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Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
Degenerative spine and joint diseases, including intervertebral disc degeneration (IDD), ossification of the spinal ligame...
Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene
Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene
Recent genome-wide association studies (GWAS) identified 518 significant loci associated with bone mineral density (BMD), ...
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
Osteoarthritis (OA) poses a significant challenge in orthopedics. Inflammatory pathways are regarded as central mechanisms...
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis
Osteoporosis (OP) is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure ...
Engineering bone/cartilage organoids: strategy, progress, and application
Engineering bone/cartilage organoids: strategy, progress, and application
The concept and development of bone/cartilage organoids are rapidly gaining momentum, providing opportunities for both fun...
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senes...
Bone loss with aging is independent of gut microbiome in mice
Bone loss with aging is independent of gut microbiome in mice
Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial fact...
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
Osteonecrosis of the femoral head (ONFH) is a common complication of glucocorticoid (GC) therapy. Recent advances demonstr...
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
Osteoarthritis (OA) is an age-related cartilage-degenerating joint disease. Mitochondrial dysfunction has been reported to...
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Osteopetrosis is an inherited metabolic disease, characterized by increased bone density and narrow marrow cavity. Patient...
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture ris...
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significa...
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Myeloid cells are pivotal in the inflammatory and remodeling phases of fracture repair. Here, we investigate the effect of...
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly i...
Metabolic reprogramming in skeletal cell differentiation
Metabolic reprogramming in skeletal cell differentiation
The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and miner...
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonuni...
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall surviv...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed to the dysfunction of nucleu...
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclast is critical in skeletal development and fracture healing, yet the impact and underlying mechanisms of their met...
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due to a range of genetic variants...
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients, effective treatmen...
SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion
SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion
Osteoclasts are multinucleated bone-resorbing cells, and their formation is tightly regulated to prevent excessive bone lo...
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Bone marrow stromal/stem cells (BMSCs) are generally considered as common progenitors for both osteoblasts and adipocytes ...
Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, that is not prevented by a diet high in calcium, phosphate, and lactose
Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, that is not prevented by a diet high in calcium, phosphate, and lactose
The vitamin D receptor (VDR) plays a critical role in the regulation of mineral and bone homeostasis. Upon binding of 1 ...
Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system
Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and ...
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation
Apoptosis is crucial for tissue homeostasis and organ development. In bone, apoptosis is recognized to be a main fate of o...
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