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Mitotic DNA synthesis in untransformed human cells preserves common fragile site stability via a FANCD2-driven mechanism that requires HELQ
Mitotic DNA synthesis in untransformed human cells preserves common fragile site stability via a FANCD2-driven mechanism that requires HELQ
KeywordsReplication stressCommon fragile sitesFanconi anemiaHELQUntransformed human cellsAbbreviationsLRILate Replication ...
Evolutionary engineering a larger porin using a loop-to-hairpin mechanism
Evolutionary engineering a larger porin using a loop-to-hairpin mechanism
In protein evolution, diversification is generally driven by genetic duplication. The hallmarks of this mechanism are visi...
Mechanistic insights into the interactions of Arl8b with the RUN domains of PLEKHM1 and SKIP
Mechanistic insights into the interactions of Arl8b with the RUN domains of PLEKHM1 and SKIP
Lysosomes are dynamic and acidic organelles destined for the cellular turnover and recycling of intracellular and endocyto...
Characterization of a (p)ppApp synthetase belonging to a new family of polymorphic toxin associated with temperate phages
Characterization of a (p)ppApp synthetase belonging to a new family of polymorphic toxin associated with temperate phages
Polygonum Cuspidate (P. cuspidatum) is a traditional topical preparation of Chinese medicine. The aim of this study was to...
An Innate Host Defense Protein; β2-Microglobulin Keeps a Check on α-Synuclein Amyloid Assembly: Implications in Parkinson's disease
An Innate Host Defense Protein; β2-Microglobulin Keeps a Check on α-Synuclein Amyloid Assembly: Implications in Parkinson's disease
Most proteins fold into well-defined 3D structures through a controlled mechanism of protein homeostasis governed by an ex...
The smallest infectious substructure encoding the prion strain structural determinant revealed by spontaneous dissociation of misfolded prion protein assemblies
The smallest infectious substructure encoding the prion strain structural determinant revealed by spontaneous dissociation of misfolded prion protein assemblies
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Analysis of reconstituted tripartite complex supports avidity-based recruitment of Hsp70 by substrate bound J-domain protein
Analysis of reconstituted tripartite complex supports avidity-based recruitment of Hsp70 by substrate bound J-domain protein
Author links open overlay panel, , , , , , , , , , , , , Highlights•biochemical reconstitution of the tripartite Hsp70-JDP...
Amyloid aggregation is potently slowed down by osmolytes due to compaction of partially folded state
Amyloid aggregation is potently slowed down by osmolytes due to compaction of partially folded state
The process of forming soluble and insoluble amyloid aggregates in vivo has been long regarded as the molecular cause of n...
Role of Translesion DNA Synthesis in the metabolism of replication-associated nascent strand gaps
Role of Translesion DNA Synthesis in the metabolism of replication-associated nascent strand gaps
Genomic instability is a cellular vulnerability and a driver of tumorigenesis, therefore considered to be a hallmark of ca...
Mammalian DNA ligases; roles in maintaining genome integrity
Mammalian DNA ligases; roles in maintaining genome integrity
The presence of DNA single- and, in particular, double-strand breaks promotes genomic instability by enhancing interaction...
BRCA1/2 haploinsufficiency: exploring the impact of losing one allele
BRCA1/2 haploinsufficiency: exploring the impact of losing one allele
Author links open overlay panel, AbstractSince their discovery in the late 20th century, significant progress has been mad...
Kinetics of translating ribosomes determine the efficiency of programmed stop codon readthrough
Kinetics of translating ribosomes determine the efficiency of programmed stop codon readthrough
Author links open overlay panel, , , , , , AbstractDuring translation, a stop codon on the mRNA signals the ribosomes to t...
Internal proton transfer in the activation of heliorhodopsin
Internal proton transfer in the activation of heliorhodopsin
Many organisms sense sunlight using rhodopsins, which are integral membrane proteins that bind retinal chromophores.1 Rhod...
CoMemMoRFPred: sequence-based prediction of MemMoRFs by combining predictors of intrinsic disorder, MoRFs and disordered lipid-binding regions
CoMemMoRFPred: sequence-based prediction of MemMoRFs by combining predictors of intrinsic disorder, MoRFs and disordered lipid-binding regions
Intrinsically disordered proteins (IDPs) contain one or more intrinsically disordered regions (IDRs), which are sequence s...
The UV-A receptor CRY-DASH1 up- and downregulates proteins involved in different plastidial pathways
The UV-A receptor CRY-DASH1 up- and downregulates proteins involved in different plastidial pathways
KeywordsChlamydomonas reinhardtiicentral carbon metabolismchlorophyll biosynthesislight signalingphotoreceptorAbbreviation...
