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Carcinogenic effect of human tumor-derived cell-free filtrates in nude mice
Carcinogenic effect of human tumor-derived cell-free filtrates in nude mice
Cancer remains a worldwide cause of morbidity and mortality. Investigational research efforts have included the administra...
Machine learning approaches to cryoEM density modification differentially affect biomacromolecule and ligand density quality
Machine learning approaches to cryoEM density modification differentially affect biomacromolecule and ligand density quality
The application of machine learning to cryogenic electron microscopy (cryoEM) data analysis has added a valuable set of to...
Risk factors and metabolomics of mild cognitive impairment in type 2 diabetes mellitus
Risk factors and metabolomics of mild cognitive impairment in type 2 diabetes mellitus
Objective: This study aimed to explore the risk factors, metabolic characteristics, and potential biomarkers of mild cogni...
Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes
Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes
Background: Dormant ribosomes are typically associated with preservation factors to protect themselves from degradation un...
Unraveling the evolutionary origin of the P5CS gene: a story of gene fusion and horizontal transfer
Unraveling the evolutionary origin of the P5CS gene: a story of gene fusion and horizontal transfer
The accumulation of proline in response to the most diverse types of stress is a widespread defense mechanism. In prokaryo...
Novel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI
Novel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI
Introduction: Acute kidney injury (AKI) is one of the most common causes of organ failure in critically ill patients. Foll...
Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast
Unraveling the prognostic significance of RGS gene family in gastric cancer and the potential implication of RGS4 in regulating tumor-infiltrating fibroblast
Regulator of G-protein signaling (RGS) proteins are regulators of signal transduction mediated by G protein-coupled recept...
Gasdermin B (GSDMB) in psoriatic patients–a preliminary comprehensive study on human serum, urine and skin
Gasdermin B (GSDMB) in psoriatic patients–a preliminary comprehensive study on human serum, urine and skin
Psoriasis is one of the most common skin diseases and a crucial issue to manage in contemporary dermatology. The search fo...
PhbZIP2 regulates photosynthesis-related genes in an intertidal macroalgae, Pyropia haitanensis, under stress
PhbZIP2 regulates photosynthesis-related genes in an intertidal macroalgae, Pyropia haitanensis, under stress
Intertidal macroalgae are important research subjects in stress biology. Basic region-leucine zipper transcription factors...
Proteomic analysis reveals a potential role for extracellular vesicles within the erythroblastic island niche
Proteomic analysis reveals a potential role for extracellular vesicles within the erythroblastic island niche
Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of the vast ...
Current strategies for early epithelial ovarian cancer detection using miRNA as a potential tool
Current strategies for early epithelial ovarian cancer detection using miRNA as a potential tool
Ovarian cancer is one of the most aggressive and significant malignant tumor forms in the female reproductive system. It i...
Mesenchymal stem cells in craniofacial reconstruction: a comprehensive review
Mesenchymal stem cells in craniofacial reconstruction: a comprehensive review
Craniofacial reconstruction faces many challenges, including high complexity, strong specificity, severe injury, irregular...
Editorial: GPCRs: signal transduction
Editorial: GPCRs: signal transduction
The manuscripts in this collection explore GPCR signaling (Birch et al., Matt et al., Qiu et al., Pogorelov et al.), adapt...
Transcriptomic analysis identifies the shared diagnostic biomarkers and immune relationship between Atherosclerosis and abdominal aortic aneurysm based on fatty acid metabolism gene set
Transcriptomic analysis identifies the shared diagnostic biomarkers and immune relationship between Atherosclerosis and abdominal aortic aneurysm based on fatty acid metabolism gene set
Background:Epidemiological research has demonstrated that there is a connection between lipid metabolism disorder and an i...
Convergent genetic adaptation of Escherichia coli in minimal media leads to pleiotropic divergence
Convergent genetic adaptation of Escherichia coli in minimal media leads to pleiotropic divergence
Adaptation in an environment can either be beneficial, neutral or disadvantageous in another. To test the genetic basis of...
Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients
Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients
The heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for...
A delayed and unsynchronized ovary development as revealed by transcriptome of brain and pituitary of Coilia nasus
A delayed and unsynchronized ovary development as revealed by transcriptome of brain and pituitary of Coilia nasus
Coilia nasus is an anadromous fish that has been successfully domesticated in the last decade due to its high economic val...
Identification of mulberry leaf flavonoids and evaluating their protective effects on H2O2-induced oxidative damage in equine skeletal muscle satellite cells
Identification of mulberry leaf flavonoids and evaluating their protective effects on H2O2-induced oxidative damage in equine skeletal muscle satellite cells
Introduction: Horses are susceptible to oxidative stress during strenuous endurance exercise, leading to muscle fatigue an...
Gender effect of glucose, insulin/glucagon ratio, lipids, and nitrogen-metabolites on serum HGF and EGF levels in patients with diabetes type 2
Gender effect of glucose, insulin/glucagon ratio, lipids, and nitrogen-metabolites on serum HGF and EGF levels in patients with diabetes type 2
Hepatocyte growth factor (HGF) exhibits potent growth-inducing properties across various tissues, while epidermal growth f...
Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes
Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes
CPPs, or Cell-Penetrating Peptides, offer invaluable utility in disease treatment due to their ability to transport variou...
Hsp90 inhibition leads to an increase in surface expression of multiple immunological receptors in cancer cells
Hsp90 inhibition leads to an increase in surface expression of multiple immunological receptors in cancer cells
Heat shock protein 90 (Hsp90) is a molecular chaperone important for maintaining protein homeostasis (proteostasis) in the...
Effects of N-glycans on the structure of human IgA2
Effects of N-glycans on the structure of human IgA2
The transition of IgA antibodies into clinical development is crucial because they have the potential to create a new clas...
Corrigendum: Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway
Corrigendum: Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway
Corrigendum on: Pan C, Ai C, Liang L, Zhang B, Li Q, Pu L, Wang Z, Liu W, Chen Z, Liu H and Wang X (2023) Sestrin2 protect...
Schwann cells in the normal and pathological lung microenvironment
Schwann cells in the normal and pathological lung microenvironment
The lungs are a key organ in the respiratory system. They are regulated by a complex network of nerves that control their ...
Characterization of four peptides from milk fermented with kombucha cultures and their metal complexes—in search of new biotherapeutics
Characterization of four peptides from milk fermented with kombucha cultures and their metal complexes—in search of new biotherapeutics
The most common skin diseases include eczema, psoriasis, acne, and fungal infections. There is often no effective cure for...
Chemoinformatics and machine learning techniques to identify novel inhibitors of the lemur tyrosine kinase-3 receptor involved in breast cancer
Chemoinformatics and machine learning techniques to identify novel inhibitors of the lemur tyrosine kinase-3 receptor involved in breast cancer
Breast cancer is still the largest cause of cancer death in women, and around 70% of primary breast cancer patients are es...
An IL-17A-centric response to Epstein-Barr virus DNA mediated by dendritic Cell-T cell interactions
An IL-17A-centric response to Epstein-Barr virus DNA mediated by dendritic Cell-T cell interactions
Introduction: The Epstein-Barr virus has been associated with a considerable number of autoimmune diseases. We have previo...
Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs
Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs
MicroRNAs (miRNAs) are short non-coding RNAs that play crucial roles in gene regulation, exerting post-transcriptional sil...
TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma
TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma
Introduction: Immune checkpoint inhibitors (ICIs) represent the standard therapy for metastatic melanoma. However, a few p...
SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment
SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment
Objective:Diabetic retinopathy (DR) is a severe diabetic complication that leads to severe visual impairment or blindness....
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