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Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
It is unclear how often survival benefits observed in single-center randomized controlled trials (sRCTs) involving critica...
Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Unterberg M, Ehrentraut SF, Bracht T, Wolf A, Haberl H, von Busch A, Rump K, Ziehe D, Bazzi M, Thon P, et al. Human cytome...
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identific...
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal man...
Effects of early versus delayed application of prone position on ventilation–perfusion mismatch in patients with acute respiratory distress syndrome: a prospective observational study
Effects of early versus delayed application of prone position on ventilation–perfusion mismatch in patients with acute respiratory distress syndrome: a prospective observational study
Prone position has been shown to improve oxygenation and survival in patients with early acute respiratory distress syndro...
Extending the ‘host response’ paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities
Extending the ‘host response’ paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities
Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac...
Evaluation of the sensory environment in a large tertiary ICU
Evaluation of the sensory environment in a large tertiary ICU
ICU survival is improving. However, many patients leave ICU with ongoing cognitive, physical, and/or psychological impairm...
An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury
An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury
Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelin...
Myocardial dysfunction assessed by speckle-tracking in good-grade subarachnoid hemorrhage patients (WFNS 1–2): a prospective observational study
Myocardial dysfunction assessed by speckle-tracking in good-grade subarachnoid hemorrhage patients (WFNS 1–2): a prospective observational study
Cardiac complications due to non-traumatic subarachnoid hemorrhage (SAH) are usually described using classical echocardiog...
Critical appraisal and concerns regarding a meta-analysis on prothrombin complex concentrate (PCC) for trauma-induced coagulopathy: unveiling methodological nuances and treatment variances
Critical appraisal and concerns regarding a meta-analysis on prothrombin complex concentrate (PCC) for trauma-induced coagulopathy: unveiling methodological nuances and treatment variances
Hannadjas I, James A, Davenport R, Lindsay C, Brohi K, Cole E. Prothrombin complex concentrate (PCC) for treatment of trau...
Safety of interhospital transfer for critically ill COVID-19 patients
Safety of interhospital transfer for critically ill COVID-19 patients
Furthermore, we would like to thank all collaborators, who helped in the treatment of COVID-19 patients in Tyrol, Austria....
Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock
Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock
Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to asses...
Dynamic relative regional lung strain estimated by computed tomography and electrical impedance tomography in ARDS patients
Dynamic relative regional lung strain estimated by computed tomography and electrical impedance tomography in ARDS patients
In the acute distress respiratory syndrome (ARDS), specific lung regions can be exposed to excessive strain due to heterog...
Cytokine removal: do not ban it, but learn in whom and when to use it
Cytokine removal: do not ban it, but learn in whom and when to use it
Ethics approval and consent to participate Not applicable. ...
Relationship between the shape of intracranial pressure pulse waveform and computed tomography characteristics in patients after traumatic brain injury
Relationship between the shape of intracranial pressure pulse waveform and computed tomography characteristics in patients after traumatic brain injury
Midline shift and mass lesions may occur with traumatic brain injury (TBI) and are associated with higher mortality and mo...
Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes
Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes
Sepsis is a medical emergency with potentially life-threatening consequences. Patients play a crucial role in preventing a...
Comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Factors influencing withdrawal of life-supporting treatment in cervical spinal cord injury: a large multicenter observational cohort study
Factors influencing withdrawal of life-supporting treatment in cervical spinal cord injury: a large multicenter observational cohort study
Traumatic spinal cord injury (SCI) leads to profound neurologic sequelae, and the provision of life-supporting treatment s...
Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes
Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes
Severe weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific i...
Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors
Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors
The mortality benefit of VV-ECMO in ARDS has been extensively studied, but the impact on long-term functional outcomes of ...
Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study
Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study
Sepsis survivors commonly experience functional impairment, which may limit return to work. We investigated return to work...
From pressure to tension: a model of damaging inflation stress
From pressure to tension: a model of damaging inflation stress
Although the stretch that generates ventilator-induced lung injury (VILI) occurs within the peripheral tissue that enclose...
In-hospital extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: an analysis by time-dependent propensity score matching using a nationwide database in Japan
In-hospital extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: an analysis by time-dependent propensity score matching using a nationwide database in Japan
Extracorporeal cardiopulmonary resuscitation (ECPR) has been proposed as a rescue therapy for patients with refractory car...
Dynamic change of PaO2 may affect the association between hyperoxemia and prognosis
Dynamic change of PaO2 may affect the association between hyperoxemia and prognosis
I am writing to provide a comment on the recent article [1] published in Critical Care, which investigated the dose–respon...
Epidemiology of ischemic stroke and hemorrhagic stroke in venoarterial extracorporeal membrane oxygenation
Epidemiology of ischemic stroke and hemorrhagic stroke in venoarterial extracorporeal membrane oxygenation
While venoarterial extracorporeal membrane oxygenation (V-A ECMO) provides lifesaving support for cardiopulmonary failure,...
Application of CO2 clearance to estimate cardiac output in patients with venoarterial extracorporeal membrane oxygenation
Application of CO2 clearance to estimate cardiac output in patients with venoarterial extracorporeal membrane oxygenation
Patients supported by VA-ECMO are characterized by end-organ hypoperfusion due to low CO (cardiac output) and hypotension....
Association between early enteral nutrition and mortality in critically ill patients
Association between early enteral nutrition and mortality in critically ill patients
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Analysis of static parameters in retrospective studies: limitations and interpretation
Analysis of static parameters in retrospective studies: limitations and interpretation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Interpretable machine learning models for predicting venous thromboembolism in the intensive care unit: an analysis based on data from 207 centers
Interpretable machine learning models for predicting venous thromboembolism in the intensive care unit: an analysis based on data from 207 centers
Venous thromboembolism (VTE) is a severe complication in critically ill patients, often resulting in death and long-term d...
Quantitative analysis of early apparent diffusion coefficient values from MRIs for predicting neurological prognosis in survivors of out-of-hospital cardiac arrest: an observational study
Quantitative analysis of early apparent diffusion coefficient values from MRIs for predicting neurological prognosis in survivors of out-of-hospital cardiac arrest: an observational study
This study aimed to quantitatively analyse ultra-early brain diffusion-weighted magnetic resonance imaging (DW-MRI) findin...
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