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Editorial: Non-coding RNAs as emerging players in the development, diagnosis, and treatment of cancer
Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), small interfering RNAs (siRNAs), long non-coding RNAs (lncRNAs), a...
Corrigendum: Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme
In the published article, there was an error in the Funding statement. A Funding statement was not included. However, the ...
Editorial: Intracellular trafficking and membrane dynamics in health and disease
Intracellular trafficking is a tightly regulated process of membrane dynamics that facilitates the exchange of cargos betw...
Editorial: When predictions meet experiments: the future of structure determination
Figuring out the “protein folding problem,” that is predicting protein structure from its amino acid sequence, has posed a...
Visualization of renal rotenone accumulation after oral administration and in situ detection of kidney injury biomarkers via MALDI mass spectrometry imaging
Visualization of renal rotenone accumulation after oral administration and in situ detection of kidney injury biomarkers via MALDI mass spectrometry imaging
The examination of drug accumulation within complex biological systems offers valuable insights into the molecular aspects...
Skeletal muscle feature of different populations in large yellow croaker (Larimichthys crocea): from an epigenetic point of view
Skeletal muscle feature of different populations in large yellow croaker (Larimichthys crocea): from an epigenetic point of view
Fish skeletal muscle is composed of well-defined fiber types. In order to identify potential candidate genes affecting mus...
Therapeutic potential and action mechanisms of licochalcone B: a mini review
Therapeutic potential and action mechanisms of licochalcone B: a mini review
Licochalcone B (LicB), a chalcone derived from Glycyrrhiza uralensis and Glycyrrhiza glabra, has received considerable att...
Recent progress of exosomal lncRNA/circRNA–miRNA–mRNA axis in lung cancer: implication for clinical application
Recent progress of exosomal lncRNA/circRNA–miRNA–mRNA axis in lung cancer: implication for clinical application
Lung cancer is the leading cause of death among malignant tumors in the world. High lung cancer mortality rate is due to m...
Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach
Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach
BackgroundThe ongoing global health crisis of COVID-19, and particularly the challenges posed by recurrent infections of t...
Study on the metabolic effects of hexavalent chromium [Cr (VI)] on rat astrocytes using un-targeted metabolomics
Study on the metabolic effects of hexavalent chromium [Cr (VI)] on rat astrocytes using un-targeted metabolomics
Introduction: Hexavalent chromium [Cr (VI)] has been identified as a human carcinogen and environmental pollutant capable ...
Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases
Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases
BackgroundCOVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). Each disease pha...
Towards interpretable Cryo-EM: disentangling latent spaces of molecular conformations
Towards interpretable Cryo-EM: disentangling latent spaces of molecular conformations
Molecules are essential building blocks of life and their different conformations (i.e., shapes) crucially determine the f...
Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug docking
Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug docking
BackgroundDiabetic foot ulcers are the most common and serious complication of diabetes mellitus, the high morbidity, mort...
Capturing Legionella pneumophila effector enzymes using a ubiquitin derived photo-activatable probe
Capturing Legionella pneumophila effector enzymes using a ubiquitin derived photo-activatable probe
Upon infection of host cells the Legionella pneumophila bacterium releases a multitude of effector enzymes into the host’s...
The future of cancer treatment: combining radiotherapy with immunotherapy
The future of cancer treatment: combining radiotherapy with immunotherapy
Radiotherapy (RT) and immunotherapy (IT) are the powerful tools for cancer treatment which act through the stimulation of ...
Understanding the impact of in vitro transcription byproducts and contaminants
Understanding the impact of in vitro transcription byproducts and contaminants
The success of messenger (m)RNA-based vaccines against SARS-CoV-2 during the COVID-19 pandemic has led to rapid growth and...
Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin
Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin
Introduction: Colistin (CMS) is used for the curation of infections caused by multidrug-resistant bacteria. CMS is constra...
Inactive metallopeptidase homologs: the secret lives of pseudopeptidases
Inactive metallopeptidase homologs: the secret lives of pseudopeptidases
Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of perform...
Bibliometric analysis on CRISPR/Cas: a potential Sherlock Holmes for disease detection
Bibliometric analysis on CRISPR/Cas: a potential Sherlock Holmes for disease detection
CRISPR has revolutionized illness detection by using precision gene editing to identify specific sequences in recent years...
Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry
Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry
In laboratory medicine, measurement results are often expressed as proportions of concentrations or counts. These proporti...
RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses in Caenorhabditis elegans
RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses in Caenorhabditis elegans
Environmental conditions experienced early in the life of an animal can result in gene expression changes later in its lif...
Gestational diabetes mellitus: Impacts on fetal neurodevelopment, gut dysbiosis, and the promise of precision medicine
Gestational diabetes mellitus: Impacts on fetal neurodevelopment, gut dysbiosis, and the promise of precision medicine
Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting approximately 16.5% of pregnancies worldwide ...
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids
Introduction: Carnitine O-octanoyltransferase (CROT) is a well-established peroxisomal enzyme involved in liver fatty acid...
Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication
Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication
Extracellular vesicles (EVs) serve as messengers for intercellular communication, yet the precise mechanisms by which reci...
Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges
Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges
Exosomal microRNAs (miRNAs) have great potential in the fight against hepatocellular carcinoma (HCC), the fourth most comm...
Single-cell sequencing and multiple machine learning algorithms to identify key T-cell differentiation gene for progression of NAFLD cirrhosis to hepatocellular carcinoma
Single-cell sequencing and multiple machine learning algorithms to identify key T-cell differentiation gene for progression of NAFLD cirrhosis to hepatocellular carcinoma
Introduction: Hepatocellular carcinoma (HCC), which is closely associated with chronicinflammation, is the most common liv...
Automated classification of group B Streptococcus into different clonal complexes using MALDI-TOF mass spectrometry
Automated classification of group B Streptococcus into different clonal complexes using MALDI-TOF mass spectrometry
ObjectivesTo evaluate the performance of Matrix-Assisted Laser Desorption/Ionization Time-of Flight Mass Spectra (MALDI-TO...
A method for the analysis of the oligomerization profile of the Huntington’s disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation
A method for the analysis of the oligomerization profile of the Huntington’s disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation
Conformational diseases, such as Alzheimer’s, Parkinson’s and Huntington’s diseases as well as ataxias and fronto-temporal...
Immunotherapy in melanoma: advances, pitfalls, and future perspectives
Immunotherapy in melanoma: advances, pitfalls, and future perspectives
Cutaneous melanoma is the deadliest and most aggressive form of skin cancer owing to its high capacity for metastasis. Ove...
Diagnostic model for hepatocellular carcinoma using small extracellular vesicle-propagated miRNA signatures
Diagnostic model for hepatocellular carcinoma using small extracellular vesicle-propagated miRNA signatures
BackgroundHepatocellular carcinoma (HCC) is the most common type of liver cancer. Small extracellular vesicles (sEVs) are ...
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