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The role of interferon in the thymus
The role of interferon in the thymus
Volume 84, October 2023, 102389Author links open overlay panel, Interferons (IFNs) are a family of proteins that are gener...
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
COVID-19 is an inflammatory disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2), whose manifest...
Pharma — manufacturing: the unappreciated and overlooked indispensable skill
Pharma — manufacturing: the unappreciated and overlooked indispensable skill
In 2019, when the Covid-19 pandemic quickly spread throughout the world, mRNA vaccines literally became a global life-save...
Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
The eradication of polio during the latter half of the 20th century can be considered one of the greatest medical triumphs...
Outer membrane vesicle-based intranasal vaccines
Outer membrane vesicle-based intranasal vaccines
Delivery of vaccines via the mucosal route is regarded as the most effective mode of immunization to counteract infectious...
An easy pill to swallow: oral recombinant vaccines for the 21st century
An easy pill to swallow: oral recombinant vaccines for the 21st century
The predominant method of vaccine administration worldwide continues to be intramuscular injection. However, this approach...
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs) conserved structures express...
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Cell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-i...
Developments in oral enterotoxigenic Escherichia coli vaccines
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in traveler...
Commander-in-chief: monocytes rally the troops for defense against aspergillosis
The burden of fungal infection on human health has risen significantly over the past several decades where in aggregate, t...
Viral-vectored respiratory mucosal vaccine strategies
The respiratory tract is a common portal of entry for pathogens. Respiratory infections represent the third leading cause ...
Tissue-specific macrophage immunometabolism
Macrophages are a highly diverse cell population, capable of displaying phenotypic plasticity and functional variability a...
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection
Volume 84, October 2023, 102366Author links open overlay panel, , In addition to housing the major energy-producing pathwa...
Interleukin-15 cytokine checkpoints in natural killer cell anti-tumor immunity
Volume 84, October 2023, 102364Author links open overlay panel, , Over recent years, the use of immune checkpoint inhibito...
Ubiquitination and cell-autonomous immunity
All organisms evolved strategies to protect themselves from intracellular pathogens. The processes that occur inside an in...
Granulocytes subsets and their divergent functions in host resistance to Mycobacterium tuberculosis — a ‘tipping-point’ model of disease exacerbation
Mycobacterium tuberculosis (Mtb) is the primary cause of tuberculosis (TB), which is one of the leading causes of infectio...
Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria
Macrophages are mononuclear phagocytes that act as tissue-immune sentinels and perform critical homeostatic functions, inc...
Major histocompatibility complex class I assembly within endolysosomal pathways
Cellular immunity mediated via major histocompatibility complex class I (MHC class I) antigen presentation is central to t...
ERBIN and phosphoglucomutase 3 deficiency
Primary atopic disorders — monogenic causes of symptoms associated with the effector mechanisms of type-II immunity and al...
Spatiotemporal and cell-state control of antigen presentation during tolerance and immunity
Adaptive immunity is driven by the clonal expansion of rare antigen-specific lymphocytes. With several hundred million lym...
Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edge
Multicellularity affords metazoans the luxury of sacrificing virus-infected cells by deploying dedicated programmed death ...
Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes
Host innate immune sensors are vital for the initial detection of pathogen infection. Such sensors thus need to constantly...
Nasal vaccines for pertussis
Whooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acell...
Get into the groove! The influence of TAPBPR on cargo selection
Major histocompatibility complex class-I (MHC-I) molecules are expressed in all nucleated cells and present peptide fragme...
Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: waalking the razor's edge
Multicellularity affords metazoans the luxury of sacrificing virus-infected cells by deploying dedicated programmed death ...
Role of mouse dendritic cell subsets in priming naive CD4 T cells
The priming and differentiation of CD4T cells play a central role in adaptive immunity. Upon recognizing the cognate pepti...
Molecular insights into metabolite antigen recognition by mucosal-associated invariant T cells
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T cells that are evolutionarily conserved a...
Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both?
Cross-priming was discovered in the context of in vivo cytotoxic T-cell (CTL) responses in response to minor histocompatib...
Beyond natural biology: rewiring cellular networks to study innate immunity
In the infancy of immunological research over a century ago, many discoveries were derived purely from observation. To und...
PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis
The innate immune response provides the first line of defense against infection and disease. Regulated cell death (RCD) is...
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