Disruption of Ebola NP0VP35 Inclusion Body-like Structures reduce Viral Infection
Disruption of Ebola NP0VP35 Inclusion Body-like Structures reduce Viral Infection
Ebola viruses (EBOV) are reemerging, non-segmented negative-stranded RNA viruses that cause periodic outbreaks of severe h...
WebSTR: a population-wide database of short tandem repeat variation in humans
WebSTR: a population-wide database of short tandem repeat variation in humans
Keywordsnext-generation sequencinghuman genetic variationdisease-associated variantsshort tandem repeatsgene regulatory re...
Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding
Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding
Transferrin receptor 1 (TfR) delivers iron across cellular membranes by shuttling the ion carrier protein transferrin. Thi...
Nucleosome array deformation in chromatin is sustained by bending, twisting and kinking of linker DNA.
Nucleosome array deformation in chromatin is sustained by bending, twisting and kinking of linker DNA.
Cells in tissues are affected by mechanical forces at different length and time scales. Both intracellular and extracellul...
The cytotoxic mycobacteriophage protein Phaedrus gp82 interacts with and modulates the activity of the host ATPase, MoxR
The cytotoxic mycobacteriophage protein Phaedrus gp82 interacts with and modulates the activity of the host ATPase, MoxR
Antimicrobial resistance presents a major threat to human health, and new strategies for controlling bacterial infections ...
Asymmetric structure of podophage GP4 reveals a novel architecture of three types of tail fibers
Asymmetric structure of podophage GP4 reveals a novel architecture of three types of tail fibers
The tail structures of podophages exhibit striking homology, such as T7 [1], Pam1 [2], ε15 [3], P22 [4], and P-SSP7 [5], i...
An evolutionarily conserved strategy for ribosome binding and host translation inhibition by β-coronavirus non-structural protein 1
An evolutionarily conserved strategy for ribosome binding and host translation inhibition by β-coronavirus non-structural protein 1
As obligate intracellular parasites, all viruses require the cellular gene expression machinery for replication, and many ...
Engineering bacteriophytochrome-coupled photoactivated adenylyl cyclases for enhanced optogenetic cAMP modulation
Engineering bacteriophytochrome-coupled photoactivated adenylyl cyclases for enhanced optogenetic cAMP modulation
Author links open overlay panel, , , , , , , , , , , , Highlights•bacteriophytochromes (BphP) regulate effector function b...
The 3D modules of enzyme catalysis: deconstructing active sites into distinct functional entities
The 3D modules of enzyme catalysis: deconstructing active sites into distinct functional entities
Enzyme catalysis is governed by a limited toolkit of residues and organic or inorganic co-factors. Therefore, it is expect...
Magnesium Ion-Driven Folding and Conformational Switching Kinetics of Tetracycline Binding Aptamer: Implications for in vivo Riboswitch Engineering
Magnesium Ion-Driven Folding and Conformational Switching Kinetics of Tetracycline Binding Aptamer: Implications for in vivo Riboswitch Engineering
RNA aptamers can be selected against basically any molecule of choice by an in vitro process called systematic evolution o...
K-Pro: Kinetics data on proteins and mutants
K-Pro: Kinetics data on proteins and mutants
The study of protein folding plays a crucial role in improving our understanding of protein function and of the relationsh...
Encounter complexes between the N-terminal of neurotensin with the extracellular loop 2 of the neurotensin receptor 1 steer neurotensin to the orthosteric binding pocket
Encounter complexes between the N-terminal of neurotensin with the extracellular loop 2 of the neurotensin receptor 1 steer neurotensin to the orthosteric binding pocket
Neurotensin (NT) is a linear disordered peptide that activates two different class A GPCRs, neurotensin receptor 1 (NTS1) ...
SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions
SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions
Erythropoietin-producing human hepatocellular (Eph) receptor tyrosine kinases constitute the largest subfamily within the ...
Histone H3 tail modifications alter structure and dynamics of the H1 C-terminal domain within nucleosomes
Histone H3 tail modifications alter structure and dynamics of the H1 C-terminal domain within nucleosomes
In eukaryotes, chromatin condenses genomic DNA within the nucleus and regulates DNA accessibility through a variety of mec...
Structural basis of the allosteric inhibition of human ABCG2 by nanobodies
Structural basis of the allosteric inhibition of human ABCG2 by nanobodies
Cryo-EM density maps were deposited into the Electron Microscopy Data Bank (EMDB) and the coordinates for the correspondin...
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