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Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
The human innate immune system plays a crucial role as the first line of defense against the invasion of harmful substance...
Unravelling the Immunobiology of Innate Lymphoid Cells (ILCs): Implications in Health and Disease
Unravelling the Immunobiology of Innate Lymphoid Cells (ILCs): Implications in Health and Disease
Innate lymphoid cells (ILCs) are a newly identified class of innate immune cells that are derived from multipotent hematop...
Extracellular Vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment
Extracellular Vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment
Federica Anastasi, Asia Botto, Benoit Immordino, Elisa Giovannetti, Liam A. McDonnell. Proteomics analysis of...Jordan Fyf...
Exosome-mediated metabolic reprogramming: implications in esophageal carcinoma progression and tumor microenvironment remodeling
Exosome-mediated metabolic reprogramming: implications in esophageal carcinoma progression and tumor microenvironment remodeling
Xing Niu graduated from China Medical University. Now, his research mainly focuses on the study of artificial intelligence...
Multifaceted Role of CD14 in Innate Immunity and Tissue Homeostasis
Multifaceted Role of CD14 in Innate Immunity and Tissue Homeostasis
Byung-Chul Oh obtained his Ph.D. from Seoul National University in 2001 and further improved his expertise as a postdoctor...
Role of Lipid Signalling in Extracellular Vesicles-mediated Cell-to-cell Communication
Role of Lipid Signalling in Extracellular Vesicles-mediated Cell-to-cell Communication
Prof Marco Falasca is a full-time researcher with over 30 year-experience and a track record in signal transduction in can...
The Critical Role of Osteopontin (OPN) in Fibrotic Diseases
The Critical Role of Osteopontin (OPN) in Fibrotic Diseases
Human fibrotic diseases constitute a significant human health problem, reflecting a global unmet medical need for therapeu...
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)
ACSacute coronary syndromeAMIacute myocardial infarctionANPatrial natriuretic peptideBNPbrain natriuretic peptideCADcorona...
Extracellular vesicles as a novel mediator of interkingdom communication
Extracellular vesicles as a novel mediator of interkingdom communication
Extracellular vesicles (EVs) are nanosized lipid bilayer-delimited particles secreted from almost all types of cells inclu...
Proteomics analysis of circulating small extracellular vesicles: focus on the contribution of EVs to tumor metabolism.
Proteomics analysis of circulating small extracellular vesicles: focus on the contribution of EVs to tumor metabolism.
The extracellular space of any multicellular organism contains many different components, such as ions, proteins, oligosac...
Ferroptosis in Cancer Immunity and Immunotherapy: Multifaceted Interplay and Clinical Implications
Ferroptosis in Cancer Immunity and Immunotherapy: Multifaceted Interplay and Clinical Implications
Recently, the study of the types of non-apoptotic cell death, such as necroptosis, pyroptosis, and ferroptosis, has drawn ...
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells
The tumor microenvironment (TME) is a multifaceted and dynamic system that plays a crucial role in tumor initiation, progr...
Extracellular Vesicles: Emerging Mediators of Cell Communication in Gastrointestinal Cancers Exhibiting Metabolic Abnormalities
Prof. Godefridus J Peters from VUmc Cancer Center Amsterdam, Netherlands is an internationally reputed scientist in the fi...
Exosomes as a modulator of immune resistance in human cancers
The tumor microenvironment (TME) is a community consisting of tumor cells, various types of non-cancerous cells (e.g., imm...
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer
Dr. Guichen Li, professor and chief physician of Pancreaticobiliary Surgery department, the First Affiliated Hospital of C...
The role of microglial activation on ischemic stroke: modulation by fibroblast growth factors
Ischemic stroke is one of the leading causes of death and disability globally, which accounts for approximately 87% of all...
Role of Exosomes in Transferring Chemoresistance Through Modulation of Cancer Glycolytic Cell Metabolism
Elisa Giovannetti, MD, PhD. received her M.D. and Ph.D. with full marks and from the University of Pisa, Italy, in 2000 an...
Brain-Derived Neurotrophic Factor: Its Role in Energy Balance and Cancer Cachexia
Brain-derived neurotrophic factor (BDNF) is one of the most studied members of the neurotrophin family. It is ubiquitously...
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury
Guilherme Pasetto Fadanni holds a Bachelor's degree in Biological Sciences (2016) and a Master's degree in Pharmacology (2...
Recent advances in the treatment of IBD: Targets, mechanisms and related therapies
Dr. Bin Di, Ph.D. is a professor of pharmaceutical analysis and vice-dean of School of Pharmacy in the China Pharmaceutica...
Extracellular Vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus
Associate Professor Salomon is the head of the Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group...
Growth differentiation factor 11: A new hope for the treatment of cardiovascular diseases
Growth differentiation factor 11 (GDF11) is a secreted protein derived from dental pulp and was initially discovered by Na...
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: insights and future directions
Pancreatic ductal adenocarcinoma (PDAC) is resistant and aggressive to most standard chemotherapies [1]. The five-year sur...
Lipid Metabolism in regulation of B cell development and autoimmunity
B cells are an important component of adaptive immunity and are exposed to different environments throughout development a...
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?
Neoplasms are major public health problem in the world [1], [2]. Digestive system neoplasms are one of the common malignan...
mTOR in programmed cell death and its therapeutic implications
Yawen Xie received her Bachelor’s Degree at West China School of Medicine, Sichuan University. At present, she is a postgr...
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases
Interleukin-33 (IL-33), also known as IL-1F11, was identified as a new member of the IL-1 family of cytokines in 2005. Thi...
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation
Exosomes, a heterogeneous group of vesicles secreted by most cells, carry various biomolecular materials, including bioact...
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression
Cancers remain the main killer worldwide [1], [2], [3], [4]. A malignant tumor is a multi-etiological, systemic, and compl...
Acinar Cells and the Development of Pancreatic Fibrosis
The pancreas, which is the second largest gland in the human body after the liver, has both endocrine and exocrine functio...
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