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Editorial: Casein kinases in human diseases
Editorial: Casein kinases in human diseases
140 years after the discovery of the first phosphoprotein (i.e. casein), the research on protein kinases (in humans about ...
The enigma of ultraviolet radiation stress granules: Research challenges and new perspectives
The enigma of ultraviolet radiation stress granules: Research challenges and new perspectives
Stress granules (SGs) are non-membrane bound cytoplasmic condensates that form in response to a variety of different stres...
Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics
Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics
The cystine/glutamate antiporter system xc− (Sxc−) belongs to the SLC7 family of plasma membrane transporters. It exports ...
Cellular functions of the ClpP protease impacting bacterial virulence
Cellular functions of the ClpP protease impacting bacterial virulence
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a cen...
The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
DNA damage response (DDR) deficiencies result in genome instability, which is one of the hallmarks of cancer. Poly (ADP-ri...
The repertoire of protein-sulfatide interactions reveal distinct modes of sulfatide recognition
The repertoire of protein-sulfatide interactions reveal distinct modes of sulfatide recognition
Sulfatide is an abundant glycosphingolipid in the mammalian nervous system, kidney, trachea, gastrointestinal tract, splee...
Co-crystalization reveals the interaction between AtYchF1 and ppGpp
Co-crystalization reveals the interaction between AtYchF1 and ppGpp
AtYchF1 is an unconventional G-protein in Arabidopsis thaliana that exhibits relaxed nucleotide-binding specificity. The b...
Identifying individuals using proteomics: are we there yet?
Identifying individuals using proteomics: are we there yet?
Multi-omics approaches including proteomics analyses are becoming an integral component of precision medicine. As clinical...
Caspase-1 and the inflammasome promote polycystic kidney disease progression
Caspase-1 and the inflammasome promote polycystic kidney disease progression
We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (...
Advanced assessment through intact glycopeptide analysis of Infliximab’s biologics and biosimilar
Advanced assessment through intact glycopeptide analysis of Infliximab’s biologics and biosimilar
Characterization of therapeutic monoclonal antibodies (mAbs) represents a major challenge for analytical sciences due to t...
Hepatocellular carcinoma risk-stratification based on ASGR1 in circulating epithelial cells for cancer interception
Hepatocellular carcinoma risk-stratification based on ASGR1 in circulating epithelial cells for cancer interception
Purpose: Lack of diagnostic and prognostic biomarkers in hepatocellular carcinoma impedes stratifying patients based on th...
The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS
The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS
More than a decade ago, studies on cellular cisplatin accumulation via active membrane transport established the role of t...
Thermal tuning of protein hydration in a hyperthermophilic enzyme
Thermal tuning of protein hydration in a hyperthermophilic enzyme
Water at the protein surface is an active biological molecule that plays a critical role in many functional processes. Usi...
Tuning gold-based surface functionalization for streptavidin detection: A combined simulative and experimental study
Tuning gold-based surface functionalization for streptavidin detection: A combined simulative and experimental study
A rationally designed gold-functionalized surface capable of capturing a target protein is presented using the biotin–stre...
Fluorescence microscopy imaging of a neurotransmitter receptor and its cell membrane lipid milieu
Fluorescence microscopy imaging of a neurotransmitter receptor and its cell membrane lipid milieu
Hampered by the diffraction phenomenon, as expressed in 1873 by Abbe, applications of optical microscopy to image biologic...
Cryo-EM structure of the diapause chaperone artemin
Cryo-EM structure of the diapause chaperone artemin
The protein artemin acts as both an RNA and protein chaperone and constitutes over 10% of all protein in Artemia cysts dur...
A perspective on Drosophila genetics and its insight into human neurodegenerative disease
A perspective on Drosophila genetics and its insight into human neurodegenerative disease
Drosophila has been long appreciated as a classic genetic system for its ability to define gene function in vivo. Within t...
Identifying SM-miRNA associations based on layer attention graph convolutional network and matrix decomposition
Identifying SM-miRNA associations based on layer attention graph convolutional network and matrix decomposition
The accurate prediction of potential associations between microRNAs (miRNAs) and small molecule (SM) drugs can enhance our...
PCW-A1001, AI-assisted de novo design approach to design a selective inhibitor for FLT-3(D835Y) in acute myeloid leukemia
PCW-A1001, AI-assisted de novo design approach to design a selective inhibitor for FLT-3(D835Y) in acute myeloid leukemia
Treating acute myeloid leukemia (AML) by targeting FMS-like tyrosine kinase 3 (FLT-3) is considered an effective treatment...
Quality assessment of virus-like particle: A new transmission electron microscopy approach
Quality assessment of virus-like particle: A new transmission electron microscopy approach
Transmission electron microscopy (TEM) is a gold standard analytical method for nanoparticle characterization and is playi...
Nucleosomes and their complexes in the cryoEM era: Trends and limitations
Nucleosomes and their complexes in the cryoEM era: Trends and limitations
Twenty-five years have passed since the appearance of the first atomistic model of the nucleosome structure, and since the...
Increasing quantitation in spatial single-cell metabolomics by using fluorescence as ground truth
Increasing quantitation in spatial single-cell metabolomics by using fluorescence as ground truth
Imaging mass spectrometry (MS) is becoming increasingly applied for single-cell analyses. Multiple methods for imaging MS-...
Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells
Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells
Introduction: The immunomodulatory effect of physical activity can impact insulin signaling differentially in adipose tiss...