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Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model
ABSTRACT BTZ-043, a suicide inhibitor of the Mycobacterium tuberculosis cell wall synthesis decaprenylphosphoryl-beta-D-ri...
Antimicrobial effects of Medicines for Malaria Venture Pathogen Box compounds on strains of Neisseria gonorrhoeae
Antimicrobial effects of Medicines for Malaria Venture Pathogen Box compounds on strains of Neisseria gonorrhoeae
ABSTRACT Therapeutic options for Neisseria gonorrhoeae are limited due to emerging global resistance. New agents and treat...
Standardization of an antiviral pipeline for human norovirus in human intestinal enteroids demonstrates nitazoxanide has no to weak antiviral activity
Standardization of an antiviral pipeline for human norovirus in human intestinal enteroids demonstrates nitazoxanide has no to weak antiviral activity
ABSTRACTHuman noroviruses (HuNoVs) are the leading cause of acute gastroenteritis. In immunocompetent hosts, symptoms usua...
Are envelope stress responses essential for persistence to β-lactams in Escherichia coli?
Are envelope stress responses essential for persistence to β-lactams in Escherichia coli?
ABSTRACTBacterial persistence to antibiotics defines the ability of small sub-populations of sensitive cells within an iso...
Bronchopulmonary penetration of isavuconazole in lung transplant recipients
Bronchopulmonary penetration of isavuconazole in lung transplant recipients
ABSTRACTIsavuconazole’s (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmona...
Erratum for Wang et al., “α-Mangostin Exhibits a Therapeutic Effect on Spinal Cystic Echinococcosis by Affecting Glutamine Metabolism”
Erratum for Wang et al., “α-Mangostin Exhibits a Therapeutic Effect on Spinal Cystic Echinococcosis by Affecting Glutamine Metabolism”
American Society for Microbiology ("ASM") is committed to maintaining your confidence and trust with respect to the inform...
Examining the activity of cefepime-taniborbactam against Burkholderia cepacia complex and Burkholderia gladioli isolated from cystic fibrosis patients in the United States
Examining the activity of cefepime-taniborbactam against Burkholderia cepacia complex and Burkholderia gladioli isolated from cystic fibrosis patients in the United States
ABSTRACT The novel clinical-stage β-lactam-β-lactamase inhibitor combination, cefepime-taniborbactam, demonstrates promisi...
Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections
Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections
ABSTRACT The clinical relevance of bacteriuria following antibiotic treatment of complicated urinary tract infections in c...
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis
ABSTRACT Accumulating evidence supports the use of higher doses of rifampicin for tuberculosis (TB) treatment. Rifampicin ...
Long-term evaluation of clinical success and safety of omadacycline in nontuberculous mycobacteria infections: a retrospective, multicenter cohort of real-world health outcomes
Long-term evaluation of clinical success and safety of omadacycline in nontuberculous mycobacteria infections: a retrospective, multicenter cohort of real-world health outcomes
ABSTRACT Infections due to nontuberculous mycobacteria (NTM) continue to increase in prevalence, leading to problematic cl...
Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis in vivo
Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis in vivo
ABSTRACT Cryptococcus neoformans (Cn) is an encapsulated neurotropic fungal pathogen and the causative agent of cryptococc...
Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water
Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water
ABSTRACT Klebsiella pneumoniae carbapenemase-2 (KPC-2) presents a clinical threat as this β-lactamase confers resistance t...
A US-based national surveillance study for the susceptibility and epidemiology of Clostridioides difficile isolates with special reference to ridinilazole: 2020–2021
A US-based national surveillance study for the susceptibility and epidemiology of Clostridioides difficile isolates with special reference to ridinilazole: 2020–2021
ABSTRACT We have previously reported on the susceptibility and epidemiology of Clostridioides difficile isolates from six ...
Disrupting the infectious disease ecosystem in the digital precision health era innovations and converging emerging technologies
Disrupting the infectious disease ecosystem in the digital precision health era innovations and converging emerging technologies
ABSTRACT This commentary explores the convergence of precision health and evolving technologies, including the critical ro...
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
ABSTRACT Antimicrobial resistance has made a sizeable impact on public health and continues to threaten the effectiveness ...
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
ABSTRACT Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The curr...
Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles
Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles
ABSTRACT Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by W...
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms
ABSTRACT Multidrug resistance (MDR) transporters such as ATP-Binding Cassette (ABC) and Major Facilitator Superfamily prot...
Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
ABSTRACT Plasmodium falciparum causes the most severe malaria and is exposed to various environmental and physiological st...
Dissemination of IncI plasmid encoding bla CTX-M-1 is not hampered by its fitness cost in the pig’s gut
Dissemination of IncI plasmid encoding bla CTX-M-1 is not hampered by its fitness cost in the pig’s gut
ABSTRACT Multiresistance plasmids belonging to the IncI incompatibility group have become one of the most pervasive plasmi...
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
ABSTRACT Cefmetazole is active against extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) and is a potentia...
Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces Staphylococcus aureus infection and reduces Escherichia coli infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces Staphylococcus aureus infection and reduces Escherichia coli infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
ABSTRACT We have previously reported promising in vivo activity of the first-generation 2-aminopyramidine robenidine analo...
Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling
Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling
ABSTRACT A double ampC (AmpCG183D) and ampD (AmpDH157Y) genes mutations have been identified by whole genome sequencing in...
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates
ABSTRACT In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of...
In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus
In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus
ABSTRACT The emergence of disinfectant-resistant microorganisms poses a significant threat to public health. These resilie...
A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics
A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics
ABSTRACTNovel antibacterial agents and strategies are urgently needed to fight against the ongoing global antibiotic resis...
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
ABSTRACT Drug-resistant Mycobacterium tuberculosis is a worldwide health-care problem rendering current tuberculosis (TB) ...
Impact of acquired broad-spectrum β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam β-lactamase inhibitors in Escherichia coli
Impact of acquired broad-spectrum β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam β-lactamase inhibitors in Escherichia coli
ABSTRACTThe impact of β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and ...
Treatment pathways, switches, and inappropriate treatment during invasive pulmonary aspergillosis: real-world experiences from a global research network study
Treatment pathways, switches, and inappropriate treatment during invasive pulmonary aspergillosis: real-world experiences from a global research network study
ABSTRACT Despite advancements in diagnosing and treating invasive pulmonary aspergillosis (IPA), there is limited knowledg...
The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
ABSTRACT As new treatment alternatives for Mycobacterium abscessus complex (MABC) are urgently needed, we determined the m...
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