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Structure–function of type I and III interferons
Structure–function of type I and III interferons
The interferons (IFNs) are a family of innate immune cytokines that are central in providing a rapid response to pathogens...
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis
Interferons (IFNs) are soluble mediators of antiviral defense, with well-defined molecular mechanisms underlying their pro...
Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence
Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence
Professor Elizabeth Hartland is the director and CEO of Hudson Institute of Medical Research and the head of the Departmen...
Differential induction of T-cell tolerance by tumour fibroblast subsets
Differential induction of T-cell tolerance by tumour fibroblast subsets
Many epithelial cancers are still immunotherapy-resistant [1]. A feature common to epithelial cancers is the infiltration ...
Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment
Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment
Tumour necrosis factor (TNF) is a primary mediator of inflammatory processes by facilitating cell death, immune cell activ...
Editorial overview: The march of mucosal vaccines
Editorial overview: The march of mucosal vaccines
Dr. Meritxell Genescà is a senior investigator at the Infectious Diseases Department of the Vall d′Hebron Research Institu...
Differential signaling by type-I and type-III interferons in mucosa
Differential signaling by type-I and type-III interferons in mucosa
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Recent advances in enterotoxin vaccine adjuvants
Recent advances in enterotoxin vaccine adjuvants
Enterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of chol...
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cance...
Animal models of shigellosis: a historical overview
Animal models of shigellosis: a historical overview
Shigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and...
The future of vaccination in Latin America: learning from the COVID-19 pandemic
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Just over 3 years after the start of the COVID-19 pandemic that claimed the lives of millions of people around the world, ...
Challenges and opportunities in the development of mucosal mRNA vaccines
Challenges and opportunities in the development of mucosal mRNA vaccines
mRNA vaccines offer a host of complementary advantages to more traditional vaccine modalities such as DNA, protein/peptide...
The role of interferon in the thymus
The role of interferon in the thymus
Volume 84, October 2023, 102389Author links open overlay panel, Interferons (IFNs) are a family of proteins that are gener...
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation
COVID-19 is an inflammatory disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2), whose manifest...
Pharma — manufacturing: the unappreciated and overlooked indispensable skill
Pharma — manufacturing: the unappreciated and overlooked indispensable skill
In 2019, when the Covid-19 pandemic quickly spread throughout the world, mRNA vaccines literally became a global life-save...
Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
Lessons learned from the successful polio vaccine experience not learned or applied with the development and implementation of the COVID-19 vaccines
The eradication of polio during the latter half of the 20th century can be considered one of the greatest medical triumphs...
Outer membrane vesicle-based intranasal vaccines
Outer membrane vesicle-based intranasal vaccines
Delivery of vaccines via the mucosal route is regarded as the most effective mode of immunization to counteract infectious...
An easy pill to swallow: oral recombinant vaccines for the 21st century
An easy pill to swallow: oral recombinant vaccines for the 21st century
The predominant method of vaccine administration worldwide continues to be intramuscular injection. However, this approach...
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs) conserved structures express...
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Cell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-i...
Developments in oral enterotoxigenic Escherichia coli vaccines
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in traveler...
Commander-in-chief: monocytes rally the troops for defense against aspergillosis
The burden of fungal infection on human health has risen significantly over the past several decades where in aggregate, t...
Viral-vectored respiratory mucosal vaccine strategies
The respiratory tract is a common portal of entry for pathogens. Respiratory infections represent the third leading cause ...
Tissue-specific macrophage immunometabolism
Macrophages are a highly diverse cell population, capable of displaying phenotypic plasticity and functional variability a...
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection
Volume 84, October 2023, 102366Author links open overlay panel, , In addition to housing the major energy-producing pathwa...
Interleukin-15 cytokine checkpoints in natural killer cell anti-tumor immunity
Volume 84, October 2023, 102364Author links open overlay panel, , Over recent years, the use of immune checkpoint inhibito...
Ubiquitination and cell-autonomous immunity
All organisms evolved strategies to protect themselves from intracellular pathogens. The processes that occur inside an in...
Granulocytes subsets and their divergent functions in host resistance to Mycobacterium tuberculosis — a ‘tipping-point’ model of disease exacerbation
Mycobacterium tuberculosis (Mtb) is the primary cause of tuberculosis (TB), which is one of the leading causes of infectio...
Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria
Macrophages are mononuclear phagocytes that act as tissue-immune sentinels and perform critical homeostatic functions, inc...
Major histocompatibility complex class I assembly within endolysosomal pathways
Cellular immunity mediated via major histocompatibility complex class I (MHC class I) antigen presentation is central to t...
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