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How I personalize fluid therapy in septic shock?
How I personalize fluid therapy in septic shock?
During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue oxygenation, but it poses tw...
Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era
Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era
Lucia Gandini  ORCID: orcid....
Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis
Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis
The gut microbiome plays a pivotal role in the progression of sepsis. However, the specific mechanism of gut microbiota an...
Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses
Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other se...
Only the new beginning of VAP quality control
Only the new beginning of VAP quality control
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Angiotensin 1–7 in an experimental septic shock model
Angiotensin 1–7 in an experimental septic shock model
Alterations in the renin–angiotensin system have been implicated in the pathophysiology of septic shock. In particul...
Mechanical power of ventilation and driving pressure: two undervalued parameters for pre extracorporeal membrane oxygenation ventilation and during daily management?
Mechanical power of ventilation and driving pressure: two undervalued parameters for pre extracorporeal membrane oxygenation ventilation and during daily management?
The current ARDS guidelines highly recommend lung protective ventilation which include plateau pressure (Pplat &...
Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management
Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management
To determine the clinical feasibility of novel serum biomarkers in out-of-hospital cardiac arrest (OHCA) patients treated ...
Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19
Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19
The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). The us...
Extracorporeal cardiopulmonary resuscitation for adult out-of-hospital cardiac arrest patients: time-dependent propensity score-sequential matching analysis from a nationwide population-based registry
Extracorporeal cardiopulmonary resuscitation for adult out-of-hospital cardiac arrest patients: time-dependent propensity score-sequential matching analysis from a nationwide population-based registry
There is inconclusive evidence regarding the effectiveness of extracorporeal cardiopulmonary resuscitation (ECPR) for out-...
“Reply on: statistics on steroids—how recognizing competing risks gets us closer to the truth about COVID-19-associated VAP”
“Reply on: statistics on steroids—how recognizing competing risks gets us closer to the truth about COVID-19-associated VAP”
Ethics approval and consent to participate No patient was i...
A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest
A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest
This study aimed to assess the effect of different blood pressure levels on global cerebral metabolism in comatose patient...
Can artificial intelligence help for scientific writing?
Can artificial intelligence help for scientific writing?
This paper discusses the use of Artificial Intelligence Chatbot in scientific writing. ChatGPT is a type of chatbot, devel...
Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study
Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study
So far, the few prospective studies on near-death experience (NDE) were carried out only in intensive care unit (ICU) pati...
The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review
The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review
During high-flow nasal cannula (HFNC) therapy, flow plays a crucial role in the physiological effects. However, there is n...
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate le...
Response to the Letter by Spurling and Colleagues
Response to the Letter by Spurling and Colleagues
Ethics approval and consent to participate Not applicable. ...
Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia
Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia
Pseudomonas aeruginosa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug r...
Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity
Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity
Sepsis is characterized by a dysregulated immune response to infection. The complement system plays an important role in t...
Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers
Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers
Whether surrogate decision makers regret decisions about the use of life support for incapacitated, critically ill patient...
Norepinephrine formulation for equivalent vasopressive score
Norepinephrine formulation for equivalent vasopressive score
Kotani and colleagues should be commended for comparing the vasopressive effects of most vasopressors available on the mar...
Response to: The difference in the association between included ECPR patients and neurological outcomes
Response to: The difference in the association between included ECPR patients and neurological outcomes
We express our gratitude to Hifumi and their associates for their interest in our manuscript pertaining to the utilization...
Time-controlled adaptive ventilation in patients with ARDS—lack of protocol adherence: a systematic review
Time-controlled adaptive ventilation in patients with ARDS—lack of protocol adherence: a systematic review
Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory dis...
Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome
Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) patients with different lung morphology have distinct pulmonary mechanical dysf...
Rationale for sequential extracorporeal therapy (SET) in sepsis
Rationale for sequential extracorporeal therapy (SET) in sepsis
Sepsis and septic shock remain drivers for morbidity and mortality in critical illness. The clinical picture of patients p...
COVID-19 does not influence functional status after ARDS therapy
COVID-19 does not influence functional status after ARDS therapy
Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, es...
Dead space ventilation-related indices: bedside tools to evaluate the ventilation and perfusion relationship in patients with acute respiratory distress syndrome
Dead space ventilation-related indices: bedside tools to evaluate the ventilation and perfusion relationship in patients with acute respiratory distress syndrome
Cumulative evidence has demonstrated that the ventilatory ratio closely correlates with mortality in acute respiratory dis...
A pleural drainage tube misplaced into the right atrium
A pleural drainage tube misplaced into the right atrium
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Assessing oral comprehension with an eye tracking based innovative device in critically ill patients and healthy volunteers: a cohort study: authors' response
Assessing oral comprehension with an eye tracking based innovative device in critically ill patients and healthy volunteers: a cohort study: authors' response
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Does tidal volume challenge improve the feasibility of pulse pressure variation in patients mechanically ventilated at low tidal volumes? A systematic review and meta-analysis
Does tidal volume challenge improve the feasibility of pulse pressure variation in patients mechanically ventilated at low tidal volumes? A systematic review and meta-analysis
Pulse pressure variation (PPV) has been widely used in hemodynamic assessment. Nevertheless, PPV is limited in low tidal v...
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