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Evolutionary Changes in Pathology and Our Understanding of Disease
Evolutionary Changes in Pathology and Our Understanding of Disease
The history of pathology involves human dissections, autopsies, microscopy, as well as the development of histopathologica...
A Comparison of Tissue Dissection Techniques for Diagnostic, Prognostic, and Theragnostic Analysis of Human Disease
A Comparison of Tissue Dissection Techniques for Diagnostic, Prognostic, and Theragnostic Analysis of Human Disease
Histopathology has historically been the critical technique for the diagnosis and treatment of human disease. Today, genom...
Tissue Fixation with a Formic Acid-Deprived Formalin Better Preserves DNA Integrity over Time
Tissue Fixation with a Formic Acid-Deprived Formalin Better Preserves DNA Integrity over Time
<b><i>Introduction:</i></b> Optimization of pre-analytic procedures and tissue processing is a bas...
PKCι Is a Promising Prognosis Biomarker and Therapeutic Target for Pancreatic Cancer
PKCι Is a Promising Prognosis Biomarker and Therapeutic Target for Pancreatic Cancer
<b><i>Background:</i></b> As the highest prevalent pancreatic cancer, pancreatic ductal adenocarci...
Assessment of Predictive Biomarkers in Breast Cancer: Challenges and Updates
Assessment of Predictive Biomarkers in Breast Cancer: Challenges and Updates
The management of patients with breast cancer (BC) relies on the assessment of a defined set of well-established prognosti...
Characterization of the Immune Microenvironment in Inflammatory Breast Cancer Using Multiplex Immunofluorescence
Characterization of the Immune Microenvironment in Inflammatory Breast Cancer Using Multiplex Immunofluorescence
<b><i>Introduction:</i></b> Inflammatory breast cancer (IBC) is an aggressive form of breast cance...
DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis
DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis
<b><i>Introduction:</i></b> Studies on pancreatic neuroendocrine tumors (PanNETs) regarding loss o...
Sustained Inflammation of Breast Tumors after Needle Biopsy
Sustained Inflammation of Breast Tumors after Needle Biopsy
<b><i>Introduction:</i></b> Needle biopsy is essential for definitive diagnosis of breast malignan...
Receptor Status after Neoadjuvant Therapy of Breast Cancer: Significance and Implications
Receptor Status after Neoadjuvant Therapy of Breast Cancer: Significance and Implications
Neoadjuvant chemotherapy (NACT) is now established in routine management of early breast cancer. Alterations in oestrogen ...
Protocadherin B9 Is Associated with Tumorigenesis and Cancer Progression in Colorectal Cancer
Protocadherin B9 Is Associated with Tumorigenesis and Cancer Progression in Colorectal Cancer
<b><i>Background:</i></b> Genes encoding transmembrane proteins expressed specifically in cancer c...
Aurora Kinase A Is an Independent Predictor of Invasive Recurrence in Breast Ductal Carcinoma in situ
Aurora Kinase A Is an Independent Predictor of Invasive Recurrence in Breast Ductal Carcinoma in situ
<b><i>Introduction:</i></b> Aurora Kinase A (AURKA/STK15) has a role in centrosome duplication and...
Molecularly Confirmed Female Donor-Transmitted Lobular Breast Cancer to Male following Renal Transplantation
Molecularly Confirmed Female Donor-Transmitted Lobular Breast Cancer to Male following Renal Transplantation
<b><i>Introduction:</i></b> Lobular breast cancer represents 10%–15% of breast cancers in women bu...
Unusual Patterns of HER2 Expression in Breast Cancer: Insights and Perspectives
Unusual Patterns of HER2 Expression in Breast Cancer: Insights and Perspectives
The biomarker human epidermal growth factor receptor-2 (HER2) has represented the best example of successful targeted ther...
Trophoblast Cell Surface Antigen 2 Expression in Human Tumors: A Tissue Microarray Study on 18,563 Tumors
Trophoblast Cell Surface Antigen 2 Expression in Human Tumors: A Tissue Microarray Study on 18,563 Tumors
<b><i>Introduction:</i></b> Trophoblast cell surface antigen 2 (TROP2) is the target of sacituzuma...
Quality Issues in Diagnostic Immunohistochemistry in Breast Pathology
Quality Issues in Diagnostic Immunohistochemistry in Breast Pathology
Immunohistochemistry techniques have been incorporated into surgical pathology for nearly a half-century and have since be...
Protocadherin B9 Is Associated with Human Esophageal Squamous Cell Carcinoma Progression
Protocadherin B9 Is Associated with Human Esophageal Squamous Cell Carcinoma Progression
<b><i>Introduction:</i></b> Esophageal cancer is the sixth leading cause of cancer-related death w...
Immunohistochemistry Applied to Breast Cytological Material
Immunohistochemistry Applied to Breast Cytological Material
Fine-needle aspiration biopsies (FNABs) of the breast are minimally invasive procedures enabling the diagnosis of suspicio...