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DNA repair deficiencies and neurodegeneration
DNA repair deficiencies and neurodegeneration
Neurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer’s Disease i...
Genomic stress and impaired DNA repair in Alzheimer disease
Genomic stress and impaired DNA repair in Alzheimer disease
Alzheimer disease (AD) was first described in 1906 by German psychiatrist and neuroanatomist Dr. Alois Alzheimer [1]. In t...
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
Volume 138, June 2024, 103677Author links open overlay panelJing Ge a, Le P. Ngo a, Simran Kaushal a, Ian J. Tay a, Elina ...
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans
Preserving the integrity of the genome is crucial for the proper functioning and survival of the cell [1]. The structural ...
Deletions initiated by the vaccinia virus TopIB protein in yeast
Deletions initiated by the vaccinia virus TopIB protein in yeast
The processes of transcription and replication require the separation of complementary DNA strands to allow the correspond...
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking
Cells survive exposure to various external genotoxic factors, such as UV light or environmental toxins due to a set of DNA...
What are the DNA lesions underlying formaldehyde toxicity?
What are the DNA lesions underlying formaldehyde toxicity?
The simplest and most reactive naturally occurring aldehyde is formaldehyde (CH2O). It has been known since the 1940’s tha...
Mitochondrial Transcription Factor A (TFAM) Has 5'-Deoxyribose Phosphate Lyase Activity in Vitro
Mitochondrial Transcription Factor A (TFAM) Has 5'-Deoxyribose Phosphate Lyase Activity in Vitro
Human mitochondrial DNA (mtDNA) is a circular DNA molecule with 16,569 base pairs. mtDNA encodes a set of RNAs and essenti...
Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine
Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine
Chain-terminating nucleotide/nucleoside analogs (CTNAs) have been used successfully as antiviral and anti-cancer drugs [1]...
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity
DNA Repair-related photosensitivity syndromes are heterogeneous heritable skin diseases characterized by photosensitivity ...
A-T neurodegeneration and DNA damage-induced transcriptional stress
A-T neurodegeneration and DNA damage-induced transcriptional stress
The DNA damage response is initiated by Phosphoinositide 3-Kinase-Related Kinases (PIKKs) ATR (ATM- and Rad3-Related), DNA...
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
The preservation of genome integrity is essential for cell homeostasis. It is determined not only by accurate DNA replicat...
RNF4 prevents genomic instability caused by chronic DNA under-replication
RNF4 prevents genomic instability caused by chronic DNA under-replication
Eukaryotic genome stability is maintained by a complex and diverse set of molecular processes. One class of enzymes that p...
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site
RAD51C is a tumor suppressor important during the homologous recombination (HR) DNA repair pathway [1]. HR is a high-fidel...
DNA Polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA Polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
Kunkel Thomas A.: Writing – review & editing, Resources, Funding acquisition. Pedersen Lars C.: Writing – review &...
Microglial inflammation in genome instability: a neurodegenerative perspective
Microglial inflammation in genome instability: a neurodegenerative perspective
The maintenance of genome stability is crucial for cell homeostasis and tissue integrity. Numerous human neuropathologies ...
“Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory”
“Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory”
KeywordsDNA damagealkyladenine DNA glycosylasegene expressionneurodevelopmentbehaviorData availabilityThe RNA sequencing d...
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress
KeywordsDNA damage responseSuper-resolution GSDIM microscopyDDR foci characteristicsNanostructure of DDR fociγ-irradiation...
Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1
Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1
When proteins are properly purified, experimental results hold the distinct advantage of directly observing protein behavi...
Chromosomal single-strand break repair and neurological disease: implications on transcription and emerging genomic tools
Chromosomal single-strand break repair and neurological disease: implications on transcription and emerging genomic tools
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Corrigendum to “Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J” [DNA Repair 9 (2010) 1170-1175]
Corrigendum to “Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J” [DNA Repair 9 (2010) 1170-1175]
Volume 134, February 2024, 103631Author links open overlay panelWooi Loon Ng a, Dan Yan a, Xiangming Zhang a, Yin-Yuan Mo ...
Catalytic activity of OGG1 is impaired by Zinc deficiency
Catalytic activity of OGG1 is impaired by Zinc deficiency
Reactive oxygen species (ROS) generated by exogenous agents and endogenous cellular processes contribute to DNA base modif...
Ku80 is indispensable for repairing DNA double-strand breaks at highly methylated sites in human HCT116 cells
Ku80 is indispensable for repairing DNA double-strand breaks at highly methylated sites in human HCT116 cells
In eukaryotic cells, the nucleus DNA is folded into high-dimensional structures, which determines spatial interaction betw...
DONSON: Slding in 2 the limelight.
DONSON: Slding in 2 the limelight.
For over a decade, it has been known that yeast Sld2, Dpb11, GINS and Polε form the pre-loading complex (pre-LC), which is...
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process
Reactive oxygen species (ROS) are a major threat to genomic integrity and believed to be one of the etiologies of cancers....
Cutting Edge Perspectives in Genome Maintenance X
Cutting Edge Perspectives in Genome Maintenance X
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways
The demand for direct observation of biomolecular interactions provides new insights into the molecular mechanisms underly...
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
Available online 13 December 2023, 103613Author links open overlay panel, , AbstractRAD51 recombinase plays a central role...
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an att...
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
DNA is considered a major target for ionizing radiation (IR)-based therapies [1], [2], [3]. Exposure of cells to IR has lo...
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