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Osteomodulin downregulation is associated with osteoarthritis development
Osteomodulin downregulation is associated with osteoarthritis development
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD)...
Interoceptive regulation of skeletal tissue homeostasis and repair
Interoceptive regulation of skeletal tissue homeostasis and repair
Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process kn...
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signa...
α-parvin controls chondrocyte column formation and regulates long bone development
α-parvin controls chondrocyte column formation and regulates long bone development
Endochondral ossification requires proper control of chondrocyte proliferation, differentiation, survival, and organizatio...
Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms
Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms
The bone extracellular matrix (ECM) contains minerals deposited on highly crosslinked collagen fibrils and hundreds of non...
Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression
Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression
Due to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed to inves...
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
The bony skeleton is continuously renewed throughout adult life by the bone remodeling process, in which old or damaged bo...
Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any...
Correction: FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis
Correction: FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Small-molecule amines: a big role in the regulation of bone homeostasis
Small-molecule amines: a big role in the regulation of bone homeostasis
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration ...
Correction: mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence through regulating the sodium channel Scn1a
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Causal associations of brain structure with bone mineral density: a large-scale genetic correlation study
Causal associations of brain structure with bone mineral density: a large-scale genetic correlation study
In this study, we aimed to investigate the causal associations of brain structure with bone mineral density (BMD). Based o...
Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma
Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma
Heterotopic ossification (HO) is a pathological process resulting in aberrant bone formation and often involves synovial l...
Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation
Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation
A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is indispensable for the maintena...
Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT
Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT
A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metaboli...
A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss
A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss
Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in...
Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies ...
Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and dev...
CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ
CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ
Dysregulated lineage commitment of mesenchymal stem cells (MSCs) contributes to impaired bone formation and an imbalance b...
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma
Osteosarcoma (OS) is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity. St...
FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
The specific pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) is still not fully understood, and ...
New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis
New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis
Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases leading to increased bone resorption. Preven...
Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice
Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice
Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene mutations lead to fragile X syndrome, cognitive disorders, and, in som...
Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion
Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion
Peritendinous adhesion formation (PAF) can substantially limit the range of motion of digits. However, the origin of myofi...
Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells
Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells
Myeloid-derived suppressor cells (MDSCs) are bone marrow (BM)-derived immunosuppressive cells in the tumor microenvironmen...
Bone serves as a transfer station for secondary dissemination of breast cancer
Bone serves as a transfer station for secondary dissemination of breast cancer
Metastasis is responsible for the majority of deaths among breast cancer patients. Although parallel polyclonal seeding ha...
Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate
Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate
Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate, where chondrocytes accumul...
Reversal of the diabetic bone signature with anabolic therapies in mice
Reversal of the diabetic bone signature with anabolic therapies in mice
The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood; and antiresorptive ag...
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