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Synthesis of Biological Studies of 3-Trideuteromethylated Chromones and their Heteroatom Analogues
The bioactive trideuteromethylated chromones and their heteroatom analogues were synthesized via trideuteromethylation of ...
Enantioselective Synthesis of α-Chiral Sulfonates through Palladium-Catalyzed Tsuji-Trost Sulfonylation with Sulfur Dioxide
α-Chiral sulfonates have remained largely uncharted territory, primarily due to the intrinsic difficulties associated with...
Bipolarsterol A, a steroid with an unprecedented 6/5/6/5 carbon skeleton from the phytopathogenic fungus Bipolaris oryzae
Bipolarsterols A−H (1−8), eight undescribed steroids were isolated from Bipolaris oryzae, along with nine known congeners....
Ball-milling and piezoelectric materials enabled radical trifluoromethylation of enamides and acrylamides
A mechanochemical radical direct C(sp2)-H trifluoromethylation of enamide derivatives was developed using Togni II reagent...
From conventional to dual Co/photoredox mediated reductive coupling of alkynes and alkenes
Metal-catalyzed reductive coupling reactions between alkenes and alkynes are a long-standing tradition as a way to create ...
Palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of indoles with α-oxocarboxylic acids via C−H activation
Herein, we report a novel palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of C2-tethered indoles ...
Organocatalytic Enantioselective [2 + 2] Cycloadditions towards Chiral Fused -Trifluoromethyl Azetidines
Access to relatively high energy azetidines in enantioenriched form via a function- and diversity-oriented approach is hig...
Palladium-Catalyzed Decarboxylative Domino Synthesis of Fused Quinolin-2(1H)-one Scaffolds Containing Perfluoroalkyl Unit
A novel palladium-catalyzed domino radical cyclization and C-H activation/decarboxylation of 1,7-enynes with o-bromobenzoi...
A Persistent Concealed Non-Kekulé Nanographene: Synthesis and in-situ Characterization
Concealed non-Kekulé (CNK) nanographenes have recently gained attention as promising non-Kekulé model systems du...
Solvent-dependent fluorescence sensing of Cu2+, Hg2+, and CN‒ based on thiosemicarbazone-functionalized pillar[5]arene and its applications in actual water samples and molecular logic gates
A novel solvent-dependent fluorescent probe P5T based onapillar[5]arene containing a thiosemicarbazone unit has been synth...
Synthesis and Antibacterial Evaluation of Prenylacridone Alkaloids and Analogues
A concise total synthesis of natural prenylacridone alkaloids, N-methylcycloatalaphylline A, N-methylbuxifoliadine D, buxi...
Recent advances of calcium(II) triflimide in organic synthesis
Environmentally benign calcium(II) triflimide has emerged as a sustainable substitute for transition-metal catalysts, rare...
In situ generated aza-π-allylpalladium zwitterions as nucleophilic triggers for enantioselective [4 + 2] cycloaddition with electron-deficient alkenes toward functionalized chiral piperidines
Aza-π-allylpalladium zwitterions, in situ generated from Pd-catalyzed decarboxylation of methylene cyclic carbamates, have...
Access to Fluorinated Dienes through Hydrofluorination of 2-En-4-ynoates
The hydrofluorination of enynes has been developed for the synthesis of fluorinated dienes. Using a pyridinium tetrafluoro...
Synthesis of Pyrrolo[1,2-a]quinoxalines via an Electrochemical C(sp3)-H Functionalization
An efficient iodine-mediated electrochemical C(sp3)-H cyclization was developed under mild conditions. A variety of functi...
Tandem Synthesis of Enantioenriched Spirolactones via One-Pot Heck-Matsuda Reactions Directly from Nitroarenes
We report herein a novel, efficient, and expeditious approach for enantioselective intramolecular carbonylative Heck-Matsu...
Synthesis of Cyclic Phosphonium-Borate Compounds through Reaction of Benzynes and Frustrated Lewis Pairs
A practical method for the construction of stable zwitterionic phosphonium-borate compounds via trapping of benzynes by ph...
Rhodium-Catalyzed [3 + 2] Cycloaddition of in situ Generated Nitrile Ylides with Alkenes: A Route to Quaternary 2-Trifluoromethyl-1-Pyrrolines
Trifluoromethylated heterocycles with a C−CF3 stereogenic center are prevalent scaffolds in many bioactive small molecules...
Ag-Catalyzed and Difluorocarbene-Promoted Amide-Ylide Rearrangement: Synthesis of 3-Salicyloylpyridines
Herein, we report an Ag-catalyzed and difluorocarbene-promoted amide-ylide rearrangement strategy. This strategy utilizes ...
Ag(I)-linked Bis-calix[4]pyrrole Molecular Capsule and its Selective Recognition of Fluoride Anion
A well-defined “four-wall” capsule (3) was constructed based on the coordination-driven self-assembly of a tetratopic pyri...
Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions
An environmental-friendly and safe method has been developed to synthesize 1,5-disubstituted 1,2,3-triazoles containing di...
Solvent-controlled C2/C3-regioselective ring-opening/coupling of aziridines with amines and CS2: synthesis of 2-aminoethyl dithiocarbamates
This study presents a solvent-controlled C2/C3-regioselective ring-opening/coupling of aziridines with amines and CS2, yie...
Photoredox trifluoromethylation of isocyanides to access 2-trifluoromethylated quinolines and indoles
We herein report a divergent synthesis of 2-CF₃ substituted quinolines and indoles via photoredox radical trifluoromethyla...
Palladium-Catalyzed Three-Component Annulation Reaction Involving Multiple C─H Activation
The Pd-catalyzed ring-forming reaction via multiple C─H activation provides an efficient strategy to access cyclic ring sy...
Stereocontrolled desymmetrization of 2,5-cyclohexadienones via organocatalytic domino sulfa-1,6-/1,4-addition or sulfa-1,6- /1,4-/sulfa-1,4-addition reactions
We have developed a desymmetrization of 2,5-cyclohexadienones tethered 3-cyano-4-styrylcoumarins via the amino-squaramide ...
Cyclizative Dearomative Rearrangement of Pyridines with Isocyanates
Dearomatizationof pyridines is a robust synthetic method to access aza-heterocycles. Simultaneously, intermolecular cycliz...
Tf2O-Induced Selective 1,3-Transposition/Cyclization of Ynones in DMF
A chemo and regio-selective system for activating C=O and S=O bonds under transition metal-free conditions is described. T...
Modular Synthesis of β-Oxygen-containing Sulfones from Alkenes through Hexatungstate-catalyzed Cascade Hydroxysulfenylation/ Selective Oxidation
β-Oxygen-containing sulfones are versatile building blocks in pharmaceuticals and chemical industry. Despite notable advan...
Mechanochemical Decarbonylative Transformation of Amide Group to OCF3 and CF3 Functionalities under Ruthenium Catalysis
A novel strategy has been introduced for the selective activation of N–C(O) moiety in primary aromatic amides through the ...
Transformation of benzocorrole isomer into pyrrole-containing polycyclic molecules via copper-mediated cleavage and annulation
We present the oxidative transformation of a corrole isomer, namely, dibenzocorrorin (3), featuring a modified connectivit...
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