SCI时时刷

search
The value of vaccines
Volume 78, October 2022, 102243Optimizing vaccine spending depends on recognizing the full value of vaccination (VoV). Exi...
Immunometabolic alterations in lupus: where do they come from and where do we go from there?
Volume 78, October 2022, 102245Highlights•Immunometabolism dysregulations in lupus have multifactorial origins.•Contributi...
Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus
Available online 14 September 2022, 102252Highlights•SARS-CoV-2 and influenza A virus dysregulate human innate immune resp...
Classical- and bioconjugate vaccines: comparison of the structural properties and immunological response
Volume 78, October 2022, 102235Highlights•Chemical conjugates are obtained by covalent coupling of polysaccharide to carri...
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine design
Volume 78, October 2022, 102234Highlights•Vaccine development during the COVID-19 pandemic lacked thorough insight of CoPs...
Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations
Volume 77, August 2022, 102233Highlights•Various types of T cells infiltrate the brains and cerebrospinal fluid of patient...
Adaptive immune responses to Kaposi’s sarcoma-associated herpesvirus
Volume 77, August 2022, 102230Highlights•T cell responses to KSHV are diverse and weak compared to other herpesviruses.•CD...
Harnessing IgG Fc glycosylation for clinical benefit
Volume 77, August 2022, 102231Highlights•IgG-mediated activities are regulated by IgG subclass, Fc glycosylation, and Type...
Immune responses to Toxoplasma gondii
Volume 77, August 2022, 102226Highlights•Toxoplasma gondii evokes a strong innate and adaptive immune response in the host...
Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease
Isaac M Chiu is an Associate Professor of Immunology in the Blavatnik Institute and Department of Immunology at Harvard Me...
Resolving adjuvant mode of action to enhance vaccine efficacy
Volume 77, August 2022, 102229Highlights•Adjuvants can be incorporated into vaccines to enhance the magnitude, functionali...
Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces
Volume 77, August 2022, 102227Highlights•Atypical B cells (ABCs) are expanded in malaria and autoimmune diseases..•ABCs ar...
Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
Volume 77, August 2022, 102228Highlights•Post-acute sequelae of SARS-CoV-2 (PASC) are associated with persistent inflammat...
New insights and approaches for analyses of immunopeptidomes
Volume 77, August 2022, 102216Human leucocyte antigen (HLA) molecules play a key role in health and disease by presenting ...
Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide loading of MHC molecules
Volume 77, August 2022, 102218Highlights•The genomic organisation of the MHC varies enormously across jawed vertebrates.•T...
Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells
Volume 77, August 2022, 102217Highlights•Thymoproteasomes and immunoproteasomes contribute to the development of CD8+ T ce...
Messenger ribonucleic acid vaccines against infectious diseases: current concepts and future prospects
Volume 77, August 2022, 102214Highlights•Decades of progress have led to safe, immunogenic, and efficacious mRNA vaccines....
Bioinspired vaccines to enhance MHC class-I antigen cross-presentation
Volume 77, August 2022, 102215Highlights•Cross-presentation is important for cellular immunity against pathogens and cance...
Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants
Volume 77, August 2022, 102189Highlights•Studies suggest adjuvants could induce epigenetic reprogramming of myeloid cells....
Neuroimmune crosstalk in the skin: a delicate balance governing inflammatory processes
Volume 77, August 2022, 102212Highlights•The skin is rich in immune cells and somatosensory nerve endings.•Primary sensory...
Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty
Volume 77, August 2022, 102211Tissue-resident memory T cells (TRM) represent a subset of antigen-experienced T cells that ...
Viral vector vaccines
Volume 77, August 2022, 102210Highlights•The safety of adenoviral vector vaccines is now well-established•Viral vector vac...
Principles and practical applications of structure-based vaccine design
Volume 77, August 2022, 102209Highlights•Summary of the basic principles of structure-based vaccine design.•Review of rece...
Mast cell–neuron axis in allergy
Volume 77, August 2022, 102213The peripheral nervous system and the immune system are virtually distributed in all organs ...
Trained immunity: implications for vaccination
Volume 77, August 2022, 102190Highlights•Trained immunity is induced in a variety of innate immune cell types.•Central and...
Epigenetic adjuvants: durable reprogramming of the innate immune systemsy with adjuvants
Volume 77, August 2022, 102189Highlights•Studies suggest adjuvants could induce epigenetic reprogramming of myeloid cells....
Immunological insights in the treatment of chronic hepatitis B
Volume 77, August 2022, 102207Highlights•Reducing HBV antigen levels per se may not restore virus-specific T-cell response...
The vicious cycle governing the brain–immune system relationship in neurodegenerative diseases
Volume 76, June 2022, 102182Highlights•The brain's privilege does not imply immune isolation, but rather, a unique mode of...
T cell immunity to cytomegalovirus infection
Volume 77, August 2022, 102185T cell responses are critical for controlling cytomegalovirus (CMV) infection. However, CMV ...