SCI时时刷

search
Cutting-edge Perspectives in Genome Maintenance IX]
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Double-strand break repair and mis-repair in 3D
Available online 17 November 2022, 103430ABSTRACTDNA double-strand breaks (DSBs) are lesions that arise frequently from ex...
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate
Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are DNA-dependent poly(ADP-ribose)transferases localized in nucleus. They ...
Partial Deletions of the Autoregulatory C-Terminal Domain of Artemis and Their Effect on Its Nuclease Activity
Artemis is a 692 aa nuclease that is essential for opening hairpins during vertebrate V(D)J recombination. Artemis is also...
A moving target for drug discovery: structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein.
BRCA-ness phenotype, a signature of many breast and ovarian cancers, manifests as deficiency in homologous recombination, ...
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A
Uracil DNA glycosylase (UDG) can excise uracil from DNA, thus playing an essential role in counteracting mutations. The ge...
Cellular regulation and stability of DNA replication forks in eukaryotic cells
Genomic DNA in yeast and human cells harbors approximately 2,000 and a few million DNA replication barriers, respectively....
Transgenic Mice Harboring Direct Repeat Substrates Reveal Key Underlying Causes of Homologous Recombination in vivo
Homology directed repair is a critical process for maintaining the genome of mammalian cells. While considered to be relat...
THE DNA DAMAGE INDUCED IMMUNE RESPONSE: IMPLICATIONS FOR CANCER THERAPY
Genomic instability is a hallmark of tumourigenesis, influencing tumour development and progression. In particular, defect...
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice
Available online 3 October 2022, 103410Highlights•SMUG1 modulates fat metabolism in mice•SMUG1- knockout mice develop a fa...
Genome integrity and inflammation in the nervous system
Preservation of genomic integrity is crucial for nervous system development and function. DNA repair deficiency results in...
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability
Histone Post-Translational Modifications (PTMs) play fundamental roles in mediating DNA-related processes such as transcri...
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair
Volume 119, November 2022, 103405Highlights•During DNA mismatch repair (MMR), Msh2-Msh6 recruits Mlh1-Pms1 to DNA.•Mlh1, b...
Variation in G-quadruplex Sequence and Topology Differentially Impacts Human DNA Polymerase Fidelity
G-quadruplexes (G4s), a type of non-B DNA, play important roles in a wide range of molecular processes, including replicat...
MutS recognition of mismatches within primed DNA replication intermediates
Available online 6 September 2022, 103392Highlights•MutS interacts with primed replication DNA structures.•MutS adopts a m...
O-GlcNAc transferase is important for homology-directed repair
Available online 6 September 2022, 103394Highlights•O-GlcNAc transferase (OGT) is important for homology-directed repair (...
A DNA Replication Fork-centric View of the Budding Yeast DNA Damage Response
Available online 30 August 2022, 103393Highlights•Stalled DNA replication forks trigger activation of the DDR checkpoint•T...
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus
Available online 27 August 2022, 103390HIGHLIGHTS•Staphylococcus aureus Nfo protein (SaNfo) is a highly efficient AP endon...
Tyrosyl-DNA phosphodiesterase 1 excises the 3′-DNA-ALKBH1 cross-link and its application for 3′-DNA-ALKBH1 cross-link characterization by LC-MS/MS
Available online 27 August 2022, 103391Highlights•The 3′-PUA-ALKBH1 cross-link is unstable but long-lived.•ALKBH1 cross-li...
Review of DNA repair enzymes in bacteria: with a major focus on AddAB and RecBCD
Available online 24 August 2022, 103389AbstractDNA recombination repair systems are essential for organisms to maintain ge...
From fluorescent foci to sequence: illuminating DNA double strand break repair by high-throughput sequencing technologies
Available online 19 August 2022, 103388Highlights•According to the guidelines of Elsevier, this is only required for full ...
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery
Available online 18 August 2022, 103387Highlights•DNA is packaged in nucleosomes consisting of four histones proteins incl...
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development
Available online 4 August 2022, 103386AbstractSpermatogenesis is a complex developmental process. During this process, mal...
Replication dependent and independent mechanisms of GAA repeat instability
Available online 3 August 2022, 103385Highlights•Large expansions of (GAA)n repeats in the first intron of the FXN gene ca...
Roles of phosphatases in eukaryotic DNA replication initiation control
Available online 1 August 2022, 103384Highlights•How do protein phosphatases contribute to DNA replication control?•Phosph...
Unpaved roads: How the DNA damage response navigates endogenous genotoxins
Available online 2 August 2022, 103383Highlights•We highlight prominent sources of endogenous DNA damage and their mechani...
The fast-growing business of Serine ADP-ribosylation
Available online 29 July 2022, 103382Highlights•Serine-ADPr is a widespread PTM in DNA damage, synthesized by the HPF1/PAR...
To indel or not to indel: factors influencing mutagenesis during chromosomal break end joining
Available online 30 July 2022, 103380HIGHLIGHTS•DNA double-strand break (DSB) end joining can cause insertions/deletions (...
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase
Available online 26 July 2022, 103381Highlights•Murine FAM72A is relocalized to nuclei by the UNG2 isoform of uracil-DNA g...