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FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia
FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia
Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes lead to chondrodysplasia and craniosynostoses...
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification
Mechanical stress modulates bone formation and organization of the extracellular matrix (ECM), the interaction of which af...
Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity
Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity
Fibrotic remodeling of nucleus pulposus (NP) leads to structural and mechanical anomalies of intervertebral discs that pro...
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis
Osteocytes are the main cells in mineralized bone tissue. Elevated osteocyte apoptosis has been observed in lytic bone les...
Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair
Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair
The cranial mesenchyme, originating from both neural crest and mesoderm, imparts remarkable regional specificity and compl...
Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections
Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensi...
Tree shrew as a new animal model for musculoskeletal disorders and aging
Tree shrew as a new animal model for musculoskeletal disorders and aging
Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (M...
Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation
Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation
Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossificat...
Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans
Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans
Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symp...
MYSM1 attenuates osteoarthritis by recruiting PP2A to deubiquitinate and dephosphorylate RIPK2
MYSM1 attenuates osteoarthritis by recruiting PP2A to deubiquitinate and dephosphorylate RIPK2
Osteoarthritis (OA), the most prevalent degenerative joint disease, is marked by cartilage degradation and pathological al...
Skeletal interoception and prospective application in biomaterials for bone regeneration
Skeletal interoception and prospective application in biomaterials for bone regeneration
Accumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metab...
Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness
Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness
Proteoglycans, key components of non-collagenous proteins in the bone matrix, attract water through their negatively charg...
Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
Degenerative spine and joint diseases, including intervertebral disc degeneration (IDD), ossification of the spinal ligame...
Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene
Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene
Recent genome-wide association studies (GWAS) identified 518 significant loci associated with bone mineral density (BMD), ...
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
Osteoarthritis (OA) poses a significant challenge in orthopedics. Inflammatory pathways are regarded as central mechanisms...
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis
Osteoporosis (OP) is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure ...
Engineering bone/cartilage organoids: strategy, progress, and application
Engineering bone/cartilage organoids: strategy, progress, and application
The concept and development of bone/cartilage organoids are rapidly gaining momentum, providing opportunities for both fun...
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senes...
Bone loss with aging is independent of gut microbiome in mice
Bone loss with aging is independent of gut microbiome in mice
Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial fact...
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
Osteonecrosis of the femoral head (ONFH) is a common complication of glucocorticoid (GC) therapy. Recent advances demonstr...
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
Osteoarthritis (OA) is an age-related cartilage-degenerating joint disease. Mitochondrial dysfunction has been reported to...
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Osteopetrosis is an inherited metabolic disease, characterized by increased bone density and narrow marrow cavity. Patient...
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture ris...
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significa...
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Myeloid cells are pivotal in the inflammatory and remodeling phases of fracture repair. Here, we investigate the effect of...
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly i...
Metabolic reprogramming in skeletal cell differentiation
Metabolic reprogramming in skeletal cell differentiation
The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and miner...
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonuni...
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall surviv...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
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