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A cilia-bound unconventional secretory pathway for Drosophila odorant receptors
A cilia-bound unconventional secretory pathway for Drosophila odorant receptors
Post-translational transport is a vital process which ensures that each protein reaches its site of function. Though most ...
Chromosome-level genome assembly of Hippophae tibetana provides insights into high-altitude adaptation and flavonoid biosynthesis
Chromosome-level genome assembly of Hippophae tibetana provides insights into high-altitude adaptation and flavonoid biosynthesis
As an endemic shrub of the Qinghai-Tibetan Plateau (QTP), the distribution of Hippophae tibetana Schlecht. ranges between ...
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and ...
A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses
A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses
Response to oxidative stress is universal in almost all organisms and the mitochondrial membrane protein, BbOhmm, negative...
Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and g...
Fossil-calibrated molecular clock data enable reconstruction of steps leading to differentiated multicellularity and anisogamy in the Volvocine algae
Fossil-calibrated molecular clock data enable reconstruction of steps leading to differentiated multicellularity and anisogamy in the Volvocine algae
Throughout its nearly four-billion-year history, life has undergone evolutionary transitions in which simpler subunits hav...
Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekeeping gene regulation
Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekeeping gene regulation
Regulation of transcription is central to the emergence of new cell types during development, and it often involves activa...
High incidence of imperforate vagina in ADGRA3-deficient mice
High incidence of imperforate vagina in ADGRA3-deficient mice
Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe...
Bacterial accumulation in intestinal folds induced by physical and biological factors
Bacterial accumulation in intestinal folds induced by physical and biological factors
The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dyna...
Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture
Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture
Trans-differentiation of human-induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an effi...
Cue-driven microbial cooperation and communication: evolving quorum sensing with honest signaling
Cue-driven microbial cooperation and communication: evolving quorum sensing with honest signaling
Quorum sensing (QS) is the ability of microorganisms to assess local clonal density by measuring the extracellular concent...
Molecular control of cellulosic fin morphogenesis in ascidians
Molecular control of cellulosic fin morphogenesis in ascidians
The tunicates form a group of filter-feeding marine animals closely related to vertebrates. They share with them a number ...
MAPK-dependent control of mitotic progression in S. pombe
MAPK-dependent control of mitotic progression in S. pombe
Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the env...
OsmiR319-OsPCF5 modulate resistance to brown planthopper in rice through association with MYB proteins
OsmiR319-OsPCF5 modulate resistance to brown planthopper in rice through association with MYB proteins
The brown planthopper (BPH) is a kind of piercing-sucking insect specific to rice, with the damage tops the list of pathog...
Phylogenomics resolves the higher-level phylogeny of herbivorous eriophyoid mites (Acariformes: Eriophyoidea)
Phylogenomics resolves the higher-level phylogeny of herbivorous eriophyoid mites (Acariformes: Eriophyoidea)
Eriophyoid mites (Eriophyoidea) are among the largest groups in the Acariformes; they are strictly phytophagous. The highe...
Single-cell RNA sequencing integrated with bulk RNA sequencing analysis identifies a tumor immune microenvironment-related lncRNA signature in lung adenocarcinoma
Single-cell RNA sequencing integrated with bulk RNA sequencing analysis identifies a tumor immune microenvironment-related lncRNA signature in lung adenocarcinoma
Recently, long non-coding RNAs (lncRNAs) have been demonstrated as essential roles in tumor immune microenvironments (TIME...
Evolution of compound eye morphology underlies differences in vision between closely related Drosophila species
Evolution of compound eye morphology underlies differences in vision between closely related Drosophila species
Insects have evolved complex visual systems and display an astonishing range of adaptations for diverse ecological niches....
The fitness trade-off between growth and stress resistance determines the phenotypic landscape
The fitness trade-off between growth and stress resistance determines the phenotypic landscape
A central challenge in biology is to discover a principle that determines individual phenotypic differences within a speci...
An odorant receptor mediates the avoidance of Plutella xylostella against parasitoid
An odorant receptor mediates the avoidance of Plutella xylostella against parasitoid
Ecosystems are brimming with myriad compounds, including some at very low concentrations that are indispensable for insect...
Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila
Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila
Mitochondria participate in various cellular processes including energy metabolism, apoptosis, autophagy, production of re...
Modeling antibody drug conjugate potential using a granzyme B antibody fusion protein
Modeling antibody drug conjugate potential using a granzyme B antibody fusion protein
Antibody drug conjugates (ADCs) constitute a promising class of targeted anti-tumor therapeutics that harness the selectiv...
DNA methylation haplotype block signatures responding to Staphylococcus aureus subclinical mastitis and association with production and health traits
DNA methylation haplotype block signatures responding to Staphylococcus aureus subclinical mastitis and association with production and health traits
DNA methylation has been documented to play vital roles in diseases and biological processes. In bovine, little is known a...
Introgressions lead to reference bias in wheat RNA-seq analysis
Introgressions lead to reference bias in wheat RNA-seq analysis
RNA-seq is a fundamental technique in genomics, yet reference bias, where transcripts derived from non-reference alleles a...
Integrative systems biology of wheat susceptibility to Fusarium graminearum uncovers a conserved gene regulatory network and identifies master regulators targeted by fungal core effectors
Integrative systems biology of wheat susceptibility to Fusarium graminearum uncovers a conserved gene regulatory network and identifies master regulators targeted by fungal core effectors
Plant diseases are driven by an intricate set of defense mechanisms counterbalanced by the expression of host susceptibili...
Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations
Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations
The underrepresentation of human genomic resources from Southern Chinese populations limited their health equality in the ...
A CTL − Lys immune function maintains insect metamorphosis by preventing gut bacterial dysbiosis and limiting opportunistic infections
A CTL − Lys immune function maintains insect metamorphosis by preventing gut bacterial dysbiosis and limiting opportunistic infections
Gut bacteria are beneficial to the host, many of which must be passed on to host offspring. During metamorphosis, the midg...
Origin and diversity of Capsella bursa-pastoris from the genomic point of view
Origin and diversity of Capsella bursa-pastoris from the genomic point of view
Capsella bursa-pastoris, a cosmopolitan weed of hybrid origin, is an emerging model object for the study of early conseque...
The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish
The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish
Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the development of the venous vasculature, bot...
Evolution of ancient satellite DNAs in extant alligators and caimans (Crocodylia, Reptilia)
Evolution of ancient satellite DNAs in extant alligators and caimans (Crocodylia, Reptilia)
Crocodilians are one of the oldest extant vertebrate lineages, exhibiting a combination of evolutionary success and morpho...
Genomics insights into flowering and floral pattern formation: regional duplication and seasonal pattern of gene expression in Camellia
Genomics insights into flowering and floral pattern formation: regional duplication and seasonal pattern of gene expression in Camellia
The formation and domestication of ornamental traits are influenced by various aspects, such as the recognition of estheti...
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