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Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir
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Mechanisms and Regulation of Replication Fork Reversal
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Regulation, Functional Impact, and Therapeutic Targeting of APOBEC3A in Cancer
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Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.
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DSB-induced oxidative stress: Uncovering crosstalk between DNA damage response and cellular metabolism
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Protein-Protein Interactions in the core Nucleotide Excision Repair pathway
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DNA-PK: a synopsis beyond synapsis.
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Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases
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PARticular MARks: Histone ADP-ribosylation and the DNA damage response
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Mediator complex in transcription regulation and DNA repair: relevance for human diseases
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Replication initiation sites and zones in the mammalian genome: where are they located and how are they defined?
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Methylation and hydroxymethylation of cytosine alter efficiency of activity and fidelity of translesion DNA polymerases
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New facets in the chromatin-based regulation of genome maintenance
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KBM-mediated interactions with KU80 Promote Cellular Resistance to DNA Replication Stress in CHO cells
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Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis
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FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair
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Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity
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Broken Strands, Broken Minds: Exploring the Nexus of DNA Damage and Neurodegeneration
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The roles of TonEBP in the DNA damage response: from DNA damage bypass to R-loop resolution
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Exploring factors influencing choice of DNA double-strand break repair pathways
Exploring factors influencing choice of DNA double-strand break repair pathways
Eukaryotic cells repair DNA double-stranded breaks (DSBs) through two primary pathways: end-joining or resection-mediated ...
The dynamics and Regulation of PARP1 and PARP2 in response to DNA damage and during replication
The dynamics and Regulation of PARP1 and PARP2 in response to DNA damage and during replication
PARP1 and PARP2 are early responders to DNA strand breaks. They belong to the ADP-ribosyl transferase diphtheria toxin-lik...
The mutagenic consequences of defective DNA repair
The mutagenic consequences of defective DNA repair
Available online 18 May 2024, 103694Author links open overlay panel, Highlights•Defective DNA repair elevates the rates of...
Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations
Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations
DNA damage has the potential to alter many essential cellular processes through blocked or error-prone replication and tra...
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
Cellular metabolism contributes to the production of reactive nitrogen intermediates (RNI), and reactive oxygen species (R...
The role of rRNA in maintaining genome stability
The role of rRNA in maintaining genome stability
Over the past few decades, unbiased approaches such as genetic screening and protein affinity purification have unveiled n...
Cdc48/p97 segregase: spotlight on DNA-protein crosslinks
Cdc48/p97 segregase: spotlight on DNA-protein crosslinks
The ATP-dependent molecular chaperone Cdc48 (in yeast) and its human counterpart p97 (also known as VCP), are essential fo...
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
Radiotherapy is one of the key treatment modalities for cancer, responsible for ~ 50% of cancer cures. DNA damage response...
Pold4 Subunit of Replicative Polymerase δ Promotes Fork Slowing at Broken Templates
Pold4 Subunit of Replicative Polymerase δ Promotes Fork Slowing at Broken Templates
The polymerase δ (Polδ) is a critical enzyme responsible for synthesizing nascent DNA strands in the eukaryotic genome [1]...
NEIL3: a unique DNA glycosylase involved in interstrand DNA crosslink repair
NEIL3: a unique DNA glycosylase involved in interstrand DNA crosslink repair
Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to ...
DNA repair deficiencies and neurodegeneration
DNA repair deficiencies and neurodegeneration
Neurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer’s Disease i...
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