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Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles
The Ugi reaction has obtained broad interest due to mild reaction conditions and high variability. The versatile Ugi adduc...
Electrooxidative iridium-catalyzed sp2 C−H activation-annulation leading to cationic π-extended heteroaromatics
This study demonstrates an electrochemically driven, Ir(III)-catalyzed method for pyridine-, azo-, and purine-directed ole...
Photoredox/Cu dual catalyzed 1,4-cyanosulfonylation enabled by remote cyano migration
A photoredox/Cu dual catalyzed 1,4-cyanosulfonylation of NHPI esters with readily available sodium arylsulfinates has been...
A Ligand-assisted Manganese-enabled Direct C-H Difluoromethylation of Arenes
The incorporation of a difluoromethyl group within an aromatic ring is highly desirable. However, studies based on direct ...
Asymmetric Synthesis of 1H-pyrazolo[3,4-b]pyridine Analogues Catalyzed by Chiral-at-Metal Rh(III) Complexes
An efficient asymmetric Friedel-Craft-type alkylation /Cyclization of 5-aminopyrazoles with α,β-unsaturated 2-acyl imidazo...
Photoredox-Enabled Ring-Opening of Cyclobutanes via the Formation of a Carbon Radical
The high strain energy of cyclobutanes has been utilized for the selective ring-opening, enabling the synthesis of valuabl...
Total Synthesis of (‒)-Deglycocadambine
The first total synthesis of monoterpene indole alkaloid (–)-deglycocadambine is achieved in 12 steps with (+)-genipin as ...
Copper-Catalyzed Allenynylative C–P Couplings of Diynylic Acetates with Hydrophosphoryl Compounds Leading to Phosphorylated Allenynes
A highly efficient copper-catalyzed coupling reaction of diynylic acetates with hydrophosphoryl compounds is developed bas...
Synthesis of Fluoro-Benzoxazepines via I(III)/BF3·Et2O-Enabled 1,2-Aryl Migration/Fluorination Cascade
A metal-free oxidative fluorination reaction of o-alkenyl aryl ureas to construct benzoxazepine skeleton was accomplished ...
Catalytic Asymmetric Formal (2 + 3) Cycloaddition Involving Methyl-Substituted 2-Indolylmethanols
A catalytic asymmetric formal (2 + 3) cycloaddition of methyl-substituted 2-indolylmethanols with 3-substituted-2-indolylm...
Metal-free C−H borylation of heterocycles by merging photoredox and hydrogen atom transfer catalysis
Reported herein is a method that merges organophotoredox and hydrogen atom transfer catalysis to enable the C−H borylation...
Dirhodium-Catalyzed One-Step Cascade Intermolecular 1,4-Diamination via Cyclopropanation
This work presents a novel dirhodium-catalyzed method for the conversion of aromatic hydrocarbons to 1,4-diamines using N-...
Mechanistic studies on Cu(NO3)2/TEMPO-catalyzed aerobic oxidation of alcohols to carboxylic acids
Oxidation of alcohols to carbonyl compounds is one of the most important and fundamental reactions in organic chemistry. S...
Ni/Photoredox-catalyzed coupling of aryl bromides and methylenecyclopropanes via selective distal bond cleavage
C(sp3) hybridized fragments have been widely explored for the formation of crucial Ni-alkyl intermediates in the field of ...
Zwitterion Detection with a Fluorescent Squaramide Cryptand: A Study in Size-Dependent Salt Recognition and Sensing
We report the synthesis of a novel squaramide based cryptand incorporating both anion and cation binding domains, and a fl...
Synthesis of N-triflyl aldimines catalyzed by imino-λ3-iodane
We report a catalytic synthesis of N-triflyl aldimines from aldehydes and triflylamide using imino-λ3-iodane generated in ...
Brønsted Base Catalyzed Reppe Sulfonylation Reaction
Reppe carbonylation is well-studied and extensively employed in industry, while the exploration and development of the Rep...
Photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical
A reagent for the introduction of 1,1,1,3,3,3-hexafluoroisopropyl group is described. The reagent was obtained on a multi ...
Photoredox-catalyzed three-component carbotrifluoromethylation of alkenes via radical-radical cross-coupling
In this study, we establish an efficient photocatalytic strategy for three-component carbotrifluoromethylation of alkenes....
Recent Progress in Asymmetric Rearrangement Reactions Mediated by Chiral Brønsted Acids
Rearrangement reactions, a fundamental tool for constructing complex molecules, offer an atom-economical approach to targe...
Quinoidal π-extension of dipyranylidene derivatives: towards efficient dopants for n-type organic semiconductors
Quinoidal π-extended dipyranylidene derivatives, 2,2',6,6'-tetraphenyl-2,2'-p-quinobis(4,4'-dipyranylidene...
Photocatalyzed dehalogenative deuteration with silacarboxylic acids as halogen-atom transfer agents
Deuterated chemicals are widely utilized in a broad range of disciplines and dehalogenative deuteration of organohalides r...
Copper-Catalyzed Pentafluoroethylation of Aryl/Alkenyl Iodides with Pentafluoroethylsilane
A copper-catalyzed pentafluoroethylation of aryl/alkenyl iodides is described. Compared to other available methods, this p...
Alkali Ion Controlled Chemoselective Indolation of Allylic Alcohols by Base Catalysis
Although the transition-metal-catalyzed cascade reaction of allylic alcohols has achieved great success, there are rare se...