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Born again: The many lives of metformin
Born again: The many lives of metformin
Repurposing of medications—getting US Food and Drug Administration (FDA) approval to use an old drug for a new indication—...
Petaloid dermatosis affecting the scalp and genitalia
Petaloid dermatosis affecting the scalp and genitalia
A 41-year-old-male presented with a 1-month history of pruritic lesions on his scalp, neck, and penis. He had attempted a ...
Cutaneous metastasis from gastric carcinoma
Cutaneous metastasis from gastric carcinoma
A 75-year-old man presented with a 3-month history of asymptomatic nodules with alopecia on the scalp. He said that 3 year...
Why 25-dehydroxyvitamin D is a negative acute-phase reactant
Why 25-dehydroxyvitamin D is a negative acute-phase reactant
To the Editor: In previous publications, we presented evidence that 25-dehydroxyvitamin D (25[OH]D) in serum behaves as a ...
Persistent rectal pain leading to diffuse pustules
Persistent rectal pain leading to diffuse pustules
A 34-year-old male with a history of syphilis and with human immunodeficiency virus on a home regimen of dolutegravir and ...
Should I consider metformin therapy for weight loss in patients with obesity but without diabetes?
Should I consider metformin therapy for weight loss in patients with obesity but without diabetes?
Yes. Evidence supports the weight-loss effects of metformin in adults with obesity and without type 2 diabetes. The magnit...
If a patient has cirrhosis, should I correct coagulation abnormalities before a minor invasive procedure?
If a patient has cirrhosis, should I correct coagulation abnormalities before a minor invasive procedure?
A 56-year-old man with a history of cirrhosis is hospitalized with decompensated liver cirrhosis, ascites, and encephalopa...
A practical guide for buprenorphine initiation in the primary care setting
A practical guide for buprenorphine initiation in the primary care setting
ABSTRACTBuprenorphine is a safe and effective treatment for opioid use disorder but remains underutilized because a major ...
When should pharmacologic therapies be used for uremic pericarditis?
When should pharmacologic therapies be used for uremic pericarditis?
Renal replacement therapies are the mainstay of treatment for uremic pericarditis and should be initiated as soon as possi...
Mpox: Keep it on the differential
Mpox: Keep it on the differential
ABSTRACTIn its current global outbreak, mpox has exhibited several novel clinical presentations that clinicians should be ...
To prophylax or not to prophylax for endocarditis: Still a question
To prophylax or not to prophylax for endocarditis: Still a question
On the surface, the question does not seem complicated. Infective endocarditis (IE) is a bad disease. In most published ca...
Computed tomography of the head
Computed tomography of the head
To the Editor: While I agree with Dr. Muth and colleagues1 that computed tomography (CT) of the head is overused, the clai...
In Reply: Computed tomography of the head
In Reply: Computed tomography of the head
We thank Dr. Ganatra for his comments regarding our 1-Minute Consult.1 In particular, he has brought to our attention rece...
Severe skin rashes
Severe skin rashes
To the Editor: In the June issue, Jaroenpuntaruk et al1 described the early diagnosis and management of severe drug erupti...
In Reply: Severe skin rashes
In Reply: Severe skin rashes
We thank Drs. Zhang, Wu, and Chen for their interest in our article and their helpful points. We agree that many cases of ...
Getting to the root of the problem: Should my patient receive antibiotics before dental procedures to prevent infective endocarditis?
Getting to the root of the problem: Should my patient receive antibiotics before dental procedures to prevent infective endocarditis?
There has been some confusion within the medical community about antibiotic prophylaxis for specific patient populations b...
'Kissing tonsils and splenic infarction from infectious mononucleosis
'Kissing tonsils and splenic infarction from infectious mononucleosis
A 36-year-old man presented to the emergency department with severe pain in the left upper quadrant. This was preceded by ...
Hoarseness: When to observe and when to refer
Hoarseness: When to observe and when to refer
ABSTRACTThe terms hoarseness and dysphonia are used interchangeably, and both describe a type of altered vocal quality aff...
A new policy update on breastfeeding: What all clinicians need to know
A new policy update on breastfeeding: What all clinicians need to know
ABSTRACTAlthough the 2022 policy statement on breastfeeding from the American Academy of Pediatrics primarily addresses cl...
Unilateral green pleural effusion in a 22-year-old woman
Unilateral green pleural effusion in a 22-year-old woman
A 22-year-old medical student presented with dyspnea while walking to class. She reported slowly progressive dyspnea, fati...
Evaluating troponin elevation in patients with chronic kidney disease and suspected acute coronary syndrome
Evaluating troponin elevation in patients with chronic kidney disease and suspected acute coronary syndrome
ABSTRACTMany patients with chronic kidney disease have chronically elevated cardiac troponin levels, and if they present w...
Late complications after allogeneic hematopoietic cell transplant: What primary care physicians can do
Late complications after allogeneic hematopoietic cell transplant: What primary care physicians can do
ABSTRACTSurvivors of allogeneic hematopoietic cell transplant (HCT) face the risk of many serious complications in the lon...
Unexplained pathology is not always autoimmune
Unexplained pathology is not always autoimmune
The evolution of our understanding of human disease has been a remarkable journey, spanning centuries of scientific progre...
Asymptomatic oral plaques and erosion
Asymptomatic oral plaques and erosion
A 47-year-old male presented with a 4-week history of asymptomatic plaques and erosion on the left buccal mucosa and lower...
Acute left-sided colonic diverticulitis: A surgeons perspective on the ACP guidelines
Acute left-sided colonic diverticulitis: A surgeons perspective on the ACP guidelines
The updated guidelines on the management of acute left-sided colonic diverticulitis from the American College of Physician...
How do I diagnose and treat my patients amiodarone-induced thyrotoxicosis?
How do I diagnose and treat my patients amiodarone-induced thyrotoxicosis?
A diagnosis of amiodarone-induced thyrotoxicosis (AIT) should be considered in a patient started on amiodarone therapy who...
A new paradigm for adult ADHD: A focused strategy to monitor treatment
A new paradigm for adult ADHD: A focused strategy to monitor treatment
Medical professionals face a significant challenge when treating adults with attention deficit hyperactivity disorder (ADH...
Surgical de-escalation: Are we ready for 'observation of benign high-risk breast lesions found on core needle biopsy?
Surgical de-escalation: Are we ready for 'observation of benign high-risk breast lesions found on core needle biopsy?
One focus of the article by Vegunta and colleagues1 in this issue of the Journal is whether benign proliferative lesions s...
Atypical hyperplasia of the breast: Clinical cases and management strategies
Atypical hyperplasia of the breast: Clinical cases and management strategies
ABSTRACTAtypical hyperplasia of the breast is a histopathologic lesion identified incidentally on image-guided breast biop...
Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
ABSTRACTPostural orthostatic tachycardia syndrome (POTS)—sustained tachycardia upon standing without orthostatic hypotensi...
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