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Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis
Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis
Joint pain and osteoarthritis can occur as coronavirus disease 2019 (COVID-19) sequelae after infection. However, little i...
We must learn from past outbreaks
To successfully tackle the current mpox public-health emergency, we must learn from past outbreaks to focus research quest...
Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans
Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans
Genomic copy number changes are associated with antifungal drug resistance and virulence across diverse fungal pathogens, ...
Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts
Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts
Parasitic nematodes have an intimate, chronic and lifelong exposure to vertebrate tissues. Here we mined 41 published para...
Discovery of CO2 tolerance genes associated with virulence in the fungal pathogen Cryptococcus neoformans
Discovery of CO2 tolerance genes associated with virulence in the fungal pathogen Cryptococcus neoformans
Cryptococcus neoformans is a ubiquitous soil fungus and airborne pathogen that causes over 180,000 deaths each year. Crypt...
Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly
Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly
Human microbiota assembly commences at birth, seeded by both maternal and environmental microorganisms. Ecological theory ...
An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host
An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host
A limited number of bacteria are able to colonize the nuclei of eukaryotes. ‘Candidatus Endonucleobacter’ infe...
Continental-scale associations of Arabidopsis thaliana phyllosphere members with host genotype and drought
Continental-scale associations of Arabidopsis thaliana phyllosphere members with host genotype and drought
Plants are colonized by distinct pathogenic and commensal microbiomes across different regions of the globe, but the facto...
Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice
Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice
Mycobacterium tuberculosis (Mtb) infects several lung macrophage populations, which have distinct abilities to restrict Mt...
An S-methyltransferase that produces the climate-active gas dimethylsulfide is widespread across diverse marine bacteria
An S-methyltransferase that produces the climate-active gas dimethylsulfide is widespread across diverse marine bacteria
Hydrogen sulfide (H2S), methanethiol (MeSH) and dimethylsulfide (DMS) are abundant sulfur gases with roles in biogeochemic...
Neurospora intermedia from a traditional fermented food enables waste-to-food conversion
Neurospora intermedia from a traditional fermented food enables waste-to-food conversion
Fungal fermentation of food and agricultural by-products holds promise for improving food sustainability and security. How...
Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation
Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation
Aspergillus fumigatus causes aspergillosis and relies on asexual spores (conidia) for initiating host infection. There is ...
Understanding emerging and re-emerging viruses to facilitate pandemic preparedness
Understanding emerging and re-emerging viruses to facilitate pandemic preparedness
On 8–11 April 2024, a Keystone meeting on human immunodeficiency virus and emerging and re-emerging viruses convened...
Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis
Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis
Mounting evidence indicates that antibodies can contribute towards control of tuberculosis (TB). However, the underlying m...
Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities
Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities
An important host defence mechanism against pathogens is intracellular killing, which is achieved through phagocytosis, a ...
Bacteria induce metabolic perturbations in ticks
Bacteria induce metabolic perturbations in ticks
A metabolomics approach to study microbe–tick interactions reveals that host β-aminoisobutyric acid contributes...
The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis
The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis
Fusobacterium nucleatum can bind to host cells and potentiate intestinal tumorigenesis. Here we used a genome-wide screen ...
Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification
Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification
Severe coronavirus disease 2019 and post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in...
Host–gut microbiota crosstalk predicts neuroinflammation
Host–gut microbiota crosstalk predicts neuroinflammation
Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, out...
Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut
Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut
Resource competition is a driver of gut microbiota composition. Bacteria can outcompete metabolically similar rivals throu...
Gut epithelial electrical cues drive differential localization of enterobacteria
Gut epithelial electrical cues drive differential localization of enterobacteria
Salmonella translocate to the gut epithelium via microfold cells lining the follicle-associated epithelium (FAE). How Salm...
Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection
Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection
Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targe...
Author Correction: A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme
Author notesThese authors contributed equally: Wei Chen, Di Wang.Authors and AffiliationsState Key Laboratory for Biology ...
Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites
Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites
The bloom and bust patterns of microalgae in aquatic systems contribute massively to global biogeochemical cycles. The dec...
Translating between science and politics as a government adviser
Translating between science and politics as a government adviser
Moving from academia to government was challenging, but learning to translate evidence-based results into policy decisions...
Evolutionary origin of the tropical race 4 banana pathogen and mechanisms of its virulence
Evolutionary origin of the tropical race 4 banana pathogen and mechanisms of its virulence
Fusarium oxysporum f. sp. cubense tropical race 4 is threatening worldwide banana production. This study revealed a distin...
Virulence of banana wilt-causing fungal pathogen Fusarium oxysporum tropical race 4 is mediated by nitric oxide biosynthesis and accessory genes
Virulence of banana wilt-causing fungal pathogen Fusarium oxysporum tropical race 4 is mediated by nitric oxide biosynthesis and accessory genes
Fusarium wilt of banana, caused by Fusarium oxysporum f. sp. cubense (Foc), is one of the most damaging plant diseases kno...
Darwin’s expedition revisited to reveal the evolution of plant–microbe interactions on Galápagos
Darwin’s expedition revisited to reveal the evolution of plant–microbe interactions on Galápagos
SMP was funded by the Universidad San Francisco de Quito (USFQ) and the Netherlands Institute of Ecology (NIOO-KNAW). Scal...
Quantitative principles of microbial metabolism shared across scales
Quantitative principles of microbial metabolism shared across scales
Metabolism is the complex network of chemical reactions occurring within every cell and organism, maintaining life, mediat...
Author Correction: Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus
Stephanie GrondPresent address: Institute of Organic Chemistry, University of Tübingen, Tübingen, GermanyThese authors con...
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