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Inflammasome-independent pyroptosis
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The tumor-driven antibody-mediated immune response in cancer
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Type III interferons in innate and adaptive immunity in the respiratory tract
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Mapping and modelling human B cell maturation in the germinal centre
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Adaptive immune receptor germline gene variation
Adaptive immune receptor germline gene variation
Recognition of antigens by T cell receptors (TCRs) and B cell receptors (BCRs) is a key step in lymphocyte activation. T a...
The antiviral state of the cell: lessons from SARS-CoV-2
The antiviral state of the cell: lessons from SARS-CoV-2
Innate immunity provides a rapid response to viral infections, independent of prior exposure to a specific virus 1•, 2•. I...
Yin and yang of interferons: lessons from the coronavirus disease 2019 (COVID-19) pandemic
Yin and yang of interferons: lessons from the coronavirus disease 2019 (COVID-19) pandemic
Underlying this seemingly restored world, recovering from the spread of severe acute respiratory syndrome coronavirus 2 (S...
In search of a function for human type III interferons: insights from inherited and acquired deficits
In search of a function for human type III interferons: insights from inherited and acquired deficits
Almost 70 years after the discovery of type I interferons (IFNs) in 1957 by Isaacs and Lindenmann 1, 2, and type II IFN in...
Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons
Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons
Volume 87, April 2024, 102425Author links open overlay panel, , Interferons (IFNs) are an integral component of the host i...
Regulation of type I and type III interferon induction in response to pathogen sensing
Regulation of type I and type III interferon induction in response to pathogen sensing
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Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function
Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function
Effective high-affinity, long-term humoral immunity requires T cell help provided by a subset of differentiated CD4+ T cel...
Nutritional modulation of antitumor immunity
Nutritional modulation of antitumor immunity
Immunotherapy regimens include immune checkpoint blockade (e.g. anti-Programmed cell death protein 1/Programmed death-liga...
Structure–function of type I and III interferons
Structure–function of type I and III interferons
The interferons (IFNs) are a family of innate immune cytokines that are central in providing a rapid response to pathogens...
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Interferons (IFNs) are soluble mediators of antiviral defense, with well-defined molecular mechanisms underlying their pro...
Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence
Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence
Professor Elizabeth Hartland is the director and CEO of Hudson Institute of Medical Research and the head of the Departmen...
Differential induction of T-cell tolerance by tumour fibroblast subsets
Differential induction of T-cell tolerance by tumour fibroblast subsets
Many epithelial cancers are still immunotherapy-resistant [1]. A feature common to epithelial cancers is the infiltration ...
Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment
Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment
Tumour necrosis factor (TNF) is a primary mediator of inflammatory processes by facilitating cell death, immune cell activ...
Editorial overview: The march of mucosal vaccines
Editorial overview: The march of mucosal vaccines
Dr. Meritxell Genescà is a senior investigator at the Infectious Diseases Department of the Vall d′Hebron Research Institu...
Differential signaling by type-I and type-III interferons in mucosa
Differential signaling by type-I and type-III interferons in mucosa
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Recent advances in enterotoxin vaccine adjuvants
Recent advances in enterotoxin vaccine adjuvants
Enterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of chol...
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cance...
Animal models of shigellosis: a historical overview
Animal models of shigellosis: a historical overview
Shigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and...
The future of vaccination in Latin America: learning from the COVID-19 pandemic
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Just over 3 years after the start of the COVID-19 pandemic that claimed the lives of millions of people around the world, ...
Challenges and opportunities in the development of mucosal mRNA vaccines
Challenges and opportunities in the development of mucosal mRNA vaccines
mRNA vaccines offer a host of complementary advantages to more traditional vaccine modalities such as DNA, protein/peptide...
The role of interferon in the thymus
The role of interferon in the thymus
Volume 84, October 2023, 102389Author links open overlay panel, Interferons (IFNs) are a family of proteins that are gener...
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
COVID-19 is an inflammatory disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2), whose manifest...
Pharma — manufacturing: the unappreciated and overlooked indispensable skill
Pharma — manufacturing: the unappreciated and overlooked indispensable skill
In 2019, when the Covid-19 pandemic quickly spread throughout the world, mRNA vaccines literally became a global life-save...
Outer membrane vesicle-based intranasal vaccines
Outer membrane vesicle-based intranasal vaccines
Delivery of vaccines via the mucosal route is regarded as the most effective mode of immunization to counteract infectious...
An easy pill to swallow: oral recombinant vaccines for the 21st century
An easy pill to swallow: oral recombinant vaccines for the 21st century
The predominant method of vaccine administration worldwide continues to be intramuscular injection. However, this approach...