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Elucidation of the mechanisms of inter-domain coupling in the monomeric state of Enzyme I by high-pressure NMR
Elucidation of the mechanisms of inter-domain coupling in the monomeric state of Enzyme I by high-pressure NMR
Enzyme I (EI) initiates the carbohydrate phosphotransferase system (PTS), a signal transduction pathway that controls the ...
CATH 2024: CATH-AlphaFlow Doubles the Number of Structures in CATH and Reveals Nearly 200 New Folds
CATH 2024: CATH-AlphaFlow Doubles the Number of Structures in CATH and Reveals Nearly 200 New Folds
CATH (https://www.cathdb.info) classifies domain structures from experimental protein structures in the PDB and predicted ...
ModFOLD9: A Web Server for Independent Estimates of 3D Protein Model Quality
ModFOLD9: A Web Server for Independent Estimates of 3D Protein Model Quality
Accurate models of protein tertiary structures are now available from numerous advanced prediction methods, although the a...
Membrane atg8ylation in canonical and noncanonical autophagy
Membrane atg8ylation in canonical and noncanonical autophagy
Membrane atg8ylation is a process of modification of diverse cellular membranes by ubiquitin-like mammalian ATG8 proteins ...
DockThor-VS: a Free Platform for Receptor-Ligand Virtual Screening
DockThor-VS: a Free Platform for Receptor-Ligand Virtual Screening
Docking-based virtual screening is a structure-based drug design approach widely used by the scientific community to assis...
NNDB: An expanded database of nearest neighbor parameters for predicting stability of nucleic acid secondary structures
NNDB: An expanded database of nearest neighbor parameters for predicting stability of nucleic acid secondary structures
Nearest neighbor thermodynamic approaches are the cornerstone of popular RNA secondary structure design and prediction too...
PrimPol Variant V102A with Altered Primase and Polymerase Activities
PrimPol Variant V102A with Altered Primase and Polymerase Activities
In 2005, based on in silico analysis, the protein encoded by human gene CCDC111 was identified as a potential primase belo...
A Commentary on Multi-omics Data Integration in Systems Vaccinology
A Commentary on Multi-omics Data Integration in Systems Vaccinology
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
KMT2 Family of H3K4 Methyltransferases: Enzymatic Activity-dependent and -independent Functions
KMT2 Family of H3K4 Methyltransferases: Enzymatic Activity-dependent and -independent Functions
Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases are critical for gene regulation, cell differentiation, ani...
Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription
Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription
Journal of Molecular BiologyVolume 436, Issue 7, 1 April 2024, 168376Author links open overlay panel, Highlights•Site-spec...
Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation
Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation
DNA methylation is a well-studied epigenetic modification that has key roles in regulating gene expression, maintaining ge...
C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies
C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies
In humans, specific aberrations in β-globin results in sickle cell disease and β-thalassemia, symptoms of which can be ame...
Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective
Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective
Since Strahl and Allis proposed the “language of covalent histone modifications”, a host of experimental studies have shed...
Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in Transcriptional Attenuation
Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in Transcriptional Attenuation
Spindlin1 is a histone reader with three Tudor-like domains and its transcriptional co-activator activity could be attenua...
IHMCIF: An Extension of the PDBx/mmCIF Data Standard for Integrative Structure Determination Methods
IHMCIF: An Extension of the PDBx/mmCIF Data Standard for Integrative Structure Determination Methods
IHMCIF (github.com/ihmwg/IHMCIF) is a data information framework that supports archiving and disseminating macromolecular ...
C-terminal domain of T4 gene 32 protein enables rapid filament reorganization and dissociation
C-terminal domain of T4 gene 32 protein enables rapid filament reorganization and dissociation
Bacteriophage T4 gene 32 protein (gp32) is a single-stranded DNA (ssDNA) binding protein essential for DNA replication. gp...
