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A US-based national surveillance study for the susceptibility and epidemiology of Clostridioides difficile isolates with special reference to ridinilazole: 2020–2021
A US-based national surveillance study for the susceptibility and epidemiology of Clostridioides difficile isolates with special reference to ridinilazole: 2020–2021
ABSTRACT We have previously reported on the susceptibility and epidemiology of Clostridioides difficile isolates from six ...
Disrupting the infectious disease ecosystem in the digital precision health era innovations and converging emerging technologies
Disrupting the infectious disease ecosystem in the digital precision health era innovations and converging emerging technologies
ABSTRACT This commentary explores the convergence of precision health and evolving technologies, including the critical ro...
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
ABSTRACT Antimicrobial resistance has made a sizeable impact on public health and continues to threaten the effectiveness ...
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
ABSTRACT Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The curr...
Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles
Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles
ABSTRACT Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by W...
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms
ABSTRACT Multidrug resistance (MDR) transporters such as ATP-Binding Cassette (ABC) and Major Facilitator Superfamily prot...
Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
ABSTRACT Plasmodium falciparum causes the most severe malaria and is exposed to various environmental and physiological st...
Dissemination of IncI plasmid encoding bla CTX-M-1 is not hampered by its fitness cost in the pig’s gut
Dissemination of IncI plasmid encoding bla CTX-M-1 is not hampered by its fitness cost in the pig’s gut
ABSTRACT Multiresistance plasmids belonging to the IncI incompatibility group have become one of the most pervasive plasmi...
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
ABSTRACT Cefmetazole is active against extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) and is a potentia...
Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces Staphylococcus aureus infection and reduces Escherichia coli infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces Staphylococcus aureus infection and reduces Escherichia coli infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
ABSTRACT We have previously reported promising in vivo activity of the first-generation 2-aminopyramidine robenidine analo...
Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling
Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling
ABSTRACT A double ampC (AmpCG183D) and ampD (AmpDH157Y) genes mutations have been identified by whole genome sequencing in...
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates
ABSTRACT In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of...
In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus
In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus
ABSTRACT The emergence of disinfectant-resistant microorganisms poses a significant threat to public health. These resilie...
A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics
A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics
ABSTRACTNovel antibacterial agents and strategies are urgently needed to fight against the ongoing global antibiotic resis...
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
ABSTRACT Drug-resistant Mycobacterium tuberculosis is a worldwide health-care problem rendering current tuberculosis (TB) ...
Impact of acquired broad-spectrum β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam β-lactamase inhibitors in Escherichia coli
Impact of acquired broad-spectrum β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam β-lactamase inhibitors in Escherichia coli
ABSTRACTThe impact of β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and ...
Treatment pathways, switches, and inappropriate treatment during invasive pulmonary aspergillosis: real-world experiences from a global research network study
Treatment pathways, switches, and inappropriate treatment during invasive pulmonary aspergillosis: real-world experiences from a global research network study
ABSTRACT Despite advancements in diagnosing and treating invasive pulmonary aspergillosis (IPA), there is limited knowledg...
The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
ABSTRACT As new treatment alternatives for Mycobacterium abscessus complex (MABC) are urgently needed, we determined the m...
Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient
Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient
Campylobacter bacteremia is an uncommon disease that mainly occurs in immunocompromised patients and is associated with an...
Case Commentary: Successful Use of Cefepime/Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant New Delhi Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Infection in an Adult Patient with Acute T-Cell Leukemia
Case Commentary: Successful Use of Cefepime/Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant New Delhi Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Infection in an Adult Patient with Acute T-Cell Leukemia
Multidrug-resistant/extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa (PA) are critical antimicrobial resistance...
Ceftolozane-Tazobactam Versus Ceftazidime-Avibactam for the Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa: a Multicenter Cohort Study
Ceftolozane-Tazobactam Versus Ceftazidime-Avibactam for the Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa: a Multicenter Cohort Study
Ceftolozane-tazobactam (C-T) and ceftazidime-avibactam (CAZ-AVI) are two novel antimicrobials that retain activity against...
New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens
New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens
Two strains of Streptococcus pneumoniae, one expressing the methyltransferase Erm(B) and the other negative for erm(B), we...
Iohexol-Measured Glomerular Filtration Rate and Urinary Biomarker Changes between Vancomycin and Vancomycin Plus Piperacillin-Tazobactam in a Translational Rat Model
Iohexol-Measured Glomerular Filtration Rate and Urinary Biomarker Changes between Vancomycin and Vancomycin Plus Piperacillin-Tazobactam in a Translational Rat Model
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobact...
Multiplicity of blaKPC Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307
Multiplicity of blaKPC Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307
In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified i...
The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo
The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo
Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic en...
Ceftolozane-Tazobactam against Pseudomonas aeruginosa Cystic Fibrosis Clinical Isolates in the Hollow-Fiber Infection Model: Challenges Imposed by Hypermutability and Heteroresistance
Ceftolozane-Tazobactam against Pseudomonas aeruginosa Cystic Fibrosis Clinical Isolates in the Hollow-Fiber Infection Model: Challenges Imposed by Hypermutability and Heteroresistance
Pseudomonas aeruginosa remains a challenge in chronic respiratory infections in cystic fibrosis (CF). Ceftolozane-tazobact...
Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy
Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy
Candida (Clavispora) lusitaniae is a rare, emerging non-albicans Candida species that can cause life-threatening invasive ...
Mitochondrial Membrane-Associated Protein Mba1 Confers Antifungal Resistance by Affecting the Production of Reactive Oxygen Species in Aspergillus fumigatus
Mitochondrial Membrane-Associated Protein Mba1 Confers Antifungal Resistance by Affecting the Production of Reactive Oxygen Species in Aspergillus fumigatus
Azole resistance in the human fungal pathogen Aspergillus fumigatus is becoming a major threat to global health. To date, ...
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
ABSTRACT Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavita...
Characterization of Mycobacterium abscessus colony-biofilms based on bi-dimensional images
Characterization of Mycobacterium abscessus colony-biofilms based on bi-dimensional images
ABSTRACT Mycobacterium abscessus biofilm aggregates have been shown in the lungs of cystic fibrosis patients and are often...
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