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Planning and describing a microbiome data analysis
Planning and describing a microbiome data analysis
We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
Host immunity and commensal bacteria synergistically maintain intestinal homeostasis and mediate colonization resistance a...
ARF4-mediated intracellular transport as a broad-spectrum antiviral target
ARF4-mediated intracellular transport as a broad-spectrum antiviral target
Host factors that are involved in modulating cellular vesicular trafficking of virus progeny could be potential antiviral ...
Author Correction: Systematic discovery of antibacterial and antifungal bacterial toxins
These authors contributed equally: Nimrod Nachmias, Noam Dotan, Marina Campos Rocha.Department of Plant Pathology and Micr...
Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid
Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid
Intestinal crypts harbour a specific microbiota but whether and how these bacteria regulate intestinal stem cells (ISCs) o...
Publisher Correction: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
Ravi U. ShethPresent address: Kingdom Supercultures, Brooklyn, NY, USADepartment of Systems Biology, Columbia University, ...
Structural insights into tecovirimat antiviral activity and poxvirus resistance
Structural insights into tecovirimat antiviral activity and poxvirus resistance
Mpox is a zoonotic disease endemic to Central and West Africa. Since 2022, two human-adapted monkeypox virus (MPXV) strain...
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforapha...
Influenza A virus rapidly adapts particle shape to environmental pressures
Influenza A virus rapidly adapts particle shape to environmental pressures
Enveloped viruses such as influenza A virus (IAV) often produce a mixture of virion shapes, ranging from 100 nm sphe...
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
The gut microbiome modulates immunotherapy treatment responses, and this may explain why immune checkpoint inhibitors, suc...
Bacterial adhesion strategies and countermeasures in urinary tract infection
Bacterial adhesion strategies and countermeasures in urinary tract infection
Urinary tract infections (UTIs) are compounded by antimicrobial resistance, which increases the risk of UTI recurrence and...
Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
Aliphatic polyamides, or nylons, are widely used in the textile and automotive industry due to their high durability and t...
Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11
Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11
Human enteric α-defensin 5 (HD5) is an immune system peptide that acts as an important antimicrobial factor but is al...
Ensuring rigour of low-biomass microbiome research
Determining whether human organs house a resident microbiome is challenging and the findings can be controversial. However...
Design and regulation of engineered bacteria for environmental release
Design and regulation of engineered bacteria for environmental release
Emerging products of biotechnology involve the release of living genetically modified microbes (GMMs) into the environment...
Sliding clamp protein enables long-range gene silencing in a bacterial plasmid
Sliding clamp protein enables long-range gene silencing in a bacterial plasmid
Long-distance gene regulation is uncommon in bacteria, and its molecular mechanisms are unclear. Using a combination of st...
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
The local arrangement of microbes can profoundly impact community assembly, function and stability. However, our understan...
Author Correction: Aspergillus cvjetkovicii protects against phytopathogens through interspecies chemical signalling in the phyllosphere
College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, ChinaXiaoyan Fan, Haruna Matsumoto, Haorong Xu, H...
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion
Akkermansia muciniphila is a human microbial symbiont residing in the mucosal layer of the large intestine. Its main carbo...
Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation
Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation
Succinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational mod...
Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice
Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice
Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they ...
Engineering mycobacteria for vaccination and controlled human infection studies
Engineering mycobacteria for vaccination and controlled human infection studies
Two studies report the development of genetically engineered, kill-switch-encoding strains of Mycobacterium tuberculosis a...
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
Bacterial genomes have regions known as defence islands that encode diverse systems to protect against phage infection. Al...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid
Examples of long-range gene regulation in bacteria are rare and generally thought to involve DNA looping. Here, using a co...
T cell-mediated protection in absence of virus neutralizing antibodies
T cell-mediated protection in absence of virus neutralizing antibodies
Vaccine-induced neutralizing antibodies are widely considered sufficient and required for protection from yellow fever and...
The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics
The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics
The evolution of eukaryotes is a fundamental event in the history of life. The closest prokaryotic lineage to eukaryotes, ...
Predicting child health with gut microbiome development trajectories
The human gut microbiome plays a vital role in aiding digestion, regulating host immunity, metabolism, protecting against ...
Explainable artificial intelligence evolves antimicrobial peptides
Explainable artificial intelligence evolves antimicrobial peptides
An explainable deep learning model enables the identification and virtual optimization of antimicrobial peptides (AMPs) fr...
A gut microorganism turns the dial on sugar intake
A gut microorganism turns the dial on sugar intake
A Bacteroides vulgatus metabolite, pantothenate, induces secretion of the hormones GLP1 in the gut and FGF21 in the liver,...
Longitudinal phage–bacteria dynamics in the early life gut microbiome
Longitudinal phage–bacteria dynamics in the early life gut microbiome
Microbial colonization of the human gut occurs soon after birth, proceeds through well-studied phases and is affected by l...
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