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SARS and synapses
SARS and synapses
SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the e...
Age and sex influence antibody profiles associated with tuberculosis progression
Age and sex influence antibody profiles associated with tuberculosis progression
Antibody features vary with tuberculosis (TB) disease state. Whether clinical variables, such as age or sex, influence ass...
Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway
Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway
The cyclic-oligonucleotide-based anti-phage signalling system (CBASS) is a type of innate prokaryotic immune system. Compo...
Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells
Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells
Epstein–Barr virus (EBV) can infect both B cells and epithelial cells (ECs), causing diseases such as mononucleosis ...
Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis)
Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis)
The 2022 mpox virus (MPXV) outbreak was sustained by human-to-human transmission; however, it is currently unclear which f...
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii
Carbapenem-resistant Acinetobacter baumannii infections have limited treatment options. Synthesis, transport and placement...
Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence
Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence
RNA viruses, like SARS-CoV-2, depend on their RNA-dependent RNA polymerases (RdRp) for replication, which is error prone. ...
The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors
The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors
The ability to sense prey-derived cues is essential for predatory lifestyles. Under low-nutrient conditions, Arthrobotrys ...
Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice
Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice
Metabolic disease is epidemiologically linked to severe complications upon influenza virus infection, thus vaccination is ...
Narrow-spectrum antibiotic exploits metabolic differences to inhibit Pseudomonas aeruginosa
Narrow-spectrum antibiotic exploits metabolic differences to inhibit Pseudomonas aeruginosa
We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa...
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum
Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like protein 13 (PfK13). Quiescence, a ...
CryoEM structures reveal how the bacterial flagellum rotates and switches direction
CryoEM structures reveal how the bacterial flagellum rotates and switches direction
Bacterial chemotaxis requires bidirectional flagellar rotation at different rates. Rotation is driven by a flagellar motor...
Publisher Correction: Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia
These authors contributed equally: Peter T. Mee, Andrew H. Buultjens, Jane Oliver.Centre for AgriBioscience, AgriBio, Agri...
DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity
DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity
Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect and cleave invader nucleic ac...
Age-specific nasal epithelial responses to SARS-CoV-2 infection
Age-specific nasal epithelial responses to SARS-CoV-2 infection
Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in infected peopl...
Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As
Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As
Although the significance of chemical modifications on RNA is acknowledged, the evolutionary benefits and specific roles i...
Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
Giant viruses (phylum Nucleocytoviricota) are globally distributed in aquatic ecosystems. They play fundamental roles as e...
Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection
Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection
Prokaryotic antiviral defence systems are frequently toxic for host cells and stringent regulation is required to ensure s...
A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting compounds, which have multiple ...
From sustainable feedstocks to microbial foods
From sustainable feedstocks to microbial foods
Climate change-induced alterations in weather patterns, such as frequent and severe heatwaves, cold waves, droughts, flood...
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections for which the development of antibiotics is urge...
Making HTLV-1 and those affected visible
Carolina Rosadas explains why we need more research investigating human T lymphotropic virus type 1 (HTLV-1) infections, a...
Data availability is the golden rule in research
As the saying goes, sharing is caring — but when it comes to the data underlying primary research papers published a...
Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles
Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles
Dormant prophages protect lysogenic cells by expressing diverse immune systems, which must avoid targeting their cognate p...
Author Correction: Rhinoviruses usurp STING for replication
Authors and AffiliationsVirology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Hea...
Longitudinal dynamics of farmer and livestock nasal and faecal microbiomes and resistomes
Longitudinal dynamics of farmer and livestock nasal and faecal microbiomes and resistomes
Globally, half a billion people are employed in animal agriculture and are directly exposed to the associated microorganis...
Low-dose dengue virus 3 human challenge model: a phase 1 open-label study
Low-dose dengue virus 3 human challenge model: a phase 1 open-label study
Dengue human infection models present an opportunity to explore the potential of a vaccine, anti-viral or immuno-compound ...
Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis
Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with short- and long-term neurologica...
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Cri...
Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still needed, particularly for in...
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