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Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo
Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo
Despite the identification of numerous molecular pathways modulating cardiac hypertrophy its pathogenesis is not completel...
Quantitative plasma profiling by 1H NMR-based metabolomics: impact of sample treatment
Quantitative plasma profiling by 1H NMR-based metabolomics: impact of sample treatment
Introduction: There is evidence that sample treatment of blood-based biosamples may affect integral signals in nuclear mag...
Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach
Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach
Background: Cancer-associated fibroblasts (CAFs) of ovarian cancer (OvC) are the most prevalent element of the tumor micro...
Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy
Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy
Aims: To analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR) and prognosis of advanced gastric cancer...
Assembly and disassembly of branched ubiquitin chains
Assembly and disassembly of branched ubiquitin chains
Protein ubiquitylation is an essential post-translational modification that regulates nearly all aspects of eukaryotic cel...
Hydroxyurea pharmacokinetics and precision dosing in low-resource settings
Hydroxyurea pharmacokinetics and precision dosing in low-resource settings
Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia (SCA). Escalation to maximum tol...
PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potential therapeutic management of SARS-CoV-2 infection
PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potential therapeutic management of SARS-CoV-2 infection
The emergence and re-emergence of viral diseases, which cause significant global mortality and morbidity, are the major co...
Probing protein stability: towards a computational atomistic, reliable, affordable, and improvable model
Probing protein stability: towards a computational atomistic, reliable, affordable, and improvable model
We present an improved application of a recently proposed computational method designed to evaluate the change of free ene...
Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis
Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis
Proliferative forms of glomerulonephritis are characterized by the influx of leukocytes, albuminuria, and loss of kidney f...
Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient
Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient
Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF transmembrane conductance regulator (...
TGFβ signaling pathways in human health and disease
TGFβ signaling pathways in human health and disease
Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of...
lncRNAs-EZH2 interaction as promising therapeutic target in cutaneous melanoma
lncRNAs-EZH2 interaction as promising therapeutic target in cutaneous melanoma
Melanoma is the most lethal skin cancer with increasing incidence worldwide. Despite a great improvement of diagnostics an...
Glycomimetic antagonists of BC2L-C lectin: insights from molecular dynamics simulations
Glycomimetic antagonists of BC2L-C lectin: insights from molecular dynamics simulations
Opportunistic infections from multidrug-resistant pathogens such as Burkholderia cenocepacia are a threatening risk for ho...
Single-cell RNA-seq uncovers distinct pathways and genes in endothelial cells during atherosclerosis progression
Single-cell RNA-seq uncovers distinct pathways and genes in endothelial cells during atherosclerosis progression
Background: Atherosclerosis (AS) is a chronic inflammatory disease involving various cell types, cytokines, and adhesion m...
The XBB.1.5 slightly increase the binding affinity for host receptor ACE2 and exhibit strongest immune escaping features: molecular modeling and free energy calculation
The XBB.1.5 slightly increase the binding affinity for host receptor ACE2 and exhibit strongest immune escaping features: molecular modeling and free energy calculation
Introduction: The current XBB variant of SARS-CoV-2 with the strongest immune escaping properties is currently the most do...
Prediction of prognosis and immunotherapy response in breast cancer based on neutrophil extracellular traps-related classification
Prediction of prognosis and immunotherapy response in breast cancer based on neutrophil extracellular traps-related classification
Neutrophil extracellular traps (NETs), a network of DNA histone complexes and proteins released by activated neutrophils, ...
Casticin as potential anticancer agent: recent advancements in multi-mechanistic approaches
Casticin as potential anticancer agent: recent advancements in multi-mechanistic approaches
Plants, with their range of pharmacologically active molecules, represent the most promising source for the production of ...
Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning
Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning
Background: Diazoxide is a selective mitochondrial-sensitive potassium channel opening agent that has a definite effect on...
Untargeted metabolomics approach and molecular networking analysis reveal changes in chemical composition under the influence of altitudinal variation in bamboo species
Untargeted metabolomics approach and molecular networking analysis reveal changes in chemical composition under the influence of altitudinal variation in bamboo species
Bamboo species have traditionally been used as building material and potential source of bioactive substances, as they pro...
X-ray crystallography and sickle cell disease drug discovery—a tribute to Donald Abraham
X-ray crystallography and sickle cell disease drug discovery—a tribute to Donald Abraham
X-ray crystallography and structure-based drug discovery have played a major role in the discovery of antisickling agents ...
Unsupervised neural network for single cell Multi-omics INTegration (UMINT): an application to health and disease
Unsupervised neural network for single cell Multi-omics INTegration (UMINT): an application to health and disease
Multi-omics studies have enabled us to understand the mechanistic drivers behind complex disease states and progressions, ...
Redox state and metabolic responses to severe heat stress in lenok Brachymystax lenok (Salmonidae)
Redox state and metabolic responses to severe heat stress in lenok Brachymystax lenok (Salmonidae)
In order to provide new insights into the physiological responses of lenok (Brachymystax lenok: Salmonidae) to acute and s...
Editorial: the role of mitochondrial endoplasmic reticulum contact sites in human health and disease
Editorial: the role of mitochondrial endoplasmic reticulum contact sites in human health and disease
Shore and Tata introduced the concept of physical connections between the ER and mitochondria over four decades ago throug...
DPP-4 inhibitors for treating T2DM - hype or hope? an analysis based on the current literature
DPP-4 inhibitors for treating T2DM - hype or hope? an analysis based on the current literature
DPP-4 inhibition is an interesting line of therapy for treating Type 2 Diabetes Mellitus (T2DM) and is based on promoting ...
Identifying a novel cuproptosis-related necroptosis gene subtype-related signature for predicting the prognosis, tumor microenvironment, and immunotherapy of hepatocellular carcinoma
Identifying a novel cuproptosis-related necroptosis gene subtype-related signature for predicting the prognosis, tumor microenvironment, and immunotherapy of hepatocellular carcinoma
Background: Cuproptosis and necroptosis represent two distinct programmed cell death modalities implicated in neoplastic p...
Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids
Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids
Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the developm...
Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies
Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies
Heparan sulfate-binding proteins (HSBPs) are structurally diverse extracellular and membrane attached proteins that intera...
FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC
FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC
Background: Endometrial cancer (UCEC) is a highly heterogeneous gynecologic malignancy that exhibits variable prognostic o...
Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
Introduction: Hepsin is a type II transmembrane serine protease and its expression has been linked to greater tumorigenici...
The carboxypeptidase B and carbonic anhydrase genes play a reproductive regulatory role during multiple matings in Ophraella communa
The carboxypeptidase B and carbonic anhydrase genes play a reproductive regulatory role during multiple matings in Ophraella communa
Seminal fluid proteins (SFPs) are key factors in sexual reproduction and are transferred to females during mating with spe...
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