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Functional omics of ORP7 in primary endothelial cells
Functional omics of ORP7 in primary endothelial cells
Many members of the oxysterol-binding protein-related protein (ORP) family have been characterized in detail over the past...
The 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae
The 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae
The complete mitochondrial respiratory chain is a precondition for maintaining cellular energy supply, development, and me...
Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data
Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data
RNA velocity, as an extension of trajectory inference, is an effective method for understanding cell development using sin...
Pheromone relay networks in the honeybee: messenger workers distribute the queen’s fertility signal throughout the hive
Pheromone relay networks in the honeybee: messenger workers distribute the queen’s fertility signal throughout the hive
The harmonious operation of many insect societies depends upon colony-wide dissemination of a non-volatile pheromone produ...
The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding
The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding
Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contras...
Revisiting microgenderome: detecting and cataloguing sexually unique and enriched species in human microbiomes
Revisiting microgenderome: detecting and cataloguing sexually unique and enriched species in human microbiomes
Microgenderome or arguably more accurately microsexome refers to studies on sexual dimorphism of human microbiomes aimed a...
CRISPR/Cas9-induced double-strand breaks in the huntingtin locus lead to CAG repeat contraction through DNA end resection and homology-mediated repair
CRISPR/Cas9-induced double-strand breaks in the huntingtin locus lead to CAG repeat contraction through DNA end resection and homology-mediated repair
The expansion of CAG/CTG repeats in functionally unrelated genes is a causative factor in many inherited neurodegenerative...
Species specificity and specificity diversity (SSD) framework: a novel method for detecting the unique and enriched species associated with disease by leveraging the microbiome heterogeneity
Species specificity and specificity diversity (SSD) framework: a novel method for detecting the unique and enriched species associated with disease by leveraging the microbiome heterogeneity
Differentiating the microbiome changes associated with diseases is challenging but critically important. Majority of exist...
Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryote
Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryote
In trypanosomatids, a group of unicellular eukaryotes that includes numerous important human parasites, cis-splicing has b...
Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling
Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling
Inflammatory bowel disease (IBD), a persistent gastrointestinal disease, is featured with impaired gut immunity. Previous ...
Protists and protistology in the Anthropocene: challenges for a climate and ecological crisis
Protists and protistology in the Anthropocene: challenges for a climate and ecological crisis
Eukaryotic microorganisms, or “protists,” while often inconspicuous, play fundamental roles in the Earth ecosy...
Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated CaV1.2 c...
The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies
The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard of care involves maximal surgery ...
Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation
Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation
The tree shrew (Tupaia belangeri) is a promising emerging model organism in biomedical studies, notably due to their evolu...
Serological evidence of sarbecovirus exposure along Sunda pangolin trafficking pathways
Serological evidence of sarbecovirus exposure along Sunda pangolin trafficking pathways
Early in the coronavirus disease 2019 (COVID-19) pandemic, Sunda pangolins (Manis javanica) involved in the illegal wildli...
A novel human protein-coding locus identified using a targeted RNA enrichment technique
A novel human protein-coding locus identified using a targeted RNA enrichment technique
Accurate and comprehensive genomic annotation, including the full list of protein-coding genes, is vital for understanding...
Multiple losses of aKRAB from PRDM9 coincide with a teleost-specific intron size distribution
Multiple losses of aKRAB from PRDM9 coincide with a teleost-specific intron size distribution
Primary transcripts are largely comprised of intronic sequences that are excised and discarded shortly after synthesis. In...
Temperature-dependent dynamics of energy stores in Drosophila
Temperature-dependent dynamics of energy stores in Drosophila
Understanding how ectotherms manage energy in response to temperature is crucial for predicting their responses to climate...
Bayesian tip-dated timeline for diversification and major biogeographic events in Muroidea (Rodentia), the largest mammalian radiation
Bayesian tip-dated timeline for diversification and major biogeographic events in Muroidea (Rodentia), the largest mammalian radiation
Extinct organisms provide vital information about the time of origination and biogeography of extant groups. The developme...
The golden genome annotation of Ganoderma lingzhi reveals a more complex scenario of eukaryotic gene structure and transcription activity
The golden genome annotation of Ganoderma lingzhi reveals a more complex scenario of eukaryotic gene structure and transcription activity
It is generally accepted that nuclear genes in eukaryotes are located independently on chromosomes and expressed in a mono...
Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
Dietary restriction (DR) has multiple beneficial effects on health and longevity and can also improve the efficacy of cert...
Ancient genomes from the Tang Dynasty capital reveal the genetic legacy of trans-Eurasian communication at the eastern end of Silk Road
Ancient genomes from the Tang Dynasty capital reveal the genetic legacy of trans-Eurasian communication at the eastern end of Silk Road
Ancient Chang’an in the Tang Dynasty (618–907 AD) was one of the world’s largest and most populated citi...
Eurasian spruce bark beetle detects lanierone using a highly expressed specialist odorant receptor, present in several functional sensillum types
Eurasian spruce bark beetle detects lanierone using a highly expressed specialist odorant receptor, present in several functional sensillum types
Insects detect odours using odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) in the antennae. Ecologi...
Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics
Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics
Wolbachia incompatible insect technique (IIT) programs have been shown in field trials to be highly effective in suppressi...
Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes
Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes
Tissue engineering techniques offer new strategies to understand complex processes in a controlled and reproducible system...
Long-term survival of asexual Zymoseptoria tritici spores in the environment
Long-term survival of asexual Zymoseptoria tritici spores in the environment
The fungal phytopathogen Zymoseptoria tritici, causal agent of the economically damaging Septoria tritici blotch of wheat,...
Motif-guided identification of KRAS-interacting proteins
Motif-guided identification of KRAS-interacting proteins
For decades, KRAS has always been a huge challenge to the field of drug discovery for its significance in cancer progressi...
Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation
Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation
Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic...
Building an eDNA surveillance toolkit for invasive rodents on islands: can we detect wild-type and gene drive Mus musculus?
Building an eDNA surveillance toolkit for invasive rodents on islands: can we detect wild-type and gene drive Mus musculus?
Invasive management strategies range from preventing new invasive species incursions to eliminating established population...
CRBPSA: CircRNA-RBP interaction sites identification using sequence structural attention model
CRBPSA: CircRNA-RBP interaction sites identification using sequence structural attention model
Due to the ability of circRNA to bind with corresponding RBPs and play a critical role in gene regulation and disease prev...
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