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Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Author Correction: Insights and implications of sexual dimorphism in osteoporosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration
Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothe...
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the tra...
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth ...
Skeletal interoception in osteoarthritis
Skeletal interoception in osteoarthritis
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals afte...
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be...
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite ex...
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture
The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating b...
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
While hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellu...
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis
Osteoarthritis (OA) is a common degenerative disease worldwide and new therapeutics that target inflammation and the cross...
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. Howeve...
A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis
A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the bone health of patients with...
Aging impairs the osteocytic regulation of collagen integrity and bone quality
Aging impairs the osteocytic regulation of collagen integrity and bone quality
Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish ...
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of ce...
Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles
Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles
Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting ...
Author Correction: Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Author Correction: Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia
RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia
Fibrous dysplasia (FD) is a rare, disabling skeletal disease for which there are no established treatments. Growing eviden...
Insights and implications of sexual dimorphism in osteoporosis
Insights and implications of sexual dimorphism in osteoporosis
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitectu...
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, sy...
A new perspective on intervertebral disc calcification—from bench to bedside
A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to unders...
The role and applications of extracellular vesicles in osteoporosis
The role and applications of extracellular vesicles in osteoporosis
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture...
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized ...
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but ...
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as ...
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent tr...
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve end...
Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40)
Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40)
Given afferent functions, sensory nerves have recently been found to exert efferent effects and directly alter organ physi...
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amou...
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders. Glucose has been consider...
Structure and function of the membrane microdomains in osteoclasts
Structure and function of the membrane microdomains in osteoclasts
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed ...
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