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GSRF-DTI: a framework for drug-target interaction prediction based on a drug-target pair network and representation learning on a large graph
GSRF-DTI: a framework for drug-target interaction prediction based on a drug-target pair network and representation learning on a large graph
Identification of potential drug-target interactions (DTIs) with high accuracy is a key step in drug discovery and reposit...
Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb
Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb
Metabolite-associated cell communications play critical roles in maintaining human biological function. However, most exis...
SNMP1 is critical for sensitive detection of the desert locust aromatic courtship inhibition pheromone phenylacetonitrile
SNMP1 is critical for sensitive detection of the desert locust aromatic courtship inhibition pheromone phenylacetonitrile
Accurate detection of pheromones is crucial for chemical communication and reproduction in insects. In holometabolous flie...
AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity
AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity
Pre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiologi...
Endosomal protein DENND10/FAM45A integrates extracellular vesicle release with cancer cell migration
Endosomal protein DENND10/FAM45A integrates extracellular vesicle release with cancer cell migration
Mounting evidence shows that tumor-derived extracellular vesicles (EVs) are critical constituents in the tumor microenviro...
Integration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes
Integration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes
Horizontal gene transfer (HGT) events have rarely been reported in gymnosperms. Gnetum is a gymnosperm genus comprising 25...
Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior
Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior
The VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce ...
Multi-genome comparisons reveal gain-and-loss evolution of anti-Mullerian hormone receptor type 2 as a candidate master sex-determining gene in Percidae
Multi-genome comparisons reveal gain-and-loss evolution of anti-Mullerian hormone receptor type 2 as a candidate master sex-determining gene in Percidae
The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chro...
Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis
Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis
The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transit...
Opportunities to produce food from substantially less land
Opportunities to produce food from substantially less land
The vast majority of the food we eat comes from land-based agriculture, but recent technological advances in agriculture a...
Comparative genomics of the primary endosymbiont Buchnera aphidicola in aphid hosts and their coevolutionary relationships
Comparative genomics of the primary endosymbiont Buchnera aphidicola in aphid hosts and their coevolutionary relationships
Coevolution between modern aphids and their primary obligate, bacterial endosymbiont, Buchnera aphidicola, has been previo...
A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo
A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo
Most tail-anchored (TA) membrane proteins are delivered to the endoplasmic reticulum through a conserved posttranslational...
The venom and telopodal defence systems of the centipede Lithobius forficatus are functionally convergent serial homologues
The venom and telopodal defence systems of the centipede Lithobius forficatus are functionally convergent serial homologues
Evolution of novelty is a central theme in evolutionary biology, yet studying the origins of traits with an apparently dis...
PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
Inherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degener...
A novel single-cell model reveals ferroptosis-associated biomarkers for individualized therapy and prognostic prediction in hepatocellular carcinoma
A novel single-cell model reveals ferroptosis-associated biomarkers for individualized therapy and prognostic prediction in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a prevalent malignancy with a pressing need for improved therapeutic response and progno...
ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppres...
3D exploration of gene expression in chicken embryos through combined RNA fluorescence in situ hybridization, immunofluorescence, and clearing
3D exploration of gene expression in chicken embryos through combined RNA fluorescence in situ hybridization, immunofluorescence, and clearing
Fine characterization of gene expression patterns is crucial to understand many aspects of embryonic development. The chic...
A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of ...
Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
In yeasts belonging to the subphylum Saccharomycotina, genes encoding components of the main metabolic pathways, like alco...
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type ...
msBERT-Promoter: a multi-scale ensemble predictor based on BERT pre-trained model for the two-stage prediction of DNA promoters and their strengths
msBERT-Promoter: a multi-scale ensemble predictor based on BERT pre-trained model for the two-stage prediction of DNA promoters and their strengths
A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing a role in initiating gene ...
Asymmetry between the dorsal and ventral digging valves of the female locust: function and mechanics
Asymmetry between the dorsal and ventral digging valves of the female locust: function and mechanics
The female locust is equipped with unique digging tools, namely two pairs of valves—a dorsal and a ventral—uti...
Single-base resolution quantitative genome methylation analysis in the model bacterium Helicobacter pylori by enzymatic methyl sequencing (EM-Seq) reveals influence of strain, growth phase, and methyl homeostasis
Single-base resolution quantitative genome methylation analysis in the model bacterium Helicobacter pylori by enzymatic methyl sequencing (EM-Seq) reveals influence of strain, growth phase, and methyl homeostasis
Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTas...
Co-habiting ants and silverfish display a converging feeding ecology
Co-habiting ants and silverfish display a converging feeding ecology
Various animal taxa have specialized to living with social hosts. Depending on their level of specialization, these symbio...
Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids
Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids
Regulation of transcription by DNA methylation in 5’-CpG-3’ context is a widespread mechanism allowing differe...
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis
The innate immune system serves as the first line of host defense. Transforming growth factor-β–activated kinas...
Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight
Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight
Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-...
Modality-specific effects of threat on self-motion perception
Modality-specific effects of threat on self-motion perception
Threat and individual differences in threat-processing bias perception of stimuli in the environment. Yet, their effect on...
Exonuclease editor promotes precision of gene editing in mammalian cells
Exonuclease editor promotes precision of gene editing in mammalian cells
Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency ...
Insights into the biocontrol and plant growth promotion functions of Bacillus altitudinis strain KRS010 against Verticillium dahliae
Insights into the biocontrol and plant growth promotion functions of Bacillus altitudinis strain KRS010 against Verticillium dahliae
Verticillium wilt, caused by the fungus Verticillium dahliae, is a soil-borne vascular fungal disease, which has caused gr...
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