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Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-rec...
Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera
Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera
Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a hetero...
Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera)
Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera)
Reactive derivatives of oxygen (reactive oxygen species; ROS) are essential in signalling networks of all aerobic life. Re...
Rapid and sensitive single-cell RNA sequencing with SHERRY2
Rapid and sensitive single-cell RNA sequencing with SHERRY2
Prevalent single-cell transcriptomic profiling (scRNA-seq) methods are mainly based on the synthesis and enrichment of ful...
Scientific rewards for biomedical specialization are large and persistent
Scientific rewards for biomedical specialization are large and persistent
While specialization plays an essential role in how scientific research is pursued, we understand little about its effects...
First characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome
First characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome
B chromosomes are extra elements found in several eukaryote species. Usually, they do not express a phenotype in the host....
NF90 interacts with components of RISC and modulates association of Ago2 with mRNA
NF90 interacts with components of RISC and modulates association of Ago2 with mRNA
Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms...
Coevolution of the olfactory organ and its receptor repertoire in ray-finned fishes
Coevolution of the olfactory organ and its receptor repertoire in ray-finned fishes
Ray-finned fishes (Actinopterygii) perceive their environment through a range of sensory modalities, including olfaction. ...
Multidimensional associations between nutrient intake and healthy ageing in humans
Multidimensional associations between nutrient intake and healthy ageing in humans
Little is known about how normal variation in dietary patterns in humans affects the ageing process. To date, most analyse...
Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relev...
Paternal hypoxia exposure primes offspring for increased hypoxia resistance
Paternal hypoxia exposure primes offspring for increased hypoxia resistance
In a time of rapid environmental change, understanding how the challenges experienced by one generation can influence the ...
Genomic signatures and evolutionary history of the endangered blue-crowned laughingthrush and other Garrulax species
Genomic signatures and evolutionary history of the endangered blue-crowned laughingthrush and other Garrulax species
The blue-crowned laughingthrush (Garrulax courtoisi) is a critically endangered songbird endemic to Wuyuan, China, with po...
Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation
Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation
T cell activation leads to increased expression of the receptor for the iron transporter transferrin (TfR) to provide iron...
Lineage tracing shows that cell size asymmetries predict the dorsoventral axis in the sea star embryo
Lineage tracing shows that cell size asymmetries predict the dorsoventral axis in the sea star embryo
Cell size asymmetries are often linked to cell fate decisions, due to cell volumes and cell fate determinants being unequa...
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium
Calmodulin (CaM) is an evolutionarily conserved eukaryotic multifunctional protein that functions as the major sensor of i...
Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs
Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs
Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is int...
Griottes: a generalist tool for network generation from segmented tissue images
Griottes: a generalist tool for network generation from segmented tissue images
Microscopy techniques and image segmentation algorithms have improved dramatically this decade, leading to an ever increas...
Elucidating the picocyanobacteria salinity divide through ecogenomics of new freshwater isolates
Elucidating the picocyanobacteria salinity divide through ecogenomics of new freshwater isolates
Cyanobacteria are the major prokaryotic primary producers occupying a range of aquatic habitats worldwide that differ in l...
Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination
Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination
Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homo...
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC
High-throughput live-cell imaging is a powerful tool to study dynamic cellular processes in single cells but creates a bot...
Hmga2 protein loss alters nuclear envelope and 3D chromatin structure
Hmga2 protein loss alters nuclear envelope and 3D chromatin structure
The high-mobility group Hmga family of proteins are non-histone chromatin-interacting proteins which have been associated ...
Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus
Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus
ATP-dependent chromatin remodeling complexes are multi-protein machines highly conserved across eukaryotic genomes. They c...
Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice
Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice
Neuropsychiatric disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), are common, multi-factorial and...
Frontloading of stress response genes enhances robustness to environmental change in chimeric corals
Frontloading of stress response genes enhances robustness to environmental change in chimeric corals
Chimeras are genetically mixed entities resulting from the fusion of two or more conspecifics. This phenomenon is widely d...
Dynamic enhancer transcription associates with reprogramming of immune genes during pattern triggered immunity in Arabidopsis
Dynamic enhancer transcription associates with reprogramming of immune genes during pattern triggered immunity in Arabidopsis
Enhancers are cis-regulatory elements present in eukaryote genomes, which constitute indispensable determinants of gene re...
Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcr...
Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan
Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan
Yunnan is located in Southwest China and consists of great cultural, linguistic, and genetic diversity. However, the genom...