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Current understanding of osteoarthritis pathogenesis and relevant new approaches
Current understanding of osteoarthritis pathogenesis and relevant new approaches
Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the...
Biomechanics and mechanobiology of the bone matrix
Biomechanics and mechanobiology of the bone matrix
The bone matrix plays an indispensable role in the human body, and its unique biomechanical and mechanobiological properti...
Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA) remain unknown. No pharmacological ...
Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration
Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration
The restoration of bone defects caused by osteoporosis remains a challenge for surgeons. Strontium ranelate has been appli...
Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway
Ammonia plays an important role in cellular metabolism. However, ammonia is considered a toxic product. In bone marrow-der...
Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation
Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation
Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in...
Correction to: RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation
Correction to: RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis
Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis
Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial persistence. Staphylo...
Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling
Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling
Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becomi...
Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153
Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153
Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation....
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same su...
GsαR201C and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells
GsαR201C and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells
The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis...
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5
Physical mechanical stimulation can maintain and even increase bone mass. Here, we report an important role of osteocytic ...
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis
Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis (RA). Fatty acid-bi...
Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation
Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation
Type II collagen-positive (Col2+) cells have been reported as skeletal stem cells (SSCs), but the contribution of Col2+ pr...
Mechanisms of bone pain: Progress in research from bench to bedside
Mechanisms of bone pain: Progress in research from bench to bedside
The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets...
Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma
Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma
The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet ...
Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation
Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation
Toll-like receptors (TLRs) play pivotal roles in inflammation and provide important links between the immune and skeletal ...
Progress in osteoarthritis research by the National Natural Science Foundation of China
Progress in osteoarthritis research by the National Natural Science Foundation of China
Osteoarthritis (OA) in China is gradually becoming an important scientific research area that has had a significant impact...
Prospects and challenges of dynamic DNA nanostructures in biomedical applications
Prospects and challenges of dynamic DNA nanostructures in biomedical applications
The physicochemical nature of DNA allows the assembly of highly predictable structures via several fabrication strategies,...
Correction: A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration
These authors contributed equally: Yishan Chen, Yeke Yu, Ya WenDr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and...
Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model
Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model
Spondylocarpotarsal syndrome (SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal...
A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration
A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration
Articular cartilage damage is a universal health problem. Despite recent progress, chondrocyte dedifferentiation has sever...
The role of sphingosine-1-phosphate in bone remodeling and osteoporosis
The role of sphingosine-1-phosphate in bone remodeling and osteoporosis
Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruptio...
Progression in translational research on spinal cord injury based on microenvironment imbalance
Progression in translational research on spinal cord injury based on microenvironment imbalance
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable bur...
Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing
Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing
Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating ost...
Circular RNA circStag1 promotes bone regeneration by interacting with HuR
Circular RNA circStag1 promotes bone regeneration by interacting with HuR
Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitectu...
The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling
The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling
Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. H...