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Viruses change; we can, too
Viruses change; we can, too
Maybe we are coming out of the COVID-19 tunnel. Not that it is gone, it certainly is not. And we are currently dealing wit...
Smallpox and monkeypox: Looking back and looking ahead
Smallpox and monkeypox: Looking back and looking ahead
ABSTRACTThe monkeypox (mpox) epidemic was declared a global health emergency in July 2022. The mpox virus belongs to the s...
Mass under the lip
Mass under the lip
A 60-year-old man was referred by his primary care physician to the oral and maxillofacial surgery clinic with a mass unde...
What is the rationale for the laboratory workup for suspected pheochromocytomas and paragangliomas?
What is the rationale for the laboratory workup for suspected pheochromocytomas and paragangliomas?
Selection of screening tests for pheochromocytomas and paragangliomas (PPGLs) is best guided by high clinical suspicion. T...
Fundic gland polyps: Should my patient stop taking PPIs?
Fundic gland polyps: Should my patient stop taking PPIs?
Fundic gland polyps (FGPs) associated with proton pump inhibitors (PPIs) are generally considered benign, and patients wit...
Colovesical fistula in men with chronic urinary tract infection: A diagnostic challenge
Colovesical fistula in men with chronic urinary tract infection: A diagnostic challenge
The diagnosis of colovesical fistula is clinical and a challenge for any clinician irrespective of training or specialty. ...
The cost of 'free: Advising patients about sponsored genetic testing
The cost of 'free: Advising patients about sponsored genetic testing
In recent years, we have witnessed sponsored genetic testing providing an alternative to out-of-pocket or insurance-billed...
Update on current contraceptive options: A case-based discussion of efficacy, eligibility, and use
Update on current contraceptive options: A case-based discussion of efficacy, eligibility, and use
ABSTRACTWith high rates of unintended pregnancy in the United States, it is crucial for clinicians to be well-informed abo...
To repeat or not to repeat? Measuring bone mineral density during anti-resorptive therapy or a drug holiday
To repeat or not to repeat? Measuring bone mineral density during anti-resorptive therapy or a drug holiday
ABSTRACTAn initial bone mineral density (BMD) measurement is used to diagnose osteoporosis and decide whether patients nee...
Myasthenia gravis: An update for internists
Myasthenia gravis: An update for internists
Myasthenia gravis (MG) is an uncommon neuromuscular disorder with an estimated prevalence likely under 1 per 10,000. But k...
Our Peer-Reviewers For 2022
Our Peer-Reviewers For 2022
We thank those who reviewed manuscripts submitted to the Cleveland Clinic Journal of Medicine in 2022. Reviewing papers fo...
Oral leukoplakia and oral cancer
Oral leukoplakia and oral cancer
A 56-year-old male was referred by his dentist with noticeable worsening of vitiligo of the tongue, which had been diagnos...
What are the treatment options for myasthenia gravis if first-line agents fail?
What are the treatment options for myasthenia gravis if first-line agents fail?
If the patient with myasthenia gravis (MG) has been taking adequate doses of a first-line medication, typically pyridostig...
The constellation of vitamin D, the acute-phase response, and inflammation
The constellation of vitamin D, the acute-phase response, and inflammation
In 2016, laboratory tests to detect vitamin D deficiency were ordered more than 10 million times for Medicare patients, up...
A 50-year-old man presents with shortness of breath
A 50-year-old man presents with shortness of breath
A 50-year-old man with a history of bilateral carpal tunnel syndrome presented with progressive shortness of breath on exe...
Vitamin D: A metabolic bone disease perspective
Vitamin D: A metabolic bone disease perspective
In this issue of the Journal, Antonelli and colleagues1 present an important reminder that vitamin D levels are lowered du...
Resistant hypertension: A stepwise approach
Resistant hypertension: A stepwise approach
ABSTRACTResistant hypertension can be challenging to manage, but a stepwise approach to diagnosis, evaluation, and treatme...
Myasthenia gravis: Frequently asked questions
Myasthenia gravis: Frequently asked questions
ABSTRACTMyasthenia gravis is a disorder of neuromuscular junction transmission, the result of antibodies against the post-...
Some complexities of diabetes and the heart
Some complexities of diabetes and the heart
Patients with diabetes are at greater risk of coronary artery disease, including severe and diffuse coronary disease, than...
Median rhomboid glossitis caused by tongue-brushing
Median rhomboid glossitis caused by tongue-brushing
A previously healthy 57-year-old woman presented to the hospital with a month-long history of painful sensations in the to...
What are my obligations to my incarcerated patient?
What are my obligations to my incarcerated patient?
A 45-year-old man is brought to the emergency department with a self-inflicted forearm laceration. He is incarcerated and ...
Which patients hospitalized with alcohol withdrawal syndrome should receive high-dose parenteral thiamine?
Which patients hospitalized with alcohol withdrawal syndrome should receive high-dose parenteral thiamine?
All patients hospitalized with alcohol withdrawal syndrome who have severe or complicated withdrawal (eg, severe symptoms,...
Bone turnover markers to monitor oral bisphosphonate therapy
Bone turnover markers to monitor oral bisphosphonate therapy
ABSTRACTBisphosphonates are widely used as first-line therapy to slow bone loss and decrease fracture risk in postmenopaus...
Central vision loss in a 44-year-old woman
Central vision loss in a 44-year-old woman
A 44-year-old woman presented to the emergency department following 1 week of sudden, painless, central vision loss in the...
Making best use of bone turnover markers to monitor oral bisphosphonate therapy
Making best use of bone turnover markers to monitor oral bisphosphonate therapy
We now have more agents than ever before to treat osteoporosis, including newer anabolic drugs such as teriparatide, abalo...
Statins may increase diabetes, but benefit still outweighs risk
Statins may increase diabetes, but benefit still outweighs risk
ABSTRACTData have been accumulating on the risk of developing type 2 diabetes in patients receiving statins and on the pot...
Update in cutaneous manifestations of COVID-19: Special populations
Update in cutaneous manifestations of COVID-19: Special populations
ABSTRACTCutaneous abnormalities were among the first clinical findings reported in patients infected with SARS-CoV-2 at th...
Test ordering: Balancing the good for the many with the good for the one
Test ordering: Balancing the good for the many with the good for the one
This issue of the Journal includes 3 articles on how we order clinical tests. One article relates to screening and treatin...
Asymptomatic granules on the buccal mucosa
Asymptomatic granules on the buccal mucosa
An otherwise healthy 35-year-old man was referred to the dentistry and oral surgery department with asymptomatic granules ...
Ignore e-cigarettes at your patients peril
Ignore e-cigarettes at your patients peril
Cigarette smoking is the leading cause of preventable deaths, with more than 1 billion tobacco smokers worldwide.1,2 This ...