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Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements
Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily a...
In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases
In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases
Proteases that cleave ubiquitin or ubiquitin-like proteins (UBLs) are critical players in maintaining the homeostasis of t...
Editorial: Bioengineered nanoparticles in cancer therapy, Volume III
Editorial: Bioengineered nanoparticles in cancer therapy, Volume III
Nanotechnology has brought great advances in different fields, and medicine has not escaped from this (Zarrintaj et al. 20...
Exosomal microRNAs in breast cancer: towards theranostic applications
Exosomal microRNAs in breast cancer: towards theranostic applications
Breast cancer is one of the top two reproductive cancers responsible for high rates of morbidity and mortality among women...
Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy
Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy
Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides...
Transposable elements as scaffold/matrix attachment regions: shaping organization and functions in genomes
Transposable elements as scaffold/matrix attachment regions: shaping organization and functions in genomes
The hierarchical structure of eukaryotic genomes has regulatory layers, one of them being epigenetic “indexing” of the gen...
Tumor cell stemness in gastrointestinal cancer: regulation and targeted therapy
Tumor cell stemness in gastrointestinal cancer: regulation and targeted therapy
The cancer stem cells are a rare group of self-renewable cancer cells capable of the initiation, progression, metastasis a...
Harnessing microRNA-enriched extracellular vesicles for liquid biopsy
Harnessing microRNA-enriched extracellular vesicles for liquid biopsy
Extracellular microRNAs (miRNAs) can be detected in body fluids and hold great potential as cancer biomarkers. Extracellul...
Iron-induced kidney cell damage: insights into molecular mechanisms and potential diagnostic significance of urinary FTL
Iron-induced kidney cell damage: insights into molecular mechanisms and potential diagnostic significance of urinary FTL
Background: Iron overload can lead to organ and cell injuries. Although the mechanisms of iron-induced cell damage have be...
Gene expression in metastatic breast cancer—patterns in primary tumors and metastatic tissue with prognostic potential
Gene expression in metastatic breast cancer—patterns in primary tumors and metastatic tissue with prognostic potential
Background: Metastatic breast cancer (MBC) is the main cause of breast cancer-related death. The outcome of MBC varies, an...
2′-19F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions
2′-19F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions
Protein-RNA interactions are central to numerous cellular processes. In this work, we present an easy and straightforward ...
Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends
Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends
Objective: The aim of this study was to conduct a bibliometric analysis of the literature on “Extracellular Vesicles in th...
Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells
Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells
Background: The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability...
Deciphering non-canonical ubiquitin signaling: biology and methodology
Deciphering non-canonical ubiquitin signaling: biology and methodology
Ubiquitination is a dynamic post-translational modification that regulates virtually all cellular processes by modulating ...
Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans
Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans
Copper (Cu) is an essential trace element, however an excess is toxic due to its redox properties. Cu homeostasis therefor...
Insights into Hsp90 mechanism and in vivo functions learned from studies in the yeast, Saccharomyces cerevisiae
Insights into Hsp90 mechanism and in vivo functions learned from studies in the yeast, Saccharomyces cerevisiae
The molecular chaperone Hsp90 (Heat shock protein, 90 kDa) is an abundant and essential cytosolic protein required fo...
Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes
Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes
In Type 1 and Type 2 diabetes, pancreatic β-cell survival and function are impaired. Additional etiologies of diabetes inc...
Sex-specific nociceptor modulation of the apical periodontitis transcriptome
Sex-specific nociceptor modulation of the apical periodontitis transcriptome
Introduction: Apical periodontitis (AP) is a painful disease that develops quickly following dental infections and is prim...