoglobulin pharmacokinetics in humans using polymorphic determinants in IgG1 constant domains
Abstract Clinical efficacy of intravenous immunoglobulin treatment (IVIg) is related to its pharmacokinetic (PK) profile. ...
Imprint of unconventional T cell response in acute hepatitis C persists despite successful early antiviral treatment
Imprint of unconventional T cell response in acute hepatitis C persists despite successful early antiviral treatment
Abstract Unconventional T cells (UTCs) are a heterogenous group of T cells that typically exhibit rapid responses towards ...
COVID‐19 specific metabolic imprint yields insights into multi organ‐system perturbations
COVID‐19 specific metabolic imprint yields insights into multi organ‐system perturbations
Abstract COVID-19 affects multiple organ-systems. Recent studies have indicated perturbations in the circulating metabolom...
AIDS patient with severe T cell depletion achieved control but not clearance of SARS‐CoV‐2 infection
AIDS patient with severe T cell depletion achieved control but not clearance of SARS‐CoV‐2 infection
Corresponding Author Department of Experimental and Clinical Medicine, Universi...
An integrative genomics approach identifies KDM4 as a modulator of trained immunity
An integrative genomics approach identifies KDM4 as a modulator of trained immunity
Abstract Innate immune cells are able to build memory characteristics via a process termed trained immunity. Host factors ...
CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells
CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells
Corresponding Author Department of Cell Biology, Institute of Biomedical Engine...
Interleukin‐7‐dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes
Interleukin‐7‐dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes
Abstract The important role of IL-7 in the generation of self-reactive T-cells in autoimmune diseases is well established....
TLR9 signalling inhibits Plasmodium liver infection by macrophage activation
TLR9 signalling inhibits Plasmodium liver infection by macrophage activation
Abstract Recognition of pathogen-associated molecular patterns (PAMPs) through Toll-like receptors (TLRs) plays a pivotal ...
T cells expressing multiple co‐inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice
T cells expressing multiple co‐inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice
Abstract Overwhelming activation of T cells in acute malaria is associated with severe outcomes. Thus, counter-regulation ...
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