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Fine-tuning of the Hsc70-based human protein disaggregase machinery by the distinctive C-terminal extension of Apg2
Apg2, one of the three cytosolic Hsp110 chaperones in humans, supports reactivation of unordered and ordered protein aggre...
Reprogramming of Activated Pancreatic Stellate Cells via Mechanical Modulation of Transmembrane Force-sensitive N-cadherin Receptor
Cancer is a major cause of death that threatens human health worldwide1. It has been estimated that there are 19.3 million...
The structure of Saccharomyces cerevisiae arginyltransferase 1 (ATE1)
Post-translational modifications (PTMs) are important covalent modifications of proteins that can target nearly 75% of ami...
Structural studies reveal unique non-canonical regulators of G protein signaling homology (RH) domains in sorting nexins
Sorting nexins (SNXs) are a large group of proteins defined by presence of a conserved phox homology (PX) domain, which me...
Effects of N-terminal acetylation on the aggregation of disease-related α-synuclein variants
Mutations in the SCNA gene, which encodes the protein α-synuclein, have been linked with early onset Parkinson’s disease. ...
Quantifying shear-induced margination and adhesion of platelets in microvascular blood flow
Thrombosis is a serious condition where one or more blood clots form inside the blood vessels, which prevents blood from f...
Ca2+ and Mg2+ Influence the Thermodynamics of Peptide-Membrane Interactions
Interactions between peptides/proteins and lipid membranes are involved in every aspect of cellular function. They are als...
The role of O-antigen in P1 transduction of Shigella flexneri and Escherichia coli with its alternative S' tail fibre
Enterobacteria phage P1 expresses two types of tail fibre, S and S'. Despite the wide usage of phage P1 for transduction, ...
Disorder in the human Skp1 structure is the key to its adaptability to bind many different proteins in the SCF complex assembly
The Ubiquitin proteasome system (UPS) is responsible for tagging proteins with ubiquitin and targeting them for degradatio...
Defective Human SRP Induces Protein Quality Control and Triggers Stress Response
Highlights•Human SRP targets secretory proteins to ER and protects their mRNAs.•SRP54 depletion globally downregulates sec...
Patterns and Crucial Regulation of Alternative Splicing During Early Development in Zebrafish
The flow of genomic information, from DNA to RNA to protein, is a highly complex process in organisms. One of the importan...
Domain-Based Protein Docking with Extremely Large Conformational Changes
Protein-protein interactions are fundamental to many biological processes in living cells. To understand in detail the mec...
Membrane Tethering of SepF, a Membrane Anchor for the Mycobacterium tuberculosis Z-ring
Journal of Molecular BiologyVolume 434, Issue 21, 15 November 2022, 167817AbstractBacterial cell division begins with the ...
Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations
Age is the greatest risk factor for developing cells with genome instability and most types of cancer14. There are strong ...
Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state
Journal of Molecular BiologyVolume 434, Issue 20, 30 October 2022, 167801Highlights•Ribosome containing neuronal RNA granu...
Genome-regulated Assembly of a ssRNA Virus May Also Prepare It for Infection
Many single-stranded, positive-sense RNA viruses regulate assembly of their infectious virions by forming multiple, cognat...
Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8
ABCAdenosine-triphosphate-binding cassetteNBDNucleotide binding domainRCTReverse cholesterol transportTICETransintestinal ...
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
Journal of Molecular BiologyVolume 434, Issue 20, 30 October 2022, 167796Highlights•Nsp15 is a uridine-specific endoribonu...
Terminase Subunits from the Pseudomonas-Phage E217
The genome-packaging motor of tailed bacteriophages and herpesviruses is a multi-subunit nanomachine1, 2, 3, 4 formed by s...
Ligand-mediated Structural Dynamics of a Mammalian Pancreatic KATP Channel
Coordinates and cryoEM density maps for KATP channel models of the Kir6.2 tetramer core plus one SUR1 subunit have been de...
Signal Peptide-rheostat Dynamics Delay Secretory Preprotein Folding
N-terminal signal peptides have evolved as a means of sorting secretory preproteins from cytoplasmic ones, predominantly i...
Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP
Journal of Molecular BiologyVolume 434, Issue 17, 15 September 2022, 167747Highlights•BetP is critical for responses to hy...
α-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties
Synucleinopathies are a group of neurodegenerative disorders that are marked by the presence of intracellular inclusion bo...
Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding
Roundabout (Robo) receptors and their Slit ligands are well known axon guidance molecules that were originally identified ...
Human Immunodeficiency Virus Type 2 Capsid Protein Mutagenesis Reveals Amino Acid Residues Important for Virus Particle Assembly
Human immunodeficiency virus (HIV) belongs to the lentivirus genus of the Retroviridae. To date, HIV has infected more tha...
Integration of Multiple, Diverse Methods to Identify Biologically Significant Marker Genes
Identification of genes that reliably mark distinct cell types is key to leveraging single-cell RNA sequencing to better u...