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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinuclea...
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging
Bone marrow adipocytes (BMAds) affect bone homeostasis, but the mechanism remains unclear. Here, we showed that exercise i...
Retraction Note: Circular RNA circStag1 promotes bone regeneration by interacting with HuR
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development
FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development
Stem/progenitor cells differentiate into different cell lineages during organ development and morphogenesis. Signaling pat...
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signa...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Degenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subseq...
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) ...
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Extracellular matrix (ECM) stiffening is a typical characteristic of cartilage aging, which is a quintessential feature of...
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally a...
Author Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Author Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border...
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and imp...
Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration
Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration
Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without ...
Pannexins in the musculoskeletal system: new targets for development and disease progression
Pannexins in the musculoskeletal system: new targets for development and disease progression
During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication cha...
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothe...
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the tra...
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth ...
Skeletal interoception in osteoarthritis
Skeletal interoception in osteoarthritis
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals afte...
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be...
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite ex...
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture
The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating b...
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
While hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellu...
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis
Osteoarthritis (OA) is a common degenerative disease worldwide and new therapeutics that target inflammation and the cross...
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. Howeve...
A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis
A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the bone health of patients with...
Aging impairs the osteocytic regulation of collagen integrity and bone quality
Aging impairs the osteocytic regulation of collagen integrity and bone quality
Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish ...
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of ce...
Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles
Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles
Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting ...
Author Correction: Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Author Correction: Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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