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DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae
Genome sequencing of model organisms, including the yeast S. cerevisiae [1] and the annotation of all the open-reading fra...
Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability
In the baker’s yeast Saccharomyces cerevisiae, NuA4 and SWR1-C, two multisubunit complexes, are involved in histone acetyl...
The DHX9 helicase interacts with human DNA Polymerase δ4 and stimulates its activity in D-loop extension synthesis
The replication of the genome by exquisitely accurate DNA polymerases is critical for the maintenance of genomic stability...
The nucleotide excision repair proteins through the lens of molecular dynamics simulations
DNA repair-related diseases, such as xeroderma pigmentosum (XP), trichothiodystrophy (TTD), Cockayne syndrome (CS), Cerebr...
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis
BRC is a signature motif and defining element of the BRCA2 family of proteins. After the gene for human BRCA2, the foundin...
CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε
Faithful replication of genomic DNA is essential for maintaining genomic stability. The high fidelity of eukaryotic replic...
A bibliometric analysis of research on R-loop: landscapes, highlights and trending topics
R-loop is a necessary intermediate in specific cellular processes. To profile the landscapes, highlights, and trending top...
Saccharomyces cerevisiae apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links
Genomic DNA in all organisms is constantly threatened by different kinds of endogenous and exogenous agents, yielding a va...
Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression
In the face of daily damage to DNA, the ability of mammalian cells to maintain a stable genome is dependent on the functio...
Biochemical Characterization and Mutational Studies of Endonuclease Q from the Hyperthermophilic Euryarchaeon Thermococcus gammatolerans
As a stable double-strand molecule harboring genetic information, DNA is always damaged by endogenously physiological cond...
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria
Cyanobacteria are the most primitive photosynthetic oxygen evolving prokaryotes that are ubiquitously found in nature [1]....
Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast
Available online 29 March 2023, 103489Author links open overlay panel, , , , , AbstractTranscription in Saccharomyces cere...
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae
Available online 30 March 2023, 103488Author links open overlay panel, ABSTRACTThe genome must be monitored to ensure its ...
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols
Genomic DNA is susceptible to damage by endogenous and exogenous factors. Multiple DNA repair systems have evolved to prot...
Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi
Across Latin America, an estimated 6 million people suffer from Chagas disease (CD), a chronic debilitating illness that h...
A novel role for Mms2 in the control of spontaneous mutagenesis and Pol3 abundance
Mms2 is a ubiquitin E2-variant protein with a very well-documented function in the tolerance pathway that protects both hu...
Ionic Strength Modulates Excision of Uracil by SMUG1 from Nucleosome Core Particles
The ionic environment of the eukaryotic cell is dynamic and can broadly affect cellular processes. Fluctuations in ionic s...
DNA damage-induced stalling of transcription drives aging through gene expression imbalance
Available online 9 March 2023, 103483Author links open overlay panel, AbstractAge-related changes in gene expression have ...
Urinary 8-hydroxy-2’-deoxyguanosine Levels are Elevated in Patients With IDH1-wildtype Glioblastoma and are Associated With Tumor Recurrence in Gliomas
Glial tumors also known as gliomas, are the most widespread form of central nervous system (CNS) neoplasm [1], [2]. In acc...
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains
The BRCA1 C-terminal (BRCT) domain is an interaction module that allows the host protein to bind to various biological sub...
Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing
E. coli has been a model organism for genetic analysis for many decades [1], and it is still widely used to gain insights ...
Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility
Base excision repair (BER) is an evolutionarily conserved DNA repair pathway that is essential for the repair and resoluti...
The Dual Role of DNA Repair Protein MGMT in Cancer Prevention and Treatment
Genome stability is affected by environmental, endogenous, and inherited factors. DNA alkylating agents are genotoxic chem...
A Homogeneous Fluorescence Assay for Rapid and Sensitive Quantification of the Global Level of Abasic Sites in Genomic DNA
Intact DNA sequences can be efficiently amplified and detected by using polymerase chain reaction (PCR) technology, even o...
Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways
Cancer is one of the leading healthcare burdens with nearly 10 million deaths occurred globally in 2020 [1]. The number of...
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction
Genomic DNA in the live cell constantly undergoes various molecular lesions due to endogenous and exogenous factors [1]. T...
UV light-induced dual promoter mutations dismantle the telomeric guardrails in melanoma
Available online 30 December 2022, 103446Author links open overlay panelAbstractUnderstanding how benign nevi can progress...
Kinome-wide Screening Uncovers A Role for Bromodomain Protein 3 in DNA Double-stranded Break Repair
Most living organisms have evolved at least two discrete mechanisms to repair DNA double-stranded breaks (DSBs): homology ...
Replication stress drives chromosomal instability in fibroblasts of childhood cancer survivors with second primary neoplasms
Most sporadic cancers arising in early childhood are of unknown etiology and represent devastating diagnoses. Encouragingl...
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”
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