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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study
IntroductionOvarian cancer is one of the most common and lethal malignancy of the female reproductive system (Cortez et al...
Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes
1 IntroductionHypertension in children is an increasingly recognized public health concern, with an estimated prevalence r...
Plasma proteome fingerprint in kidney diseases
1 IntroductionUnderstanding the molecular foundations of disease development opens up new opportunities for designing nove...
Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis
IntroductionMelanoma is an aggressive and highly lethal form of skin cancer, responsible for around 60%–70% of all skin ca...
Editorial: Metabolomics and transcriptomics in biomarker discovery: mass spectrometric techniques in volatilome research
The central dogma of molecular biology traces a path from genomic sequence information represented in DNA to transcribed m...
First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls
IntroductionGestational diabetes mellitus (GDM) defined as hyperglycemia first recognised in pregnancy (World Health Organ...
Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines
1 IntroductionColorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide, accounting for approximat...
Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology
1 IntroductionThe human intestinal epithelium functions as a critical interface between the body and external environment,...
Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study
1 IntroductionBreast cancer (BCa) is the most prevalent cancer among women worldwide and a leading cause of death. In 2020...
Deciphering olfactory receptor binding mechanisms: a structural and dynamic perspective on olfactory receptors
1 IntroductionOlfactory receptors are classified as a subset of G-protein coupled receptors (GPCRs), which are integral to...
Artificial molecular motors in biological applications
1 IntroductionNatural molecular motors are integral to the proper functioning of living organisms, facilitating fundamenta...
Dissecting the biophysical mechanisms of oleate hydratase association with membranes
1 IntroductionMembrane-targeting domains are essential for recruiting signaling molecules to membranes, and protein associ...
Recent advances of lysine lactylation in prokaryotes and eukaryotes
1 IntroductionLysine lactylation is an emerging post-translational modification (PTM) that influences a variety of cellula...
Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis
1 BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder among women of reproductive age, aff...
Editorial: Modelling esophageal adenocarcinoma
Esophageal cancer remains a significant global health concern with a persistently poor prognosis and high mortality rate (...
Anticarcinogenic cationic peptides derived from tryptic hydrolysis of β-lactoglobulin
1 IntroductionThe oxidative stress engendered by the reactive oxygen species engenders significantly affects several age-a...
Review of cancer cell volatile organic compounds: their metabolism and evolution
1 IntroductionA potential relationship between odors emitted by the human body and malignant diseases (e.g., cancer) is an...
Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum
1 IntroductionThe corpus luteum (CL) is a heterogeneous endocrine gland that arises cyclically from the follicular cells o...
The N17 domain of huntingtin as a multifaceted player in Huntington’s disease
IntroductionHuntington’s disease (HD) is the most common dominantly inherited neurological disorder, and is characterized ...
Comparative analysis of anticoagulant influence on PMI estimation based on porcine blood metabolomics profile measured using GC-MS
Accurate post-mortem interval (PMI) estimation is essential in forensic investigations.Although various methods for PMI de...
Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway
1 IntroductionAge-related osteoporosis constitutes a metabolic bone disorder marked by systemic bone loss, prominently pre...
Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis
IntroductionMultiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system...
Exploring the causal role of plasma metabolites and metabolite ratios in prostate cancer: a two-sample Mendelian randomization study
Background: Prostate cancer (PCa), the most prevalent malignant neoplasm in males, involves complex biological mechanisms ...
Identification and validation of reference genes for quantitative gene expression analysis under 409 and 415 nm antimicrobial blue light treatment
IntroductionThe increase in antibiotic resistance has been extensively reported (Hawkey, 2008; Robinson et al., 2016; Woc-...
Identification and validation of five ferroptosis-related molecular signatures in keloids based on multiple transcriptome data analysis
1 IntroductionKeloid scarring, a complex fibroproliferative dermatosis, remains poorly understood in terms of its pathogen...
The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients
1 IntroductionSince the emergence of COVID-19 in late 2019, the virus has led to over 776 million confirmed cases and more...
Editorial: Revolutionizing life sciences: the nobel leap in artificial intelligence-driven biomodeling
Within the research world, 2024 will be remembered as the year of Nobel Prizes for Artificial Intelligence (AI). The one f...
Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis
1 IntroductionChronic rhinosinusitis (CRS) is a complex inflammatory disorder of the nasal sinus mucosa, characterized by ...
LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers
1 IntroductionCancer has high incidence and fatality rate, and is steadily overtaking stroke and coronary heart disease as...
ProAD – A database of rotary ion-translocating ATPases in prokaryotic genomes
Rotary ion-translocating ATPases (ATP synthases) are multi-subunit membrane enzymes that catalyze the synthesis of ATP fro...
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