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Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission
Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission
Over the last two decades, it has been established that glucose metabolic fluxes in neurons and astrocytes are proportiona...
MRI evaluation of cerebral metabolic rate of oxygen (CMRO2) in obstructive sleep apnea
MRI evaluation of cerebral metabolic rate of oxygen (CMRO2) in obstructive sleep apnea
Patients with obstructive sleep apnea (OSA) are at elevated risk of developing systemic vascular disease and cognitive dys...
Validation of external and internal exposome of the findings associated to cerebral small vessel disease: A Mendelian randomization study
Validation of external and internal exposome of the findings associated to cerebral small vessel disease: A Mendelian randomization study
The exposome characterizes all environmental exposures and their impact on a disease. To determine the causally-associated...
Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling
Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling
Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind Alzheim...
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study
It is commonly believed that cerebrospinal fluid (CSF) movement is facilitated by blood vessel wall movements (i.e., hemod...
Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia
Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia
Prior studies have described high venous signal qualitatively using arterial spin labelling (ASL) in patients with sickle ...
Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke
Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke
Injectable hydrogels can generate and support pro-repair environments in injured tissue. Here we used a slow-releasing dru...
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging
Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central nervous system disorders. Like ...
Systematic validation of structural brain networks in cerebral small vessel disease
Systematic validation of structural brain networks in cerebral small vessel disease
Cerebral small vessel disease (SVD) is considered a disconnection syndrome, which can be quantified using structural brain...
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke
The metabolic reprogramming of peripheral CD4+ T cells that occurs after stroke can lead to imbalanced differentiation of ...
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states
Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-dependent (BOLD) signal have shown gr...
Trans-cerebral HCO3− and PCO2 exchange during acute respiratory acidosis and exercise-induced metabolic acidosis in humans
Trans-cerebral HCO3− and PCO2 exchange during acute respiratory acidosis and exercise-induced metabolic acidosis in humans
This study investigated trans-cerebral internal jugular venous-arterial bicarbonate ([HCO3−]) and carbon dioxide tension (...
A reference tissue forward model for improved PET accuracy using within-scan displacement studies
A reference tissue forward model for improved PET accuracy using within-scan displacement studies
We report a novel forward-model implementation of the full reference tissue model (fFTRM) that addresses the fast-exchange...
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion
White matter injury is a critical pathological characteristic during ischemic stroke. Oligodendrocyte precursor cells part...
Quantitative susceptibility mapping as a measure of cerebral oxygenation in neonatal piglets
Quantitative susceptibility mapping as a measure of cerebral oxygenation in neonatal piglets
Prominence of cerebral veins using susceptibility weighted magnetic resonance imaging (SWI) has been used as a qualitative...
Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-β deposition in patients with mild cognitive impairment
Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-β deposition in patients with mild cognitive impairment
Mounting evidence suggests that amyloid-β (Aβ) and vascular etiologies are intertwined in the pathogenesis of Alzheimer’s ...
Deep medullary veins are associated with widespread brain structural abnormalities
Deep medullary veins are associated with widespread brain structural abnormalities
Our aim is to investigate the association of cerebral deep medullary veins (DMVs) with white matter microstructural integr...
Predicting cerebral infarction in patients with atrial fibrillation using machine learning: The Fushimi AF registry
Predicting cerebral infarction in patients with atrial fibrillation using machine learning: The Fushimi AF registry
The CHADS2 and CHA2DS2-VASc scores are widely used to assess ischemic risk in the patients with atrial fibrillation (AF). ...
Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults
Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults
Blood oxygenation level-dependent (BOLD) or arterial spin labeling (ASL) MRI with hypercapnic stimuli allow for measuring ...
Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke
Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke
Intracerebral cell therapy (CT) is emerging as a new therapeutic paradigm for stroke. However, the impact of physical ther...
Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy
Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy
There is growing evidence for the vascular contribution to cognitive impairment and dementia in Alzheimer’s disease (AD) a...
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques*
Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques*
Cerebrovascular reactivity (CVR), the capacity of the brain to increase cerebral blood flow (CBF) to meet changes in physi...
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes
Knowledge about the dynamic metabolism and function of cerebrospinal fluid (CSF) physiology has rapidly progressed in rece...
Lumen-oriented versus wall-oriented treatment strategies for intracranial aneurysms – A systematic review of suggested therapeutic concepts
Lumen-oriented versus wall-oriented treatment strategies for intracranial aneurysms – A systematic review of suggested therapeutic concepts
The development of new treatment strategies for intracranial aneurysms (IAs) has been and continues to be a major interest...
Tissue-type plasminogen activator induces TNF-α-mediated preconditioning of the blood-brain barrier
Tissue-type plasminogen activator induces TNF-α-mediated preconditioning of the blood-brain barrier
Ischemic tolerance is a phenomenon whereby transient exposure to a non-injurious preconditioning stimulus triggers resista...
D* from diffusion MRI reveals a correspondence between ventricular cerebrospinal fluid volume and flow in the ischemic rodent model
D* from diffusion MRI reveals a correspondence between ventricular cerebrospinal fluid volume and flow in the ischemic rodent model
Quantitative measurement of cerebrospinal fluid (CSF) flow and volume and longitudinal monitoring of CSF dynamics provide ...
White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK biobank cohort study
White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK biobank cohort study
Small vessel disease is associated with age, mean blood pressure (MAP) and blood pressure pulsatility (PP). We used data f...
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are markers of cerebral oxygen homeostasis ...
Effect of drug interventions on cerebral haemodynamics in ischaemic stroke patients
Effect of drug interventions on cerebral haemodynamics in ischaemic stroke patients
The ischaemic penumbra is sensitive to alterations in cerebral perfusion. A myriad of drugs are used in acute ischaemic st...
How can integrative physiology advance stroke research and stroke care?
How can integrative physiology advance stroke research and stroke care?
1. Nogueira RC, Aries M, Minhas JS, et al. Review of studies on dynamic cerebral autoregulation in the acute phase of stro...
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