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Migrant health matters
Reports of diphtheria cases in asylum seekers in the UK remind us that understanding and mitigating the risks posed by inf...
Tracking outbreak dynamics using within-host variation
I.D.-B. is affiliated to the National Institute for Health and Care Research Health Protection Research Unit (NIHR HPRU) i...
Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity
Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity
Despite advances in sequencing, lack of standardization makes comparisons across studies challenging and hampers insights ...
Ancient origin and constrained evolution of the division and cell wall gene cluster in Bacteria
Ancient origin and constrained evolution of the division and cell wall gene cluster in Bacteria
The division and cell wall (dcw) gene cluster in Bacteria comprises 17 genes encoding key steps in peptidoglycan synthesis...
Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization
Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization
The fungal gut microbiota (mycobiota) has been implicated in diseases that disturb gut homeostasis, such as inflammatory b...
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum
The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes, and an esse...
Safety and immunogenicity of a prefusion non-stabilized spike protein mRNA COVID-19 vaccine: a phase I trial
Safety and immunogenicity of a prefusion non-stabilized spike protein mRNA COVID-19 vaccine: a phase I trial
Effective mRNA SARS-CoV-2 vaccines are available but need to be stored in freezers, limiting their use to countries that h...
Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the ...
Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial
Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial
Measuring immune correlates of disease acquisition and protection in the context of a clinical trial is a prerequisite for...
Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission
Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral variants that can emerge t...
Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations
Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations
The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. We isolated and sequenced a vi...
Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex
Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex
The type III-E CRISPR–Cas system uses a single multidomain effector called Cas7-11 (also named gRAMP) to cleave RNA ...
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming RNA and DNA phages by binding to complemen...
Mixotrophy in depth
Mixotrophy in depth
Prochlorococcus is the most abundant photosynthetic organism in the ocean, but single-cell measurements and model simulati...
Methanotrophy by a Mycobacterium species that dominates a cave microbial ecosystem
Methanotrophy by a Mycobacterium species that dominates a cave microbial ecosystem
So far, only members of the bacterial phyla Proteobacteria and Verrucomicrobia are known to grow methanotrophically under ...
Single-cell measurements and modelling reveal substantial organic carbon acquisition by Prochlorococcus
Single-cell measurements and modelling reveal substantial organic carbon acquisition by Prochlorococcus
Marine phytoplankton are responsible for about half of the photosynthesis on Earth. Many are mixotrophs, combining photosy...
Combining pathogen and host metagenomics for a better sepsis diagnostic
Combining pathogen and host metagenomics for a better sepsis diagnostic
Combining simultaneous host and pathogen metagenomic profiles in a cohort of hospitalized and critically ill patients allo...
Capsid adaptation defines pandemic HIV
Capsid adaptation defines pandemic HIV
Pandemic viruses cause major global disease burden and economic disruption. We investigated pandemic HIV-1(M) to understan...
Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice
Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice
Klebsiella spp. that secrete the DNA-alkylating enterotoxin tilimycin colonize the human intestinal tract. Numbers of toxi...
Evasion of cGAS and TRIM5 defines pandemic HIV
Evasion of cGAS and TRIM5 defines pandemic HIV
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans, only one, leading to human immunodefici...
Bacteriophage genome engineering with CRISPR–Cas13a
Bacteriophage genome engineering with CRISPR–Cas13a
Jumbo phages such as Pseudomonas aeruginosa ФKZ have potential as antimicrobials and as a model for uncovering basic...
Pneumococcal within-host diversity during colonization, transmission and treatment
Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve surveillance and reconstruct...
Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion
Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion
Defence-associated sirtuins (DSRs) comprise a family of proteins that defend bacteria from phage infection via an unknown ...
Comprehensive transcription terminator atlas for Bacillus subtilis
Comprehensive transcription terminator atlas for Bacillus subtilis
The transcriptome-wide contributions of Rho-dependent and intrinsic (Rho-independent) transcription termination mechanisms...
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion
Argonaute (Ago) proteins are found in all three domains of life. The so-called long Agos are composed of four major domain...
Defending Earth’s terrestrial microbiome
Defending Earth’s terrestrial microbiome
Microbial life represents the majority of Earth’s biodiversity. Across disparate disciplines from medicine to forest...
SARS-CoV-2 Omicron variant emerged under immune selection
SARS-CoV-2 Omicron variant emerged under immune selection
The SARS-CoV-2 Omicron variant (B.1.1.529 lineage) escapes antibodies that neutralize the ancestral virus. We tested human...
Computational identification of a systemic antibiotic for Gram-negative bacteria
Computational identification of a systemic antibiotic for Gram-negative bacteria
Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to their restrictive penetration...
Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants
Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants
The development of the gut microbiome from birth plays important roles in short- and long-term health, but factors influen...