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Ten Years of Anti-CRISPR Research
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Missense3D-PPI: a web resource to predict the impact of missense variants at protein interfaces using 3D structural data
Residues on the protein surface that are not directly involved in function generally are more tolerant to amino acid subst...
CryoRes: Local Resolution Estimation of Cryo-EM Density Maps by Deep Learning
Cryo-electron microscopy (cryo-EM) has become one of the major technologies for high-resolution structure determination of...
iQDeep: an integrated web server for protein scoring using multiscale deep learning models
Protein scoring is a critical component of protein structure prediction 1, 2, 3, 4, 5. Protein scoring has been gaining no...
CM2D3: Furnishing the human interactome with structural models of protein complexes derived by comparative modeling and docking
The human interactome is composed of around half a million interactions according to recent estimations and it is only for...
GutBug: A tool for prediction of human gut bacteria mediated biotransformation of biotic and xenobiotic molecules using machine learning
Author links open overlay panel, , AbstractDietary components and bioactive molecules present in functional foods and nutr...
Anti-CRISPR Proteins
Author links open overlay panel, , Section snippetsDeclaration of Competing InterestThe authors declare that they have no ...
PrePPI: A structure informed proteome-wide database of protein-protein interactions
The identification of proteins that interact with one another is a challenging problem of central importance in fundamenta...
RNAprofiling 2.0: Enhanced cluster analysis of structural ensembles
The method of sampling RNA secondary structures from the Boltzmann distribution [1], [2] under the nearest neighbor thermo...
Recognition mechanism of a novel gabapentinoid drug, mirogabalin, for recombinant human α2δ1, a voltage-gated calcium channel subunit
Mirogabalin is a novel gabapentinoid drug with a hydrophobic bicyclo substituent on the γ-aminobutyric acid moiety that ta...
Cryo-electron microscopy reveals the structure of the nuclear pore complex
The nuclear pore complex (NPC) is a giant protein assembly that penetrates the double layers of the nuclear membrane. The ...
The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinsically disordered protein
Proteins that do not have a defined 3D structure over all or part of their sequence, but nevertheless have biological acti...
Unravelling the tripartite interactions among Hepatitis E virus RNA, miR-140 and hnRNP K: Running title: Interactions between HEV-RNA, miR-140 and hnRNP K
Hepatitis E virus (HEV) is a positive-sense single-stranded RNA virus that is a common cause of acute viral hepatitis worl...
WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins
The comparison of protein structures is a crucial problem in structural biology. In the early works [1], [2], the use of r...
Phage against the machine: discovery and mechanism of type V anti-CRISPRs
Translation initiation in eukaryotes relies on a complex network of interactions that are continuously reorganized through...
Differential Structural Features of Two Mutant ADAR1p150 Zα Domains Associated with Aicardi-Goutières Syndrome
We are having a few technical issues and our site is currently unavailable. We are working to get it back online as qui...
SSP: An in silico tool for Salmonella species serotyping using the sequences of O-antigen biosynthesis proteins and H-antigen filament proteins
Salmonella is a Gram-negative, facultatively anaerobic, rod-shaped (bacillus) bacterial genus belonging to the Enterobacte...
Highly performing automatic detection of structural chromosomal abnormalities using Siamese architecture
Chromosomes contain the genetic information of every cell. Chromosomal abnormalities are divided into two categories: abno...
An insect viral protein disrupts stress granule formation in mammalian cells
Cells respond to environmental conditions such as oxidative stress, ER stress, proteotoxic stress, nutrient starvation, he...
RiboGalaxy: A Galaxy-based web platform for ribosome profiling data processing - 2023 update
Ribosome profiling (Ribo-Seq) captures a “snapshot” of ribosomes’ locations at the entire transcriptome of a cell at sub-c...
Diverse mechanisms of CRISPR-Cas9 inhibition by type II anti-CRISPR proteins
Bacteria and archaea protect themselves from attack by foreign genetic elements such as plasmids, transposons, and phages,...
Activity and structural dynamics of human ABCA1 in a lipid membrane
The eukaryotic Plasma Membrane (PM) houses thousands of Membrane Proteins (MPs), which perform countless necessary functio...
Differential Structural Features of Two Mutant ADAR1p150 Zα Domains Cause Aicardi-Goutières Syndrome
Author links open overlay panel, , , , AbstractThe Zα domain of ADARp150 is critical for proper Z-RNA substrate binding an...
Why Does Synergistic Activation of WASP, but Not N-WASP, by Cdc42 and PIP2 Require Cdc42 Prenylation?
Human Wiskott-Aldrich syndrome protein (WASP) and neural WASP (N-WASP) are homologous proteins that contain intrinsically ...
Methods for Cryo-EM Single Particle Reconstruction of Macromolecules Having Continuous Heterogeneity
Over the past few years, the combination of cryo-electron microscopy (cryo-EM) imaging and single-particle analysis has be...
In silico approaches for prediction of anti-CRISPR proteins
Author links open overlay panel, , Highlights•Numerous viruses infecting bacteria and archaea encode one or more proteins ...
Global analysis of multi-mutants to improve protein function
The identification of amino acid substitutions that both enhance the stability and function of a protein is a key challeng...
Intrinsically disordered chromatin protein NUPR1 binds to the enzyme PADI4
KeywordsPADI4protein-protein interactionscitrullinationfluorescencemolecular modelingAbbreviationsDAPI 4′6-diamidino-2-phe...
Corrigendum to “Human Cardiac Myosin Binding Protein C: Structural Flexibility within an Extended Modular Architecture” [J. Mol. Biol. 414(5) (2011) 735–748]
Author links open overlay panelCy M. Jeffries 1, Yanling Lu 1, Robert M.G. Hynson 1, James E. Taylor 1 2, Mercedes Ballest...
ProSeqAProDB: Prosequence assisted protein Database
Attaining an active three-dimensional conformation through folding of the linear polypeptide chain synthesized on the ribo...
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