AHoJ-DB: A PDB-wide assignment of apo & holo relationships based on individual protein-ligand interactions
AHoJ-DB: A PDB-wide assignment of apo & holo relationships based on individual protein-ligand interactions
Recent advances in methodology and processing power have slingshot structural biology to the forefront of biological resea...
TENET: Triple-Enhancement based Graph Neural Network for Cell-cell Interaction Network Reconstruction from Spatial Transcriptomics
TENET: Triple-Enhancement based Graph Neural Network for Cell-cell Interaction Network Reconstruction from Spatial Transcriptomics
The understanding of cellular communication and its significance in coordinating various biological processes underscores ...
Folding of class IIa HDAC derived peptides into α-helices upon binding to myocyte enhancer factor-2 in complex with DNA
Folding of class IIa HDAC derived peptides into α-helices upon binding to myocyte enhancer factor-2 in complex with DNA
The myocyte enhancer factor 2 (MEF2) protein family belongs to the MADS-box superfamily of transcription factors (TFs) and...
CAPRI-Q: The CAPRI resource evaluating the quality of predicted structures of protein complexes
CAPRI-Q: The CAPRI resource evaluating the quality of predicted structures of protein complexes
Author links open overlay panel, , , , , , , Highlights:•CAPRI has catalyzed the development and defines the state of the ...
Anthrax Toxin: Model System for Studying Protein Translocation
Anthrax Toxin: Model System for Studying Protein Translocation
Cells are compartmentalized by membrane bilayers, isolating individual organelles in the cell and separating the extracell...
Highly Reactive Group I Introns Ubiquitous in Pathogenic Fungi
Highly Reactive Group I Introns Ubiquitous in Pathogenic Fungi
Systemic fungal infections are a growing public health threat, and yet viable antifungal drug targets are limited as fungi...
Skp2-Cyclin A Interaction Is Necessary for Mitotic Entry and Maintenance of Diploidy
Skp2-Cyclin A Interaction Is Necessary for Mitotic Entry and Maintenance of Diploidy
Journal of Molecular BiologyVolume 436, Issue 8, 15 April 2024, 168505Author links open overlay panel, , , , Highlights•Sk...
Control of Munc13-1 Activity by Autoinhibitory Interactions Involving the Variable N-terminal Region
Control of Munc13-1 Activity by Autoinhibitory Interactions Involving the Variable N-terminal Region
Neurons communicate through neurotransmitters that are released from presynaptic terminals through Ca2+-evoked synaptic ve...
Mechanisms of Translation-coupled Quality Control
Mechanisms of Translation-coupled Quality Control
Aberrant translation is a major cause of protein homeostasis disruption, leading to the accumulation of faulty proteins an...
Loss of Preproinsulin Interaction with Signal Recognition Particle Activates Protein Quality Control, Decreasing mRNA Stability
Loss of Preproinsulin Interaction with Signal Recognition Particle Activates Protein Quality Control, Decreasing mRNA Stability
The protein hormone insulin is synthesized and secreted by pancreatic β-cells in response to rising blood glucose levels.1...
Folded Alpha Helical Putative New Proteins from Apilactobacillus kunkeei
Folded Alpha Helical Putative New Proteins from Apilactobacillus kunkeei
Journal of Molecular BiologyVolume 436, Issue 6, 15 March 2024, 168490Author links open overlay panel, , , , , , , , , Hig...
Short Peptide Amyloids Are a Potential Sequence Pool for the Emergence of Proteins
Short Peptide Amyloids Are a Potential Sequence Pool for the Emergence of Proteins
Journal of Molecular BiologyVolume 436, Issue 6, 15 March 2024, 168495Author links open overlay panel, , , , Highlights•On...
Interpreting Combinatorial Epigenetic Modifications for Biological Meaning
Interpreting Combinatorial Epigenetic Modifications for Biological Meaning
T. KouzaridesChromatin modifications and their functionCell(2007)S. Maurer-Stroh et al.The Tudor domain 'Royal Family': Tu...