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Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
As host’s first line of defense, innate immune cells not only recognize various pathogen-associated molecular patterns (PA...
Macrophage Migration Inhibitor factor (MIF): Potential Role in Cognitive Impairment Disorders
Macrophage Migration Inhibitor factor (MIF): Potential Role in Cognitive Impairment Disorders
MIF, a 12.5 kDa cytokine discovered in 1993, is produced by T cells and modulates the inflammatory responses [1]. It plays...
From Orphan to Oncogene: The Role of GPR35 in Cancer and Immune modulation
From Orphan to Oncogene: The Role of GPR35 in Cancer and Immune modulation
GPCRs, a family of transmembrane proteins representing 3% of the human genome, play a pivotal role in cellular signaling a...
INTERLEUKINS and INTERFERONS IN MESENCHYMAL STROMAL STEM CELL-BASED GENE THERAPY of CANCER
INTERLEUKINS and INTERFERONS IN MESENCHYMAL STROMAL STEM CELL-BASED GENE THERAPY of CANCER
Mesenchymal stromal stem cells (MSCs) are the most widely clinically studied cell type within the scope of both regenerati...
When Pyro(ptosis) Meets Palm(itoylation)
When Pyro(ptosis) Meets Palm(itoylation)
Pyroptosis is a type of programmed cell death that is involved in host defense against microbial infections and the regula...
Cytokines and Soluble Mediators as Architects of Tumor Microenvironment Reprogramming in Cancer Therapy
Cytokines and Soluble Mediators as Architects of Tumor Microenvironment Reprogramming in Cancer Therapy
Traditionally, cancer has been viewed primarily as a disease of unchecked cellular proliferation, with treatments predomin...
Semaphorins and the bone marrow microenvironment: new candidates that influence the hematopoietic system
Semaphorins and the bone marrow microenvironment: new candidates that influence the hematopoietic system
Beneath the hard surfaces of the bone lies the source of all blood cells: the bone marrow (BM) [1]. When compared with oth...
Targeting NKG2D/NKG2DL Axis In Multiple Myeloma Therapy
Targeting NKG2D/NKG2DL Axis In Multiple Myeloma Therapy
Rong Fu received her M.D. degree from the Chinese Union Medical College in 2002. She is the vice president of Tianjin Medi...
Signaling Crosstalk between Mesenchymal Stem Cells and Tumor Cells: Implications for Tumor Suppression or Progression
Signaling Crosstalk between Mesenchymal Stem Cells and Tumor Cells: Implications for Tumor Suppression or Progression
Mona Alibolandi received her Ph.D. degree in Medical Biotechnology in 2015 from Mashhad University of Medical Sciences, Ir...
Exogenous Drugs-Induced Mouse Models of Atopic Dermatitis
Exogenous Drugs-Induced Mouse Models of Atopic Dermatitis
Atopic Dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by erythema, dryness, edema, skin ...
Targeting Interleukin-17 in Radiation-Induced Toxicity and Cancer Progression
Targeting Interleukin-17 in Radiation-Induced Toxicity and Cancer Progression
Multidisciplinary therapy provided concurrently, sequentially, or in a response-adapted stepwise manner is routinely utili...
Therapeutic implications of the interplay between Interferons and ER in breast cancer
Therapeutic implications of the interplay between Interferons and ER in breast cancer
Breast cancer is a highly heterogeneous disease with a multitude of molecular pathways that interact in the tumor microenv...
Navigating IL-6: From Molecular Mechanisms to Therapeutic Breakthroughs.
Navigating IL-6: From Molecular Mechanisms to Therapeutic Breakthroughs.
Dr.S.Jubie, Associate Professor, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty, She pursued a B.Ph...
Myeloid-derived Growth Factor and its Effects on Cardiovascular and Metabolic Diseases
Myeloid-derived Growth Factor and its Effects on Cardiovascular and Metabolic Diseases
Professor Guangda Xiang, M.D. & Ph.D. He is a chief physician at department of endocrinology, general hospital of cent...
Regulation of Regulated Cell Death by Extracellular Vesicles in Acute Kidney Injury and Chronic Kidney Disease
Regulation of Regulated Cell Death by Extracellular Vesicles in Acute Kidney Injury and Chronic Kidney Disease
Kidney disease is one of the growing causes of disability and death worldwide, and CKD is projected to rise to fifth place...
Advances in Extracellular Vesicles as Mediators of Cell-to-Cell Communication in Pregnancy
Advances in Extracellular Vesicles as Mediators of Cell-to-Cell Communication in Pregnancy
Professor Carlos Salomon (PhD, DMedSc, MSc, BSc (Hons)) Professor Salomon is the head of the Translational Extracellular V...
Unveiling Cytokine Charge Disparity as a Potential Mechanism for Immune Regulation
Unveiling Cytokine Charge Disparity as a Potential Mechanism for Immune Regulation
Inflammation usually serves a protective role in minimizing injury or infection. Pathogen-Associated Molecular Patterns (P...
Decoding the roles of heat shock proteins in liver cancer
Decoding the roles of heat shock proteins in liver cancer
Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer cases and is one of the most common ...
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases
Yong-ming Yao, MD., Ph.D., Professor of Surgery, Director of Translational Medicine Research Center, Medical Innovation Re...
COVID-19: from emerging variants to vaccination
COVID-19: from emerging variants to vaccination
The vigorous spread of SARS-CoV-2 resulted in the rapid infection of millions of people worldwide and devastation of not o...
Harnessing the Potential of CD40 Agonism in Cancer Therapy
Harnessing the Potential of CD40 Agonism in Cancer Therapy
Dr. Chi Yan is an Assistant Professor in the Department of Pharmacology at Vanderbilt University School of Medicine, Nashv...
Radiation-targeted immunotherapy: a new perspective in cancer radiotherapy
Radiation-targeted immunotherapy: a new perspective in cancer radiotherapy
Radiation therapy is widely used in cancer treatment[1], [2]. Its mechanism is to destroy the DNA of cancer cells through ...
The impact of COVID-19 on cancer patients
The impact of COVID-19 on cancer patients
In December 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus causing Coronavirus di...
An emerging paradigm of CXCL12 involvement in the metastatic cascade
An emerging paradigm of CXCL12 involvement in the metastatic cascade
George S. Karagiannis, D.V.M, Ph.D. is an assistant professor in the Department of Microbiology and Immunology at the Albe...
Progranulinopathy: A Diverse Realm of Disorders Linked to Progranulin Imbalances
Progranulinopathy: A Diverse Realm of Disorders Linked to Progranulin Imbalances
Progranulin (PGRN), also known as granulin–epithelin precursor (GEP), proepithelin, acrogranin, and GP88/PC-cell derived g...
Immunosuppressive Tumor Microenvironment and Uterine Fibroids:Role in Collagen Synthesis
Immunosuppressive Tumor Microenvironment and Uterine Fibroids:Role in Collagen Synthesis
Uterine fibroids (UF), also known as leiomyoma, is a benign uterine tumor with an unclear etiology that predominately affe...
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: biological and clinical aspects
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: biological and clinical aspects
Andrea Pretta is a MD specialized in Medical Oncology and a Researcher He works in the Medical Oncology Department at the ...
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
Dr. Bin Di, Ph.D. is a professor of pharmaceutical analysis and vice-dean of School of Pharmacy in the China Pharmaceutica...
The Odyssey of cGAS: from Cytosol to Nucleus
The Odyssey of cGAS: from Cytosol to Nucleus
Dr. Li is an Associate Professor at Tulane University, New Orleans, LA, USA. He received a Ph.D. from Wuhan University in ...