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NHC-Catalyzed Stereoselective Synthesis of Spirooxindole Lactones by in situ Generated Oxindole-embedded o-Quinone Methides and Aldehydes
A novel N-heterocyclic carbene-catalyzed asymmetric [4 + 2] annulation of in situ generated oxindole-embedded o-quinone me...
Catalytic Ortho C-H Methylation and Trideuteromethylation of Arylthianthrenium Salts via the Catellani Strategy
We reported a Pd/NBE cooperative catalyzed ortho C−H methylation and trideuteromethylation of arylthianthrenium salts, ena...
Halogen-Bond-Promoted Direct Cross-Coupling of Ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with Coumarins/Quinolinones
Herein, we developed a practical method for the direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with...
Regioselective Oxidative Cleavage of Conjugated Dienes to Access α,β–Unsaturated Nitriles
A highly regioselective oxidative cleavage method has been developed for the synthesis of α,β-unsaturated nitriles from un...
Efficient Synthesis of Benzophosphole Oxides by Ag-Promoted Radical Cycloisomerization
Cycloisomerization reactions involving C–P bond formation have been overlooked to prepare P-heterocycles. We discovered he...
Iridium-Catalyzed Asymmetric Hydrogenation of 5-Hydroxypicolinate Pyridinium Salts under Batch and Flow: Stereodefined Access to Cis-Configurated Hydroxypiperidine Esters
The stereoselective synthesis of 2,5-disubstituted piperidines, which is a common structural motif in bioactive compounds ...
Thiourea as a Precatalyst for the Electron Donor–Acceptor Complex Photoactivation Platform of Oxime Esters
A novel electron donor–acceptor (EDA) complex catalysis strategy has been developed, employing N,N'-bis[3,5-bis(triflu...
Cr-mediated Photocatalytic Decarboxylative Coupling of alpha-Oxo Acids with Benzylic Pyridinium Salts
Herein, we report the chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium s...
Substituents-Controlled Divergent Cyclization Reactions of Benzo[c][1,2]dithiol-3-ones and Hexahydro-1,3,5-triazines
The first divergent cyclization reactions of benzo[c][1,2]dithiol-3-ones to assemble six- and eight-membered N-containing ...
Concise synthesis of succinimide-fused densely 1,3-cyclohexadienes via Co-catalyzed [2+2+2] cycloaddition of 1,6-diynes and maleimides
Herein, we report a new route towards succinimide-fused densely 1,3-cyclohexadienes through the reaction of 1,6-diynes wit...
Expedient Deaminative Phosphorylation and Sulfonylation of Benzylic Tertiary Amines Enabled by Difluorocarbene
Organophosphines and sulfones have a wide range of applications and they are prevalent in bioactive molecules as well as p...
Diverting the Mannich Reaction to Access 2,2-Disubstituted Indolin-3-ones by Merging 1,2-Aryl Migration and Copper-Catalyzed Aerobic Oxidation
The venerable Mannich reaction using p-anisidine, aldehyde, and a nucleophile affords a linear α-secondary amine motif. He...
Selective Nickel-Catalyzed Disulfuration of Alkyl Halides with Di/Trithiosulfonates
The utilization of electrophilic di/trithiosulfonates in nickel-catalyzed reductive coupling for selective conversion has ...
Visible-light Induced [1, 3]-Brook Rearrangements of α-Ketoacylsilanes and Its Subsequent Trapping in a Tandem Annulation with 1, 3, 5-Triazinanes and Azomethine Imines
An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazi...
Palladium-catalyzed and ligand-controlled divergent cycloadditions of vinylidenecyclopropane-diesters with para-quinone methides enabled by zwitterionic π-propargyl palladium species
A palladium-catalyzed divergent synthesis of spiro-cyclohexadienone with a five- or a six-membered ring by a cycloaddition...
Photochemical [2 + 2 + 1] annulation of 2-vinyloxy arylalkynes with bromomalonates via energy transfer
A photochemical [2 + 2 + 1] radical annulation of 2-vinyloxy arylalkynes with bromomalonates has been developed. This prot...
Metal-Free Cascade O-H Double Insertion Between I(III)/S(VI)-Ylides, Carboxylic Acids, and Alcohols: Modular Access to Unsymmetrical α,α-O,O-Substituted Ketones
The synthesis of unsymmetrical α,α-O,O-substituted ketones via O-H double insertion is appealing but remains constrained d...
Correction: Stereodivergent and enantioselective total syntheses of isochaetominines A–C and four pairs of isochaetominine C enantiomers: a six-step approach
Correction for ‘Stereodivergent and enantioselective total syntheses of isochaetominines A–C and four pairs of isochaetomi...
Selective deletion of one carbon atom from C60 through benzylamine mediated reactions
Selective deletion of carbon atom(s) from the spherical skeleton results in norfullerene derivatives. Among the numerous f...
Development of a photoenzymatic one-pot hybrid system for the direct synthesis of 3, 3-disubstituted indole-2-ketone from N-methyl indole
The effective combination of photocatalysis and enzyme catalysis has been widely utilized for the synthesis of high-value-...
Aculeatones A and B, Epimeric Lovastatin Derivatives with a 6/6/3-Tricyclic Carbon Skeleton from Aspergillus aculeatus and Their Chemical Transformation
Lovastatin and its derivatives are well-known as a type of lipid-lowering drugs in medicinal chemistry of natural products...
Synthesis of Oxindole Fused 1,3-Oxazepanes via Hydride Transfer Initiated Ring Expansion of Pyrrolidine
An efficient B(C6F5)3 catalyzed protocol for the synthesis of oxindole fused 1,3-oxazepanes from pyrrolidine substituted a...
Metal-Free Photoinduced Denitrogenative Alkylation of Vinyl Azides with Alkyl Radicals toward Ketones
A simple and general approach for synthesis of ketones via metal-free denitrogenative alkylation of vinyl azides with redo...
Copper-Catalyzed Oxidative Sulfenylation and Alkylation of Indolin-2-ones for Direct Construction of Sulfur-Substituted Quaternary Carbons
The selective functionalized of ubiquitous C(sp3)–H bonds for constructing complex molecules is a highly sought-after meth...
NHCs and Photoredox Catalysis Dual-Catalyzed 1,4-Mono-/di-fluoromenthylative Acylation of 1,3-Enynes
Mono/difluoromethyl (CFH2/CF2H) group could act as a metabolically stable bioisostere of lipophilic hydrogen bond donors, ...
Correction: Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids
Correction for ‘Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids’ by Junjie Ying et al., Org. Chem. Front...
Cobalt-catalysed Csp3-Cps3 cross-coupling of Benzyl Katritzky Pyridinium Salts with Callyl-O Electrophiles
Herein we report a Co-catalysed reductive cross-coupling to form Csp3-Csp3 bonds from two non-halogenated electrophiles su...
NBN/BNB-Doped phenalenyl homo- and heterodyads: structural uniformity but optoelectronic diversity
Phenalenyl anions and cations are fundamentally interesting but highly reactive complementary species. One way to tame thi...
Assemble ionic supramolecular polymers using decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery
Three ionic supramolecular polymers (ISPs) have been assembled from an imidazolium-modified decacationic pillar[5]arene (P...
A retro-Mannich mediated transformation of Morita–Baylis–Hillman ketones to saturated imidazo[1,2-a]pyridines
Explicit evidence of a retro-Mannich reaction triggered by a vicinal diamine upon its interaction with Morita-Baylis-Hillm...
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