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Catalytic enantioselective and site-specific Friedel−Crafts alkylation of 4-aminoindoles with β,γ-alkynyl-α-ketoimines for the synthesis of C7-functionalized indoles
Chiral phosphoric acid-catalyzed enantioselective Friedel−Crafts alkylation of 4‑aminoindoles with β,γ-alkynyl-α-ketoimine...
Viologen–Cycloparaphenylene Hybrids: Luminescent Molecular Nanocarbons for Anion Binding and Specific Vapor Sorption†
Two viologen-like macrocyclic receptors, [1]2+ and [2]2+, merging a bent oligophenylene loop with a (para-xylylene)bispyri...
N-Aryl/Heteroaryl Oxaziridines: From Photochemical Synthesis to Reactivity Investigation in Heteroatom Transfer Reactions
The reactivity of oxaziridines is significantly influenced by the substituents on the nitrogen atom. Despite extensive stu...
Catalyst-Free Synthesis of Unsymmetrical ureas from COS and Amines: a Strategy for Selectivity Regulation
A novel and mild method for the highly selective synthesis of asymmetric urea from amines and COS has been established. Th...
Lewis Acids Catalyzed Regiodivergent N-alkylation of Indazoles with Donor-Acceptor Cyclopropanes
N-alkyl Indazoles are highly privileged skeleton in pharmaceutical applications. Generally, N1 and N2-alkyl indazoles repr...
Ligand-Controlled Rh(I) -Catalyzed Intramolecular Alkyne Sila-Cyclization: Divergent Catalysis and Mechanistic Studies
The synthesis of structurally diverse silacycles is crucial for the silicon-containing drug and agrochemical development. ...
Direct Aminosulfonylation of Electron-rich (hetero)Arenes Utilizing tert-Butyl Chlorosulfonylcarbamate with Diisopropylethylamine
Sulfonamides, especially primary aryl sulfonamides are very important scaffolds not only because of the wide applications ...
(BO)2-doped tetrathia[7]helicenes: synthesis and properties-change induced by “BO bonds inversion”
Helical distortion of polyaromatic hydrocarbons gives rise to a special class of π-conjugated systems, namely helicenes. O...
Photoinduced Ullmann-Type Cross-Coupling Reactions: Mechanistic Insights and Emerging Challenges
Photoinduced Ullmann-type cross-coupling reactions have become a significant advancement in organic synthesis, providing a...
Brønsted Acid-Catalyzed Solvent-Controlled Regioselective Thiolation of 2-Furylcarbinols
A novel p-toluenesulfonic acid-catalyzed solvent-controlled regioselective thiolation of 2-furylcarbinols for the efficien...
Synthesis and derivatization of an isomer of N-heterotriangulene bearing five-, six- and seven-membered rings around the central nitrogen atom
The functionalization of N-heterotriangulenes has been extensively investigated for their potentials as optoelectronic mat...
Iridium-Catalyzed Asymmetric Allenylic Substitution of Tertiary Racemic Allenylic Alcohols with Indoles
We report an allenylic substitution of racemic tertiary allenylic alcohols with indoles by a cooperative catalyst consisti...
Ortho-allylation of anilines with vinylaziridines in hexafluoroisopropanol
Transition-metal-free reaction of N,N-dialkylanilines with 1-sulfonyl-2-vinylaziridines in hexafluoroisopropanol in air ga...
Visible Light-Mediated Deoxygenation Protocol for Synthesis of Dipeptide, Amide and Ester without Racemization
A green and sustainable visible light-induced triphenylphosphine-promoted deoxygenation strategy to generate acyl radicals...
Hierarchical Supramolecular Assembly based on Metal Coordination of Asymmetric Ligand Pairs and Host-Guest Recognition
Three distinct monomers were synthesized, namely CD2, E2, and F2. Monomer CD2 is composed of a crown ether group (B21C7) a...
