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Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
ABSTRACT Antimicrobial resistance has made a sizeable impact on public health and continues to threaten the effectiveness ...
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
ABSTRACT Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The curr...
Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles
Diethylcarbamazine elicits Ca2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles
ABSTRACT Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by W...
Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
ABSTRACT Plasmodium falciparum causes the most severe malaria and is exposed to various environmental and physiological st...
Dissemination of IncI plasmid encoding bla
CTX-M-1 is not hampered by its fitness cost in the pig’s gut
Dissemination of IncI plasmid encoding bla CTX-M-1 is not hampered by its fitness cost in the pig’s gut
ABSTRACT Multiresistance plasmids belonging to the IncI incompatibility group have become one of the most pervasive plasmi...
In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus
In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus
ABSTRACT The emergence of disinfectant-resistant microorganisms poses a significant threat to public health. These resilie...
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
ABSTRACT Drug-resistant Mycobacterium tuberculosis is a worldwide health-care problem rendering current tuberculosis (TB) ...
The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
ABSTRACT As new treatment alternatives for Mycobacterium abscessus complex (MABC) are urgently needed, we determined the m...
The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo
The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo
Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic en...
Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy
Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy
Candida (Clavispora) lusitaniae is a rare, emerging non-albicans Candida species that can cause life-threatening invasive ...
Characterization of Mycobacterium abscessus colony-biofilms based on bi-dimensional images
Characterization of Mycobacterium abscessus colony-biofilms based on bi-dimensional images
ABSTRACT Mycobacterium abscessus biofilm aggregates have been shown in the lungs of cystic fibrosis patients and are often...