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Identification of novel CDH23 heterozygous variants causing autosomal recessive nonsyndromic hearing loss
Identification of novel CDH23 heterozygous variants causing autosomal recessive nonsyndromic hearing loss
Hearing loss adversely impacts language development, acquisition, and the social and cognitive maturation of affected chil...
Digital insights into Pseudomonas aeruginosa PBH03: in-silico analysis for genomic toolbox and unraveling cues for heavy metal bioremediation
Digital insights into Pseudomonas aeruginosa PBH03: in-silico analysis for genomic toolbox and unraveling cues for heavy metal bioremediation
The genomes of publicly available electroactive Pseudomonas aeruginosa strains are currently limited to in-silico analyses...
Prognostic and immunological role of LASP2 in clear cell renal cell carcinoma
Prognostic and immunological role of LASP2 in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) represents a common renal carcinoma subtype influenced by the immune microenvironm...
Identification of SNPs associated with fatty acid contents in mutant soybean lines by a genome-wide association study
Identification of SNPs associated with fatty acid contents in mutant soybean lines by a genome-wide association study
Vegetable oils are primarily composed of unsaturated fatty acids. Soybean [Glycine max (L.) Merr.] oil, accounting for 28%...
Baihu Jia Renshen Decoction may improve skeletal muscle and adipose tissue functions of type I diabetic rats by affecting pancreatic β-cell function
Baihu Jia Renshen Decoction may improve skeletal muscle and adipose tissue functions of type I diabetic rats by affecting pancreatic β-cell function
Baihu Jia Renshen Decoction (BJRD) is used for diabetes mellitus (DM) management in clinics. To elucidate the potential me...
Propylparaben-induced endoplasmic reticulum stress triggers G2/M phase cell cycle arrest and initiates caspase-3-dependent apoptosis in human lung cells
Propylparaben-induced endoplasmic reticulum stress triggers G2/M phase cell cycle arrest and initiates caspase-3-dependent apoptosis in human lung cells
Propylparaben (PrP) is commonly used as an antimicrobial agent in food, cosmetics, and pharmaceuticals. While recent studi...
CKAP4 is a potential therapeutic target to overcome resistance to EGFR-TKIs in lung adenocarcinoma
CKAP4 is a potential therapeutic target to overcome resistance to EGFR-TKIs in lung adenocarcinoma
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are standard treatments for non-small cell lung ca...
Dual-specificity phosphatase 23 functions as a promising prognostic biomarker in non-small cell lung cancer
Dual-specificity phosphatase 23 functions as a promising prognostic biomarker in non-small cell lung cancer
The mechanical remodeling of tumor microenvironment is critical for non-small cell lung cancer (NSCLC) progression. Dual-s...
Identification of genetic loci enriched in obese or lean T2D cases in the Korean population
Identification of genetic loci enriched in obese or lean T2D cases in the Korean population
Obesity causes many complex diseases including type 2 diabetes (T2D). Obesity increases the risk of T2D in Europeans, but ...
Extracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis
Extracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis
Metastasis is one of the major challenges in the treatment of colorectal cancer (CRC), during which cancer-associated fibr...
The diverse landscape of RNA modifications in cancer development and progression
The diverse landscape of RNA modifications in cancer development and progression
RNA modifications, a central aspect of epitranscriptomics, add a regulatory layer to gene expression by modifying RNA func...
Expression profiles of TNF-Alpha and HERV-K Env proteins in multiple types of colon and lung disease
Expression profiles of TNF-Alpha and HERV-K Env proteins in multiple types of colon and lung disease
Human endogenous retroviruses (HERVs) were integrated into the human genome millions of years ago and have since prolifera...
The facilitated osteogenic differentiation by extracellular proline treatment in in vitro cell cultivation using MC3T3E1 and hPDLF
The facilitated osteogenic differentiation by extracellular proline treatment in in vitro cell cultivation using MC3T3E1 and hPDLF
Proline is a major substrate in collagen biosynthesis and is required for collagen molecule formations. However, detailed ...
Potential role of ARG1 c.57G > A variant in Argininemia
Potential role of ARG1 c.57G > A variant in Argininemia
Argininemia (OMIM: 207800), as well as arginase deficiency, a disorder of the urea cycle caused by deficiency of arginase ...
miR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells
miR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells
Dry eye disease (DED) is an ocular illness caused by insufficient tear secretion or poor tear quality, and inflammation is...
Population genetics analysis based on mitochondrial cytochrome c oxidase subunit I (CO1) gene sequences of Cottus koreanus in South Korea
Population genetics analysis based on mitochondrial cytochrome c oxidase subunit I (CO1) gene sequences of Cottus koreanus in South Korea
The freshwater sculpin Cottus koreanus is endemic to the Korean Peninsula and has a fluvial life history. However, its pop...
Identification and expression analysis of the SPL gene family during flower bud differentiation in Rhododendron molle
Identification and expression analysis of the SPL gene family during flower bud differentiation in Rhododendron molle
The family of SQUAMOSA promoter binding protein-like (SPL) transcription factors is essential for regulating plant growth ...
A combination of upstream alleles involved in rice heading hastens natural long-day responses
A combination of upstream alleles involved in rice heading hastens natural long-day responses
The female parental line Jinbuol (JBO, early heading) and two recombinant isogenic lines, JSRIL1 and JSRIL2, have been sho...
Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia)
Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia)
In Korea, only Polygala tenuifolia is registered as Polygalae Radix in the pharmacopoeia, while in China, both P. tenuifol...
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis
Darier’s disease (DD) is a skin disorder caused by mutations in the ATP2A2 gene. Researchers have been investigating...
Granzyme mRNA-miRNA interaction and its implication to functional impact
Granzyme mRNA-miRNA interaction and its implication to functional impact
Granzyme activity can affect the processing and stability of miRNAs within target cells. They also could induce changes in...
Enhanced adaptive permutation test with negative binomial distribution in genome-wide omics datasets
Enhanced adaptive permutation test with negative binomial distribution in genome-wide omics datasets
The permutation test has been widely used to provide the p-values of statistical tests when the standard test statistics d...
Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway
Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway
We have previously reported anatomical, histological, and gene expression characteristics of the nodal structure of rat sk...
Striate palmoplantar keratoderma: a novel DSG1 mutation, combined with an LDLR mutation
Striate palmoplantar keratoderma: a novel DSG1 mutation, combined with an LDLR mutation
Palmoplantar keratoderma (PPK) is a heterogeneous group of disorders characterized by abnormal thickening of the skin on t...
Bacterial profile-based body fluid identification using a machine learning approach
Bacterial profile-based body fluid identification using a machine learning approach
Identifying the origins of biological traces is critical for the reconstruction of crime scenes in forensic investigations...
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity
Congenital anomalies of the knee are a spectrum of rare disorders with wide clinical and genetic variability, which are ma...
Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease
Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease
Parkinson’s disease (PD) is a progressive neuro-degenerative disorder most common in older adults which is associate...
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment
Biallelic variants in the CLRN2 gene have been reported to cause autosomal recessive profound hearing impairment in humans...
Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing
Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing
Hepatocellular carcinoma (HCC) is a highly malignant tumor; however, its immune microenvironment and mechanisms remain elu...
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin
Streptococcus agalactiae (S. agalactiae) is a highly pathogenic bacterial pathogen in aquatic animals. Our previous study ...
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