Chiral CpxRhIII-Catalyzed Enantioselective C-H Annulation to Access Fused Tricyclic Sulfur-Stereogenic and Medium-sized aza-Heterocycles
We report herein a chiral CpxRhIII-catalyzed asymmetric sp2 C-H bond activation/annulation reaction of free NH-sulfoximine...
Iridium-Catalyzed Highly Enantioselective and Chemodivergent Coupling Reaction of Vinyl Azides and Vinyl Benzoxazinones
The first Iridium-catalyzed enantioselective coupling reaction of vinyl azides and vinyl benzoxazinones is presented. Viny...
Deuterium Exchange of Pyrrolic NH Protons Accelerated by Fluoride and Bicarbonate in CDCl3, CD3CN, and DMSO-d6
The anion binding features of pyrrole- and benzene-strapped calix[4]pyrroles 1 and 2, in particular, for F– and HCO3– have...
Rhodium-catalyzed synthesis of N-substituted 3-acylpyrroles from enaminones and vinylene carbonate
Skeletal editing is a highly efficient strategy for modifying the core scaffolds of drug molecules, with multi-atomic edit...
Convergent Synthetic Approaches to Polycyclic Aromatic Dicarboximides
Polycyclic aromatic dicarboximides (PADIs) as represented by naphthalene and perylene bis(dicarboximide) are useful molecu...
Transition-Metal Free Approaches to Access N-Heterocycles and Valuable Intermediates from Aryldiazonium Salts
Efforts for the discovery of novel and efficient synthetic methods to achieve valuable N-fused heterocycles is an importan...
Catalytic Atroposelective Friedel-Crafts Alkylation to Access Axially Chiral C2-Arylindoles via Dynamic Kinetic Resolutions
Indole-based atropisomers have emerged as an important backbone in drug discovery and novel catalyst/ligand design. Howeve...
Intermolecular Defluorinative 1,2-Diamination of Fluoroalkenyl Iodides with Sulfonamides: Synthesis of Acyclic and Cyclic Fluorinated 1,2-Enediamines
Alkene diamination represents one of the most straightforward strategies for 1,2-diamine derivatives synthesis. However, t...
Mechanistic insights into rhodium-catalyzed C−H activation and annulation using vinyl acetate to access cinnolines and cinnolin-4(1H)-ones
Transition metal-catalyzed C−H activation and annulation involving vinyl acetate remains a significant challenge, and the ...
π-extended regioisomeric dithienoacenes fused pyrenes: structures, properties, and application in field-effect transistors
The development of π-conjugated semiconducting molecules with fused rings has been a focus of research in organic electron...
Visible Light-Mediated [1+2+2] Cycloaddition Reaction of Nitroarenes and Alkenes
We report a visible light-mediated [1+2+2] cycloaddition reaction between nitroarenes and alkenes, conducted under mild co...
Hemilabile P,N-Ligand-Assisted Gold Catalyzed Hiyama Allylation to Access Allylarenes and 1,4-Dienes Derivatives
Oxidant-free gold-catalyzed reactions are emerging as a novel synthetic tool for organic transformations. Here in, we repo...
Influence of hydrogen bonds and π-π stacking on the self-assembly of aryldipyrrolidones
We report on the self-assembly behaviour in solution and solid-state of two newly designed bisdendronized aryldipyrrolidon...
PIFA-Mediated cyclization of methyl(2-(1-phenylvinyl)phenyl)sulfane for the concise, flexible, and scalable de novo synthesis of C3-arylated benzo[b]thiophenes
The well-decorated arylated benzo[b]thiophene scaffold is a pivotal structural motif with diverse applications in medicina...
Rh-Catalysed Hydroacyloxylation of Cyclopropenes: Regio- and Diastereoselective Synthesis of Acyloxycyclopropanes
Cyclopropyl carboxylates are essential building blocks in biological and medicinal chemistry. However, their accessibility...
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