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Imaging cytomegalovirus infection and ensuing immune responses
The cytomegaloviruses (CMVs), a genus of members of a beta herpesvirus family, adapted perfectly to their mammalian hosts ...
Determinants of persistent Salmonella infections
Gram-negative Salmonella bacteria are ingested with contaminated food or transmitted via the fecal-oral route. Pathogenic ...
Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation
Despite prophylactic or preemptive pharmacological treatment, cytomegalovirus (CMV) seropositivity and reactivation of rem...
Genome and population dynamics during chronic infection with Helicobacter pylori
Helicobacter pylori is an important bacterial pathogen of humans. It infects more than one half of the human population, u...
αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients
Patients with end-stage organ failure benefit from recent advances in solid organ transplantation (SOT). Immunosuppressive...
T-bethighCD21low B cells: the need to unify our understanding of a distinct B cell population in health and disease
More than 20 years ago, an expansion of a B cell population characterized by the low expression of the complement receptor...
Innate immune activation and modulatory factors of Helicobacter pylori towards phagocytic and nonphagocytic cells
Volume 82, June 2023, 102301Author links open overlay panel, , , Helicobacter pylori is an intriguing obligate host-associ...
Editorial overview: Innate immunity – 2023: Just in time defense
John Hiscott, Ph.D. is Professor and Director of the Pasteur Laboratories, Istituto Pasteur-Fondazione Cenci Bolognetti in...
Bystander activation in memory and antigen-inexperienced memory-like CD8 T cells
KeywordsMemory T cellsCD8+ T cellsbystander responseantigen-inexperienced memory-like T cellsinnate-like lymphocytesIFNγNK...
Making sense of plasma cell heterogeneity
Upon encounter with their cognate antigen, B cells become activated, proliferate, undergo immunoglobulin class switch reco...
T-helper-2 cells and atopic disease: lessons learnt from inborn errors of immunity
In the Western world, allergic and atopic diseases such as atopic dermatitis, food and environmental allergies, allergic r...
Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity
Inborn errors of immunity (IEI) delineate redundant and essential defense mechanisms in humans. We review 15 autosomal-dom...
Recent insights into the mechanisms of anaphylaxis
Anaphylaxis is an acute life-threatening systemic allergic reaction that can have a wide range of clinical manifestations,...
Editorial overview: Autoimmunity 2022
Mariana Kaplan, M.D., is Senior Investigator and Chief of the Systemic Autoimmunity Branch as well as Deputy Scientific Di...
Cytokine-mediated STAT-dependent pathways underpinning human B-cell differentiation and function
B cells arise from pluripotent stem cells via iterative steps occurring in the bone marrow during B-cell development. This...
Nr4a nuclear receptors: markers and modulators of antigen receptor signaling
Nr4a1–3 encode a small family of orphan nuclear hormone receptors with transcriptional activity. Their expression reflects...
T-cell–B-cell collaboration in the lung
Collaboration between T and B cells in secondary lymphoid organs is a crucial component of adaptive immunity, but lymphocy...
Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines
Nonreplicating adenovirus-based vectors have been successfully implemented as prophylactic vaccines against infectious vir...
Immune checkpoint receptors in autoimmunity
Signaling through the T-cell receptor (TCR) drives multiple downstream processes, including T-cell activation, differentia...
Functional heterogeneity in the memory B-cell response
Volume 80, February 2023, 102281Author links open overlay panelMost vaccines induce robust antibody and memory B-cell (MBC...
Type-1 interferon-dependent and -independent mechanisms in cyclic GMP–AMP synthase–stimulator of interferon genes-driven auto-inflammation
Volume 80, February 2023, 102280Author links open overlay panelThe cyclic cyclic gaunosine monophosphate adenosine monopho...
Lung tissue-resident memory T cells: the gatekeeper to respiratory viral (re)-infection
Respiratory viral infections are a leading cause of mortality, causing an estimated two million deaths per year [1]. Respi...
Editorial overview: Special section on immune responses to chronic infections
Rosemary Rochford, PhD is a Professor of Immunology and Microbiology at the University of Colorado at the Anschutz Medical...
HyperIgE in hypomorphic recombination-activating gene defects
Volume 80, February 2023, 102279Author links open overlay panelHighlights•Hypomorphic RAG mutations cause a spectrum of cl...
Insights into the pathogenesis of allergic disease from dedicator of cytokinesis 8 deficiency
Volume 80, February 2023, 102277Author links open overlay panelClinical observations and mechanistic studies in dedicator ...
Editorial overview: Vaccines
Rino Rappuoli is Chief Scientist and Head External R&D at GSK Vaccines, based in Siena, Italy, and Professor at Imperi...
Innate antiviral immunity and immunometabolism in hepatocytes
The human liver mediates whole-body metabolism, systemic inflammation and responses to hepatotropic pathogens. Hepatocytes...
The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention
Autoimmunity can be considered as the presence of self-reactive adaptive immune components, and autoimmune diseases can be...
Evolving concepts of host–pathobiont interactions in autoimmunity
Volume 80, February 2023, 102265Author links open overlay panelAutoimmune diseases are complex, multifactorial diseases wi...
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite
Upon activation by a virus or bacteria or their products, macrophages and other immune cells undergo dramatic metabolic ch...
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